Table 1: Molecular Biology and Genetics

Table 1 lists units of study available to students in the Bachelor of Science and combined degrees. The units are available to students enrolled in other degrees in accordance with their degree resolutions.

Unit of study Credit points A: Assumed knowledge P: Prerequisites C: Corequisites N: Prohibition Session

Molecular Biology and Genetics

For a major in Molecular Biology and Genetics, the minimum requirement is 24 credit points from senior units of study listed below.
Junior units of study
MBLG1001
Molecular Biology and Genetics (Intro)
6    A 6 credit points of Junior Biology and 6 credit points of Junior Chemistry.
N MBLG1901 or MBLG1991
Semester 2
MBLG1901
Molecular Biology and Genetics (Adv)
6    A [( 85 or above in HSC Biology or equivalent) AND (85 or above in HSC Chemistry or equivalent)] OR [( 75 or above in one junior biology unit) AND (75 or above in one junior chemistry unit)]
N MBLG1001 or MBLG1991

Note: Department permission required for enrolment

Semester 2
MBLG1991
Molecular Biology and Genetics (SSP)
6    A [( 90 or above in HSC Biology or equivalent) AND (90 or above in HSC Chemistry or equivalent)] OR [( 85 or above in one junior biology unit) AND (85 or above in one junior chemistry unit)]
N MBLG1001 or MBLG1901

Note: Department permission required for enrolment

Semester 2
Intermediate units of study
6 credit points of Intermediate Biochemistry units (taken from BCHM2071/2971 and/or BCHM2072/2972) are a pre-requisite for BCHM3071/3971 and BCHM3072/3972, which are required for a major in Molecular Biology and Genetics.
BCHM2071
Protein Biochemistry
6    P (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX)
N BCHM2011 or BCHM2971


Recommended concurrent units of study: MBLG2071 and BCHM2072 for progression to Senior Biochemistry.
Semester 2
BCHM2971
Protein Biochemistry (Advanced)
6    P (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991)
N BCHM2071


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
Semester 2
BCHM2072
Human Biochemistry
6    P (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX)
N BCHM2002 or BCHM2102 or BCHM2972 or BCHM2902 or BCHM2112 or BMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and BCHM2071 for progression to Senior Biochemistry.
Semester 1
BCHM2972
Human Biochemistry (Advanced)
6    P (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991)
N BCHM2072 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2071 or BCHM2971) for progression to Senior Biochemistry.
Semester 1
MBLG2071
Molecular Biology and Genomics
6    P (MBLG1001 or MBLG1901 or MBLG1991) and 12 credit points of CHEM1XXX
N BCHM2001 or MBLG2111 or MBLG2871 or BCHM2901 or AGCH2001 or MBLG2901 or BCHM2101 or MBLG2101 or MBLG2971 or MBLG2771 or MBLG2001


Recommended concurrent units of study: (BCHM2071 or BCHM2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
Semester 1
MBLG2971
Molecular Biology and Genomics (Adv)
6    P 12 credit points of CHEM1XXX and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991)
N MBLG2901 or MBLG2001 or BCHM2001 or AGCH2001 or MBLG2101 or MBLG2871 or MBLG2111 or MBLG2771 or BCHM2101 or MBLG2071 or BCHM2901
Semester 1
MBLG2072
Genetics and Genomics
6    P 6 credit points of BIOL1XXX and (MBLG1001 or MBLG1901 or MBLG1991) and 6 credit points of CHEM1XXX
N MBLG2002 or MBLG2972 or MBLG2102 or MBLG2902


For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
Semester 2
MBLG2972
Genetics and Genomics (Advanced)
6    P [An average mark of 75 in (6 credit points of BIOL1XXX) and (MBLG1001 or MBLG1901 or MBLG1991)] and (6 credit points of CHEM1XXX).
N MBLG2002 or MBLG2072 or MBLG2102 or MBLG2902


For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
Semester 2
Senior units of study
BCHM3071
Molecular Biology and Biochemistry-Genes
6    P [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3001 or BCHM3901 or BCHM3971
Semester 1
BCHM3971
Molecular Biology and Biochem-Genes (Adv)
6    P [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points from BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3901 or BCHM3001 or BCHM3071
Semester 1
BCHM3072
Human Molecular Cell Biology
6    P [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3972 or BCHM3004 or BCHM3002 or BCHM3902 or BCHM3904
Semester 2
BCHM3972
Human Molecular Cell Biology (Advanced)
6    P [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3072 or BCHM3004 or BCHM3902 or BCHM3904 or BCHM3002
Semester 2
BIOL3018
Gene Technology and Genomics
6    P (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX)
N BIOL3918
Semester 1
BIOL3918
Gene Technology and Genomics (Adv)
6    P An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX).
N BIOL3018
Semester 1
BIOL3026
Developmental Genetics
6    P (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX)
N BIOL3926 or BIOL3929
Semester 2
BIOL3926
Developmental Genetics (Advanced)
6    P An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX).
N BIOL3929 or BIOL3026
Semester 2

Molecular Biology and Genetics

For a major in Molecular Biology and Genetics, the minimum requirement is 24 credit points from senior units of study listed below.
Junior units of study
MBLG1001 Molecular Biology and Genetics (Intro)

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 2 Classes: Two 1-hour lectures per week; one 1-hour tutorial and one 4-hour practical per fortnight Prohibitions: MBLG1901 or MBLG1991 Assumed knowledge: 6 credit points of Junior Biology and 6 credit points of Junior Chemistry. Assessment: One 2.5-hour exam (60%), Lab reports (15%), assignments (10%), prac test (15%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
The lectures in this unit of study introduce the "Central Dogma" of molecular biology and genetics -i.e., the molecular basis of life. The course begins with the information macromolecules in living cells: DNA, RNA and protein, and explores how their structures allow them to fulfill their various biological roles. This is followed by a review of how DNA is organised into genes leading to discussion of replication and gene expression (transcription and translation). The unit concludes with an introduction to the techniques of molecular biology and, in particular, how these techniques have led to an explosion of interest and research in Molecular Biology. The practical component complements the lectures by exposing students to experiments which explore the measurement of enzyme activity, the isolation of DNA and the 'cutting' of DNA using restriction enzymes. However, a key aim of the practicals is to give students higher level generic skills in computing, communication, criticism, data analysis/evaluation and experimental design.
Textbooks
Introduction to Molecular Biology MBLG1001 & MBLG1901, 3rd edition compiled by D. Hancock, G. Denyer and B. Lyon, Pearson ISBN 978 1 4860 0039 5
MBLG1901 Molecular Biology and Genetics (Adv)

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 2 Classes: Two 1-hour lectures per week; one 1-hour tutorial and one 4-hour practical per fortnight. Prohibitions: MBLG1001 or MBLG1991 Assumed knowledge: [( 85 or above in HSC Biology or equivalent) AND (85 or above in HSC Chemistry or equivalent)] OR [( 75 or above in one junior biology unit) AND (75 or above in one junior chemistry unit)] Assessment: One 2.5-hour exam (60%), Lab reports (15%), assignments (10%), prac test (15%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
The lectures in this unit of study introduce the "Central Dogma" of molecular biology and genetics, i.e., the molecular basis of life. The course begins with the information macro-molecules in living cells: DNA,RNA and protein, and explores how their structures allow them to fulfill their various biological roles. This is followed by a review of how DNA is organised into genes leading to discussion of replication and gene expression (transcription and translation). The unit concludes with an introduction to the techniques of molecular biology and, in particular, how these techniques have led to an explosion of interest and research in Molecular Biology. The practical component complements the lectures by exposing students to experiments which explore the measurement of enzyme activity, the isolation of DNA and the 'cutting' of DNA using restriction enzymes. However,a key aim of the practicals is to give students higher level generic skills in computing, communication, criticism, data analysis/evaluation and experimental design. The advanced component is designed for students interested in continuing in molecular biology. It consists of 7 advanced lectures (replacing 7 regular lectures) and 3 advanced laboratory sessions (replacing 3 regular practical classes). The advanced lectures will focus on the experiments which led to key discoveries in molecular biology. The advanced practical sessions will give students the opportunity to explore alternative molecular biology experimental techniques. Attendance at MBLG1999 seminars is strongly encouraged.
Textbooks
Introduction to Molecular Biology MBLG1001 & MBLG1901, 3rd edition compiled by D. Hancock, G. Denyer and B. Lyon, Pearson ISBN 978 1 4860 0039 5
MBLG1991 Molecular Biology and Genetics (SSP)

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 2 Classes: Two 1-hour lectures per week; one 1-hour tutorial and one 4-hour practical per fortnight Prohibitions: MBLG1001 or MBLG1901 Assumed knowledge: [( 90 or above in HSC Biology or equivalent) AND (90 or above in HSC Chemistry or equivalent)] OR [( 85 or above in one junior biology unit) AND (85 or above in one junior chemistry unit)] Assessment: One 2.5 hour exam (60%), project report and presentation (15%), assignments (10%), practical test (15%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
The lectures in this unit of study introduce the "Central Dogma" of molecular biology and genetics -i.e., the molecular basis of life. Taking an experimental approach, the course begins with the information macromolecules in living cells: DNA, RNA and protein, and explores how their structures allow them to fulfil their various biological roles. This is followed by a review of how DNA is organised into genes leading to discussion of replication and gene expression (transcription and translation). The unit concludes with an introduction to the techniques of molecular biology and, in particular, how these techniques have led to an explosion of interest and research in Molecular Biology. The practical component is a synthetic biology project investigating the properties of genetically engineered organisms. It covers the same concepts and techniques as the existing MBLG1001 and MBLG1901 streams, but in a more advanced and project-style context. The aim of this project is to give students experience in using molecular biology approaches to solve current environmental and medical problems. In the context of this research students will have the opportunity to develop higher level generic skills in computing, communication, critical analysis, problem solving, data analysis/evaluation and experimental design.
Textbooks
Introduction to Molecular Biology & Genetics (3rd Edition) Pearson ISBN 978 1 4860 0039 5, Nature Science education (Macmillan)
Intermediate units of study
6 credit points of Intermediate Biochemistry units (taken from BCHM2071/2971 and/or BCHM2072/2972) are a pre-requisite for BCHM3071/3971 and BCHM3072/3972, which are required for a major in Molecular Biology and Genetics.
BCHM2071 Protein Biochemistry

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX) Prohibitions: BCHM2011 or BCHM2971 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: MBLG2071 and BCHM2072 for progression to Senior Biochemistry.
This unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are introduced together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1001 and is ideally suited to students studying intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The practical course will nurture technical skills in biochemistry and will include protein preparation, the analysis of protein structure and enzymatic assays.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2.
BCHM2971 Protein Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: BCHM2071 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
This advanced unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are discussed together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1X01 and is ideally suited to students studying Intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The advanced practical course will nurture technical skills in protein biochemistry and will include protein preparation, the interpretation of protein structure, enzymatic assays and biochemical analysis.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2
BCHM2072 Human Biochemistry

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, 8-10 optional tutorials, increasing in frequency towards the exams, and 2-3 hours per week of practical Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX) Prohibitions: BCHM2002 or BCHM2102 or BCHM2972 or BCHM2902 or BCHM2112 or BMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work (25%), in semester assignments (10%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and BCHM2071 for progression to Senior Biochemistry.
This unit of study aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. The chemical reactions that occur inside cells are described in the first series of lectures, Cellular Metabolism. Aspects of the molecular architecture of cells that enable them to transduce messages and communicate with each other are described in the second half of the unit of study, Signal Transduction. At every stage there is emphasis on the 'whole body' consequences of reactions, pathways and processes. Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilisation and how the mix of fuels is regulated (especially under different physiological circumstances such as starvation and exercise). The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion and absorption and transport of nutrients. Signal Transduction covers how communication across membranes occurs (i.e. via surface receptors and signaling cascades). This allows detailed molecular discussion of the mechanism of hormone action and intracellular process targeting. The practical component complements the lectures by exposing students to experiments that investigate the measurement of glucose utilisation using radioactive tracers and the design of biochemical assay systems. During the unit of study, generic skills are nurtured by frequent use of analytical and problem solving activities. Opportunities are provided to redesign and repeat experiments so as to provide a genuine research experience. Student exposure to generic skills will be extended by the introduction of exercises designed to teach oral communication, instruction writing and planning skills.
BCHM2972 Human Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, 8-10 optional tutorials increasing in frequency towards the exams, and 2-3 hours per week of practical. Prerequisites: (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: BCHM2072 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work (25%), in semester assignments (10%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2071 or BCHM2971) for progression to Senior Biochemistry.
This advanced unit aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. The chemical reactions that occur inside cells are described in the first series of lectures, Cellular Metabolism. Aspects of the molecular architecture of cells that enable them to transduce messages and communicate with each other are described in the second half of the unit of study, Signal Transduction. At every stage there is emphasis on the 'whole body' consequences of reactions, pathways and processes. Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilization and how the mix of fuels is regulated (especially under different physiological circumstances such as starvation and exercise). The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion and absorption and transport of nutrients. Signal Transduction covers how communication across membranes occurs (i.e., via surface receptors and signaling cascades). This allows detailed molecular discussion of the mechanism of hormone action and intracellular process targeting. The practical component complements the lectures by exposing students to experiments that investigate the measurement of glucose utilisation using radioactive tracers and the design of biochemical assay systems. During the unit of study, generic skills are nurtured by frequent use of analytical and problem solving activities. Opportunities are provided to redesign and repeat experiments so as to provide a genuine research experience. Student exposure to generic skills will be extended by the introduction of exercise designed to teach oral communication, instruction writing and planning skills.
The differences between the advanced and regular versions of this Unit of Study is in the in-semester assignments and some of the practical sessions.
MBLG2071 Molecular Biology and Genomics

Credit points: 6 Teacher/Coordinator: Dr Markus Holfer Session: Semester 1 Classes: Two 1-hour lectures per week and one 4-hour practical per fortnight. Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and 12 credit points of CHEM1XXX Prohibitions: BCHM2001 or MBLG2111 or MBLG2871 or BCHM2901 or AGCH2001 or MBLG2901 or BCHM2101 or MBLG2101 or MBLG2971 or MBLG2771 or MBLG2001 Assessment: One 2.5-hour exam, practical work, laboratory reports (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (BCHM2071 or BCHM2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model system as well as perform plasmid isolation and DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2971 Molecular Biology and Genomics (Adv)

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 1 Classes: Two 1-hour lectures per week; one 4-hour practical per fortnight. Prerequisites: 12 credit points of CHEM1XXX and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: MBLG2901 or MBLG2001 or BCHM2001 or AGCH2001 or MBLG2101 or MBLG2871 or MBLG2111 or MBLG2771 or BCHM2101 or MBLG2071 or BCHM2901 Assessment: One 2.5-hour exam, practical work, laboratory reports. Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
The content is based on the standard unit MBLG2071 but certain aspects will be investigated in greater depth and at a more advanced level. The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model system as well as perform plasmid isolation and DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2072 Genetics and Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Penny Smith Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: 6 credit points of BIOL1XXX and (MBLG1001 or MBLG1901 or MBLG1991) and 6 credit points of CHEM1XXX Prohibitions: MBLG2002 or MBLG2972 or MBLG2102 or MBLG2902 Assessment: One 2 hour exam (50%), laboratory reports and quizzes (50%). Practical field work: 3 hours per week Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
This unit of study brings together traditional genetic analysis and modern molecular biology to study genetics of all life forms from humans and other complex multicellular organisms through to single celled organisms such as bacteria. Students will be introduced to complex modes of Mendelian inheritance, including those involved in human diseases. The molecular basis for different patterns of inheritance will be discussed. The interaction of genes and gene products will be illustrated by the examination of the molecular genetics of development. The application of genomics to the study of genetic variation, molecular evolution and gene function in humans and model organisms will also be described. In the practical sessions students will investigate the genetics of a variety of prokaryotic and eukaryotic organisms in order to illustrate concepts covered in the lecture material. Students will develop familiarity and competence with equipment used in molecular genetic analysis, bioinformatics, microscopy and statistical tests. This unit of study provides a suitable foundation for senior biology units of study, which can lead to a major in Biology, and successful completion of this unit of study is required in order to progress in the Molecular Biology and Genetics major.
MBLG2972 Genetics and Genomics (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Penny Smith Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: [An average mark of 75 in (6 credit points of BIOL1XXX) and (MBLG1001 or MBLG1901 or MBLG1991)] and (6 credit points of CHEM1XXX). Prohibitions: MBLG2002 or MBLG2072 or MBLG2102 or MBLG2902 Assessment: One 2-hour exam (50%), laboratory reports and quizzes (50%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
The content of MBLG2972 will be based on MBLG2072 but qualified students will participate in alternative components at a more advanced level. The content and nature of these components may vary from year to year but includes a practical project in the laboratory to improve molecular biology skills
Senior units of study
BCHM3071 Molecular Biology and Biochemistry-Genes

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3001 or BCHM3901 or BCHM3971 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2011.
BCHM3971 Molecular Biology and Biochem-Genes (Adv)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points from BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3901 or BCHM3001 or BCHM3071 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
The lecture component of this unit of study is the same as BCHM3071. Qualified students will attend seminars/practical classes in which more sophisticated topics in gene expression and manipulation will be covered.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2011.
BCHM3072 Human Molecular Cell Biology

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3972 or BCHM3004 or BCHM3002 or BCHM3902 or BCHM3904 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BCHM3972 Human Molecular Cell Biology (Advanced)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3072 or BCHM3004 or BCHM3902 or BCHM3904 or BCHM3002 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
The lecture component of this unit of study is the same as BCHM3072. Qualified students will attend seminars/practical classes in which more sophisticated topics in modern molecular cell biology will be covered.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BIOL3018 Gene Technology and Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 1 Classes: Two 1-hour lectures and one 3-hour practical per week. Prerequisites: (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX) Prohibitions: BIOL3918 Assessment: One 2-hour exam (60%), assignments (40%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
A unit of study with lectures, practicals and tutorials on the application of recombinant DNA technology and the genetic manipulation of prokaryotic and eukaryotic organisms. Lectures cover the applications of molecular genetics in biotechnology and consider the regulation, impact and implications of genetic engineering and genomics. Topics include biological sequence data and databases, comparative genomics, the cloning and expression of foreign genes in bacteria, yeast, animal and plant cells, novel human and animal therapeutics and vaccines, new diagnostic techniques for human and veterinary disease, and the genetic engineering of animals and plants. Practical work may include nucleic acid isolation and manipulation, gene cloning and PCR amplification, DNA sequencing and bioinformatics, immunological detection of proteins, and the genetic transformation and assay of plants.
BIOL3918 Gene Technology and Genomics (Adv)

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 1 Classes: Two 1-hour lectures and one 3-hour practical per week. Prerequisites: An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX). Prohibitions: BIOL3018 Assessment: One 2-hour exam (60%), assignments (40%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Qualified students will participate in alternative components of BIOL3018 Gene Technology and Genomics. The content and nature of these components may vary from year to year.
BIOL3026 Developmental Genetics

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 2 Classes: Twenty-four 1 hour lectures/tutorials per semester and up to 3 hours laboratory per week. Prerequisites: (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX) Prohibitions: BIOL3926 or BIOL3929 Assessment: One 2-hour exam, assignments (100%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Developmental genetics discusses major concepts and our current understanding of developmental biology with an emphasis on molecular genetics. The developmental genetics of animal and plant systems will be investigated, along with approaches used to determine gene function in relation to development of complex multicellular organisms. Topics include the features and resources for model organisms; the generation of mutants for forward and reverse genetics; the application of mutants to the study gene function and gene networks; spatial and temporal gene expression in pattern formation; quantitative trait loci analysis; utility of genome wide association studies; epigenetics in relation to inheritance; genome information in the study of human genetics. Reference will be made to the use of modern techniques in developmental biology such as transgenics, recombinant DNA technology, tissue-specific expression analysis. Various methods of genetic mapping will be covered. Practical work complements the theoretical aspects of the course and develops important skills in genetics.
BIOL3926 Developmental Genetics (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 2 Classes: Twenty-four 1 hour lectures/tutorials per semester and up to 3 hours laboratory per week. Prerequisites: An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX). Prohibitions: BIOL3929 or BIOL3026 Assessment: One 2-hour exam, assignments (100%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Qualified students will participate in alternative components to BIOL3026 Developmental Genetics. The content and nature of these components may vary from year to year. Some assessment will be in an alternative format to components of BIOL3026.