Table 1: Medicinal Chemistry

Table 1 lists units of study available to students in the Bachelor of Science and combined degrees. The units are available to students enrolled in other degrees in accordance with their degree resolutions.

Unit of study Credit points A: Assumed knowledge P: Prerequisites C: Corequisites N: Prohibition Session

Medicinal Chemistry

For a major in Medicinal Chemistry, the minimum requirement is 24 credit points comprising:
(i) PCOL3011/3911 and PCOL3012/3912; and
(ii) CHEM3110/3910 and CHEM3115/3915.
Note that there are intermediate prerequisites for the core senior units of study. Junior and intermediate units of study should be selected to permit progression to the required senior units of study.
PCOL3011
Toxicology
6    P PCOL2011 and PCOL2012. For BMedSc: 18 credit points of BMED including BMED2401 or (BMED2801 and BMED2802)
N PCOL3911, PCOL3001, PCOL3901
Semester 1
PCOL3911
Toxicology (Advanced)
6    P Distinction average in PCOL2011 and PCOL2012. For BMedSc: Distinction average in 18 credit points of BMED units including BMED2401 or (BMED2801 and BMED2802).
N PCOL3901, PCOL3011, PCOL3001
Semester 1
PCOL3012
Drug Design and Development
6    P PCOL2011 and PCOL2012. For BMedSc: 18 credit points of BMED including BMED2401 or (BMED2801 and BMED2802).
N PCOL3901, PCOL3001, PCOL3912
Semester 1
PCOL3912
Drug Design and Development (Adv)
6    P Distinction average in PCOL2011 and PCOL2012. For BMedSc: Distinction average in 18 credit points of BMED units including BMED2401 or (BMED2801 and BMED2802).
N PCOL3012, PCOL3901, PCOL3001
Semester 1
CHEM3110
Biomolecules: Properties and Reactions
6    P (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916).
N CHEM3910
Semester 1
CHEM3910
Biomolecules: Properties & Reactions Adv
6    P Credit or better in (CHEM2401 or CHEM2911 or CHEM2915)
N CHEM3110
Semester 1
CHEM3115
Synthetic Medicinal Chemistry
6    P (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916)
N CHEM3915
Semester 2
CHEM3915
Synthetic Medicinal Chemistry (Adv)
6    P Credit or better in (CHEM2401 or CHEM2911 or CHEM2915)
N CHEM3115
Semester 2

Medicinal Chemistry

For a major in Medicinal Chemistry, the minimum requirement is 24 credit points comprising:
(i) PCOL3011/3911 and PCOL3012/3912; and
(ii) CHEM3110/3910 and CHEM3115/3915.
Note that there are intermediate prerequisites for the core senior units of study. Junior and intermediate units of study should be selected to permit progression to the required senior units of study.
PCOL3011 Toxicology

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: PCOL2011 and PCOL2012. For BMedSc: 18 credit points of BMED including BMED2401 or (BMED2801 and BMED2802) Prohibitions: PCOL3911, PCOL3001, PCOL3901 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of retrospective data.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3911 Toxicology (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: Distinction average in PCOL2011 and PCOL2012. For BMedSc: Distinction average in 18 credit points of BMED units including BMED2401 or (BMED2801 and BMED2802). Prohibitions: PCOL3901, PCOL3011, PCOL3001 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3011. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: Dr Lenka Munoz Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: PCOL2011 and PCOL2012. For BMedSc: 18 credit points of BMED including BMED2401 or (BMED2801 and BMED2802). Prohibitions: PCOL3901, PCOL3001, PCOL3912 Assessment: One 2 hour exam, in class quizzes, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and ACE inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 6th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Adv)

Credit points: 6 Teacher/Coordinator: Dr Lenka Munoz Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: Distinction average in PCOL2011 and PCOL2012. For BMedSc: Distinction average in 18 credit points of BMED units including BMED2401 or (BMED2801 and BMED2802). Prohibitions: PCOL3012, PCOL3901, PCOL3001 Assessment: One 2 hour exam, in class quizzes, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 6th edition. Oxford University Press. 2013.
CHEM3110 Biomolecules: Properties and Reactions

Credit points: 6 Session: Semester 1 Classes: Two 1-hour lectures and one 4-hour practical per week. Prerequisites: (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916). Prohibitions: CHEM3910 Assessment: One 2-hour exam, prac reports (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
DNA, proteins and carbohydrates represent three classes of essential biomolecules present in all biological systems. This unit will cover the structure, reactivity and properties of biomolecules and the building blocks from which these molecules are assembled. Interactions between biomolecules and metal ions, small molecules and other biomolecules will be covered and the chemical tools for studying biomolecules highlighted. The design and synthesis of small molecules which mimic the functions of biomolecules will also be illustrated.
CHEM3910 Biomolecules: Properties & Reactions Adv

Credit points: 6 Session: Semester 1 Classes: Two 1-hour lectures, one 1-hour seminar and one 4-hour practical per week. Prerequisites: Credit or better in (CHEM2401 or CHEM2911 or CHEM2915) Prohibitions: CHEM3110 Assessment: One 2-hour exam, prac reports (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
DNA, proteins and carbohydrates represent three classes of essential biomolecules present in all biological systems. This unit will cover the structure, reactivity and properties of biomolecules and the building blocks from which these molecules are assembled. Interactions between biomolecules and metal ions, small molecules and other biomolecules will be covered and the chemical tools for studying biomolecules highlighted. The design and synthesis of small molecules which mimic the functions of biomolecules will also be illustrated. CHEM3910 students attend the same lectures as CHEM3110 students but attend an additional advanced seminar series comprising one lecture a week for 12 weeks.
CHEM3115 Synthetic Medicinal Chemistry

Credit points: 6 Session: Semester 2 Classes: Two 1-hour lectures and one 4-hour practical per week. Prerequisites: (CHEM2401 or CHEM2911 or CHEM2915) and (CHEM2402 or CHEM2912 or CHEM2916) Prohibitions: CHEM3915 Assessment: One 2-hour exam, written assignments, prac reports (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
The development of new pharmaceuticals fundamentally relies on the ability to design and synthesize new compounds. Synthesis is an enabling discipline for medicinal chemistry - without it, the development of new drugs cannot progress from design to implementation, and ultimately to a cure. This unit will tackle important factors in drug design, and will highlight the current arsenal of methods used in the discovery of new drugs, including rational drug design, high throughput screening and combinatorial chemistry. We will develop a logical approach to planning a synthesis of a particular target structure. The synthesis and chemistry of heterocycles, which comprise some 40% of all known organic compounds and are particularly common in pharmaceuticals, will be outlined. Examples will include important ring systems present in biological systems, such as pyrimidines and purines (DNA and RNA), imidazole and thiazole (amino acids and vitamins) and porphyrins (natural colouring substances and oxygen carrying component of blood). Throughout the course, the utility of synthesis in medicinal chemistry will be illustrated with case studies such as anti-influenza (Relenza), anaesthetic (benzocaine), anti-inflammatory (Vioxx), antihypertensive (pinacidil) and cholesterol-lowering (Lovastatin) drugs.
CHEM3915 Synthetic Medicinal Chemistry (Adv)

Credit points: 6 Session: Semester 2 Classes: Two 1 hour lectures, one 1 hour seminar and one 4 hour practical per week. Prerequisites: Credit or better in (CHEM2401 or CHEM2911 or CHEM2915) Prohibitions: CHEM3115 Assessment: One 2 hour exam, written assignments, prac reports (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
The development of new pharmaceuticals fundamentally relies on the ability to design and synthesize new compounds. Synthesis is an enabling discipline for medicinal chemistry - without it, the development of new drugs cannot progress from design to implementation, and ultimately to a cure. This unit will tackle important factors in drug design, and will highlight the current arsenal of methods used in the discovery of new drugs, including rational drug design, high throughput screening and combinatorial chemistry. We will develop a logical approach to planning a synthesis of a particular target structure. The synthesis and chemistry of heterocycles, which comprise some 40% of all known organic compounds and are particularly common in pharmaceuticals, will be outlined. Examples will include important ring systems present in biological systems, such as pyrimidines and purines (DNA and RNA), imidazole and thiazole (amino acids and vitamins) and porphyrins (natural colouring substances and oxygen carrying component of blood). Throughout the course, the utility of synthesis in medicinal chemistry will be illustrated with case studies such as anti-influenza (Relenza), anaesthetic (benzocaine), anti-inflammatory (Vioxx), antihypertensive (pinacidil) and cholesterol-lowering (Lovastatin) drugs. CHEM3915 students attend the same lectures as CHEM3115 students, but attend an additional advanced seminar series comprising one lecture a week for 12 weeks.