Associate Professor Agisilaos Kourmatzis
Associate Head of School (Research)
School of Aerospace, Mechanical and Mechatronic Engineering
Dr. Kourmatzis graduated with a PhD in Fluid Dynamics from the University of Southampton, UK (2011) after completing Bachelors and Masters degrees in Mechanical Engineering from the University of Nottingham and Imperial College London respectively. He was a postdoctoral research associate at the University of Sydney from 2011-2015 and was elected a Chartered Professional Engineer (CEng) with the Institution of Mechanical Engineers in 2014. He held an academic position at Macquarie University from 2015-2017, helping to pioneer the new mechanical engineering program there, prior to re-joining USyd as a Lecturer in 2017. He was a SOAR Fellow at USYD from 2018-2019, appointed to Senior Lecturer in 2021 and to Associate Professor in 2023. In 2024 he spun out ASK Scientia Pty Ltd, a university spin out commercializing optical diagnostic technology for the aerosol and pharmaceutical sector. His research is in two-phase flows (aerosols/sprays/powders), turbulence, and laser diagnostics, and is supported by both industry and government. Industry/organizations he has partnered with and/or consulted for include public organizations such as the US-FDA and Great Barrier Reef Foundation and private industry such as Mitsubishi Heavy Industries and Proveris Scientific.
Multiphase flows are all around us, from ocean sprays and aerosol paints to fuel-injected engines and drug inhalers. Dr Agisilaos Kourmatzis’s research into understanding and managing these types of flows has far-reaching implications for our environment, our society and our health. He has contributed over 100 publications to this field of research and where available: pre-prints may be found here:-peer reviewed journal papersor here: peer reviewed journal papers.
“A multiphase flow generally consists of a particular phase of matter, such as a liquid droplet or a solid particle, moving or flowing within a different phase, such as a gas.
“My research focuses on developing new and more efficient ways of controlling these types of flows, on improving our understanding of the fundamental science involved, but also on developing new technologies to characterize these flows.
“For example, with a drug inhaler we want to improve targeting of the drug aerosol, hence reducing the overall dose required without negatively affecting the treatment outcome, and with a fuel spray injector, particularly now with renewable and synthetic fuels, we want to understand how we can optimize fuel/air mixing whilst also reducing emissions, and bringing us in line with net-zero.
“All of my research ultimately comes down to improving efficiency and reducing waste, which in an industrial context not only saves on cost but is much better for our environment, and in a health context, leads to improved treatment outcomes.
“My research has had a direct impact on a broad range of organizations, from the US-FDA, Mitsubishi Heavy Industries, Proveris Scientific, Venso Labs, and the Great Barrier Reef Foundation. A substantial portion of my research is now finding its way into a University spin-out company where I am a co-founder.
"What I really love about multiphase flows is how complicated they are. There is a lot engineering that needs to go in to characterizing and understanding something so complicated. So you end up developing a whole range of different tools and technologies that can have impact well beyond the discipline.
“I started my PhD in this field in 2008, and first joined the University of Sydney in 2011. There is an outstanding research culture here, enabling high-quality research in my field of interest while in parallel offering multiple exciting multi-disciplinary opportunities.”
AMME2261&AMME9261- Fluid Mechanics 1
AMME5292 - Applied Fluid Dynamics & turbulence
AMME4111/4112 - Honours Thesis
AMME5222/5223 - Dissertation
Completed PhD/MPhil Students
- Zhaoqi Ma-Particle Transport mechanisms in DPIs and the human upper airway (PhD 2024, supervisor)
- Daniel Yu-Modelling of turbulent atomization for marine cloud brightening (PhD 2024, co-supervisor)
- Tushar Ahmed-Electrostatically Charged Spray Combustion (PhD 2022, supervisor). First Position after Graduation: Engineering Manager at Mettler-Toledo International.
- Othman Jaber-Flow Focusing and Flow Blurring Atomization (PhD 2022, supervisor). First position after Graduation: Senior Engineer at Azendian Solutions.
- Khalid Elserfy-Dry Powder Inhaler Flows (PhD 2022, adjunct supervisor). First position after Graduation: Lecturer at Alexandria University, Egypt.
- Gajendra Singh-Air Assisted Atomization (PhD 2020, co-supervisor). First Position after Graduation: Continued as Postdoc for 1.5 years in group and then Assistant Professor at IIT Mandi, India.
- Taye Mekonnen-Optical Coherence Tomography (PhD 2020, adjunct supervisor). First Position after Graduation: Postdoctoral Scientist at the University of Houston, USA.
- Aaron Gutteridge-Air Assisted Atomization (MPhil 2019, supervisor). First Positition after Graduation: Project Engineer at Sofraco Engineering Systems.
- Phuong Pham-Biodiesel Sprays (PhD 2016, co-supervisor). First Position after Graduation: Continued as Postdoc for 2 years in group and then Associate Professor at Le Quy Don Tech. University, Vietnam.
Completed Postdoctoral Research Associates:
- Dr. Gajendra Singh (1.5 year postdoc position). First Position after completion of Postdoc: Assistant Professor at IIT Mandi, India.
- Dr. Albyn Lowe (2 year postdoc position). First Position after completion of Postdoc: Data Scientist for McLaren Racing, UK.
- Dr. Yilong Zhang (2 year postdoc position). First position after completion of Postdoc: Research Engineer at Navy, Australia.
- Dr. Liam Milton-McGurk (3 year postdoc position). First position after completion of Postdoc: Senior Research Fellow at Macquarie University, Australia.
- Optical Coherence Tomography for Analysis of Deposition Mechanisms in Turbulent Flows (PDoc Researchers: Drs. Taye Mekonnen & Liam Milton-McGurk)-funded through US-FDA
- Modelling the inhalation of bushfire smoke under variable breathing (PhD Candidate: Mr. Kian Lee)-with the Heat & Health Incubator, Faculty of Medicine & Health, funded through NHMRC Ideas.
- Turbulent atomization of complex liquids (PhD Candidate: Ms. Rongying Tian)-MHI funded.
- De-agglomeration phenomena in high dose dry powder inhalers (PhD Candidate:Ms. Athiya Azeem)-with UNSW and Singmed (through ARC Linkage)
- Effervescent Atomization Processes for Marine Cloud Brightening (PhD Candidate:Mr. Joel Harper-Harris)-with the Reef Restoration and Adaptation Program (Great Barrier Reef Foundation)
- Airway flow modelling for nasal flow therapy (MPhil Candidate:Dr. Elizabeth Read)-with Royal Prince Alfred Hospital
- Managing Director of ASK Scientia Pty Ltd
- Member of the Combustion Institute
- Member of the Australasian Fluid Mechanics Society
- Chartered Engineer and Full Member of the Institution of Mechanical Engineers
- Peer Reviewer for (selection): Journal of Fluid Mechanics, Physics of Fluids, Combustion and Flame, The International Journal of Multiphase Flows, Experimental Thermal and Fluid Science, The Journal of Biomechanics, Fuel, International Journal of Pharmaceutics, and the Australian Research Council.
- 2024- Sydney Knowledge Hub PERIscope commercialization award
- 2021- Faculty of Engineering Highly Commended Award for Teaching Excellence
- 2020 -Ahmed, Kourmatzis & Masri, Paper Prize for "Initial Characterisation of a hybrid air-blast and electrostatic atomizer for spray combustion"-2019 ACS Conference
- 2019 - Faculty Teaching Commendation for AMME2261 & AMME9261 - Fluid Mechanics 1
- 2018 - "Transforming Drug and Spray Delivery Systems"Sydney Accelerator Fellowship Awards (SOAR)
- 2018 - Faculty Teaching Commendation for AMME2261-Fluid Mechanics 1
- 2017 - Lowe, Kourmatzis & Masri, Paper Prize for "On the Boundary Conditions and Stability of Moderately Dense Spray Flames"-10th ASPACC Conference
India | (IIT Mandi) Collaboration in Dry Powder Inhaler Fluid Mechanics with Asst. Prof. Gajendra Singh. |
Netherlands | (DFE Pharma (Dr. Gerald Hebbink)) Pharmaceutical Powders |
United Kingdom | (University of Southampton (Prof. John S. Shrimpton)) Collaborations on Electrohydrodynamics and Electrified Sprays |
United States | (Cornell University) Collaboration on Spray Atomisation and Modelling with Prof. Olivier Desjardins |
United States | (Food and Drug Administration) Cooperative Research Project on Dry Powder Inhalers |
United States | (Proveris Scientific (Mr. Dino Farina)) Aerosols |
Project title | Research student |
---|---|
Mixed-Mode Turbulent Combustion | Dulat KARIM |
Investigating Particle Deposition Behaviour in the Airway During Elevated Breathing and Exercise Conditions | Kian Huang LEE |
Publications
Book Chapters
- Shrimpton, J., Kourmatzis, A. (2009). Downsizing direct injection spark ignition engines: a timescale analysis. In Sergey Demidov and Jacques Bonnet (Eds.), Traffic Related Air Pollution and Internal Combustion Engines (Air, water and soil pollution science and technology series), (pp. 179-210). United States of America: Nova Science Publishers.
Journals
- Milton-McGurk, L., Kourmatzis, A., Chan, H., Cheng, S., Masri, A., Farina, D. (2024). A new LED-based extinction tomography method for measurement of aerosol surface area. Journal of Aerosol Science, 181, 106432. [More Information]
- Ma, Z., Milton-McGurk, L., Tang, P., Chan, H., Farina, D., Cheng, S., Kourmatzis, A. (2024). An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations. Journal of Aerosol Science, 177, 106320. [More Information]
- Kumar, A., Kourmatzis, A., Chan, H., Cheng, S., Singh, G. (2024). Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler. Journal of Aerosol Science, 175, 106287. [More Information]
Conferences
- Jaber, O., Kourmatzis, A., Masri, A. (2020). Initial Characterisation of Droplet Dynamics in Flow Blurring and Flow Focusing Atomization. 22nd Australasian Fluid Mechanics Conference (AFMC2020), Brisbane: The University of Queensland. [More Information]
- Masri, A., Singh, G., Kourmatzis, A. (2020). On the Dynamics of Atomization and Combustion in Turbulent Spray Flows. 22nd Australasian Fluid Mechanics Conference (AFMC2020), Brisbane: The University of Queensland. [More Information]
- Singh, G., Kourmatzis, A., Masri, A. (2020). Stability and droplet dynamics of turbulent piloted spray flames of biodiesel. 12th Asia-Pacific Conference on Combustion (ASPACC 2019), Fukuoka: The Combustion Institute.
Patents
- Cheng, S., Kourmatzis, A., Mekonnen, T., Amatoury, J. (2019). PATENT: Device, Method and System for Optical Imaging. Patent No. WO/2019/090392.
2024
- Milton-McGurk, L., Kourmatzis, A., Chan, H., Cheng, S., Masri, A., Farina, D. (2024). A new LED-based extinction tomography method for measurement of aerosol surface area. Journal of Aerosol Science, 181, 106432. [More Information]
- Ma, Z., Milton-McGurk, L., Tang, P., Chan, H., Farina, D., Cheng, S., Kourmatzis, A. (2024). An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations. Journal of Aerosol Science, 177, 106320. [More Information]
- Kumar, A., Kourmatzis, A., Chan, H., Cheng, S., Singh, G. (2024). Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler. Journal of Aerosol Science, 175, 106287. [More Information]
2023
- Usman Khan, M., Cai, X., Shen, Z., Mekonnen, T., Kourmatzis, A., Cheng, S., Gholizadeh, H. (2023). Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies. Pharmaceutics, 15(5), 1557. [More Information]
- Zhu, Q., Gou, D., Chan, H., Kourmatzis, A., Yang, R. (2023). Effects of the mouthpiece and chamber of Turbuhaler® on the aerosolization of API-only powder formulations. International Journal of Pharmaceutics, 637. [More Information]
- Gholizadeh, H., Cheng, S., Kourmatzis, A., Traini, D., Young, P., Sheikh, Z., Ong, H. (2023). In vitro interactions of aerosol formulations with human nasal epithelium using real-time monitoring of drug transport in a nasal mucosa-on-a-chip. Biosensors and Bioelectronics, 223. [More Information]
2022
- Gholizadeh, H., Cheng, S., Kourmatzis, A., Xing, H., Traini, D., Young, P., Ong, H. (2022). Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development. Bioengineering, 9(4). [More Information]
- Li, L., Zhu, Q., Gou, D., Chan, H., Kourmatzis, A., Zhao, G., Yang, R. (2022). DEM modelling of breakage behaviour of semi-brittle agglomerates subject to compaction and impaction. Powder Technology, 408. [More Information]
- Burchell, C., Kourmatzis, A., Zhao, Y., Raco, J., Mekonnen, T., Chan, H., Cheng, S. (2022). Effects of respiratory rate on the fluid mechanics of a reconstructed upper airway. Medical Engineering and Physics, 100, 103746. [More Information]
2021
- Gallagher, C., Jalalifar, S., Salehi, F., Kourmatzis, A., Cheng, S. (2021). A two-fluid model for powder fluidisation in turbulent channel flows. Powder Technology, 389, 163-177. [More Information]
- Ahmed, T., Kourmatzis, A., Masri, A. (2021). Atomization behaviour of a hybrid air-blast-electrostatic atomizer for spray combustion. Fuel, 288, 119716. [More Information]
- Jaber, O., Kourmatzis, A., Masri, A. (2021). Characterization of flow-focusing and flow-blurring modes of atomization. Energy and Fuels, 35(9), 7144-7155. [More Information]
2020
- Elserfy, K., Kourmatzis, A., Chan, H., Walenga, R., Cheng, S. (2020). Effect of an upstream grid on the fluidization of pharmaceutical carrier powders. International Journal of Pharmaceutics, 578, 1-10. [More Information]
- Singh, G., Juddoo, M., Kourmatzis, A., Dunn, M., Masri, A. (2020). Heat release zones in turbulent, moderately dense spray flames of ethanol and biodiesel. Combustion and Flame, 220, 298-311. [More Information]
- Jaber, O., Kourmatzis, A., Masri, A. (2020). Initial Characterisation of Droplet Dynamics in Flow Blurring and Flow Focusing Atomization. 22nd Australasian Fluid Mechanics Conference (AFMC2020), Brisbane: The University of Queensland. [More Information]
2019
- Gholizadeh, H., Messerotti, E., Pozzoli, M., Cheng, S., Traini, D., Young, P., Kourmatzis, A., Caramella, C., Ong, H. (2019). Application of a Thermosensitive In Situ Gel of Chitosan-Based Nasal Spray Loaded with Tranexamic Acid for Localised Treatment of Nasal Wounds. AAPS PharmSciTech, 20(7), 1-12. [More Information]
- Cheng, S., Kourmatzis, A., Mekonnen, T., Amatoury, J. (2019). PATENT: Device, Method and System for Optical Imaging. Patent No. WO/2019/090392.
- Cheng, S., Kourmatzis, A., Mekonnen, T., Gholizadeh, H., Raco, J., Chen, L., Tang, P., Chan, H. (2019). Does upper airway deformation affect drug deposition? International Journal of Pharmaceutics, 572, 2-8. [More Information]
2018
- Ahmed, T., Kourmatzis, A., Pham, X., Masri, A. (2018). Droplet evaporation modeling of electrified fatty acid methyl esters. Fuel, 231, 244-252. [More Information]
- Pham, X., Kourmatzis, A., Khan, S., Masri, A. (2018). Dual-angle micro-particle tracking velocimetry in the primary atomization zone of electrostatically charged diesel sprays. 11th Asia Pacific Conference on Combustion (ASPACC 2017), Shanghai: The Combustion Institute.
- Singh, G., Pham, X., Ye, J., Kourmatzis, A., Masri, A. (2018). High speed microscopic imaging in the near-field of electrified biodiesel sprays. 14th International Conference on Liquid Atomization and Spray Systems (ICLASS 2018), Chicago: ILASS-Americas.
2017
- Kourmatzis, A., Pham, X., Masri, A. (2017). A two-angle far-field microscope imaging technique for spray flows. Measurement Science and Technology, 28(3), 1-15. [More Information]
- Kourmatzis, A., Cheng, S., Chan, H. (2017). Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery. Expert Opinion on Drug Delivery, 15(3), 271-282. [More Information]
- Kourmatzis, A., Lowe, A., Masri, A. (2017). Conditioned Analysis of Effervescent Atomization. Journal of Energy Engineering, 143(5), 1-8. [More Information]
2016
- Kourmatzis, A., Shrimpton, J. (2016). Characteristics of electrohydrodynamic roll structures in laminar planar Couette flow. Journal of Physics D: Applied Physics, 49(4), 1-13. [More Information]
- Kourmatzis, A., Lowe, A., Masri, A. (2016). Combined effervescent and airblast atomization of a liquid jet. Experimental Thermal and Fluid Science, 75, 66-76. [More Information]
- Pham, X., Kourmatzis, A., Masri, A. (2016). Feasibility and Uncertainties Associated with Two-Angle Imaging of Sprays: A Focus on 3D Velocity Measurements. 20th Australasian Fluid Mechanics Conference (AFMC 2016), Perth: Australasian Fluid Mechanics Society.
2015
- Pham, X., Kourmatzis, A., Masri, A. (2015). A New Approach in Characterizing Secondary-Breakup Regimes for Newtonian Liquids. Australian Combustion Symposium 2015, Melbourne, Victoria: The Combustion Institute Australia & New Zealand.
- Kourmatzis, A., Masri, A. (2015). Air Assisted Atomization of Liquid Jets in Varying Levels of Turbulence. Journal of Fluid Mechanics, 764, 95-132. [More Information]
- Kourmatzis, A., Pham, X., Masri, A. (2015). Characterization of atomization and combustion in moderately dense turbulent spray flames. Combustion and Flame, 162(4), 978-996. [More Information]
2014
- Heye, C., Kourmatzis, A., Raman, V., Masri, A. (2014). A comparative study of the simulation of turbulent ethanol spray flames. 3rd International Workshop on the Turbulent Combustion of Sprays (TCS3), : Springer Netherlands. [More Information]
- Kourmatzis, A., Lowe, A., Masri, A. (2014). Atomization Instabilities in Bubble Induced Break-up. 19th Australasian Fluid Mechanics Conference, : SPIE.
- Kourmatzis, A., Shrimpton, J. (2014). Electrohydrodynamic inter-electrode flow and liquid jet characteristics in charge injection atomizers. Experiments in Fluids: experimental methods and their applications to fluid flow, 55(3), 1-13. [More Information]
2013
- Kourmatzis, A., Pham, X., Masri, A. (2013). Air assisted atomization and spray density characterization of ethanol and a range of biodiesels. Fuel, 108, 758-770. [More Information]
- Juddoo, M., Kourmatzis, A., Masri, A. (2013). An Experimental Study of Transient Effects in a Pulsed, Piloted, Non-Premixed Turbulent Jet Flame. 9th Asia-Pacific Conference on Combustion (ASPACC), Gyeongju, Korea: The Korean Society of Combustion.
- Kourmatzis, A., Masri, A. (2013). Droplet Dynamics of an Auto-Ignition Burner with Dense Spray Boundary Conditions. The Australian Combustion Symposium 2013 (ACS 2013), Perth, Australia: The Combustion Institute.
2012
- Kourmatzis, A., Ergene, E., Shrimpton, J., Kyritsis, D., Mashayek, F., Huo, M. (2012). Combined aerodynamic and electrostatic atomization of dielectric liquid jets. Experiments in Fluids: experimental methods and their applications to fluid flow, 53(1), 221-235. [More Information]
- Kourmatzis, A., Shrimpton, J. (2012). Design and charge injection characteristics of an electrostatic dielectric liquid pulsed atomizer. Journal of Electrostatics, 70(3), 249-257. [More Information]
- Kourmatzis, A., Masri, A. (2012). Multiple Stage Atomization of Fuels for use in Combustion Applications. 18th Australasian Fluid Mechanics Conference AFMC 2012, Launceston, Tasmania: Australasian Fluid Mechanics Society.
2011
- Kourmatzis, A., Shrimpton, J. (2011). Electrical and transient atomization characteristics of a pulsed charge injection atomizer using electrically insulating liquids. Journal of Electrostatics, 69(3), 157-167. [More Information]
2010
- Shrimpton, J., Kourmatzis, A. (2010). Direct Numerical Simulation of Forced Flow Dielectric EHD within Charge Injection Atomizers. IEEE Transactions on Dielectrics and Electrical Insulation, 17(6), 1838-1845.
- Kourmatzis, A., Allen, J., Shrimpton, J. (2010). Electrical and spray characteristics of a multiorifice charge-injection atomizer for electrically insulating liquids. Atomization and Sprays, 20(4), 269-280.
2009
- Shrimpton, J., Kourmatzis, A. (2009). Downsizing direct injection spark ignition engines: a timescale analysis. In Sergey Demidov and Jacques Bonnet (Eds.), Traffic Related Air Pollution and Internal Combustion Engines (Air, water and soil pollution science and technology series), (pp. 179-210). United States of America: Nova Science Publishers.
- Kourmatzis, A., Shrimpton, J. (2009). Electrohydrodynamics and charge injection atomizers: a review of the governing equations and turbulence. Atomization and Sprays, 19(11), 1045-1063. [More Information]
Selected Grants
2023
- Extreme Heat and Bushfire Smoke: Establishing Evidence-Based Acute PM2.5 Thresholds, Cross T, Kourmatzis A, National Health and Medical Research Council (NHMRC)/Ideas Grant
- Development of a laser-based testing platform for generic dry powder inhaler (DPI) products and in-silico model validation, Kourmatzis A, Chan H, Milton-McGurk L, The Food and Drug Administration (USA)/Research Support
2022
- Unravelling the mechanics of particle deposition at the micro-scale, Chan H, Kourmatzis A, Australian Research Council (ARC)/Discovery Projects (DP)
- Measurement of single- and multi-component liquid fragments (>200m) in hot air, Masri A, Kourmatzis A, Dunn M, Cleary M, Mitsubishi Heavy Industries Pty Ltd (Japan)/Client Commissioned Research
In the media
United States' FDA awards University-led team over $500,000[11-Sep-18]
UnIversity of Sydney
Multi-disciplinary research to enhance pharmaceutical inhalers.More..
ARC funding for myrtle rust and aerosol measurement technology[24-Jan-20]
UnIversity of Sydney
New Generation Technologies for Improved Measurement of Pharmaceutical Aerosols[06-Oct-20]
Business Wire
Using Concept Maps in Fluid Mechanics Teaching[07-Jun-23]
University of Sydney
Medicinal Drug Delivery From DPIs[06-Sep-23]
BioSpectrum
FDA funds Australian Research for better, affordable asthma inhalers[23-Oct-23]
University of Sydney