Professor Hala Zreiqat

Bsc (Hons) Jordan PhD UNSW
NH&MRC Senior Research Fellow
Head: Biomaterials & Tissue Engineering Research Unit
Founder & Chair of ADATE
Member of Bosch Institute
Visiting Professor at American University of Beirut (AUB)
Professor AMME

J07 - Mechanical Engineering Building
The University of Sydney

Telephone +61 2 9351 2392
Fax +61 2 9351 7060

Website ADATE - Alliance for Design and Application in Tissue Engineering

Bosch Institute

Biomaterials and Tissue Engineering Research Unit

Curriculum vitae Curriculum vitae

Biographical details

Professor Hala Zreiqat is a National Health and Medical Research Fellow, Head of the Biomaterials and Tissue Engineering Research Unit in the Faculty of Engineering, University of Sydney. Her group consists of multidisciplinary team of researchers including engineers, cell and molecular biologists and clinicians. She specializes in developing engineered biomaterials and scaffolds for skeletal tissue applications, and investigating their effect on in vitro and in vivo osteogenesis. Her team conducts research to gain greater understanding of bone/cartilage and endothelial cells biology when in contact with engineered biomaterials. She has over 80 peer-reviewed publications; 4 review papers; 12 book chapters; and over 120 abstracts in national and international meetings. She is regularly invited to give keynote and plenary presentations at major international and national conferences. She has organized / chaired a number of major international conferences/ symposia / workshops. She is the immediate past president of the Australian and New Zealand Orthopaedic research Society (2010-2012). Founder & Chair, Alliance for Design and Application in Tissue Engineering (formerly known as Sydney University Tissue Engineering Network - SuTEN, 2006 to present). Amongst her awards are: Leopold Dintenfass Memorial Award, for Excellence in Research (2012); University of Sydney Engineering Deans Research Award (2009).

Research interests

Millions of people worldwide suffer bone loss due to injury, infection, disease or abnormal skeletal development, and treatment frequently requires regeneration of new bone. Since each patient has only a limited amount of bone available for grafting, the demand for synthetic bone substitutes is high. Those currently available are far from optimal, but Professor Hala Zreiqat has developed a unique ceramic material that acts as a scaffold on which the body can regenerate new bone, then gradually degrades as it is replaced by natural bone.

"The bone substitute my team and I have developed resembles natural bone in terms of architecture, strength and porosity. So it is strong enough to withstand the loads that will be applied to it, and also contains pores that allow blood and nutrients to penetrate it. In this way it is designed to encourage normal bone growth, and to eventually be replaced by natural bone in the body.

"The fact that it actually 'kick starts' the process of bone regeneration makes it far superior to other available materials. Our tests also show that it will not be rejected by the body. In addition, we can make as many implants as we want from this material, so availability will not be a problem.

"This material has the potential to positively affect the quality of life of millions of people globally, so we are hoping to see it in use clinically within the next 10 years.

Teaching and supervision

AMME4971 - Tissue Engineering

AMME5971 - Applied Tissue Engineering

Associations

  • Member, Editorial Board, International Journal of Biomaterials Research and Engineering
  • Member, Editorial Board, Recent Patents on Biomedical Engineering
  • Associate Editor, Journal of Biomimetics, Biomaterials, and Tissue Engineering
  • Editorial Board, Journal of Medical Engineering

Awards and honours

Australian

  • Australia-Harvard Fellowship: AUD 10,000 (2013)
  • Leopold Dintenfass Memorial Award, for Excellence in Research (2012)
  • NHMRC Senior Research Fellowship: AUD 570,640 (2011-2015)
  • University of Sydney Engineering Deans Research Award (2009)
  • Australian Academy of Science Award for research undertaken at Laboratoire de Physiopathologie et Pharmacologie Articulaires, Faculté de Médicine, Université Henri Poincaré, France: AUD 10,500 (2009)
  • R Douglas Wright Biomedical Career Development Award (NHMRC): AUD 426,250 (2006-2010) Australian Academy of Science Award for research undertaken at Institute of Pathology, Johannes Gutenberg University, Mainz, Germany: AUD 11,000 (2004)
  • Australian Postgraduate Research Award (PhD scholarship): AUD 28,000 p.a. (1995-1997)

International

  • Advisor World Orthopaedic Alliance (WOA)- (October 2012-present)
  • German Academic Exchange Service (DAAD) award for research undertaken at Saarland University, Germany: AUD 10,000 (2011)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2011)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2007)
  • Invited Guest Professorship, Laboratoire de biomatériaux et polymères de spécialité, Institut Galilée, Université Paris 13: AUD 8,000 (2006)

National Collaboration

  • Prof C Little, Director, Raymond Purves Bone and Joint Research Labs, Royal North Shore Hospital, Sydney (Role of S100A8/S100A9 proteins in cartilage degeneration in osteoarthritis)
  • A/Prof Colin Dunstan, University of Sydney, Assessment of bone quality when in contact with biomaterials.
  • Associate Professor Lars Ittner, Laboratory for Translational Neurodegeneration, The Brain & Mind Research Institute, BMRI, University of Sydney. "In vivo signaling pathways involved in bone regeneration using synthetic scaffolds."
  • Dr. Peter Pivonka, Faculty of Engineering, University of Western Australia. "Use of computational modelling to estimate stiffness, strength and dissolution of the implants".
  • Associate Professor Andrew Minett, School of Chemical and Biomolecular Engineering, Facfulty of Engineering, University of Sydney. The collaboration 'focuses on creating functional nanomaterial composites for manipulating the material - biology interface. This is achieved through the incorporation of nanomaterials both into or onto hierarchical structures resulting in stronger composite materials with functional, intelligent surfaces."

In the media

  • The new bone is connected to the synthetic bone [4 Aug 2012]

    University of Sydney

    By creating a new synthetic material that acts as the foundation on which new, organic bone can grow, Professor Hala Zreiqat aims to help surgeons revolutionise bone transplants an... More...

  • Bone Scaffold [16 June 2011]

    ABC Catalyst

    Bone is the second most transplanted tissue in the world, second only to blood. While our bones have the ability to heal a simple fracture, large areas of damage require replacement material... More...

  • Sydney hosts human engineering conference [13 Nov 2008]

    ABC Radio

    Engineering body parts is in fact a growing area of research and scientists from around the world gathered at Sydney University today to discuss this issue.... More...

International links

China

(Chinese Academy of Science, Shanghai) Prof Xuanyong Liu. "Plasma spray coating for orthopaedic implant applications".

China

(Jiao Tong University) Professor Xinquan, Oral Bioengineering Lab, Shanghai Research Institute of Stomatology. "In vivo and in vitro validation of novel modified Ti-6Al-4V surfaces"

China

(University Medical College, Shantou, Guangdong) Associate Professor Guanfeng Yao, Department of Orthopaedics, the Second Affiliated Hospital. " In vivo evaluation of novel synthetic scaffolds in lumbar spine fusion".

Germany

(Charité-Universitätsmedizin Berlin) PD Dr. med.-vet. Gundula Schulze-Tanzil, Campus Benjamin Franklin Klinik für Orthopädische, Unfall- und Wiederherstellungschirurgie.

Germany

(Westphalian Wilhelms University) Prof. R. Johannes, Director, Institute of Experimental Dermatology, Muenster. "S100 protein implications in rheumatoid arthritis and osteoarthritis".

United States

(Harvard University) Professor Vicki Rosen, Department Head and Professor of Developmental Biology. "BMP signaling in synthetic biomaterials"

United States

(Stanford University) Assistant Professor Sarah Heilshorn, Department of Materials Science & Engineering. "Developing minimally-invasive delivery method for potential use in spine fusion and osteoporotic fracture."

United States

(Tufts University) Professor David Kaplan, "Biphasic scaffolds for long-term osteochondral defect repair"

United States

(University of Pennsylvania) Professor Thomas Schaer, Director, Comparative Orthopaedic Research Laboratory, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine. "In vivo performance of synthetic material in an orthopaediclly relevant large animal model".

United States

(University of South Florida) Professor Dmitry Gabrilovich, Robert Rothman Endowed Chair in Cancer Research, H. Lee Moffitt Cancer Center and Research Institute. " Skeletal phenotype in S100A9 transgeneic mice".

Selected grants

2014

  • Using 3D printing technology to develop architecturally-controlled synthetic bone substitutes; Zreiqat H, Li Q, Hyvarinen J; Australian Research Council (ARC)/Linkage Projects (LP).
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Engineering strategies for bone regeneration through microstructural design; Zreiqat H, Dunstan C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • 2013 Australia-Harvard Fellowship; Zreiqat H; Harvard Club of Australia Foundation/Australia - Harvard Fellowship.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Microstructural Design Strategies for Repairing Traumatic Skeletal Injuries; Zreiqat H, Dunstan C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • A basis for building bone: Novel biomaterials for new bone growth; Zreiqat H; DVC Research/Bridging Support Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Australia-Harvard Fellowship 2012; Zreiqat H; Harvard Club of Australia Foundation/Australia - Harvard Fellowship.

2011

  • Novel engineered nano-composite scaffolds for bone regeneration; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The Instron testing material instrument (Model 5943); Dehghani F, Weiss A, Bilek M, Zreiqat H, Dunstan C, Chrzanowski W, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The small animal bioimager; Halliday G, Hambley T, Zreiqat H, Richardson D, Holst J, Rasko J, Byrne S, Dong Q, Hong A, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Senior Research Fellowship A; Zreiqat H; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2010

  • Novel coatings for orthopaedic application; Zreiqat H, Sonnabend D, Dunstan C; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Novel scaffolds for augmenting large bone defects; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Harnessing the physiological effects of strontium and zinc to produce novel biomaterials for orthopaedic applications; Zreiqat H, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Biomaterials for orthopaedic applications; Zreiqat H; DVC Research/Bridging Support Grant.
  • Tissue Engineering and Regenerative Medicine: The Next 20 years; Zreiqat H; DVC International/IPDF Grant.

2009

  • Scaffolds for bone tissue regeneration and use in orthopaedic applications; Fick J, Pivonka P, Weston R, Zreiqat H, Wu C, Johnson K; Australian Research Council (ARC)/Linkage Projects (LP).
  • Novel coatings for orthopaedic implants; Grau G, Little D, Zreiqat H, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Developing Novel Scaffolds for Osteochondral Defects and Orthopaedic Prosthetic Coatings for Bone Tissue Regeneration and Implant Ossointegration; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2008

  • Novel Scaffolds for repairing bone defects; Zreiqat H, Little D, Dunstan C; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Developing better treatment and novel prosthetic implants for joint replacement damaged due to arthritis; Zreiqat H; Rebecca L Cooper Medical Research Foundation/Research Support.

2007

  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop A, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho J, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Effect of incorporating strontium into the surface of titanium alloy on bone cell behaviour; Zreiqat H; Australian Institute of Nuclear Science and Engineering (AINSE)/Research Grants.
  • Micro-engineered biomaterials for improved orthopedic devices and scaffolds; Zreiqat H; University of Sydney/Bridging Support.

2006

  • Histological testing of spinal implants � St. George Hospital; Zreiqat H, Diwan A; BLO University of New South Wales (Through Ortopaedic research Centre)/BLO Project.
  • Histological services on retrieved femoral heads; Zreiqat H, Gillies M; Worley Parsons Services Pty Ltd/BLO Project.
  • Mechanisms of bone formation at the device / tissue interface; Zreiqat H, Haynes D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular Mechanisms Controlling The Maintenance And Differentiation Of Skeletal Tissue/Device Interface For Biomedical Engineering Applications; Zreiqat H; National Health and Medical Research Council (NHMRC)/Career Development Fellowship.

2005

  • Improving orthopaedic/dental devices by surface chemical modification; Zreiqat H, Swain M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Mechanism of action of Zoledronnic acid in inflammatory arthritis; Zreiqat H, Binder W; Royal Australasian College of Physicians/Barbara Cameron ARA Fellowship.

Selected publications

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Book Chapters

  • Lu, Z., Roohani-Esfahani, S., Zreiqat, H. (2014). Mimicking Bone Microenvironment for Directing Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. In Gordana Vunjak-Novakovic, Kursad Turksen (Eds.), Biomimetics and Stem Cells: Methods and Protocols, (pp. 161-171). New York: Springer Science + Business Media.
  • Roohani-Esfahani, S., Zreiqat, H. (2012). Ceramic Scaffolds, Current Issues and Future Trends. In Murugan Ramalingam, Ziyad Haidar, Seeram Ramakrishna, Hisatoshi Kobayashi, Youss (Eds.), Integrated Biomaterials in Tissue Engineering, (pp. 25-46). Canada: Scrivener Press.
  • Ma, W., Ruys, A., Zreiqat, H. (2009). Diamond-like carbon (DLC) as a biocompatible coating in orthopaedic and cardiac medicine. In L Di Silvio (Eds.), Cellular Response to Biomaterials, (pp. 391-426). Cambridge, UK, Switzerland: Woodhead Publishing Limited.

Journals

  • Lu, Z., Wang, G., Roohani-Esfahani, S., Dunstan, C., Zreiqat, H. (2014). Baghdadite Ceramics Modulate the Cross Talk Between Human Adipose Stem Cells and Osteoblasts for Bone Regeneration. Tissue Engineering. Part A, 20(5-6), 992-1002. [More Information]
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a Novel Triphasic and Bioactive Ceramic and Evaluation of its in vitro and in vivo Cytocompatibility and Osteogenesis. Journal of Materials Chemistry B, article in press. [More Information]
  • Newman, P., Roohani-Esfahani, S., Zreiqat, H., Minett, A. (2014). See the extracellular forest for the nanotrees. Materials Today, 17(1), 43-44. [More Information]
  • Lu, Z., Wang, G., Dunstan, C., Chen, Y., Lu, W., Davies, B., Zreiqat, H. (2013). Activation and Promotion of Adipose Stem Cells by Tumour Necrosis Factor-Alpha Preconditioning for Bone Regeneration. Journal of Cellular Physiology, 228(8), 1737-1744. [More Information]
  • Newman, P., Minett, A., Ellis-Behnke, R., Zreiqat, H. (2013). Carbon nanotubes: Their potential and pitfalls for bone tissue regeneration and engineering. Nanomedicine: Nanotechnology, Biology, and Medicine, 9(8), 1139-1158. [More Information]
  • Zhao, X., Wang, G., Zheng, H., Lu, Z., Zhong, X., Cheng, X., Zreiqat, H. (2013). Delicate refinement of surface nanotopography by adjusting TiO2 coating chemical composition for enhanced interfacial biocompatibility. ACS Applied Materials and Interfaces, 5(16), 8203-8209. [More Information]
  • Roohani-Esfahani, S., Chen, Y., Shi, J., Zreiqat, H. (2013). Fabrication and characterization of a new, strong and bioactive ceramic scaffold for bone regeneration. Materials Letters, 107, 378-381. [More Information]
  • Li, J., Gil, E., Hayden, R., Li, C., Roohani-Esfahani, S., Kaplan, D., Zreiqat, H. (2013). Multiple Silk Coatings on Biphasic Calcium Phosphate Scaffolds: Effect on Physical and Mechanical Properties and In Vitro Osteogenic Response of Human Mesenchymal Stem Cells. Biomacromolecules, 14(7), 2179-2188. [More Information]
  • Wang, G., Lu, Z., Zhao, X., Kondyurin, A., Zreiqat, H. (2013). Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by "nanocarving" and mineralization deposition and its potential use for guiding cell behaviors. Journal of Materials Chemistry B, 1(19), 2455-2462. [More Information]
  • El Sayed, K., Marzahn, U., John, T., Hoyer, M., Zreiqat, H., Witthuhn, A., Kohl, B., Haisch, A., Schulze-Tanzil, G. (2013). PGA-associated heterotopic chondrocyte cocultures: implications of nasoseptal and auricular chondrocytes in articular cartilage repair. Journal of Tissue Engineering and Regenerative Medicine, 7(1), 61-72. [More Information]
  • Zhang, W., Wang, G., Liu, Y., Zhao, X., Zou, D., Zhu, C., Jin, Y., Huang, Q., Sun, J., Liu, X., Xinquan, J., Zreiqat, H. (2013). The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration. Biomaterials, 34(13), 3184-3195. [More Information]
  • Roohani-Esfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]
  • Wang, G., Lu, Z., Xie, K., Lu, W., Roohani-Esfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087. [More Information]
  • Lu, Z., Roohani-Esfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515. [More Information]
  • Roohani-Esfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C: Materials for Biological Applications, 32(4), 830-839. [More Information]
  • Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C: Materials for Biological Applications, 32(7), 1818-1826. [More Information]
  • Roohani-Esfahani, S., Dunstan, C., Davies, B., Pearce, S., Williams, R., Zreiqat, H. (2012). Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds. Acta Biomaterialia, 8(11), 4162-4172. [More Information]
  • Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429. [More Information]
  • Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84. [More Information]
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318. [More Information]
  • Wang, G., Liu, X., Zreiqat, H., Ding, C. (2011). Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings. Colloids And Surfaces B: Biointerfaces, 86(2), 267-274. [More Information]
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society. Interface, 8(61), 1192-1203. [More Information]
  • Roohani-Esfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581. [More Information]
  • Lu, Z., Roohani-Esfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering. Part A, 17(11/12), 1651-1661. [More Information]
  • Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through α2β1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329.
  • Wu, C., Chang, J., Zreiqat, H. (2010). Engineered Ca-Si Based Ceramics for Skeletal Tissue Reconstruction. Materials Science Foundations (monograph series), 62, 122-149. [More Information]
  • Wang, G., Zreiqat, H. (2010). Functional Coatings or Films for Hard-Tissue Applications. Materials, 3(7), 3994-4050. [More Information]
  • Wu, C., Zreiqat, H. (2010). Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery. Acta Biomaterialia, 6(3), 820-829. [More Information]
  • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245. [More Information]
  • Zreiqat, H., Yang, C., James, B., Duflou, J., Lowe, H. (2010). Probable endothelisation of bare metal stent struts extending from the left main coronary into the aorta. Journal of Thrombosis and Thrombolysis, 30(4), 500-501. [More Information]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509. [More Information]
  • Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving α2β1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering. Part A, 16(10), 3075-3084.
  • Wang, C., Karlis, G., Anderson, G., Dunstan, C., Carbone, A., Berger, G., Ploska, U., Zreiqat, H. (2009). Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants. Journal of Biomedical Materials Research. Part A, 90A(2), 419-428. [More Information]
  • Schulze-Tanzil, G., Zreiqat, H., Sabat, R., Kohl, B., Halder, A., Muller, R., John, T. (2009). Interleukin-10 and articular cartilage: Experimental therapeutical approaches in cartilage disorders. Current Gene Therapy: the international journal for in-depth reviews on gene therapy, 9(4), 631-315.
  • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430.
  • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society. Interface, 6(1), 159-168.
  • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204. [More Information]
  • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208. [More Information]
  • Zreiqat, H., James, B., Brieger, D., Kritharides, L., Lowe, H. (2008). Acute coronary stent thrombosis: Toward insights into possible mechanism using novel imaging methods. Thrombosis and Haemostasis, 99(5), 976-977. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146. [More Information]
  • Helary, G., Poussard, L., Zreiqat, H., Migonney, V. (2008). Functionalization of biomaterials for joint implant application. Bio-Medical Materials and Engineering, 18, 237-239.
  • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353. [More Information]
  • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576. [More Information]
  • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
  • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B DOI: 10.1002/jbm.b.31109(2), 346-353. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]
  • Oberholzer, A., John, T., Kohl, B., Gust, T., Muller, R., La Face, D., Hutchins, B., Zreiqat, H., Ertel, W., Schulze-Tanzil, G. (2007). Adenoviral transduction is more efficient in alginate-derived chondrocytes than in monolayer chondrocytes. Cell and Tissue Research, 328(2), 383-390. [More Information]
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2007). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628. [More Information]
  • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research. Part A, 86(2 (Online article 29 Oct 2007)), 402-410. [More Information]
  • John, T., Muller, R., Oberholzer, A., Zreiqat, H., Kohl, B., Ertel, W., Hostmann, A., Tschoeke, S., Schulze-Tanzil, G. (2007). Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro. Cytokine, 40(3), 226-234. [More Information]
  • Wu, C., Zreiqat, H. (2007). Preparation and Characteristics of Strontium Containing Bioactive CaSiO3 Ceramics. Key Engineering Materials, 330-332(I), 499-502.
  • Zreiqat, H., Howlett, C., Gronthos, S., Hume, D., Geczy, C. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38(5), 381-391. [More Information]
  • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181. [More Information]
  • Knabe, C., Kraska, B., Koch, C., Gross, U., Zreiqat, H., Stiller, M. (2006). A method for immunohistochemical detection of osteogenic markers in undecalcified bone sections. Biotechnic and Histochemistry, 81(1), 31-39.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2006). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628. [More Information]
  • Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. Key Engineering Materials, 309-311, 709-712.
  • Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science: Materials in Medicine, 16, 1199-1205. [More Information]
  • Zreiqat, H., Roest, R., Valenzuela, S., Milev, A., Ben-Nissan, B. (2005). Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates. Key Engineering Materials, 284-286, 541-544.
  • McCormick, M., Rahimi, F., Bobryshev,, Y., Gaus, K., Zreiqat, H., Cai, H., Lord,, R., Geczy, C. (2005). S100A8 and S100A9 in Human Arterial Wall: implications for atherogenesis. Journal of Biological Chemistry, 280(50), 41521-41529.
  • Knabe, C., Stiller, M., Berger, G., Reif, D., Gildenhaar, R., Hewlett, C., Zreiqat, H. (2005). The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro. Clinical Oral Implants Research, 16(1), 119-127.
  • Zreiqat, H., Valenzuela, S., Ben-Nissan, B., Roest, R., Knabe, C., Radlanski, R., Renz, H., Evans, P. (2005). The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials, 26(36), 7579-7586. [More Information]
  • Knabe, C., Berger, G., Gildenhaar, R., Meyer, J., Hewlett, C., Markovic, B., Zreiqat, H. (2004). Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro. Journal of Biomedical Materials Research. Part A, 69A(1), 145-154.
  • Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., Hatzinikolous, G., Capone, M., Holding, C., Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFκB, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions. Biomaterials, 25(13), 2507-2514. [More Information]
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Proliferation and bone-related gene expression of osteoblasts grown on hydroxyapatite ceramics sintered at different temperature. Biomaterials, 25(15), 2949-2956. [More Information]
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Quantitative Analysis of Osteoprotegerin and RANKL Expression in Osteoblast Grown on Different Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 713-716.
  • Haynes, D., Crotti, T., Zreiqat, H. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885. [More Information]
  • Knabe, C., Hewlett, C., Klar, F., Zreiqat, H. (2004). The effect of different titanium and hydroxyapatite-coated dental implant surfaces on phenotypic expression of human bone-derived cells. Journal of Biomedical Materials Research. Part A, 71A(1), 98-107. [More Information]
  • Zreiqat, H., Berger, G., Gildenhaar, R., Knabe, C. (2004). The Functional Expression of Human Bone-Derived Cells Grown on Rapidly Resorbable Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 1059-1062.
  • Knabe, C., Berger, G., Gildenhaar, R., Hewlett, C., Markovic, B., Zreiqat, H. (2004). The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics. Biomaterials, 25, 335-344.
  • Knabe, C., Berger, G., Gildenhaar, R., Klar, F., Zreiqat, H. (2004). The modulation of osteogenesis in vitro by calcium titanium phosphate coatings. Biomaterials, 25(20), 4911-4919. [More Information]
  • Zreiqat, H., Ahu Akin, F., Hewlett, C., Markovic, B., Haynes, D., Lateef, S., Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part A, 64A(1), 105-113.
  • Zreiqat, H., Kumar, R., Markovic, B., Zicat, B., Hewlett, C. (2003). Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products. Journal of Biomedical Materials Research. Part A, 65A(1), 109-117.
  • Zreiqat, H., Crotti, T., Hewlett, C., Capone, M., Markovic, B., Haynes, D. (2003). Prosthetic particles modify the expression of bone-related proteins by human osteoblastic cells in vitro. Biomaterials, 24, 337-346.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Knabe, C., Schulze-Tanzil, G., Shakibaei, G. (2003). Surface modification of bioceramics affect osteoblastic cells response. Key Engineering Materials, 240-242, 707-710.
  • Knabe, C., Hewlett, C., Markovic, B., Gildenhaar, R., Berger, G., Zreiqat, H. (2003). The functional expression of osteoblasts grown on rapidly resorbable calcium phosphates. Key Engineering Materials, 240-242(-), 679-682.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Schulze-Tanzil, G., Knabe, C., Shakibaei, G. (2002). Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 62, 175-184.

Conferences

  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
  • Roohani-Esfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Ma, W., Ruys, A., Zreiqat, H., Mason, R., Ringer, S., Liu, Z., Keast, V., Martin, P., Bendavid, A. (2006). The Biocompatibility of Diamond-Like Carbon Nano Films. International Conference on Nanoscience and Nanotechnology 2006, Brisbane, Australia: (IEEE) Institute of Electrical and Electronics Engineers.

Patents

  • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.

Magazine / Newspaper Articles

  • Lu, W., McKenzie, D., Dunstan, C., Zreiqat, H., Bilek, M. (2012). Plasma Immersion Ion Implantation Treatment of Poly-ether Ether Ketone for the Immobilization of Biomolecules on Surfaces (ID: 836). International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration.

2014

  • Lu, Z., Wang, G., Roohani-Esfahani, S., Dunstan, C., Zreiqat, H. (2014). Baghdadite Ceramics Modulate the Cross Talk Between Human Adipose Stem Cells and Osteoblasts for Bone Regeneration. Tissue Engineering. Part A, 20(5-6), 992-1002. [More Information]
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a Novel Triphasic and Bioactive Ceramic and Evaluation of its in vitro and in vivo Cytocompatibility and Osteogenesis. Journal of Materials Chemistry B, article in press. [More Information]
  • Lu, Z., Roohani-Esfahani, S., Zreiqat, H. (2014). Mimicking Bone Microenvironment for Directing Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. In Gordana Vunjak-Novakovic, Kursad Turksen (Eds.), Biomimetics and Stem Cells: Methods and Protocols, (pp. 161-171). New York: Springer Science + Business Media.
  • Newman, P., Roohani-Esfahani, S., Zreiqat, H., Minett, A. (2014). See the extracellular forest for the nanotrees. Materials Today, 17(1), 43-44. [More Information]

2013

  • Lu, Z., Wang, G., Dunstan, C., Chen, Y., Lu, W., Davies, B., Zreiqat, H. (2013). Activation and Promotion of Adipose Stem Cells by Tumour Necrosis Factor-Alpha Preconditioning for Bone Regeneration. Journal of Cellular Physiology, 228(8), 1737-1744. [More Information]
  • Newman, P., Minett, A., Ellis-Behnke, R., Zreiqat, H. (2013). Carbon nanotubes: Their potential and pitfalls for bone tissue regeneration and engineering. Nanomedicine: Nanotechnology, Biology, and Medicine, 9(8), 1139-1158. [More Information]
  • Zhao, X., Wang, G., Zheng, H., Lu, Z., Zhong, X., Cheng, X., Zreiqat, H. (2013). Delicate refinement of surface nanotopography by adjusting TiO2 coating chemical composition for enhanced interfacial biocompatibility. ACS Applied Materials and Interfaces, 5(16), 8203-8209. [More Information]
  • Roohani-Esfahani, S., Chen, Y., Shi, J., Zreiqat, H. (2013). Fabrication and characterization of a new, strong and bioactive ceramic scaffold for bone regeneration. Materials Letters, 107, 378-381. [More Information]
  • Li, J., Gil, E., Hayden, R., Li, C., Roohani-Esfahani, S., Kaplan, D., Zreiqat, H. (2013). Multiple Silk Coatings on Biphasic Calcium Phosphate Scaffolds: Effect on Physical and Mechanical Properties and In Vitro Osteogenic Response of Human Mesenchymal Stem Cells. Biomacromolecules, 14(7), 2179-2188. [More Information]
  • Wang, G., Lu, Z., Zhao, X., Kondyurin, A., Zreiqat, H. (2013). Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by "nanocarving" and mineralization deposition and its potential use for guiding cell behaviors. Journal of Materials Chemistry B, 1(19), 2455-2462. [More Information]
  • El Sayed, K., Marzahn, U., John, T., Hoyer, M., Zreiqat, H., Witthuhn, A., Kohl, B., Haisch, A., Schulze-Tanzil, G. (2013). PGA-associated heterotopic chondrocyte cocultures: implications of nasoseptal and auricular chondrocytes in articular cartilage repair. Journal of Tissue Engineering and Regenerative Medicine, 7(1), 61-72. [More Information]
  • Zhang, W., Wang, G., Liu, Y., Zhao, X., Zou, D., Zhu, C., Jin, Y., Huang, Q., Sun, J., Liu, X., Xinquan, J., Zreiqat, H. (2013). The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration. Biomaterials, 34(13), 3184-3195. [More Information]
  • Roohani-Esfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]

2012

  • Wang, G., Lu, Z., Xie, K., Lu, W., Roohani-Esfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087. [More Information]
  • Lu, Z., Roohani-Esfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515. [More Information]
  • Roohani-Esfahani, S., Zreiqat, H. (2012). Ceramic Scaffolds, Current Issues and Future Trends. In Murugan Ramalingam, Ziyad Haidar, Seeram Ramakrishna, Hisatoshi Kobayashi, Youss (Eds.), Integrated Biomaterials in Tissue Engineering, (pp. 25-46). Canada: Scrivener Press.
  • Roohani-Esfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohani-Esfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C: Materials for Biological Applications, 32(4), 830-839. [More Information]
  • Lu, W., McKenzie, D., Dunstan, C., Zreiqat, H., Bilek, M. (2012). Plasma Immersion Ion Implantation Treatment of Poly-ether Ether Ketone for the Immobilization of Biomolecules on Surfaces (ID: 836). International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration.
  • Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C: Materials for Biological Applications, 32(7), 1818-1826. [More Information]
  • Roohani-Esfahani, S., Dunstan, C., Davies, B., Pearce, S., Williams, R., Zreiqat, H. (2012). Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds. Acta Biomaterialia, 8(11), 4162-4172. [More Information]
  • Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429. [More Information]
  • Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84. [More Information]

2011

  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318. [More Information]
  • Wang, G., Liu, X., Zreiqat, H., Ding, C. (2011). Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings. Colloids And Surfaces B: Biointerfaces, 86(2), 267-274. [More Information]
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society. Interface, 8(61), 1192-1203. [More Information]
  • Roohani-Esfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581. [More Information]
  • Lu, Z., Roohani-Esfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering. Part A, 17(11/12), 1651-1661. [More Information]

2010

  • Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through α2β1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329.
  • Wu, C., Chang, J., Zreiqat, H. (2010). Engineered Ca-Si Based Ceramics for Skeletal Tissue Reconstruction. Materials Science Foundations (monograph series), 62, 122-149. [More Information]
  • Roohani-Esfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
  • Wang, G., Zreiqat, H. (2010). Functional Coatings or Films for Hard-Tissue Applications. Materials, 3(7), 3994-4050. [More Information]
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Wu, C., Zreiqat, H. (2010). Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery. Acta Biomaterialia, 6(3), 820-829. [More Information]
  • Wu, C., Ramaswamy, Y., Zreiqat, H. (2010). Porous diopside (CaMgSi2O6) scaffold: A promising bioactive material for bone tissue engineering. Acta Biomaterialia, 6(6), 2237-2245. [More Information]
  • Zreiqat, H., Yang, C., James, B., Duflou, J., Lowe, H. (2010). Probable endothelisation of bare metal stent struts extending from the left main coronary into the aorta. Journal of Thrombosis and Thrombolysis, 30(4), 500-501. [More Information]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
  • Li, J., Roohani-Esfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
  • Roohani-Esfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509. [More Information]
  • Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving α2β1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering. Part A, 16(10), 3075-3084.

2009

  • Wang, C., Karlis, G., Anderson, G., Dunstan, C., Carbone, A., Berger, G., Ploska, U., Zreiqat, H. (2009). Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants. Journal of Biomedical Materials Research. Part A, 90A(2), 419-428. [More Information]
  • Ma, W., Ruys, A., Zreiqat, H. (2009). Diamond-like carbon (DLC) as a biocompatible coating in orthopaedic and cardiac medicine. In L Di Silvio (Eds.), Cellular Response to Biomaterials, (pp. 391-426). Cambridge, UK, Switzerland: Woodhead Publishing Limited.
  • Schulze-Tanzil, G., Zreiqat, H., Sabat, R., Kohl, B., Halder, A., Muller, R., John, T. (2009). Interleukin-10 and articular cartilage: Experimental therapeutical approaches in cartilage disorders. Current Gene Therapy: the international journal for in-depth reviews on gene therapy, 9(4), 631-315.
  • Ramaswamy, Y., Wu, C., Zreiqat, H. (2009). Orthopedic coating materials: Considerations and applications. Expert Review of Medical Devices, 6(4), 423-430.
  • Wu, C., Ramaswamy, Y., Liu, X., Wang, G., Zreiqat, H. (2009). Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6AI-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society. Interface, 6(1), 159-168.
  • Zreiqat, H., Wu, C., Ramaswamy, Y. (2009). Preparation and application of novel Baghdadite (Ca3ZrSi2O9) Scaffolds and coatings for skeletal tissue regeneration. Patent No. WO/2009/052583. Worldwide.
  • Ramaswamy, Y., Wu, C., Dunstan, C., Hewson, B., Eindorf, T., Anderson, G., Zreiqat, H. (2009). Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta Biomaterialia, 5(8), 3192-3204. [More Information]
  • Wu, C., Ramaswamy, Y., Zhu, Y., Zheng, R., Appleyard, R., Howard, A., Zreiqat, H. (2009). The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials, 30(12), 2199-2208. [More Information]

2008

  • Zreiqat, H., James, B., Brieger, D., Kritharides, L., Lowe, H. (2008). Acute coronary stent thrombosis: Toward insights into possible mechanism using novel imaging methods. Thrombosis and Haemostasis, 99(5), 976-977. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146. [More Information]
  • Helary, G., Poussard, L., Zreiqat, H., Migonney, V. (2008). Functionalization of biomaterials for joint implant application. Bio-Medical Materials and Engineering, 18, 237-239.
  • Wu, C., Ramaswamy, Y., Boughton, P., Zreiqat, H. (2008). Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 4(2), 343-353. [More Information]
  • Wu, C., Ramaswamy, Y., Gail, D., Yang, W., Xiao, K., Zhang, L., Yin, Y., Zreiqat, H. (2008). Novel sphene coatings on Ti-6Al-4V for orthopaedic implants using sol-gel method. Acta Biomaterialia, 4, 569-576. [More Information]
  • Zhu, Y., Wu, C., Ramaswamy, Y., Kockrick, E., Simon, P., Kaskel, S., Zreiqat, H. (2008). Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering. Microporous and Mesoporous Materials, 112, 494-503.
  • Wu, C., Ramaswamy, Y., Chang, J., Woods, J., Chen, Y., Zreiqat, H. (2008). The Effect of Zn Contents on Phase Composition, Chemical Stability and Cellular Bioactivity in Zn-Ca-Si System Ceramics. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B DOI: 10.1002/jbm.b.31109(2), 346-353. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]

2007

  • Oberholzer, A., John, T., Kohl, B., Gust, T., Muller, R., La Face, D., Hutchins, B., Zreiqat, H., Ertel, W., Schulze-Tanzil, G. (2007). Adenoviral transduction is more efficient in alginate-derived chondrocytes than in monolayer chondrocytes. Cell and Tissue Research, 328(2), 383-390. [More Information]
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2007). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628. [More Information]
  • Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H. (2007). Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. Journal of Biomedical Materials Research. Part A, 86(2 (Online article 29 Oct 2007)), 402-410. [More Information]
  • John, T., Muller, R., Oberholzer, A., Zreiqat, H., Kohl, B., Ertel, W., Hostmann, A., Tschoeke, S., Schulze-Tanzil, G. (2007). Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro. Cytokine, 40(3), 226-234. [More Information]
  • Wu, C., Zreiqat, H. (2007). Preparation and Characteristics of Strontium Containing Bioactive CaSiO3 Ceramics. Key Engineering Materials, 330-332(I), 499-502.
  • Zreiqat, H., Howlett, C., Gronthos, S., Hume, D., Geczy, C. (2007). S100A8/S100A9 and their association with cartilage and bone. Journal of Molecular Histology, 38(5), 381-391. [More Information]
  • Wu, C., Ramaswamy, Y., Kwik, D., Zreiqat, H. (2007). The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 28(21), 3171-3181. [More Information]

2006

  • Knabe, C., Kraska, B., Koch, C., Gross, U., Zreiqat, H., Stiller, M. (2006). A method for immunohistochemical detection of osteogenic markers in undecalcified bone sections. Biotechnic and Histochemistry, 81(1), 31-39.
  • Ma, W., Ruys, A., Mason, R., Martin, P., Bendavid, A., Liu, Z., Ionescu, M., Zreiqat, H. (2006). DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials, 28(9), 1620-1628. [More Information]
  • Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. Key Engineering Materials, 309-311, 709-712.
  • Ma, W., Ruys, A., Zreiqat, H., Mason, R., Ringer, S., Liu, Z., Keast, V., Martin, P., Bendavid, A. (2006). The Biocompatibility of Diamond-Like Carbon Nano Films. International Conference on Nanoscience and Nanotechnology 2006, Brisbane, Australia: (IEEE) Institute of Electrical and Electronics Engineers.

2005

  • Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science: Materials in Medicine, 16, 1199-1205. [More Information]
  • Zreiqat, H., Roest, R., Valenzuela, S., Milev, A., Ben-Nissan, B. (2005). Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates. Key Engineering Materials, 284-286, 541-544.
  • McCormick, M., Rahimi, F., Bobryshev,, Y., Gaus, K., Zreiqat, H., Cai, H., Lord,, R., Geczy, C. (2005). S100A8 and S100A9 in Human Arterial Wall: implications for atherogenesis. Journal of Biological Chemistry, 280(50), 41521-41529.
  • Knabe, C., Stiller, M., Berger, G., Reif, D., Gildenhaar, R., Hewlett, C., Zreiqat, H. (2005). The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro. Clinical Oral Implants Research, 16(1), 119-127.
  • Zreiqat, H., Valenzuela, S., Ben-Nissan, B., Roest, R., Knabe, C., Radlanski, R., Renz, H., Evans, P. (2005). The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials, 26(36), 7579-7586. [More Information]

2004

  • Knabe, C., Berger, G., Gildenhaar, R., Meyer, J., Hewlett, C., Markovic, B., Zreiqat, H. (2004). Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro. Journal of Biomedical Materials Research. Part A, 69A(1), 145-154.
  • Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., Hatzinikolous, G., Capone, M., Holding, C., Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFκB, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573.
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions. Biomaterials, 25(13), 2507-2514. [More Information]
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Proliferation and bone-related gene expression of osteoblasts grown on hydroxyapatite ceramics sintered at different temperature. Biomaterials, 25(15), 2949-2956. [More Information]
  • Wang, C., Duan, Y., Markovic, B., Barbara, J., Hewlett, C., Zhang, X., Zreiqat, H. (2004). Quantitative Analysis of Osteoprotegerin and RANKL Expression in Osteoblast Grown on Different Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 713-716.
  • Haynes, D., Crotti, T., Zreiqat, H. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885. [More Information]
  • Knabe, C., Hewlett, C., Klar, F., Zreiqat, H. (2004). The effect of different titanium and hydroxyapatite-coated dental implant surfaces on phenotypic expression of human bone-derived cells. Journal of Biomedical Materials Research. Part A, 71A(1), 98-107. [More Information]
  • Zreiqat, H., Berger, G., Gildenhaar, R., Knabe, C. (2004). The Functional Expression of Human Bone-Derived Cells Grown on Rapidly Resorbable Calcium Phosphate Ceramics. Key Engineering Materials, 254-256, 1059-1062.
  • Knabe, C., Berger, G., Gildenhaar, R., Hewlett, C., Markovic, B., Zreiqat, H. (2004). The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics. Biomaterials, 25, 335-344.
  • Knabe, C., Berger, G., Gildenhaar, R., Klar, F., Zreiqat, H. (2004). The modulation of osteogenesis in vitro by calcium titanium phosphate coatings. Biomaterials, 25(20), 4911-4919. [More Information]

2003

  • Zreiqat, H., Ahu Akin, F., Hewlett, C., Markovic, B., Haynes, D., Lateef, S., Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part A, 64A(1), 105-113.
  • Zreiqat, H., Kumar, R., Markovic, B., Zicat, B., Hewlett, C. (2003). Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products. Journal of Biomedical Materials Research. Part A, 65A(1), 109-117.
  • Zreiqat, H., Crotti, T., Hewlett, C., Capone, M., Markovic, B., Haynes, D. (2003). Prosthetic particles modify the expression of bone-related proteins by human osteoblastic cells in vitro. Biomaterials, 24, 337-346.
  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Knabe, C., Schulze-Tanzil, G., Shakibaei, G. (2003). Surface modification of bioceramics affect osteoblastic cells response. Key Engineering Materials, 240-242, 707-710.
  • Knabe, C., Hewlett, C., Markovic, B., Gildenhaar, R., Berger, G., Zreiqat, H. (2003). The functional expression of osteoblasts grown on rapidly resorbable calcium phosphates. Key Engineering Materials, 240-242(-), 679-682.

2002

  • Zreiqat, H., Hewlett, C., Zannettino, A., Evans, P., Schulze-Tanzil, G., Knabe, C., Shakibaei, G. (2002). Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 62, 175-184.

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