Professor Fariba Dehghani
M.Eng The University of Shiraz Iran, PhD UNSW
Director of ARC Food Processing Training Centre
Director of Bioengineering Research
School of Chemical and Biomolecular Engineering
J01 - Chemical Engineering Building
The University of Sydney
|Telephone||+61 2 9351 4794|
|Fax||+61 2 9351 2854|
Bioengineering & Biophysics Lab
Biotechnology and Biomolecular Engineering
|Curriculum vitae||Curriculum vitae|
Professor Fariba Dehghani's work in bioengineering research focuses on developing technologies for processing biomaterials, with particular emphasis on tissue engineering and regenerative medicine.
"My research aims to develop sustainable, low-energy, benign processes for manufacturing bio-products and to reduce organic solvent consumption. For instance, currently I am looking into developing bio-inspired materials and technologies to engineer tissues and organs, and investigating whether these can translate to clinical outcomes. This involves novel materials and implant devices as well as compounds for the treatment and prevention of cardiovascular disease, viral infections, cancer, osteoporosis and a range of other health issues.
"My work focuses on synthesising biodegradable polymers, bioglasses, and hybrids with unique feature for tissue engineering. I also aim to develop materials for minimally invasive surgery and overcome current issues for injectable formulations including degradability, injectability and mechanical strength. Overcoming these will have a major impact on developing materials that can resolve many health issues, including sport injuries and bone defects. I am currently investigating applications of these new classes of biomaterials for drug delivery and cartilage and bone repair.
"Another example of my research is the use of nano- and micro-particles for targeted drug delivery - such as in the treatment of cancer. The use of such small particles as an avenue for drug delivery can improve bioavailability by enabling drugs to permeate cell walls, minimising necessary doses and side effects.
"My bioengineering research has resulted in developing a fermentation process that led to producing an oil rich in vitamin K, with greater bioavailability. The concentration of this compound is 25-fold higher than any commercially available food on the market. This oil can be used in the formulation of food products to reduce the risk of osteoporotic fractures and cardiovascular disease.
"I've been working in this field since 1998, and joined the University of Sydney in 2006. Working here provides a collegial environment where I can collaborate with other disciplines and internationally prominent research teams."
Teaching and supervision
CHNG3804 - Biochemical Engineering
CHNG5022 - Capstone Project B Extended
CHNG5222 - Dissertation A
CHNG5223 - Dissertation B
CHNG5603 - Analysis, Modelling, Control: BioPhy Sys
CHNG5605 - Bio-Products: Laboratory to Marketplace
CHNG5701 - Foundation of Conservation and Transport Processes
CHNG5804 - Foundations of Biochemical Engineering
Current research students
|Project title||Research student|
|The Effect of interpenetrating network on the Physico-Chemical Properties of Polymer-Bioactive Glass hybrid monolith for bone tissue regeneration||Sonia ANSARI|
|Microfluidic cell co-culturing toward skin-on-chip: Wound Healing||Sahar BIGLARI|
|Adjusting formulation of spray-dried particles to create high and heterogeneous porosity||Songwen TAN|
|Vitamin K for the improvement of intensive meat and livestock production systems||Tom TARENTO|
|Development of a new drug from abalone hemocyanin for treatment of herpes simplex virus (HSV)||Jiadai WU|
- Member of technical Committee of Bio-nanotechnology for Engineering in Medicine and Biology Society (EMBS, IEEE), the world's largest international society of biomedical engineers
- Chair for the EMBS Micro and Nanotechnology in Medicine Conference, Kanapali, Hawaii, 3rd -7th December 2012.
- Member of program committee for Annual International Conference on Chemistry, Chemical Engineering, and Chemical Process (CCECP 2013), Singapore, 25th -26th February 2013.
- Advisory member of the scientific committee for the International Conference on Process Intensification for Sustainable Chemical Industries (ICPI2011) Beijing, China, on June 26-29, 2011.
- Associate editor of Journal Biomaterials and Tissue Engineering
- Assessor for ARC grants (Discovery, Linkage, Future Fellows, etc)
Awards and honours
- 2013 Australia-Harvard Fellowship award
- Research award from IChemE in 2012 for the best oral presentation
- Gold Star Award from the Vice Chancellor at the University of New South Wales for a grant application (2005)
- John Brodie Medal from the Institute of Engineers, Australia for Achievement in Chemical Engineering (1999)
- A travelling award to attend the fourth international symposium of supercritical fluids in Sendai, Japan (1998)
- My research has received 10 awards from Hays Corporation and other companies in conversazione at USyd and also IChemE, since 2007 for innovation in process and material development.
In the media
- Talaie Zanjani N, Valtchev, Miranda-Saksena M, Cuthbertson A, Dienfenbach, Gomes V, Cunningham T, Dehghani F, Abalanone hemocyanin and screening methods using the same, Provisional patent No. 2014904790.
- Schindeler A, Cheng T, Valtchev P, Dehghani F, Little D, High viscosity liquid carrier materials for biotechnology and drug delivery, Provisional Patent No. 2014900566.
- Dehghani F, Kavanagh J, Regtop HL, Talbot A, Berenjian A, Mahanama R, Fermentation and in situ extraction of products, Aus. Prov. Pat. No. 2013900664.
- Dehghani F, Ravarian R, Chrzanowski W, Improved PMMA-hybrid network, Aus. Prov. Pat. No. 2013900475.
- Dehghani F, Weiss A, Wei H, Mithieux S, Fathi A, A peptide-hydrogel composite, PCT/AU 2012/001566.
- Dehghani F, Zhong X, Organometallic catalyst and preparation thereof, Patent PCT Int. Appl. (2010), WO 2010069000
- Dehghani F, Annabi N, Mithieux S, Weiss A, Hydrogels derived from biological polymers PCT Int. Appl. (2009), WO 2009105820.
- Foster, N.R., Regtop, H.L., Dehghani, F, Bustami, R.T., Chan, H-K., Synthesis of small particles. PCT Int. Appl. (2002), 43 pp CODEN: PIXXD2 WO 0245690 A1 20020613 AN2002:449482
- Foster NR; Regtop HL; Dehghani F, Preparation of small particles for pharmaceutical delivery. PCT Int. Appl. (2003), 37 pp. WO 2003047553 A1 20030612
- Foster NR; Regtop HL; Dehghani F; Tandya A, Formulation of fine particles using liquefied or dense gases. PCT Int. Appl. (2003), 36 pp., WO 2003088951, A1 20031030.
- Foster NR; Dehghani F; Combes G, Regtop H L; Particles Synthesis Apparatus and Method, 22 pp., WO2004/089524, A1 20041012.
National and International Recognition
- Our discovery for identifying the mechanism of action of hemocyanin against Herpes Simplex Virus was highlighted in ABC Catalyst Program in 2014
- Recent work in synthesis of an injectable polymer for cartilage repair was nominated as one of top ten posters in MRS 2012 in Boston, USA
- I have been invited to write more than 5 review articles and book chapters (e.g. three during the last six months for international publication)
- My research was highlighted in ARS Technica-Boston MA as a breakthrough in biomaterials (http://arstechnica.com/science/news/2008/10/near-liquid-co2-gives-a-boost-to-cell-scaffolds.ars).
- As a result of my international reputation, I am frequently interviewed for my cutting edge research for cartilage repair.
- My research for the production of vitamin K7 was a hot topic on human health news Rx one of the world's largest producer of health news in November 2011 and January 2012:
- http://food.verticalnews.com/articles/6360648.html, http://food.verticalnews.com/articles/6360648.html, http://www.newsrx.com/healtharticles/2769808.html)
- The work for vitamin K7 production was also the best postgraduate poster presentation at World Congress on Engineering and Computer Science (WCECS 2012) and IChemE 2012 at Sydney University.
Invited and Keynote Speaker:
- BIT’s 2nd Annual World Congress of Smart Materials, March 4-6, 2016, Singapore
- 2015 4th TERMIS World Congress, September 8 -11, Boston, MA, USA
- 3rd annual workshop on Micro- and Nanotechnologies in Medicine Biomaterial, Biomaterials Innovation Research Center at Brigham Woman’s Hospital, 27-31st July, Boston, MA, USA
- The Asia-Pacific Symposium on Process Intensification and Sustainability, May 9-11, 2014 Changzhou, China
- TERMIS EU 2014, Genoa, Italy, June 10-13
- Departments of Materials, Imperial College London, June 2014
- The 2014 Tissue Engineering Conference, London UK, 2 - 4th June, 2014
- NSF workshop on BioMEMS and Tissue Engineering, Cambridge, MA from July 29th-August 2nd, 2013
- 12th International Conference on Frontiers of Polymers and Advanced Materials (12th ICFPAM), 8-12 December 2013, Auckland, New Zealand.
- Tissue engineering workshop held at Harvard Medical School, Boston, US, 29th November 2012
- The International Symposium of Regenerative Medicine in World Class University (ITREN-WCU), Dankook University, Korea, 20th November 2012.
- Tissue engineering workshop in School of Mechanical Engineering, Seoul University of Technology as part of World Class University program, Seoul, Korea, 21st November 2012.
- 2011 ITREN 13th Symposium of WPI-AIMR Annual Meeting, Sendai, Japan, 21-24 February.
- The International Conference on Process Intensification for Sustainable Chemical Industries (ICPI2011) Beijing, China, on June 26-29, 2011.
- Sharif University and Baboul University of Technology, Iran, November 2010.
- 5th International Symposium on Supercritical Fluids (ISSF), Atlanta April 2000.
Biomedical engineering and technology
- A new platform for developing a compound against Herpes Simplex Virus; Dehghani F, Cunningham A, Gomes V; Australian Research Council (ARC)/Linkage Projects (LP).
- ElastoSensTM Bio2; Dehghani F, Chrzanowski W, O'Neill G, McConchie R, Chandrawati R; University of Sydney/Equipment Grant.
- Cancer invasion and metastasis: how actin networks control cell movement in 3 dimensional environments; O'Neill G, Biro M, Dehghani F, Chrzanowski W, Richardson D; DVC Research/SPARC Implementation - Cancer.
- Biothermosetting bone filler: an injectable osteoconductive repair material; Weiss A, Dehghani F; National Health and Medical Research Council (NHMRC)/Development Grants.
- Bio-inspired strategies and advances in micro and nanotechnology for Food, Medicine and Biomedical Devices; Dehghani F, Kirckpatrick C, Heilshorn S, Khademhosseini A, Choy K, Yang Y, Perego P; DVC International/IPDF Grant.
- Australia and Koreas Clean Energy Future: The Role of Innovative Technology; Chae S, Dehghani F; Australia-Korea Foundation/Research Support.
- ATVRE - Assistive Technologies for Virtual Rehabilitation Engineering; Feng D, Dehghani F, Dunstan C, Jin C, Kim J, Li Q, McEwan A, Ruys A, Brooker G, Buckley T, Cai W, Davis G, Fornusek C, Fulham M, Khadra M, Mohamed A, Murray G, Peck C, Vucetic B, Weiss A; DVC Research/Research Network Scheme (SyReNS).
- Microfluidic fabrication of engineered tissues; Khademhosseini A, Dehghani F; DVC Research/International Research Collaboration Award (IRCA).
- nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan K, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Australia-Harvard Fellowship; Dehghani F; Harvard Club of Australia Foundation/Australia - Harvard Fellowship.
- WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan K, Oliver B, Holst J; DVC Research/Equipment Grant.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Chrzanowski W, Dehghani F; BlueScope Steel - Lysaght Technology/Project Support.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Dehghani F, Chrzanowski W; Australian Research Council (ARC)/Linkage Projects (LP).
- Talking to cells - biointerface as a key parameter in communication with cells; Chrzanowski W, Brown D, Dehghani F, Hibbs D, Ravarian R, Wassef A, Wong J, Yun Y, Lee J, Jang J, Hwang J, Shin S, Shin U, Lee S, Kim H; DVC International/IPDF Grant.
- Versatile elastin based hybrid hydrogels for chondrocyte transplantation and repair; Weiss A, Dehghani F; Australian Research Council (ARC)/Discovery Projects (DP).
- Antioxidant Extraction from Wine Waste Using Sub-Super Critical Fluids; Aliakbarian B, Dehghani F; Department of Education, Employment and Workplace Relations/Endeavour Awards - Scholarships and Fellowships.
- The Instron testing material instrument (Model 5943); Dehghani F, Weiss A, Bilek M, Zreiqat H, Dunstan C, Chrzanowski W, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- qNano scanning ion occlusion spectroscopy (SIOS); Chrzanowski W, Bebawy M, Dehghani F, Chan K, Rohanizadeh R, Hawkett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Engineering of novel ferrocene-based cross-linked hybrid intelligent micelles with anti-tumour efficacy fro drug delivery; Wei H, Wei H, Dehghani F; DVC Research/Postdoctoral Research Fellowship Scheme.
- Extraction and purification of a novel glycoprotein with antiviral activity from an Australian mollusc; Dehghani F, Patane M, Cuthbertson A, Cavanagh B, Gomes V; Australian Research Council (ARC)/Linkage Projects (LP).
- Fabrication of microchannels in hydrogels; Khademhosseini A, Dehghani F; Harvard Club of Australia Foundation/Research Support.
- New fermentation and purification production technologies for menaquinone-7 for promoting bone and cardiovascular health; Regtop H, Dehghani F, Kavanagh J; Australian Research Council (ARC)/Linkage Projects (LP).
- Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants; Dehghani F, Kazarian S; Australian Research Council (ARC)/Discovery Projects (DP).
- State of the art high resolution thermal analysis suite for the life and material sciences; Stewart P, Young P, Traini D, Chan K, Murray M, Dehghani F, Hibbs D, Larson I, Warr G, Weiss A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- A rapid-rotation dense gas precipitation process for the production of pharmaceutical fine powders; Dehghani F; University of Sydney/Bridging Support.
- Carbon dioxide: Solvent, carrier and reagent, for novel polymer networks with controlled nano-architectures; Foster N, Dehghani F; Australian Research Council (ARC)/Discovery Projects (DP).