student profile: Mr Alex Bate


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Thesis work

Thesis title: PRT MEDIC: Progressive Resistance Training for MEtabolic Syndrome and Depression Integrated Care: A Randomised Controlled Trial.

Supervisors: Maria FIATARONE SINGH , Yorgi MAVROU , Trinidad VALENZUELA ARTEAGA

Thesis abstract:

�p�The PRT MEDIC study aims to determine if progressive resistance training (weight lifting) is an effective strategy to manage both metabolic syndrome and major depressive disorder. Progressive resistance training has been shown to be an effective management strategy for both metabolic syndrome and depression, but has never been studied in individuals with both conditions. A recent prospective study has shown that individuals with both these conditions have a 6.6-fold increased risk of developing type 2 diabetes within 5 years compared to healthy individuals.The primary aims of this project are to determine the effects of progressive resistance training on insulin resistance (measured using the Homeostatic Model of Assessment - 2) and depressive symptoms [assessor-rated Hamilton Depression Rating Scale (HDRS), Patient Health Questionnaire (PHQ-9) and Center for Epidemiologic Studies Depression Scale (CES-D) in adults with co-existing metabolic syndrome and major depressive disorder. Participants will be randomized to receive either progressive resistance training (PRT), 3 days per week for 12 weeks, or referred to their GP for usual care. Participants randomised to the control intervention will be referred to their GP for management of their depression and metabolic syndrome. Blinded assessments will occur pre, and post intervention.This will be the first trial of PRT for individuals with co-existing major depressive disorder, metabolic syndrome and impaired glucose tolerance, and only the 5th trial of PRT in clinical depression.�/p�

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