Table 1: Molecular Biology and Genetics

Table 1 lists units of study available to students in the Bachelor of Science and combined degrees. The units are available to students enrolled in other degrees in accordance with their degree resolutions.

Unit of study Credit points A: Assumed knowledge P: Prerequisites C: Corequisites N: Prohibition Session

Molecular Biology and Genetics

For a major in Molecular Biology and Genetics, the minimum requirement is 24 credit points from senior units of study listed below.
Junior units of study
BIOL1006
Life and Evolution
6    A HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February).
N BIOL1001 or BIOL1911 or BIOL1991 or BIOL1906 or BIOL1996
Semester 1
BIOL1906
Life and Evolution (Advanced)
6    A 85 or above in HSC Biology or equivalent.
N BIOL1001 or BIOL1911 or BIOL1991 or BIOL1006 or BIOL1996

Note: Department permission required for enrolment

Semester 1
BIOL1996
Life and Evolution (SSP)
6    A 90 or above in HSC Biology or equivalent
N BIOL1001 or BIOL1911 or BIOL1991 or BIOL1006 or BIOL1906

Note: Department permission required for enrolment

Semester 1
BIOL1007
From Molecules to Ecosystems
6    A HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February).
N BIOL1907 or BIOL1997
Semester 2
BIOL1907
From Molecules to Ecosystems (Advanced)
6    A 85 or above in HSC Biology or equivalent
N BIOL1007 or BIOL1997

Note: Department permission required for enrolment

Semester 2
BIOL1997
From Molecules to Ecosystems (SSP)
6    A 90 or above in HSC Biology or equivalent
N BIOL1007 or BIOL1907

Note: Department permission required for enrolment

Semester 2
Intermediate units of study
6 credit points of Intermediate Biochemistry units (taken from BCHM2071/2971 and/or BCHM2072/2972) are a pre-requisite for BCHM3071/3971 and BCHM3072/3972, which are required for a major in Molecular Biology and Genetics.
BCHM2071
Protein Biochemistry
6    P 6cp from (BIOL1XX7, MBLG1XXX) and 12cp from CHEM1XXX
N BCHM2011 or BCHM2971


Recommended concurrent units of study: MBLG2071 and BCHM2072 for progression to Senior Biochemistry.
Semester 2
BCHM2971
Protein Biochemistry (Advanced)
6    P 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7,MBLG1XXX)
N BCHM2071


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
Semester 2
BCHM2072
Human Biochemistry
6    P 6cp from (BIOL1XX7, MBLG1XXX) and 12cp from CHEM1XXX
N BCHM2002 or BCHM2102 or BCHM2972 or BCHM2902 or BCHM2112 or BMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and BCHM2071 for progression to Senior Biochemistry.
Semester 1
BCHM2972
Human Biochemistry (Advanced)
6    P 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7, MBLG1XXX)
N BCHM2072 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808


Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2071 or BCHM2971) for progression to Senior Biochemistry.
Semester 1
MBLG2071
Molecular Biology and Genomics
6    P 6cp from (BIOL1XX7, MBLG1XXX),and 12cp from CHEM1XXX
N BCHM2001 or MBLG2111 or MBLG2871 or BCHM2901 or AGCH2001 or MBLG2901 or BCHM2101 or MBLG2101 or MBLG2971 or MBLG2771 or MBLG2001


Recommended concurrent units of study: (BCHM2071 or BCHM2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
Semester 1
MBLG2971
Molecular Biology and Genomics (Adv)
6    P 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7,MBLG1XXX)
N MBLG2901 or MBLG2001 or BCHM2001 or AGCH2001 or MBLG2101 or MBLG2871 or MBLG2111 or MBLG2771 or BCHM2101 or MBLG2071 or BCHM2901
Semester 1
MBLG2072
Genetics and Genomics
6    P 12cp from (BIOL1XXX, MBLG1XXX) and 6cp from CHEM1XXX
N MBLG2002 or MBLG2972 or MBLG2102 or MBLG2902


For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
Semester 2
MBLG2972
Genetics and Genomics (Advanced)
6    P An average of 75 or above in [12cp from (BIOL1XXX, MBLG1XXX) and 6cp from CHEM1XXX]
N MBLG2002 or MBLG2072 or MBLG2102 or MBLG2902


For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
Semester 2
Senior units of study
BCHM3071
Molecular Biology and Biochemistry-Genes
6    P [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3001 or BCHM3901 or BCHM3971
Semester 1
BCHM3971
Molecular Biology and Biochem-Genes (Adv)
6    P [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points from BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3901 or BCHM3001 or BCHM3071
Semester 1
BCHM3072
Human Molecular Cell Biology
6    P [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3972 or BCHM3004 or BCHM3002 or BCHM3902 or BCHM3904
Semester 2
BCHM3972
Human Molecular Cell Biology (Advanced)
6    P [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)]
N BCHM3072 or BCHM3004 or BCHM3902 or BCHM3904 or BCHM3002
Semester 2
BIOL3018
Gene Technology and Genomics
6    P (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX)
N BIOL3918
Semester 1
BIOL3918
Gene Technology and Genomics (Adv)
6    P An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX).
N BIOL3018
Semester 1
BIOL3026
Developmental Genetics
6    P (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX)
N BIOL3926 or BIOL3929
Semester 2
BIOL3926
Developmental Genetics (Advanced)
6    P An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX).
N BIOL3929 or BIOL3026
Semester 2

Molecular Biology and Genetics

For a major in Molecular Biology and Genetics, the minimum requirement is 24 credit points from senior units of study listed below.
Junior units of study
BIOL1006 Life and Evolution

Credit points: 6 Teacher/Coordinator: A/Prof Charlotte Taylor Session: Semester 1 Classes: 2 lectures per week and online material and 12x3hr practicals Prohibitions: BIOL1001 or BIOL1911 or BIOL1991 or BIOL1906 or BIOL1996 Assumed knowledge: HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February). Assessment: practical eportfolio (10%), during semester exams (20%), communication (30%), summative final exam (40%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Biology is an immensely diverse science. Biologists study life at all levels, from the fundamental building blocks (genes, proteins) to whole ecosystems in which myriads of species interact. Evolution is the unifying concept that runs through the life sciences, from the origin and diversification of life to understanding behaviour, to dealing with disease. Evolution through natural selection is the framework in biology in which specific details make sense.Science builds and organises knowledge of life and evolution in the form of testable hypotheses. This unit will explore how new species, diseases and parasites continue to arise while others go extinct and discuss the role of mutations as the raw material on which selection acts. It will also explain how information is transferred between generations through DNA, RNA and proteins, transformations which affect all aspects of biological form and function. You will participate in inquiry-led practical classes integrating Life and Evolution concepts. By doing this unit of study, you will develop the ability to examine novel biological systems and understand the complex processes that have shaped those systems and organisms into what they are today.
Textbooks
Please see unit outline on LMS
BIOL1906 Life and Evolution (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Charlotte Taylor Session: Semester 1 Classes: 2 lectures per week and online material and 12x3hr practicals Prohibitions: BIOL1001 or BIOL1911 or BIOL1991 or BIOL1006 or BIOL1996 Assumed knowledge: 85 or above in HSC Biology or equivalent. Assessment: practical eportfolio (10%), during semester exams (20%), communication (30%), summative final exam (40%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Biology is an immensely diverse science. Biologists study life at all levels, from the fundamental building blocks (genes, proteins) to whole ecosystems in which myriads of species interact. Evolution is the unifying concept that runs through the life sciences, from the origin and diversification of life to understanding behaviour, to dealing with disease. Evolution through natural selection is the framework in biology in which specific details make sense.Science builds and organises knowledge of life and evolution in the form of testable hypotheses. This unit will explore how new species, diseases and parasites continue to arise while others go extinct and discuss the role of mutations as the raw material on which selection acts. It will also explain how information is transferred between generations through DNA, RNA and proteins, transformations which affect all aspects of biological form and function. Life and Evolution (Advanced) has the same overall structure as BIOL1006 but material is discussed in greater detail and at a more advanced level. Students enrolled in BIOL1906 participate in alternative components. The content and nature of these components may vary from year to year.
Textbooks
Please see unit outline on LMS
BIOL1996 Life and Evolution (SSP)

Credit points: 6 Teacher/Coordinator: A/Prof Nathan Lo and A/Prof Simon Ho Session: Semester 1 Classes: 2 lectures per week and online material and 30-36 hours of practicals Prohibitions: BIOL1001 or BIOL1911 or BIOL1991 or BIOL1006 or BIOL1906 Assumed knowledge: 90 or above in HSC Biology or equivalent Assessment: practical 60% (comprised of two practical reports, laboratory note book and seminar presentation), 40% final summative exam as per biol1906 Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Biology is an immensely diverse science. Biologists study life at all levels, from the fundamental building blocks (genes, proteins) to whole ecosystems in which myriads of species interact. Evolution is the unifying concept that runs through the life sciences, from the origin and diversification of life to understanding behaviour, to dealing with disease. Evolution through natural selection is the framework in biology in which specific details make sense.Science builds and organises knowledge of life and evolution in the form of testable hypotheses. The practical work syllabus for BIOL1996 is different to BIOL1906 (Advanced) and consists of a special project based laboratory.
Textbooks
Please see unit outline on LMS
BIOL1007 From Molecules to Ecosystems

Credit points: 6 Teacher/Coordinator: Professor Pauline Ross Session: Semester 2 Classes: 2 lectures per week and online material and 12x3hr practicals Prohibitions: BIOL1907 or BIOL1997 Assumed knowledge: HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February). Assessment: practical (50%), summative final exam (50%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . You will participate in inquiry-led practicals that reinforce the concepts in the unit. By doing this unit you will develop knowledge and skills that will enable you to play a role in finding global solutions that will impact our lives.
Textbooks
Please see unit outline on LMS
BIOL1907 From Molecules to Ecosystems (Advanced)

Credit points: 6 Teacher/Coordinator: Professor Pauline Ross Session: Semester 2 Classes: 2 lectures per week and online material and 12x3hr practicals Prohibitions: BIOL1007 or BIOL1997 Assumed knowledge: 85 or above in HSC Biology or equivalent Assessment: summative exam (50%), practical component which may include independent or group project (50%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . This unit of study has the same overall structure as BIOL1007 but material is discussed in greater detail and at a more advanced level. The content and nature of these components may vary from year to year.
Textbooks
Please see unit outline on LMS
BIOL1997 From Molecules to Ecosystems (SSP)

Credit points: 6 Teacher/Coordinator: Professor Pauline Ross Session: Semester 2 Classes: 2 lectures per week and online material Prohibitions: BIOL1007 or BIOL1907 Assumed knowledge: 90 or above in HSC Biology or equivalent Assessment: one 2-hour exam (50%), project report (50%) which includes written report and presentation Practical field work: As advised and required by the project - approximately 30-36 hours of research project in the laboratory or field Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and intervene in ecosystems to improve health. The same theory will be covered as in the advanced stream but in this Special Studies Unit, the practical component is a research project. The research will be either a synthetic biology project investigating genetically engineered organisms or organismal/ecosystems biology. Students will have the opportunity to develop higher level generic skills in computing, communication, critical analysis, problem solving, data analysis and experimental design.
Textbooks
Please see unit outline on LMS
Intermediate units of study
6 credit points of Intermediate Biochemistry units (taken from BCHM2071/2971 and/or BCHM2072/2972) are a pre-requisite for BCHM3071/3971 and BCHM3072/3972, which are required for a major in Molecular Biology and Genetics.
BCHM2071 Protein Biochemistry

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: 6cp from (BIOL1XX7, MBLG1XXX) and 12cp from CHEM1XXX Prohibitions: BCHM2011 or BCHM2971 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: MBLG2071 and BCHM2072 for progression to Senior Biochemistry.
This unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are introduced together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1001 and is ideally suited to students studying intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The practical course will nurture technical skills in biochemistry and will include protein preparation, the analysis of protein structure and enzymatic assays.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2.
BCHM2971 Protein Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7,MBLG1XXX) Prohibitions: BCHM2071 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
This advanced unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are discussed together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1X01 and is ideally suited to students studying Intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The advanced practical course will nurture technical skills in protein biochemistry and will include protein preparation, the interpretation of protein structure, enzymatic assays and biochemical analysis.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2
BCHM2072 Human Biochemistry

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, occasional webinar tutorials, and 2-3 hours per week of practicals Prerequisites: 6cp from (BIOL1XX7, MBLG1XXX) and 12cp from CHEM1XXX Prohibitions: BCHM2002 or BCHM2102 or BCHM2972 or BCHM2902 or BCHM2112 or BMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work and associated assessments (25%), in semester assignments (10%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and BCHM2071 for progression to Senior Biochemistry.
This unit of study aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. This includes the chemical reactions that occur inside cells and the molecular architecture that enables cells to transduce messages and communicate with each other. At every stage the focus is on the 'whole body' consequences of reactions, pathways and processes. The section on Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilisation and how the mix of fuels is regulated under different physiological circumstances such as starvation and exercise. The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion, absorption and transport of nutrients. The section on Signal Transduction covers how communication across membranes occurs (i.e. via surface receptors and signaling cascades) and so reveals the mechanism of hormone action and intracellular process targeting.
Textbooks
No specific text recommended
BCHM2972 Human Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, occasional webinar tutorials, and 2-3 hours per week of practicals Prerequisites: 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7, MBLG1XXX) Prohibitions: BCHM2072 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work and associated assessments (25%), in semester assignments (10%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2071 or BCHM2971) for progression to Senior Biochemistry.
This unit of study aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. This includes the chemical reactions that occur inside cells and the molecular architecture that enables cells to transduce messages and communicate with each other. At every stage the focus is on the 'whole body' consequences of reactions, pathways and processes. The section on Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilisation and how the mix of fuels is regulated under different physiological circumstances such as starvation and exercise. The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion, absorption and transport of nutrients. The section on Signal Transduction covers how communication across membranes occurs (i.e. via surface receptors and signaling cascades) and so reveals the mechanism of hormone action and intracellular process targeting.
The differences between the advanced and regular versions of this Unit of Study is in the in-semester assignments (including those related to practical classes), some of the practical sessions and some examination questions.
Textbooks
No specific text recommended
MBLG2071 Molecular Biology and Genomics

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 1 Classes: Two 1-hour lectures per week and one 4-hour practical per fortnight. Prerequisites: 6cp from (BIOL1XX7, MBLG1XXX),and 12cp from CHEM1XXX Prohibitions: BCHM2001 or MBLG2111 or MBLG2871 or BCHM2901 or AGCH2001 or MBLG2901 or BCHM2101 or MBLG2101 or MBLG2971 or MBLG2771 or MBLG2001 Assessment: One 2.5-hour exam (theory and theory of practical 70%), in-semester (practical work and assignments 30%), Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (BCHM2071 or BCHM2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model systems as well as perform plasmid isolation and DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2971 Molecular Biology and Genomics (Adv)

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 1 Classes: Two 1-hour lectures per week; one 4-hour practical per fortnight, one 2 hour poster session. Prerequisites: 12cp from CHEM1XXX and a mark of 75 or above in 6cp from (BIOL1XX7,MBLG1XXX) Prohibitions: MBLG2901 or MBLG2001 or BCHM2001 or AGCH2001 or MBLG2101 or MBLG2871 or MBLG2111 or MBLG2771 or BCHM2101 or MBLG2071 or BCHM2901 Assessment: One 2.5-hour exam (theory and theory of practical 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
The content is based on the standard unit MBLG2071 but certain aspects will be investigated in greater depth and at a more advanced level. The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model systems, clone a DNA fragment into a vector and determine its identity by perfomring a plasmid isolation and restriciton enzyme digest, use PCR to determine the geneotypes of transgenic mice as well as perform DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2072 Genetics and Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Nathan Lo Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: 12cp from (BIOL1XXX, MBLG1XXX) and 6cp from CHEM1XXX Prohibitions: MBLG2002 or MBLG2972 or MBLG2102 or MBLG2902 Assessment: One 2 hour exam (50%), laboratory reports and quizzes (50%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
This unit of study brings together traditional genetic analysis and modern molecular biology to study genetics of all life forms from humans and other complex multicellular organisms through to single celled organisms such as bacteria. Students will be introduced to complex modes of Mendelian inheritance, including those involved in human diseases. The molecular basis for different patterns of inheritance will be discussed. The interaction of genes and gene products will be illustrated by the examination of the molecular genetics of development. The application of genomics to the study of genetic variation, molecular evolution and gene function in humans and model organisms will also be described. In the practical sessions students will investigate the genetics of a variety of prokaryotic and eukaryotic organisms in order to illustrate concepts covered in the lecture material. Students will develop familiarity and competence with equipment used in molecular genetic analysis, bioinformatics, microscopy and statistical tests. This unit of study provides a suitable foundation for senior biology units of study, which can lead to a major in Biology, and successful completion of this unit of study is required in order to progress in the Molecular Biology and Genetics major.
MBLG2972 Genetics and Genomics (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Nathan Lo Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: An average of 75 or above in [12cp from (BIOL1XXX, MBLG1XXX) and 6cp from CHEM1XXX] Prohibitions: MBLG2002 or MBLG2072 or MBLG2102 or MBLG2902 Assessment: One 2-hour exam (50%), laboratory reports and quizzes (50%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
The content of MBLG2972 will be based on MBLG2072 but qualified students will participate in alternative components at a more advanced level. The content and nature of these components may vary from year to year but includes a practical project in the laboratory to improve molecular biology skills
Senior units of study
BCHM3071 Molecular Biology and Biochemistry-Genes

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3001 or BCHM3901 or BCHM3971 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2014.
BCHM3971 Molecular Biology and Biochem-Genes (Adv)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points from BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3901 or BCHM3001 or BCHM3071 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
The lecture component of this unit of study is the same as BCHM3071. Qualified students will attend seminars/practical classes in which more sophisticated topics in gene expression and manipulation will be covered.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2014.
BCHM3072 Human Molecular Cell Biology

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3972 or BCHM3004 or BCHM3002 or BCHM3902 or BCHM3904 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BCHM3972 Human Molecular Cell Biology (Advanced)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3072 or BCHM3004 or BCHM3902 or BCHM3904 or BCHM3002 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
The lecture component of this unit of study is the same as BCHM3072. Qualified students will attend seminars/practical classes in which more sophisticated topics in modern molecular cell biology will be covered.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BIOL3018 Gene Technology and Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 1 Classes: Two 1-hour lectures and one 3-hour practical per week. Prerequisites: (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX) Prohibitions: BIOL3918 Assessment: One 2-hour exam (60%), assignments (40%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
A unit of study with lectures, practicals and tutorials on the application of recombinant DNA technology and the genetic manipulation of prokaryotic and eukaryotic organisms. Lectures cover the applications of molecular genetics in biotechnology and consider the regulation, impact and implications of genetic engineering and genomics. Topics include biological sequence data and databases, comparative genomics, the cloning and expression of foreign genes in bacteria, yeast, animal and plant cells, novel human and animal therapeutics and vaccines, new diagnostic techniques for human and veterinary disease, and the genetic engineering of animals and plants. Practical work may include nucleic acid isolation and manipulation, gene cloning and PCR amplification, DNA sequencing and bioinformatics, immunological detection of proteins, and the genetic transformation and assay of plants.
BIOL3918 Gene Technology and Genomics (Adv)

Credit points: 6 Teacher/Coordinator: A/Prof Mary Byrne Session: Semester 1 Classes: Two 1-hour lectures and one 3-hour practical per week. Prerequisites: An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX). Prohibitions: BIOL3018 Assessment: One 2-hour exam (60%), assignments (40%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Qualified students will participate in alternative components of BIOL3018 Gene Technology and Genomics. The content and nature of these components may vary from year to year.
BIOL3026 Developmental Genetics

Credit points: 6 Teacher/Coordinator: Dr Jenny Saleeba Session: Semester 2 Classes: Twenty-four 1 hour lectures/tutorials per semester and up to 3 hours laboratory per week. Prerequisites: (MBLG2072 or MBLG2972) and 6 credit points from (MBLG2071 or MBLG2971 or BIOL2XXX) Prohibitions: BIOL3926 or BIOL3929 Assessment: One 2-hour exam, assignments (100%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Developmental genetics discusses major concepts and our current understanding of developmental biology with an emphasis on molecular genetics. The developmental genetics of animal and plant systems will be investigated, along with approaches used to determine gene function in relation to development of complex multicellular organisms. Topics include the features and resources for model organisms; the generation of mutants for forward and reverse genetics; the application of mutants to the study gene function and gene networks; spatial and temporal gene expression in pattern formation; quantitative trait loci analysis; utility of genome wide association studies; epigenetics in relation to inheritance; genome information in the study of human genetics. Reference will be made to the use of modern techniques in developmental biology such as transgenics, recombinant DNA technology, tissue-specific expression analysis. Various methods of genetic mapping will be covered. Practical work complements the theoretical aspects of the course and develops important skills in genetics.
BIOL3926 Developmental Genetics (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Jenny Saleeba Session: Semester 2 Classes: Twenty-four 1 hour lectures/tutorials per semester and up to 3 hours laboratory per week. Prerequisites: An average mark of 75 in (MBLG2072 or MBLG2972) and (6 credit points from MBLG2071 or MBLG2971 or BIOL2XXX). Prohibitions: BIOL3929 or BIOL3026 Assessment: One 2-hour exam, assignments (100%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
Qualified students will participate in alternative components to BIOL3026 Developmental Genetics. The content and nature of these components may vary from year to year. Some assessment will be in an alternative format to components of BIOL3026.