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Associate Professor Marlene Fransen

DipPhysio (The Netherlands) MPH PhD
Associate Professor

C43O - O Block Cumberland Campus
The University of Sydney

Telephone +61 2 9351 9829
Fax +61 2 9351 9278

Biographical details

Associate Professor Fransen has background in clinical physiotherapy and has completed a Masters of Public Health at the University of Sydney. She has considerable experience in conducting clinical trials among people with hip or knee osteoarthritis and has published widely in leading international journals. Her PhD thesis was focused on developing effective class-based exercise programs for older people with symptomatic knee osteoarthritis. Post-doctoral, Marlene has successfully completed the HIPAID study, a large multicentre trial among 900 patients undergoing elective hip replacement surgery in Australia and New Zealand and the PAFORM study evaluating hydrotherapy or Tai Chi classes for osteoarthritis. She has also worked on observational studies, including a large population-based survey of knee and back pain and disability in Inner Mongolia. Marlene is lead author on three ongoing Cochrane Systematic Reviews (Exercise for osteoarthritis of the hip, Exercise for osteoarthritis of the knee; NSAIDs for preventing heterotopic bone formation after hip replacement).
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Research interests

To improve the accessibility of effective non-pharmacological interventions for people with symptomatic osteoarthritis involving the lower limbs.
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Current projects

Marlene is currently leading two large clinical trials: The Longterm Evaluation of Glucosamine study (LEGS) evaluating the symptomatic and structural benefits of glucosamine, with or without chondroitin, among more than 600 people with symptomatic knee osteoarthritis; the MARKER study, a multicentre study evaluating a intensive exercise classes among patients who have recently undergone total knee replacement surgery.
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Themes

Clinical and Rehabilitation Sciences

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Selected grants

2013

  • Program evaluation of Osteoarthritis Awareness hub; Hunter D, Bennell K, Fransen M, Jeon Y, Jones G, Salkeld G; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • The MARKER (Maximum recovery after knee replacement) study; Fransen M, March L, Crosbie W; HCF Health and Medical Research Foundation/Project Grant.
  • The MARKER (maximum recovery after knee replacement) study; Fransen M, March L, Crosbie W; MBF Foundation Limited/Research Support.

2008

  • Outpatient rehabilitation after primary total knee replacement surgery: a multicentre randomised con; Fransen M; University of Sydney/Bridging Support.

2006

  • The Effective Non-Pharmacological Management Of Osteoarthritis; NHMRC/Research Fellowship.
  • The effect of glucosamine sulphate on structural disease progression in knee osteoarthritis; Fransen M, Day R, Edmonds J, Bridges-Webb C, Norton R, Woodward M; NHMRC/Project Grant.
  • Cost-Effectiveness Of Glucosamine Sulphate For Knee Osteoarthritis (Cogs); Edmonds J, Jan S, Day R, Fransen M, Norton R, Woodward M, Bridges-Webb C, March L, Sambrook P; NHMRC/Glucosamine Research Study.

2001

  • Randomised trial of ibuprofen for the prevention of ectopic bone-related pain and disability after hip replacement; NHMRC/Fellowship.

2000

  • Cost effectiveness of two forms of physiotherapy for osteoarthritis of the knee; Fransen M; National Health and Medical Research Council/Public Health Postgraduate Scholarships.
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Selected publications

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Book Chapters

  • Fransen, M. (2011). Osteoarthritis. In John M. Saxton (Eds.), Exercise and Chronic Disease: An evidence-based approach, (pp. 156-174). NY, USA: Routledge imprint of Taylor & Francis.
  • Pham, T., Fransen, M., Ravaud, P., Dougados, M., Ottawa Methods Group. (2004). Osteoarthritis. In P. Tugwell, B. Shea, M. Boers, P. Brooks, L.S. Simon, V. Sttrand, G. Wells (Eds.), Evidence-Based Rheumatology: Volume 40 of Evidence-Based Medicine. United Kingdom: BMJ Books.

Journals

  • Chan, E., Fransen, M., Sathappan, S., Chua, N., Chan, Y., Chua, N. (2013). Comparing the Analgesia Effects of Single-injection and Continuous Femoral Nerve Blocks with Patient Controlled Analgesia after Total Knee Arthroplasty. Journal of Arthroplasty, Article in Press.
  • Cromer, M., Foster, S., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2013). Use of 3T MRI and an unspoiled 3D fast gradient echo sequence for porcine knee cartilage volumetry: Preliminary findings. Journal of Magnetic Resonance Imaging, Article online.
  • Agaliotis, M., Bridgett, L., Nairn, L., Votrubec, M., Jan, S., Heard, R., Fransen, M. (2012). A longitudinal study of work disability among people with mild to moderate knee osteoarthritis. Annals of the Rheumatic Diseases (Online), 71(Supplement 3), 695-695.
  • Salomon, J., Vos, T., Hogan, D., Gagnon, M., Naghavi, M., Mokdad, A., Begum, N., Shah, R., Karyana, M., Kosen, S., Blyth, F., Cross, M., Driscoll, T., Fransen, M., March, L., McGill, N., Sanchez Riera, L., Smith, E., et al (2012). Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2129-2143.
  • Murray, C., Vos, T., Lozano, R., Naghavi, M., Flaxman, A., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J., et al, Blyth, F., Bridgett, L., Cross, M., Driscoll, T., Fransen, M., Leigh, J., March, L., Marks, G., McGill, N., Sanchez Riera, L., Smith, E. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2197-2223.
  • Chan, E., Fransen, M., Parker, D., Assam, P., Chua, N. (2012). Femoral nerve blocks for acute postoperative pain after knee replacement surgery (Intervention Protocol). Cochrane Database of Systematic Reviews, (7), 1-23.
  • Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S., Blyth, F., Cross, M., Driscoll, T., Fransen, M., March, L., Marks, G., Smith, E., et al (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2095-2128.
  • Wilsmore, B., Grunstein, R., Fransen, M., Woodward, M., Norton, R., Ameratunga, S. (2012). Sleep, blood pressure and obesity in 22 389 New Zealanders. Internal Medicine Journal, 42(6), 634-641.
  • Nairn, L., Fransen, M. (2012). Tai Chi as a treatment for knee osteoarthritis. Medicine Today: the peer reviewed journal of clinical practice, 13(8), 59-60.
  • Anandacoomarasamy, A., Leibman, S., Smith, G., Caterson, I., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2012). Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Annals of the Rheumatic Diseases (Online), 71(1), 26-32.
  • Vos, E., Flaxman, A., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J., Abdalla, S., Aboyans, V., Blyth, F., Bridgett, L., Cross, M., Driscoll, T., Fransen, M., Leigh, J., March, L., Marks, G., McGill, N., Sanchez Riera, L., Smith, E., et al (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2163-2196.
  • Fransen, M., Agaliotis, M., Bridgett, L., Mackay, M. (2011). Hip and Knee Pain: Role of Occupational Factors. Best Practice and Research: Clinical Rheumatology, 25(1), 81-101.
  • Fransen, M., Bridgett, L., March, L., Hoy, D., Penserga, E., Brooks, P. (2011). The epidemiology of osteoarthritis in Asia. International Journal of Rheumatic Diseases, 14(2), 113-121.
  • Fransen, M., McConnell, S., Hernandez-Molina, G., Reichenbach, S. (2010). Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage, 18(5), 613-620.
  • Naylor, J., Adie, S., Fransen, M., Dietsch, S., Harris, I. (2010). Endorsing single-unit transfusion combined with a restrictive haemoglobin transfusion threshold following knee arthroplasty. Quality and Safety in Health Care, 19, 239-243.
  • Hoy, D., Fransen, M., March, L., Brooks, P., Durham, J., Toole, M. (2010). In rural Tibet, the prevalence of lower limb pain, especially knee pain, is high: an observational study. Journal of Physiotherapy, 56(1), 49-54.
  • Ling, J., Fransen, M., Kang, X., Li, H., Ke, Y., Wang, Z., Zhang, Y., Su, S. (2010). Marked disability and high use of non-steroidal anti-inflammatory drugs associated with knee osteoarthritis in rural China: a cross-sectional population-based study. Arthritis Research and Therapy, 12(R225), 1-7.
  • Busija, L., Bridgett, L., Williams, S., OSBORNE, R., Buchbinder, R., March, L., Fransen, M. (2010). Osteoarthritis. Best Practice and Research: Clinical Rheumatology, 24, 757-768.
  • Agaliotis, M., Nairn, L., Votrubec, M., Fransen, M. (2009). Acceptability of a novel 7 day bimonthly participant diary in a long-term clinical trial among people with symptomatic knee OA. Osteoarthritis and Cartilage, 17(Supplement 1), S175-S176.
  • Anandacoomarasamy, A., Smith, G., Leibman, S., Caterson, I., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2009). Cartilage defects are associated with physical disability in obese adults. Rheumatology (Print Edition), 48(10), 1290-1293.
  • Anandacoomarasamy, A., Giuffre, B., Leibman, S., Caterson, I., Smith, G., Fransen, M., Sambrook, P., March, L. (2009). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage: Clinical associations in obese adults. Journal of Rheumatology, 36(5), 1056-1062.
  • Fransen, M., Neal, B., Cameron, I., Crawford, R., Tregonning, G., Winstanley, J., Norton, R. (2009). Determinants of heterotopic ossification after total hip replacement surgery. Hip International, 19(1), 41-46.
  • Fransen, M., McConnell, S., Hernandez-Molina, G., Reichenbach, S. (2009). Exercise for osteoarthritis of the hip. Cochrane Database of Systematic Reviews, 3(Article number CD007912), 1-24.
  • Anandacoomarasamy, A., Caterson, I., Leibman, S., Smith, G., Sambrook, P., Fransen, M., March, L. (2009). Influence of BMI on Health-related Quality of Life: Comparison Between an Obese Adult Cohort and Age-matched Population Norms. Obesity, 17(11), 2114-2118.
  • Fransen, M., McConnell, S. (2009). Land-based exercise for osteoarthritis of the knee: a metaanalysis of randomized controlled trials. Journal of Rheumatology, 36(6), 1109-1117.
  • Lin, C., March, L., Crosbie, W., Crawford, R., Graves, S., Naylor, J., Harmer, A., Jan, S., Bennell, K., Harris, I., Fransen, M., et al (2009). Maximum recovery after knee replacement - the MARKER study rationale and protocol. BMC Musculoskeletal Disorders, 10(16), 69-1-69-8.
  • Anandacoomarasamy, A., Fransen, M., March, L. (2009). Obesity and the musculoskeletal system. Current Opinion In Rheumatology, 21(1), 71-77.
  • Nairn, L., Agaliotis, M., Votrubec, M., Fransen, M. (2009). Overcoming recruitment barriers in a clinical trial evaluating dietary supplements. Annals of the Rheumatic Diseases (Online), 68(Supplement 3), 755-755.
  • Kang, X., Fransen, M., Zhang, Y., Li, H., Ke, Y., Lu, M., Su, S., Song, X., Guo, Y., Chen, J., et al (2009). The high prevalence of knee osteoarthritis in a rural Chinese population: the Wuchuan osteoarthritis study. Arthritis and Rheumatism, 61(5), 641-647.
  • Agaliotis, M., Nairn, L., Votrubec, M., Fransen, M. (2009). Usefulness of 7 day knee pain scores among people with mild to moderate knee OA participating in clinical trials. Osteoarthritis and Cartilage, 17(Supplement 1), S158-S158.
  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Giuffre, B., Chen, (., Fransen, M., Sambrook, P., March, L. (2008). Evaluation of glycosaminoglycan (GAG) content in knee cartilage using delayed gadolinium enhanced MRI of cartilage (DGEMRIC) in an obese cohort. Internal Medicine Journal, 38(Supplement 2), A7-A7.
  • Fransen, M., McConnell, S. (2008). Exercise for osteoarthritis of the knee (Review). Cochrane Database of Systematic Reviews, (4), 1-92.
  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Chen, (., Fransen, M., Sambrook, P., March, L. (2008). Musculoskeletal symptoms in an obese cohort. Internal Medicine Journal, 38(S2), A17-A17.
  • Day, R., Fransen, M. (2008). Osteoarthritis: NSAIDs or other management strategies? Medicine Today: the peer reviewed journal of clinical practice, 9(10), 71-76.
  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2008). The clinical associations of knee cartilage defects in an obese population. Osteoarthritis and Cartilage, 16(Supplement 4), S182-S182.
  • Anandacoomarasamy, A., Sambrook, P., Fransen, M., Chen, (., Zochling, J., Bagga, H., Hawkins, L., March, L. (2007). Familial associations of osteoarthritis in mother-daughter pairs – clinical, X-ray, BMD and MRI outcomes. Internal Medicine Journal, 37(S2), A34-A34.
  • Herbert, R., Fransen, M. (2007). Management of chronic knee pain:Acupuncture has no additional benefit in people taking a course of exercise. BMJ: British Medical Journal, 335(doi:10.1136/bmj.39343.501863.80), on-line-on-line.
  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2007). Physical activity for osteoarthritis management: a randomized controlled clinical trial evaluating hydrotherapy or Tai Chi classes. Arthritis and Rheumatism, 57(3), 407-414.
  • Anandacoomarasamy, A., Caterson, I., Sambrook, P., Fransen, M., March, L. (2007). The impact of obesity on the musculoskeletal system. International Journal of Obesity, 32(2), 211-222.
  • Anandacoomarasamy, A., Caterson, I., Sambrook, P., Fransen, M., March, L. (2007). The impact of obesity on the musculoskeletal system. Internal Medicine Journal, 37(S2), A35-A35.
  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2006). Hydrotherapy or Tai Chi classes for osteoarthritis. APLAR Journal of Rheumatology, 9(S1), A25-A25.
  • Fransen, M., Anderson, C., Douglas-Morris, J., MacMahon, S., Neal, B., Norton, R., Woodward, M., Cameron, I., Crawford, R., Lo, S., et al (2006). Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. BMJ: British Medical Journal, 333(7567), 519-519.
  • Fransen, M., Wilsmore, B., Winstanley, J., Woodward, M., Grunstein, R., Ameratunga, S., Norton, R. (2006). Shift work and work injury in the New Zealand Blood Donors' Health Study. Occupational and Environmental Medicine, 63(5), 352-358.
  • Naylor, J., Harmer, A., Fransen, M., Crosbie, J., Innes, L. (2006). Status of physiotherapy rehabilitation after total knee replacement in Australia. Physiotherapy Research International, 11(1), 35-47.
  • Fransen, M. (2006). The association between ectopic bone formation after hip replacement surgery and clinical outcomes. Results from the HIPAID clinical trial. Osteoarthritis and Cartilage, 14(Supplement 2), S194-S194.
  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2006). The Physical Activity for Osteoarthritis Management (PAFORM) study. A randomised controlled clinical trial evaluating hydrotherapy and Tai Chi classes. Osteoarthritis and Cartilage, 14(Supplement 2), S162-S162.
  • Fransen, M. (2006). The safety and efficacy of routine perioperative NSAIDs prophylaxis for ectopic bone formation after hip replacement surgery. A randomised clinical Trial. Osteoarthritis and Cartilage, 14(Supplement 2), S38-S38.
  • Fransen, M. (2004). Editorial: Dietary Weight Loss and Exercise for Obese Adults with Knee Osteoarthritis: Modest Weight Loss Targets, Mild Exercise, Modest Effects. Arthritis and Rheumatism, 50(5), 1366-1369.
  • Fransen, M., Neal, B. (2004). Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty (review). Cochrane Database of Systematic Reviews, (3), 1-39.
  • Fransen, M., Anderson, C., Bellamy, N., Cameron, I., Crawford, R., Douglas, I., MacMahon, S., March, L., Neal, B., Norton, R., et al (2004). Preventing chronic ectopic bone-related pain and disability after hip replacement surgery with perioperative ibuprofen. A multicenter, randomized, double-blind, placebo-controlled trial (HIPAID). Contemporary Clinical Trials, 25(2), 223-233.
  • Fransen, M. (2004). When Is Physiotherapy Appropriate? Best Practice and Research: Clinical Rheumatology, 18(4), 477-89.
  • Fransen, M., Anderson, C., Chalmers, J., Chapman, N., Davis, S., MacMahon, S., Neal, B., Sega, R., Terent, A., Tzourio, C., Woodward, M. (2003). Effects of a Perindopril-Based Blood Pressure-Lowering Regimen on Disability and Dependency in 6105 Patients With Cerebrovascular Disease: A Randomized Controlled Trial. Stroke: a journal of cerebral circulation, 34(10), 2333-2338.
  • Fransen, M., McConnell, S., Bell, M. (2003). Exercise for osteoarthritis of the hip or knee. Physiotherapy, 89(9), 516.
  • Fransen, M., Crosbie, W., Edmonds, J. (2003). Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee. Arthritis Care and Research, 49(1), 29-35.
  • Fransen, M., McConnell, S., Bell, M. (2003). Meta-analysis of exercise for OA knee: differential effect of one-to-one treatments, exercise classes and home programs. Osteoarthritis and Cartilage, 11(Supplement 1), S4-S4.
  • Fransen, M., Anderson, C., Chalmers, J., Chapman, N., Davis, S., MacMahon, S., Neal, B., Sega, R., Terent, A., Tzourio, C., Woodward, M. (2003). The effects of a perindopril-based blood pressure lowering regimen on disability and dependency in 6,105 patients with cerebrovascular disease. A randomised controlled trial. Stroke: a journal of cerebral circulation, (DOI: 10.1161/01.STR.0000091397.81767.40), 2333-2338.
  • Fransen, M., Woodward, M., Norton, R., Robinson, E., Butler, M., Campbell, A. (2002). Excess Mortality or Institutionalization After Hip Fracture: Men Are at Greater Risk Than Women. Journal of the American Geriatrics Society, 50(4), 685-690.
  • Fransen, M., Woodward, M., Norton, R., Coggan, C., Dawe, M., Sheridan, N. (2002). Risk Factors Associated With the Transition From Acute to Chronic Occupational Back Pain. Spine, 27(1), 92-98.
  • Fransen, M., McConnell, S., Bell,, M. (2002). Therapeutic Exercise for People with Osteoarthritis of the Hip or Knee. A Systematic Review. Journal of Rheumatology, 29(8), 1737-1745.
  • Fransen, M., Crosbie, W., Edmonds,, J. (2001). Physical therapy is effective for patients with osteoarthritis of the knee: a randomized controlled clinical trial. Journal of Rheumatology, 28, 156-164.

Conferences

  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2011). Quantitative analysis of the medial tibio-femoral compartment over one year. Osteoarthritis Research Society International, Austria: Osteoarthritis Research Society International.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2011). Reproducibility of Manual Segmentation of Cartilage Volume Measurements using 3T Magnetic Resonance Imaging. 20th Annual meeting of the Society for Magnetic Resonance Technologists (SMRT), Montreal, Quebec, Canada.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2010). Accuracy of Magnetic Resonance imaging data obtained from porcine knees. 20th Annual meeting of the Society for Magnetic Resonance Technologists (SMRT), Montreal, Quebec, Canada.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2010). Longitudinal use of T2 mapping in knee Osteoarthritis: A pilot study. 19th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), Canada.
  • Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Woodward, M. (2010). Retrospective and prospective reporting of knee pain and disability among people with symptomatic knee osteoarthritis. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.
  • Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Woodward, M. (2010). Screening, Recruitment and baseline characteristics of the Long-term Evaluation of Glucosamine Sulphate (LEGS) Study participants. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.
  • Agaliotis, M., Fransen, M., Nairn, L., Votrubec, M., Bridgett, L., Jan, S., Woodward, M. (2010). Work disability among people with mild to moderate knee osteoarthritis. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.
  • Naylor, J., Fransen, M., Harmer, A., Winstanley, J., Ireland, J. (2006). Outcomes following primary THR and TKR from a region with high socio-economic disadvantage. Australasian Quality and Safety Conference.

2013

  • Chan, E., Fransen, M., Sathappan, S., Chua, N., Chan, Y., Chua, N. (2013). Comparing the Analgesia Effects of Single-injection and Continuous Femoral Nerve Blocks with Patient Controlled Analgesia after Total Knee Arthroplasty. Journal of Arthroplasty, Article in Press.
  • Cromer, M., Foster, S., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2013). Use of 3T MRI and an unspoiled 3D fast gradient echo sequence for porcine knee cartilage volumetry: Preliminary findings. Journal of Magnetic Resonance Imaging, Article online.

2012

  • Agaliotis, M., Bridgett, L., Nairn, L., Votrubec, M., Jan, S., Heard, R., Fransen, M. (2012). A longitudinal study of work disability among people with mild to moderate knee osteoarthritis. Annals of the Rheumatic Diseases (Online), 71(Supplement 3), 695-695.
  • Salomon, J., Vos, T., Hogan, D., Gagnon, M., Naghavi, M., Mokdad, A., Begum, N., Shah, R., Karyana, M., Kosen, S., Blyth, F., Cross, M., Driscoll, T., Fransen, M., March, L., McGill, N., Sanchez Riera, L., Smith, E., et al (2012). Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2129-2143.
  • Murray, C., Vos, T., Lozano, R., Naghavi, M., Flaxman, A., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J., et al, Blyth, F., Bridgett, L., Cross, M., Driscoll, T., Fransen, M., Leigh, J., March, L., Marks, G., McGill, N., Sanchez Riera, L., Smith, E. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2197-2223.
  • Chan, E., Fransen, M., Parker, D., Assam, P., Chua, N. (2012). Femoral nerve blocks for acute postoperative pain after knee replacement surgery (Intervention Protocol). Cochrane Database of Systematic Reviews, (7), 1-23.
  • Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S., Blyth, F., Cross, M., Driscoll, T., Fransen, M., March, L., Marks, G., Smith, E., et al (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2095-2128.
  • Wilsmore, B., Grunstein, R., Fransen, M., Woodward, M., Norton, R., Ameratunga, S. (2012). Sleep, blood pressure and obesity in 22 389 New Zealanders. Internal Medicine Journal, 42(6), 634-641.
  • Nairn, L., Fransen, M. (2012). Tai Chi as a treatment for knee osteoarthritis. Medicine Today: the peer reviewed journal of clinical practice, 13(8), 59-60.
  • Anandacoomarasamy, A., Leibman, S., Smith, G., Caterson, I., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2012). Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Annals of the Rheumatic Diseases (Online), 71(1), 26-32.
  • Vos, E., Flaxman, A., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J., Abdalla, S., Aboyans, V., Blyth, F., Bridgett, L., Cross, M., Driscoll, T., Fransen, M., Leigh, J., March, L., Marks, G., McGill, N., Sanchez Riera, L., Smith, E., et al (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2163-2196.

2011

  • Fransen, M., Agaliotis, M., Bridgett, L., Mackay, M. (2011). Hip and Knee Pain: Role of Occupational Factors. Best Practice and Research: Clinical Rheumatology, 25(1), 81-101.
  • Fransen, M. (2011). Osteoarthritis. In John M. Saxton (Eds.), Exercise and Chronic Disease: An evidence-based approach, (pp. 156-174). NY, USA: Routledge imprint of Taylor & Francis.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2011). Quantitative analysis of the medial tibio-femoral compartment over one year. Osteoarthritis Research Society International, Austria: Osteoarthritis Research Society International.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2011). Reproducibility of Manual Segmentation of Cartilage Volume Measurements using 3T Magnetic Resonance Imaging. 20th Annual meeting of the Society for Magnetic Resonance Technologists (SMRT), Montreal, Quebec, Canada.
  • Fransen, M., Bridgett, L., March, L., Hoy, D., Penserga, E., Brooks, P. (2011). The epidemiology of osteoarthritis in Asia. International Journal of Rheumatic Diseases, 14(2), 113-121.

2010

  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2010). Accuracy of Magnetic Resonance imaging data obtained from porcine knees. 20th Annual meeting of the Society for Magnetic Resonance Technologists (SMRT), Montreal, Quebec, Canada.
  • Fransen, M., McConnell, S., Hernandez-Molina, G., Reichenbach, S. (2010). Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage, 18(5), 613-620.
  • Naylor, J., Adie, S., Fransen, M., Dietsch, S., Harris, I. (2010). Endorsing single-unit transfusion combined with a restrictive haemoglobin transfusion threshold following knee arthroplasty. Quality and Safety in Health Care, 19, 239-243.
  • Hoy, D., Fransen, M., March, L., Brooks, P., Durham, J., Toole, M. (2010). In rural Tibet, the prevalence of lower limb pain, especially knee pain, is high: an observational study. Journal of Physiotherapy, 56(1), 49-54.
  • Cromer, M., Bourne, R., Fransen, M., Fulton, R., Wang, S. (2010). Longitudinal use of T2 mapping in knee Osteoarthritis: A pilot study. 19th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), Canada.
  • Ling, J., Fransen, M., Kang, X., Li, H., Ke, Y., Wang, Z., Zhang, Y., Su, S. (2010). Marked disability and high use of non-steroidal anti-inflammatory drugs associated with knee osteoarthritis in rural China: a cross-sectional population-based study. Arthritis Research and Therapy, 12(R225), 1-7.
  • Busija, L., Bridgett, L., Williams, S., OSBORNE, R., Buchbinder, R., March, L., Fransen, M. (2010). Osteoarthritis. Best Practice and Research: Clinical Rheumatology, 24, 757-768.
  • Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Woodward, M. (2010). Retrospective and prospective reporting of knee pain and disability among people with symptomatic knee osteoarthritis. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.
  • Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Woodward, M. (2010). Screening, Recruitment and baseline characteristics of the Long-term Evaluation of Glucosamine Sulphate (LEGS) Study participants. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.
  • Agaliotis, M., Fransen, M., Nairn, L., Votrubec, M., Bridgett, L., Jan, S., Woodward, M. (2010). Work disability among people with mild to moderate knee osteoarthritis. OARSI 2010 World Congress on Osteoarthritis, Sweden: Elsevier.

2009

  • Agaliotis, M., Nairn, L., Votrubec, M., Fransen, M. (2009). Acceptability of a novel 7 day bimonthly participant diary in a long-term clinical trial among people with symptomatic knee OA. Osteoarthritis and Cartilage, 17(Supplement 1), S175-S176.
  • Anandacoomarasamy, A., Smith, G., Leibman, S., Caterson, I., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2009). Cartilage defects are associated with physical disability in obese adults. Rheumatology (Print Edition), 48(10), 1290-1293.
  • Anandacoomarasamy, A., Giuffre, B., Leibman, S., Caterson, I., Smith, G., Fransen, M., Sambrook, P., March, L. (2009). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage: Clinical associations in obese adults. Journal of Rheumatology, 36(5), 1056-1062.
  • Fransen, M., Neal, B., Cameron, I., Crawford, R., Tregonning, G., Winstanley, J., Norton, R. (2009). Determinants of heterotopic ossification after total hip replacement surgery. Hip International, 19(1), 41-46.
  • Fransen, M., McConnell, S., Hernandez-Molina, G., Reichenbach, S. (2009). Exercise for osteoarthritis of the hip. Cochrane Database of Systematic Reviews, 3(Article number CD007912), 1-24.
  • Anandacoomarasamy, A., Caterson, I., Leibman, S., Smith, G., Sambrook, P., Fransen, M., March, L. (2009). Influence of BMI on Health-related Quality of Life: Comparison Between an Obese Adult Cohort and Age-matched Population Norms. Obesity, 17(11), 2114-2118.
  • Fransen, M., McConnell, S. (2009). Land-based exercise for osteoarthritis of the knee: a metaanalysis of randomized controlled trials. Journal of Rheumatology, 36(6), 1109-1117.
  • Lin, C., March, L., Crosbie, W., Crawford, R., Graves, S., Naylor, J., Harmer, A., Jan, S., Bennell, K., Harris, I., Fransen, M., et al (2009). Maximum recovery after knee replacement - the MARKER study rationale and protocol. BMC Musculoskeletal Disorders, 10(16), 69-1-69-8.
  • Anandacoomarasamy, A., Fransen, M., March, L. (2009). Obesity and the musculoskeletal system. Current Opinion In Rheumatology, 21(1), 71-77.
  • Nairn, L., Agaliotis, M., Votrubec, M., Fransen, M. (2009). Overcoming recruitment barriers in a clinical trial evaluating dietary supplements. Annals of the Rheumatic Diseases (Online), 68(Supplement 3), 755-755.
  • Kang, X., Fransen, M., Zhang, Y., Li, H., Ke, Y., Lu, M., Su, S., Song, X., Guo, Y., Chen, J., et al (2009). The high prevalence of knee osteoarthritis in a rural Chinese population: the Wuchuan osteoarthritis study. Arthritis and Rheumatism, 61(5), 641-647.
  • Agaliotis, M., Nairn, L., Votrubec, M., Fransen, M. (2009). Usefulness of 7 day knee pain scores among people with mild to moderate knee OA participating in clinical trials. Osteoarthritis and Cartilage, 17(Supplement 1), S158-S158.

2008

  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Giuffre, B., Chen, (., Fransen, M., Sambrook, P., March, L. (2008). Evaluation of glycosaminoglycan (GAG) content in knee cartilage using delayed gadolinium enhanced MRI of cartilage (DGEMRIC) in an obese cohort. Internal Medicine Journal, 38(Supplement 2), A7-A7.
  • Fransen, M., McConnell, S. (2008). Exercise for osteoarthritis of the knee (Review). Cochrane Database of Systematic Reviews, (4), 1-92.
  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Chen, (., Fransen, M., Sambrook, P., March, L. (2008). Musculoskeletal symptoms in an obese cohort. Internal Medicine Journal, 38(S2), A17-A17.
  • Day, R., Fransen, M. (2008). Osteoarthritis: NSAIDs or other management strategies? Medicine Today: the peer reviewed journal of clinical practice, 9(10), 71-76.
  • Anandacoomarasamy, A., Caterson, I., Smith, G., Leibman, S., Giuffre, B., Fransen, M., Sambrook, P., March, L. (2008). The clinical associations of knee cartilage defects in an obese population. Osteoarthritis and Cartilage, 16(Supplement 4), S182-S182.

2007

  • Anandacoomarasamy, A., Sambrook, P., Fransen, M., Chen, (., Zochling, J., Bagga, H., Hawkins, L., March, L. (2007). Familial associations of osteoarthritis in mother-daughter pairs – clinical, X-ray, BMD and MRI outcomes. Internal Medicine Journal, 37(S2), A34-A34.
  • Herbert, R., Fransen, M. (2007). Management of chronic knee pain:Acupuncture has no additional benefit in people taking a course of exercise. BMJ: British Medical Journal, 335(doi:10.1136/bmj.39343.501863.80), on-line-on-line.
  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2007). Physical activity for osteoarthritis management: a randomized controlled clinical trial evaluating hydrotherapy or Tai Chi classes. Arthritis and Rheumatism, 57(3), 407-414.
  • Anandacoomarasamy, A., Caterson, I., Sambrook, P., Fransen, M., March, L. (2007). The impact of obesity on the musculoskeletal system. International Journal of Obesity, 32(2), 211-222.
  • Anandacoomarasamy, A., Caterson, I., Sambrook, P., Fransen, M., March, L. (2007). The impact of obesity on the musculoskeletal system. Internal Medicine Journal, 37(S2), A35-A35.

2006

  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2006). Hydrotherapy or Tai Chi classes for osteoarthritis. APLAR Journal of Rheumatology, 9(S1), A25-A25.
  • Naylor, J., Fransen, M., Harmer, A., Winstanley, J., Ireland, J. (2006). Outcomes following primary THR and TKR from a region with high socio-economic disadvantage. Australasian Quality and Safety Conference.
  • Fransen, M., Anderson, C., Douglas-Morris, J., MacMahon, S., Neal, B., Norton, R., Woodward, M., Cameron, I., Crawford, R., Lo, S., et al (2006). Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. BMJ: British Medical Journal, 333(7567), 519-519.
  • Fransen, M., Wilsmore, B., Winstanley, J., Woodward, M., Grunstein, R., Ameratunga, S., Norton, R. (2006). Shift work and work injury in the New Zealand Blood Donors' Health Study. Occupational and Environmental Medicine, 63(5), 352-358.
  • Naylor, J., Harmer, A., Fransen, M., Crosbie, J., Innes, L. (2006). Status of physiotherapy rehabilitation after total knee replacement in Australia. Physiotherapy Research International, 11(1), 35-47.
  • Fransen, M. (2006). The association between ectopic bone formation after hip replacement surgery and clinical outcomes. Results from the HIPAID clinical trial. Osteoarthritis and Cartilage, 14(Supplement 2), S194-S194.
  • Fransen, M., Nairn, L., Winstanley, J., Lam, P., Edmonds, J. (2006). The Physical Activity for Osteoarthritis Management (PAFORM) study. A randomised controlled clinical trial evaluating hydrotherapy and Tai Chi classes. Osteoarthritis and Cartilage, 14(Supplement 2), S162-S162.
  • Fransen, M. (2006). The safety and efficacy of routine perioperative NSAIDs prophylaxis for ectopic bone formation after hip replacement surgery. A randomised clinical Trial. Osteoarthritis and Cartilage, 14(Supplement 2), S38-S38.

2004

  • Fransen, M. (2004). Editorial: Dietary Weight Loss and Exercise for Obese Adults with Knee Osteoarthritis: Modest Weight Loss Targets, Mild Exercise, Modest Effects. Arthritis and Rheumatism, 50(5), 1366-1369.
  • Fransen, M., Neal, B. (2004). Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty (review). Cochrane Database of Systematic Reviews, (3), 1-39.
  • Pham, T., Fransen, M., Ravaud, P., Dougados, M., Ottawa Methods Group. (2004). Osteoarthritis. In P. Tugwell, B. Shea, M. Boers, P. Brooks, L.S. Simon, V. Sttrand, G. Wells (Eds.), Evidence-Based Rheumatology: Volume 40 of Evidence-Based Medicine. United Kingdom: BMJ Books.
  • Fransen, M., Anderson, C., Bellamy, N., Cameron, I., Crawford, R., Douglas, I., MacMahon, S., March, L., Neal, B., Norton, R., et al (2004). Preventing chronic ectopic bone-related pain and disability after hip replacement surgery with perioperative ibuprofen. A multicenter, randomized, double-blind, placebo-controlled trial (HIPAID). Contemporary Clinical Trials, 25(2), 223-233.
  • Fransen, M. (2004). When Is Physiotherapy Appropriate? Best Practice and Research: Clinical Rheumatology, 18(4), 477-89.

2003

  • Fransen, M., Anderson, C., Chalmers, J., Chapman, N., Davis, S., MacMahon, S., Neal, B., Sega, R., Terent, A., Tzourio, C., Woodward, M. (2003). Effects of a Perindopril-Based Blood Pressure-Lowering Regimen on Disability and Dependency in 6105 Patients With Cerebrovascular Disease: A Randomized Controlled Trial. Stroke: a journal of cerebral circulation, 34(10), 2333-2338.
  • Fransen, M., McConnell, S., Bell, M. (2003). Exercise for osteoarthritis of the hip or knee. Physiotherapy, 89(9), 516.
  • Fransen, M., Crosbie, W., Edmonds, J. (2003). Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee. Arthritis Care and Research, 49(1), 29-35.
  • Fransen, M., McConnell, S., Bell, M. (2003). Meta-analysis of exercise for OA knee: differential effect of one-to-one treatments, exercise classes and home programs. Osteoarthritis and Cartilage, 11(Supplement 1), S4-S4.
  • Fransen, M., Anderson, C., Chalmers, J., Chapman, N., Davis, S., MacMahon, S., Neal, B., Sega, R., Terent, A., Tzourio, C., Woodward, M. (2003). The effects of a perindopril-based blood pressure lowering regimen on disability and dependency in 6,105 patients with cerebrovascular disease. A randomised controlled trial. Stroke: a journal of cerebral circulation, (DOI: 10.1161/01.STR.0000091397.81767.40), 2333-2338.

2002

  • Fransen, M., Woodward, M., Norton, R., Robinson, E., Butler, M., Campbell, A. (2002). Excess Mortality or Institutionalization After Hip Fracture: Men Are at Greater Risk Than Women. Journal of the American Geriatrics Society, 50(4), 685-690.
  • Fransen, M., Woodward, M., Norton, R., Coggan, C., Dawe, M., Sheridan, N. (2002). Risk Factors Associated With the Transition From Acute to Chronic Occupational Back Pain. Spine, 27(1), 92-98.
  • Fransen, M., McConnell, S., Bell,, M. (2002). Therapeutic Exercise for People with Osteoarthritis of the Hip or Knee. A Systematic Review. Journal of Rheumatology, 29(8), 1737-1745.

2001

  • Fransen, M., Crosbie, W., Edmonds,, J. (2001). Physical therapy is effective for patients with osteoarthritis of the knee: a randomized controlled clinical trial. Journal of Rheumatology, 28, 156-164.
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Keywords

Physiotherapy; Physical activity; Evidence-based medicine; Arthritis; Musculoskeletal diseases

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