Dr Ramin Mostofi Zadeh Farahani

DDS, PhD
Lecturer, Department of Life Sciences

C24 - Westmead Hospital
The University of Sydney

Telephone +61 2 98458764

Biographical details

Dr Ramin Farahani is a Lecturer at the Faculty of Dentistry who conducts research on molecular biology of neurosensory systems. Dr Farahani’s research uncovered evidence of neurosensory structure within human dental pulp, similar to that seen in other neurosensory systems (e.g. olfactory tissues, retina, brain). Novel glial cells were discovered in human dental pulp with molecular fingerprints of CNS glial cells and a specialized microcirculation similar to the blood-brain barrier. Aside from evolutionary implications relating to the origin of teeth, these results may have important clinical relevance for dental caries treatment and the understanding of dental pain. Additionally his work has uncovered a novel angiogenic response restricted to neural structures orchestrated by glial elements (called testitudinal angiogenesis).

Research interests

Dr Farahani’s current research is focused on molecular mechanisms underpinning the adaptive capacity of neurosensory systems with particular emphasis on the role of non-coding DNA and microRNAs. To approach the problem, a combined evo-devo (evolutionary developmental biology) is applied in various neurosensory structures. This approach involves the study of odontoblasts as mechanosensory cells combined with mouse olfactory system for experimental purposes. In parallel, developing mouse brain is used to uncover basic aspects of adaptation and roles played by non-coding DNA in this process. He is also conducting studies to revisit pulpal pain in pulpitis models with particular emphasis on modulation of signal/noise detection capacity of odontoblasts and the role played by glial cells at a cellular level and by microRNAs at a molecular level. Other research includes the study of testitudinal angiogenesis in murine brain tissue with a view to using combined developmental and pathological approaches to better understand the processes involved in normal brain development and in pathological conditions such as stroke. Dr Farahani collaborates with Dr Manish Arora on studies documenting the archival nature of dentine, and with Dr Stephen Cox on the role of angiogenesis in excessive scar-formation associated with submucous fibrosis. In addition, ongoing work with Professor Neil Hunter include studies of the pathogenic and neurosensory processes involved in caries lesions, to better understand the mechanisms underlying the absence of pain and inflammatory response during the development of dental caries.

Keywords

Neurosensory Biology; Non-coding DNA; microRNA; angiogenesis; Anaesthetics

Selected grants

2011

  • Dental pulp microvasculature in reactionary dentinogenesis; Mostofi Zadeh Farahani R, Hunter N; Dental Board of NSW/Research Support.

2010

  • The interaction of odontoblasts and dentric pulp cells in healthy and carious human teeth; Mostofi Zadeh Farahani R, Hunter N; Australian Dental Research Foundation/Research Support.

2009

  • Growth factor expression in reactionary dentinogenesis; Mostofi Zadeh Farahani R, Hunter N; Dental Board of NSW/Research Support.

Selected publications

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Journals

  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Charadram, N., Mostofi Zadeh Farahani, R., Harty, D., Rathsam, C., Swain, M., Hunter, N. (2012). Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone, 50(1), 265-275. [More Information]
  • Harty, D., Mostofi Zadeh Farahani, R., Simonian, M., Hunter, L., Hunter, N. (2012). Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the aC region and cleavage of the N-terminal region of the BB chains of fibrinogen. Thrombosis and Haemostasis, 108(2), 236-246. [More Information]
  • Mostofi Zadeh Farahani, R., Simonian, M., Hunter, N. (2011). Blueprint of an Ancestral Neurosensory Organ Revealed in Glial Networks in Human Dental Pulp. The Journal of Comparative Neurology, 519(16), 3306-3326. [More Information]
  • Lafzi, A., Chitsazi, M., Mostofi Zadeh Farahani, R., Faramarzi, M. (2011). Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession. American Journal of Dentistry, 24(3), 143-147.
  • Mostofi Zadeh Farahani, R., Nguyen, K., Simonian, M., Hunter, N. (2010). Adaptive calcified matrix response of dental pulp to bacterial invasion in associated with establishment of a network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells. The American Journal of Pathology: cellular and molecular biology of disease, 177(4), 1901-1914. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Oskouei, S. (2010). Formocresol versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: Two Year Follow-Up. Journal of Clinical Pediatric Dentistry, 34(4), 317-321.
  • Aminabadi, N., Oskouei, S., Mostofi Zadeh Farahani, R. (2009). Dental Treatment Duration as an Indicator of the Behavior of 3- to 9- Year-old Pediatric Patients in Clinical Dental Settings. The Journal of Contemporary Dental Practice, 10(5), 23-32.
  • Aminabadi, N., Farahani, R., Sohrabi, A., Pouralibaba, F. (2009). Lingual eruption of mandibular permanent incisors: a space correlated phenomenon? The Journal of Contemporary Dental Practice, 10(1), 025-032.
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2009). The Effect of Pre-cooling the Injection Site on Pediatric Pain Perception during the Administration of Local Anesthesia. The Journal of Contemporary Dental Practice, 10(3), 43-50.
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2009). The Efficacy of a Modified Omega Wire Extension for the Treatment of Severely Damaged Primary Anterior Teeth. Journal of Clinical Pediatric Dentistry, 33(4), 283-288.
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). A clinical study of formocresol pulpotomy versus root canal therapy of vital primary incisors. Journal of Clinical Pediatric Dentistry, 32(3), 211-214.
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). Apgar index as a correlate of enamel defects of primary dentition. Oral Health & Preventive Dentistry, 6(4), 331-335.
  • Mostofi Zadeh Farahani, R. (2008). Biological mediators of wound healing: the importance of the big picture. International Wound Journal, 5(3), 414-415. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2008). Breathing aerodynamics and interactions with odontogenesis. Medical Hypotheses, 70(1), 192-193. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2008). Correlation of parenting style and pediatric behaviour guidance stategies in the dental setting: preliminary findings. Acta Odontologica Scandinavica, 66(2), 99-104. [More Information]
  • Naderpour, M., Rad, J., Ayat, E., Mesgari, M., Farahani, R., Roshangar, L., Tubbs, R., Shoja, M. (2008). Dietary L-arginine and cutaneous wound healing. Italian Journal of Anatomy and Embryology, 113(3), 135-142.
  • Zonuz, A., Rahmati, A., Mortazavi, H., Khashabi, E., Mostofi Zadeh Farahani, R. (2008). Effect of cigarette smoke exposure on the growth of Streptococcus sanguis: an in vitro study. Nicotine and Tobacco Research, 10(1), 63-67. [More Information]
  • Mostofi Zadeh Farahani, R. (2008). Endocannabinoid system and wound healing. Journal of Tissue Viability, 17(3), 100-101. [More Information]
  • Mesgarzadah, A., Mostofi Zadeh Farahani, R., Treister, N. (2008). Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer. Journal of Tissue Viability, 17(2), 38-43. [More Information]
  • Mostofi Zadeh Farahani, R., DiPietro, L. (2008). Microgravity and the implications for wound healing. International Wound Journal, 5(4), 552-561. [More Information]
  • Shokouhi, G., Tubbs, R., Shoja, M., Hadidchi, S., Ghorbanihaghjo, A., Roshangar, L., Farahani, R., Mesgari, M., Jerry Oakes, W. (2008). Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury. Child's Nervous System, 24(1), 111-117. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). Study of root canal accessibility in human primary molars. Journal of Oral Science, 50(1), 69-74. [More Information]
  • Mostofi Zadeh Farahani, R., Aminabadi, N., Kloth, L. (2008). Superficial topography of wound: a determinant of underlying biological events? Medical Hypotheses, 70(3), 525-528. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Balayi Gajan, E. (2008). The efficacy of distraction and counterstimulation in the reduction of pain reaction to intraoral injection by pediatric patients. The Journal of Contemporary Dental Practice, 9(6), 33-40.
  • Mostofi Zadeh Farahani, R., Kloth, L. (2008). The hypothesis of 'biophysical matrix contraction': wound contraction revisited. International Wound Journal, 5(3), 477-482. [More Information]
  • Mostofi Zadeh Farahani, R., Marsee, D., Baden, L., Woo, S., Treister, N. (2008). Trigeminal trophic syndrome with features of oral CMV disease. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 106(3), e15-e18. [More Information]

2012

  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Charadram, N., Mostofi Zadeh Farahani, R., Harty, D., Rathsam, C., Swain, M., Hunter, N. (2012). Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone, 50(1), 265-275. [More Information]
  • Harty, D., Mostofi Zadeh Farahani, R., Simonian, M., Hunter, L., Hunter, N. (2012). Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the aC region and cleavage of the N-terminal region of the BB chains of fibrinogen. Thrombosis and Haemostasis, 108(2), 236-246. [More Information]

2011

  • Mostofi Zadeh Farahani, R., Simonian, M., Hunter, N. (2011). Blueprint of an Ancestral Neurosensory Organ Revealed in Glial Networks in Human Dental Pulp. The Journal of Comparative Neurology, 519(16), 3306-3326. [More Information]
  • Lafzi, A., Chitsazi, M., Mostofi Zadeh Farahani, R., Faramarzi, M. (2011). Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession. American Journal of Dentistry, 24(3), 143-147.

2010

  • Mostofi Zadeh Farahani, R., Nguyen, K., Simonian, M., Hunter, N. (2010). Adaptive calcified matrix response of dental pulp to bacterial invasion in associated with establishment of a network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells. The American Journal of Pathology: cellular and molecular biology of disease, 177(4), 1901-1914. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Oskouei, S. (2010). Formocresol versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: Two Year Follow-Up. Journal of Clinical Pediatric Dentistry, 34(4), 317-321.

2009

  • Aminabadi, N., Oskouei, S., Mostofi Zadeh Farahani, R. (2009). Dental Treatment Duration as an Indicator of the Behavior of 3- to 9- Year-old Pediatric Patients in Clinical Dental Settings. The Journal of Contemporary Dental Practice, 10(5), 23-32.
  • Aminabadi, N., Farahani, R., Sohrabi, A., Pouralibaba, F. (2009). Lingual eruption of mandibular permanent incisors: a space correlated phenomenon? The Journal of Contemporary Dental Practice, 10(1), 025-032.
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2009). The Effect of Pre-cooling the Injection Site on Pediatric Pain Perception during the Administration of Local Anesthesia. The Journal of Contemporary Dental Practice, 10(3), 43-50.
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2009). The Efficacy of a Modified Omega Wire Extension for the Treatment of Severely Damaged Primary Anterior Teeth. Journal of Clinical Pediatric Dentistry, 33(4), 283-288.

2008

  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). A clinical study of formocresol pulpotomy versus root canal therapy of vital primary incisors. Journal of Clinical Pediatric Dentistry, 32(3), 211-214.
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). Apgar index as a correlate of enamel defects of primary dentition. Oral Health & Preventive Dentistry, 6(4), 331-335.
  • Mostofi Zadeh Farahani, R. (2008). Biological mediators of wound healing: the importance of the big picture. International Wound Journal, 5(3), 414-415. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2008). Breathing aerodynamics and interactions with odontogenesis. Medical Hypotheses, 70(1), 192-193. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2008). Correlation of parenting style and pediatric behaviour guidance stategies in the dental setting: preliminary findings. Acta Odontologica Scandinavica, 66(2), 99-104. [More Information]
  • Naderpour, M., Rad, J., Ayat, E., Mesgari, M., Farahani, R., Roshangar, L., Tubbs, R., Shoja, M. (2008). Dietary L-arginine and cutaneous wound healing. Italian Journal of Anatomy and Embryology, 113(3), 135-142.
  • Zonuz, A., Rahmati, A., Mortazavi, H., Khashabi, E., Mostofi Zadeh Farahani, R. (2008). Effect of cigarette smoke exposure on the growth of Streptococcus sanguis: an in vitro study. Nicotine and Tobacco Research, 10(1), 63-67. [More Information]
  • Mostofi Zadeh Farahani, R. (2008). Endocannabinoid system and wound healing. Journal of Tissue Viability, 17(3), 100-101. [More Information]
  • Mesgarzadah, A., Mostofi Zadeh Farahani, R., Treister, N. (2008). Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer. Journal of Tissue Viability, 17(2), 38-43. [More Information]
  • Mostofi Zadeh Farahani, R., DiPietro, L. (2008). Microgravity and the implications for wound healing. International Wound Journal, 5(4), 552-561. [More Information]
  • Shokouhi, G., Tubbs, R., Shoja, M., Hadidchi, S., Ghorbanihaghjo, A., Roshangar, L., Farahani, R., Mesgari, M., Jerry Oakes, W. (2008). Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury. Child's Nervous System, 24(1), 111-117. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). Study of root canal accessibility in human primary molars. Journal of Oral Science, 50(1), 69-74. [More Information]
  • Mostofi Zadeh Farahani, R., Aminabadi, N., Kloth, L. (2008). Superficial topography of wound: a determinant of underlying biological events? Medical Hypotheses, 70(3), 525-528. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Balayi Gajan, E. (2008). The efficacy of distraction and counterstimulation in the reduction of pain reaction to intraoral injection by pediatric patients. The Journal of Contemporary Dental Practice, 9(6), 33-40.
  • Mostofi Zadeh Farahani, R., Kloth, L. (2008). The hypothesis of 'biophysical matrix contraction': wound contraction revisited. International Wound Journal, 5(3), 477-482. [More Information]
  • Mostofi Zadeh Farahani, R., Marsee, D., Baden, L., Woo, S., Treister, N. (2008). Trigeminal trophic syndrome with features of oral CMV disease. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 106(3), e15-e18. [More Information]

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