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Associate Professor Hala Zreiqat

Bsc (Hons) Jordan PhD UNSW
NH&MRC Senior Research Fellow
Head: Biomaterials & Tissue Engineering
Research Laboratory Biomedical Engineering
Founder & Chair of SuTEN
Member of Bosch Institute
Visiting Professor at the American University of Beirut (AUB)
Associate Professor AMME

J07 - Mechanical Engineering Building
The University of Sydney

Telephone +61 2 9351 2392
Fax +61 2 9351 7060

Website SuTEN - Sydney University Tissue Engineering Network

Aerospace, Mechanical and Mechatronic Engineering

Bosch Institute
Curriculum vitae Curriculum vitae

Biographical details

Hala Zreiqat is a National Health and Medical Research Fellow, Head of the Tissue Engineering and Biomaterials Research Unit in the Faculty of Engineering, University of Sydney. Her group consists of multidisciplinary team of researchers including engineers, cell and molecular biologists and clinicians. She specializes in developing engineered biomaterials and scaffolds for skeletal tissue applications, and investigating their effect on in vitro and in vivo osteogenesis. Her team conducts research to gain greater understanding of bone/cartilage and endothelial cells biology when in contact with engineered biomaterials. She has over 80 peer-reviewed publications; 4 review papers; 12 book chapters; and over 120 abstracts in national and international meetings. She is regularly invited to give keynote and plenary presentations at major international and national conferences. She has organized / chaired a number of major international conferences/ symposia / workshops. She is the immediate past president of the Australian and New Zealand Orthopaedic research Society (2010-2012). Founder & Chair, University of Sydney International Tissue Engineering Network (2006-present). Amongst her awards are: Leopold Dintenfass Memorial Award, for Excellence in Research (2012); University of Sydney Engineering Deans Research Award (2009).

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Research interests

Millions of people worldwide suffer bone loss due to injury, infection, disease or abnormal skeletal development, and treatment frequently requires regeneration of new bone. Since each patient has only a limited amount of bone available for grafting, the demand for synthetic bone substitutes is high. Those currently available are far from optimal, but Associate Professor Hala Zreiqat has developed a unique ceramic material that acts as a scaffold on which the body can regenerate new bone, then gradually degrades as it is replaced by natural bone.

"The bone substitute my team and I have developed resembles natural bone in terms of architecture, strength and porosity. So it is strong enough to withstand the loads that will be applied to it, and also contains pores that allow blood and nutrients to penetrate it. In this way it is designed to encourage normal bone growth, and to eventually be replaced by natural bone in the body.

"The fact that it actually 'kick starts' the process of bone regeneration makes it far superior to other available materials. Our tests also show that it will not be rejected by the body. In addition, we can make as many implants as we want from this material, so availability will not be a problem.

"This material has the potential to positively affect the quality of life of millions of people globally, so we are hoping to see it in use clinically within the next 10 years.

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Teaching and supervision

AMME4971 - Tissue Engineering
AMME5971 - Applied Tissue Engineering

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Awards and honours


Australian

  • Australia-Harvard Fellowship: AUD 10,000 (2013)
  • Leopold Dintenfass Memorial Award, for Excellence in Research (2012)
  • NHMRC Senior Research Fellowship: AUD 570,640 (2011-2015)
  • University of Sydney Engineering Deans Research Award (2009)
  • Australian Academy of Science Award for research undertaken at Laboratoire de Physiopathologie et Pharmacologie Articulaires, Faculté de Médicine, Université Henri Poincaré, France: AUD 10,500 (2009)
  • R Douglas Wright Biomedical Career Development Award (NHMRC): AUD 426,250 (2006-2010) Australian Academy of Science Award for research undertaken at Institute of Pathology, Johannes Gutenberg University, Mainz, Germany: AUD 11,000 (2004)
  • Australian Postgraduate Research Award (PhD scholarship): AUD 28,000 p.a. (1995-1997)

International
  • Advisor World Orthopaedic Alliance (WOA)- (October 2012-present)
  • German Academic Exchange Service (DAAD) award for research undertaken at Saarland University, Germany: AUD 10,000 (2011)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2011)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2007)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2006)

National Collaboration

  • Prof C Little, Director, Raymond Purves Bone and Joint Research Labs, Royal North Shore Hospital, Sydney (Role of S100A8/S100A9 proteins in cartilage degeneration in osteoarthritis)
  • A/Prof Colin Dunstan, University of Sydney, Assessment of bone quality when in contact with biomaterials.
  • Associate Professor Lars Ittner, Laboratory for Translational Neurodegeneration, The Brain & Mind Research Institute, BMRI, University of Sydney. "In vivo signaling pathways involved in bone regeneration using synthetic scaffolds."
  • Dr. Peter Pivonka, Faculty of Engineering, University of Western Australia. "Use of computational modelling to estimate stiffness, strength and dissolution of the implants".
  • Associate Professor Andrew Minett, School of Chemical and Biomolecular Engineering, Facfulty of Engineering, University of Sydney. The collaboration 'focuses on creating functional nanomaterial composites for manipulating the material - biology interface. This is achieved through the incorporation of nanomaterials both into or onto hierarchical structures resulting in stronger composite materials with functional, intelligent surfaces."

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Selected grants

2013

  • 2013 Australia-Harvard Fellowship; Zreiqat H; Harvard Club of Australia Foundation/Australia - Harvard Fellowship.
  • Microstructural Design Strategies for Repairing Traumatic Skeletal Injuries; Zreiqat H, Dunstan C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • A basis for building bone: Novel biomaterials for new bone growth; Zreiqat H; DVC Research/Bridging Support Grant.

2012

  • Programming stem cells for bone, blood, and cartilage regeneration: current state and future prospective; Lu Z, Wang G, Zreiqat H; DVC International/IPDF Grant.
  • Australia-Harvard Fellowship 2012; Zreiqat H; Harvard Club of Australia Foundation/Australia - Harvard Fellowship.

2011

  • Senior Research Fellowship A; Zreiqat H; National Health and Medical Research Council/Career Awards: Research Fellowships.
  • Novel engineered nano-composite scaffolds for bone regeneration; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The Instron testing material instrument (Model 5943); Dehghani F, Weiss A, Bilek M, Zreiqat H, Dunstan C, Chrzanowski W, Rohanizadeh R; National Health and Medical Research Council/Equipment Grants.
  • The small animal bioimager; Halliday G, Hambley T, Zreiqat H, Richardson D, Holst J, Rasko J, Byrne S, Dong Q, Hong A, Lyons J; National Health and Medical Research Council/Equipment Grants.

2010

  • Novel coatings for orthopaedic application; Zreiqat H, Sonnabend D, Dunstan C; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Novel scaffolds for augmenting large bone defects; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Harnessing the physiological effects of strontium and zinc to produce novel biomaterials for orthopaedic applications; Zreiqat H, Dunstan C; National Health and Medical Research Council/Project Grants.
  • Biomaterials for orthopaedic applications; Zreiqat H; DVC Research/Bridging Support Grant.

2009

  • Scaffolds for bone tissue regeneration and use in orthopaedic applications; Fick J, Pivonka P, Weston R, Zreiqat H, Wu C, Pivonka P, Johnson K; Australian Research Council/Linkage Projects (LP).
  • Novel coatings for orthopaedic implants; Grau G, Little D, Zreiqat H, Dunstan C; National Health and Medical Research Council/Project Grants.
  • Developing Novel Scaffolds for Osteochondral Defects and Orthopaedic Prosthetic Coatings for Bone Tissue Regeneration and Implant Ossointegration; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2008

  • Novel Scaffolds for repairing bone defects; Zreiqat H, Little D, Dunstan C; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Developing better treatment and novel prosthetic implants for joint replacement damaged due to arthritis; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Research Support.

2007

  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop G, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho P, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; NHMRC/Equipment Grant.
  • Effect of incorporating strontium into the surface of titanium alloy on bone cell behaviour; Zreiqat H; Australian Institute of Nuclear Science and Engineering/Research Grants.
  • Micro-engineered biomaterials for improved orthopedic devices and scaffolds; Zreiqat H; University of Sydney/Bridging Support.

2006

  • Histological testing of spinal implants � St. George Hospital; Zreiqat H, Diwan A; BLO University of New South Wales (Through Ortopaedic research Centre)/BLO Project.
  • Molecular Mechanisms Controlling The Maintenance And Differentiation Of Skeletal Tissue/Device Interface For Biomedical Engineering Applications; NHMRC/R Douglas Wright Awards.
  • Histological services on retrieved femoral heads; Zreiqat H, Gillies M; Worley Parsons Services Pty Ltd/BLO Project.

2005

  • Mechanisms of bone formation at the device / tissue interface; Zreiqat H, Haynes D; NHMRC/Project Grants.
  • Improving orthopaedic/dental devices by surface chemical modification; Zreiqat H, Swain M; Australian Research Council (ARC)/Discovery: Project.
  • Mechanism of action of Zoledronnic acid in inflammatory arthritis; Zreiqat H, Binder W; Royal Australasian College of Physicians (RACP)/Barbara Cameron ARA Fellowship.
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Selected publications

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Journals

  • Wang, G., Lu, Z., Xie, K., Lu, W., Roohani-Esfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087.
  • Lu, Z., Roohani-Esfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515.
  • Roohani-Esfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312.
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, S., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C: Materials for Biological Applications, 32(4), 830-839.
  • Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C: Materials for Biological Applications, 32(7), 1818-1826.
  • Roohani-Esfahani, S., Dunstan, C., Davies, B., Pearce, S., Williams, R., Zreiqat, H. (2012). Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds. Acta Biomaterialia, 8(11), 4162-4172.
  • Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429.
  • Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318.
  • Wang, G., Liu, X., Zreiqat, H., Ding, C. (2011). Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings. Colloids And Surfaces B: Biointerfaces, 86(2), 267-274.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society. Interface, 8(61), 1192-1203.
  • Roohani-Esfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581.
  • Lu, Z., Roohani-Esfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering. Part A: Tissue Engineering, 17(11/12), 1651-1661.
  • Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through α2β1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329.
  • Wu, C., Chang, J., Zreiqat, H. (2010). Engineered Ca-Si Based Ceramics for Skeletal Tissue Reconstruction. Materials Science Foundations (monograph series), 62, 122-149.
  • Wang, G., Zreiqat, H. (2010). Functional Coatings or Films for Hard-Tissue Applications. Materials, 3(7), 3994-4050.
  • Wu, C., Zreiqat, H. (2010). Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery. Acta Biomaterialia, 6(3), 820-829.
  • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245.
  • Zreiqat, H., Yang, C., James, B., Duflou, J., Lowe, H. (2010). Probable endothelisation of bare metal stent struts extending from the left main coronary into the aorta. Journal of Thrombosis and Thrombolysis, 30(4), 500-501.
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13.
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509.
  • Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving α2β1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering. Part A: Tissue Engineering, 16(10), 3075-3084.
  • Wang, C., Karlis, G., Anderson, G., Dunstan, C., Carbone, A., Berger, G., Ploska, U., Zreiqat, H. (2009). Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants. Journal of Biomedical Materials Research. Part A, 90A(2), 419-428.
  • Schulze-Tanzil, G., Zreiqat, H., Sabat, R., Kohl, B., Halder, A., Muller, R., John, T. (2009). Interleukin-10 and articular cartilage: Experimental therapeutical approaches in cartilage disorders. Current Gene Therapy: the international journal for in-depth reviews on gene therapy, 9(4), 631-315.
  • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430.
  • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society. Interface, 6(1), 159-168.
  • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204.
  • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208.
  • Zreiqat, H., James, B., Brieger, D., Kritharides, L., Lowe, H. (2008). Acute coronary stent thrombosis: Toward insights into possible mechanism using novel imaging methods. Thrombosis and Haemostasis: international journal for vascular biology and medicine, 99(5), 976-977.
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497.
  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146.
  • Helary, G., Poussard, L., Zreiqat, H., Migonney, V. (2008). Functionalization of biomaterials for joint implant application. Bio-Medical Materials and Engineering, 18, 237-239.
  • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353.
  • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576.
  • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
  • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B DOI: 10.1002/jbm.b.31109(2), 346-353.
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402.
  • Oberholzer, A., John, T., Kohl, B., Gust, T., Muller, R., La Face, D., Hutchins, B., Zreiqat, H., Ertel, W., Schulze-Tanzil, G. (2007). Adenoviral transduction is more efficient in alginate-derived chondrocytes than in monolayer chondrocytes. Cell and Tissue Research, 328(2), 383-390.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2007). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628.
  • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research. Part A, 86(2 (Online article 29 Oct 2007)), 402-410.
  • John, T., Muller, R., Oberholzer, A., Zreiqat, H., Kohl, B., Ertel, W., Hostmann, A., Tschoeke, S., Schulze-Tanzil, G. (2007). Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro. Cytokine, 40(3), 226-234.
  • Wu, C., Zreiqat, H. (2007). Preparation and Characteristics of Strontium Containing Bioactive CaSiO3 Ceramics. Key Engineering Materials, 330-332(I), 499-502.
  • Zreiqat, H., Howlett, C., Gronthos, S., Hume, D., Geczy, C. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38(5), 381-391.
  • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181.
  • Knabe, C., Kraska, B., Koch, C., Gross, U., Zreiqat, H., Stiller, M. (2006). A method for immunohistochemical detection of osteogenic markers in undecalcified bone sections. Biotechnic and Histochemistry, 81(1), 31-39.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2006). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628.
  • Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. Key Engineering Materials, 309-311, 709-712.
  • Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science: Materials in Medicine, 16, 1199-1205.
  • Zreiqat, H., Roest, R., Valenzuela, S., Milev, A., Ben-Nissan, B. (2005). Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates. Key Engineering Materials, 284-286, 541-544.
  • McCormick, M., Rahimi, F., Bobryshev,, Y., Gaus, K., Zreiqat, H., Cai, H., Lord,, R., Geczy, C. (2005). S100A8 and S100A9 in Human Arterial Wall: implications for atherogenesis. Journal of Biological Chemistry, 280(50), 41521-41529.
  • Knabe, C., Stiller, M., Berger, G., Reif, D., Gildenhaar, R., Hewlett, C., Zreiqat, H. (2005). The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro. Clinical Oral Implants Research, 16(1), 119-127.
  • Zreiqat, H., Valenzuela, S., Ben-Nissan, B., Roest, R., Knabe, C., Radlanski, R., Renz, H., Evans, P. (2005). The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials, 26(36), 7579-7586.
  • Knabe, C., Berger, G., Gildenhaar, R., Meyer, J., Hewlett, C., Markovic, B., Zreiqat, H. (2004). Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro. Journal of Biomedical Materials Research. Part A, 69A(1), 145-154.
  • Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., Hatzinikolous, G., Capone, M., Holding, C., Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFκB, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions. Biomaterials, 25(13), 2507-2514.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Proliferation and bone-related gene expression of osteoblasts grown on hydroxyapatite ceramics sintered at different temperature. Biomaterials, 25(15), 2949-2956.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Quantitative Analysis of Osteoprotegerin and RANKL Expression in Osteoblast Grown on Different Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 713-716.
  • Haynes, D., Crotti, T., Zreiqat, H. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885.
  • Knabe, C., Hewlett, C., Klar, F., Zreiqat, H. (2004). The effect of different titanium and hydroxyapatite-coated dental implant surfaces on phenotypic expression of human bone-derived cells. Journal of Biomedical Materials Research. Part A, 71A(1), 98-107.
  • Zreiqat, H., Berger, G., Gildenhaar, R., Knabe, C. (2004). The Functional Expression of Human Bone-Derived Cells Grown on Rapidly Resorbable Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 1059-1062.
  • Knabe, C., Berger, G., Gildenhaar, R., Hewlett, C., Markovic, B., Zreiqat, H. (2004). The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics. Biomaterials, 25, 335-344.
  • Knabe, C., Berger, G., Gildenhaar, R., Klar, F., Zreiqat, H. (2004). The modulation of osteogenesis in vitro by calcium titanium phosphate coatings. Biomaterials, 25(20), 4911-4919.
  • Zreiqat, H., Ahu Akin, F., Hewlett, C., Markovic, B., Haynes, D., Lateef, S., Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part A, 64A(1), 105-113.
  • Zreiqat, H., Kumar, R., Markovic, B., Zicat, B., Hewlett, C. (2003). Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products. Journal of Biomedical Materials Research. Part A, 65A(1), 109-117.
  • Zreiqat, H., Crotti, T., Hewlett, C., Capone, M., Markovic, B., Haynes, D. (2003). Prosthetic particles modify the expression of bone-related proteins by human osteoblastic cells in vitro. Biomaterials, 24, 337-346.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Knabe, C., Schulze-Tanzil, G., Shakibaei, G. (2003). Surface modification of bioceramics affect osteoblastic cells response. Key Engineering Materials, 240-242, 707-710.
  • Knabe, C., Hewlett, C., Markovic, B., Gildenhaar, R., Berger, G., Zreiqat, H. (2003). The functional expression of osteoblasts grown on rapidly resorbable calcium phosphates. Key Engineering Materials, 240-242(-), 679-682.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Schulze-Tanzil, G., Knabe, C., Shakibaei, G. (2002). Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 62, 175-184.

Conferences

  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Ma, W., Ruys, A., Zreiqat, H., Mason, R., Ringer, S., Liu, Z., Keast, V., Martin, P., Bendavid, A. (2006). The Biocompatibility of Diamond-Like Carbon Nano Films. International Conference on Nanoscience and Nanotechnology 2006, Brisbane, Australia: (IEEE) Institute of Electrical and Electronics Engineers.

Patents

  • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.

Magazine / Newspaper Articles

  • Lu, W., McKenzie, D., Dunstan, C., Zreiqat, H., Bilek, M. (2012). Plasma Immersion Ion Implantation Treatment of Poly-ether Ether Ketone for the Immobilization of Biomolecules on Surfaces (ID: 836). International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration.

2012

  • Wang, G., Lu, Z., Xie, K., Lu, W., Roohani-Esfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087.
  • Lu, Z., Roohani-Esfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515.
  • Roohani-Esfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312.
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, S., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992.
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C: Materials for Biological Applications, 32(4), 830-839.
  • Lu, W., McKenzie, D., Dunstan, C., Zreiqat, H., Bilek, M. (2012). Plasma Immersion Ion Implantation Treatment of Poly-ether Ether Ketone for the Immobilization of Biomolecules on Surfaces (ID: 836). International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration.
  • Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C: Materials for Biological Applications, 32(7), 1818-1826.
  • Roohani-Esfahani, S., Dunstan, C., Davies, B., Pearce, S., Williams, R., Zreiqat, H. (2012). Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds. Acta Biomaterialia, 8(11), 4162-4172.
  • Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429.
  • Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84.

2011

  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318.
  • Wang, G., Liu, X., Zreiqat, H., Ding, C. (2011). Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings. Colloids And Surfaces B: Biointerfaces, 86(2), 267-274.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society. Interface, 8(61), 1192-1203.
  • Roohani-Esfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581.
  • Lu, Z., Roohani-Esfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering. Part A: Tissue Engineering, 17(11/12), 1651-1661.

2010

  • Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through α2β1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329.
  • Wu, C., Chang, J., Zreiqat, H. (2010). Engineered Ca-Si Based Ceramics for Skeletal Tissue Reconstruction. Materials Science Foundations (monograph series), 62, 122-149.
  • Wang, G., Zreiqat, H. (2010). Functional Coatings or Films for Hard-Tissue Applications. Materials, 3(7), 3994-4050.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Wu, C., Zreiqat, H. (2010). Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery. Acta Biomaterialia, 6(3), 820-829.
  • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245.
  • Zreiqat, H., Yang, C., James, B., Duflou, J., Lowe, H. (2010). Probable endothelisation of bare metal stent struts extending from the left main coronary into the aorta. Journal of Thrombosis and Thrombolysis, 30(4), 500-501.
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13.
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509.
  • Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving α2β1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering. Part A: Tissue Engineering, 16(10), 3075-3084.

2009

  • Wang, C., Karlis, G., Anderson, G., Dunstan, C., Carbone, A., Berger, G., Ploska, U., Zreiqat, H. (2009). Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants. Journal of Biomedical Materials Research. Part A, 90A(2), 419-428.
  • Schulze-Tanzil, G., Zreiqat, H., Sabat, R., Kohl, B., Halder, A., Muller, R., John, T. (2009). Interleukin-10 and articular cartilage: Experimental therapeutical approaches in cartilage disorders. Current Gene Therapy: the international journal for in-depth reviews on gene therapy, 9(4), 631-315.
  • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430.
  • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society. Interface, 6(1), 159-168.
  • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.
  • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204.
  • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208.

2008

  • Zreiqat, H., James, B., Brieger, D., Kritharides, L., Lowe, H. (2008). Acute coronary stent thrombosis: Toward insights into possible mechanism using novel imaging methods. Thrombosis and Haemostasis: international journal for vascular biology and medicine, 99(5), 976-977.
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497.
  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146.
  • Helary, G., Poussard, L., Zreiqat, H., Migonney, V. (2008). Functionalization of biomaterials for joint implant application. Bio-Medical Materials and Engineering, 18, 237-239.
  • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353.
  • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576.
  • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
  • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B DOI: 10.1002/jbm.b.31109(2), 346-353.
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402.

2007

  • Oberholzer, A., John, T., Kohl, B., Gust, T., Muller, R., La Face, D., Hutchins, B., Zreiqat, H., Ertel, W., Schulze-Tanzil, G. (2007). Adenoviral transduction is more efficient in alginate-derived chondrocytes than in monolayer chondrocytes. Cell and Tissue Research, 328(2), 383-390.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2007). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628.
  • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research. Part A, 86(2 (Online article 29 Oct 2007)), 402-410.
  • John, T., Muller, R., Oberholzer, A., Zreiqat, H., Kohl, B., Ertel, W., Hostmann, A., Tschoeke, S., Schulze-Tanzil, G. (2007). Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro. Cytokine, 40(3), 226-234.
  • Wu, C., Zreiqat, H. (2007). Preparation and Characteristics of Strontium Containing Bioactive CaSiO3 Ceramics. Key Engineering Materials, 330-332(I), 499-502.
  • Zreiqat, H., Howlett, C., Gronthos, S., Hume, D., Geczy, C. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38(5), 381-391.
  • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181.

2006

  • Knabe, C., Kraska, B., Koch, C., Gross, U., Zreiqat, H., Stiller, M. (2006). A method for immunohistochemical detection of osteogenic markers in undecalcified bone sections. Biotechnic and Histochemistry, 81(1), 31-39.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2006). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628.
  • Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. Key Engineering Materials, 309-311, 709-712.
  • Ma, W., Ruys, A., Zreiqat, H., Mason, R., Ringer, S., Liu, Z., Keast, V., Martin, P., Bendavid, A. (2006). The Biocompatibility of Diamond-Like Carbon Nano Films. International Conference on Nanoscience and Nanotechnology 2006, Brisbane, Australia: (IEEE) Institute of Electrical and Electronics Engineers.

2005

  • Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science: Materials in Medicine, 16, 1199-1205.
  • Zreiqat, H., Roest, R., Valenzuela, S., Milev, A., Ben-Nissan, B. (2005). Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates. Key Engineering Materials, 284-286, 541-544.
  • McCormick, M., Rahimi, F., Bobryshev,, Y., Gaus, K., Zreiqat, H., Cai, H., Lord,, R., Geczy, C. (2005). S100A8 and S100A9 in Human Arterial Wall: implications for atherogenesis. Journal of Biological Chemistry, 280(50), 41521-41529.
  • Knabe, C., Stiller, M., Berger, G., Reif, D., Gildenhaar, R., Hewlett, C., Zreiqat, H. (2005). The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro. Clinical Oral Implants Research, 16(1), 119-127.
  • Zreiqat, H., Valenzuela, S., Ben-Nissan, B., Roest, R., Knabe, C., Radlanski, R., Renz, H., Evans, P. (2005). The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials, 26(36), 7579-7586.

2004

  • Knabe, C., Berger, G., Gildenhaar, R., Meyer, J., Hewlett, C., Markovic, B., Zreiqat, H. (2004). Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro. Journal of Biomedical Materials Research. Part A, 69A(1), 145-154.
  • Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., Hatzinikolous, G., Capone, M., Holding, C., Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFκB, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions. Biomaterials, 25(13), 2507-2514.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Proliferation and bone-related gene expression of osteoblasts grown on hydroxyapatite ceramics sintered at different temperature. Biomaterials, 25(15), 2949-2956.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Quantitative Analysis of Osteoprotegerin and RANKL Expression in Osteoblast Grown on Different Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 713-716.
  • Haynes, D., Crotti, T., Zreiqat, H. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885.
  • Knabe, C., Hewlett, C., Klar, F., Zreiqat, H. (2004). The effect of different titanium and hydroxyapatite-coated dental implant surfaces on phenotypic expression of human bone-derived cells. Journal of Biomedical Materials Research. Part A, 71A(1), 98-107.
  • Zreiqat, H., Berger, G., Gildenhaar, R., Knabe, C. (2004). The Functional Expression of Human Bone-Derived Cells Grown on Rapidly Resorbable Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 1059-1062.
  • Knabe, C., Berger, G., Gildenhaar, R., Hewlett, C., Markovic, B., Zreiqat, H. (2004). The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics. Biomaterials, 25, 335-344.
  • Knabe, C., Berger, G., Gildenhaar, R., Klar, F., Zreiqat, H. (2004). The modulation of osteogenesis in vitro by calcium titanium phosphate coatings. Biomaterials, 25(20), 4911-4919.

2003

  • Zreiqat, H., Ahu Akin, F., Hewlett, C., Markovic, B., Haynes, D., Lateef, S., Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part A, 64A(1), 105-113.
  • Zreiqat, H., Kumar, R., Markovic, B., Zicat, B., Hewlett, C. (2003). Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products. Journal of Biomedical Materials Research. Part A, 65A(1), 109-117.
  • Zreiqat, H., Crotti, T., Hewlett, C., Capone, M., Markovic, B., Haynes, D. (2003). Prosthetic particles modify the expression of bone-related proteins by human osteoblastic cells in vitro. Biomaterials, 24, 337-346.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Knabe, C., Schulze-Tanzil, G., Shakibaei, G. (2003). Surface modification of bioceramics affect osteoblastic cells response. Key Engineering Materials, 240-242, 707-710.
  • Knabe, C., Hewlett, C., Markovic, B., Gildenhaar, R., Berger, G., Zreiqat, H. (2003). The functional expression of osteoblasts grown on rapidly resorbable calcium phosphates. Key Engineering Materials, 240-242(-), 679-682.

2002

  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Schulze-Tanzil, G., Knabe, C., Shakibaei, G. (2002). Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 62, 175-184.
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International links

China

(Chinese Academy of Science, Shanghai) Prof Xuanyong Liu. "Plasma spray coating for orthopaedic implant applications".

China

(Jiao Tong University) Professor Xinquan, Oral Bioengineering Lab, Shanghai Research Institute of Stomatology. "In vivo and in vitro validation of novel modified Ti-6Al-4V surfaces"

China

(University Medical College, Shantou, Guangdong) Associate Professor Guanfeng Yao, Department of Orthopaedics, the Second Affiliated Hospital. " In vivo evaluation of novel synthetic scaffolds in lumbar spine fusion".

Germany

(Charité-Universitätsmedizin Berlin) PD Dr. med.-vet. Gundula Schulze-Tanzil, Campus Benjamin Franklin Klinik für Orthopädische, Unfall- und Wiederherstellungschirurgie.

Germany

(Westphalian Wilhelms University) Prof. R. Johannes, Director, Institute of Experimental Dermatology, Muenster. "S100 protein implications in rheumatoid arthritis and osteoarthritis".

United States

(Harvard University) Professor Vicki Rosen, Department Head and Professor of Developmental Biology. "BMP signaling in synthetic biomaterials"

United States

(Stanford University) Assistant Professor Sarah Heilshorn, Department of Materials Science & Engineering. "Developing minimally-invasive delivery method for potential use in spine fusion and osteoporotic fracture."

United States

(Tufts University) Professor David Kaplan, "Biphasic scaffolds for long-term osteochondral defect repair"

United States

(University of Pennsylvania) Professor Thomas Schaer, Director, Comparative Orthopaedic Research Laboratory, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine. "In vivo performance of synthetic material in an orthopaediclly relevant large animal model".

United States

(University of South Florida) Professor Dmitry Gabrilovich, Robert Rothman Endowed Chair in Cancer Research, H. Lee Moffitt Cancer Center and Research Institute. " Skeletal phenotype in S100A9 transgeneic mice".

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