Professor Michael Kassiou

BSc PhD UNSW
Professor of Medicinal Chemistry
Associate Dean Research and Innovation
(Faculty of Health Sciences)

C43A - Jeffrey Miller Admin Building Cumberland Campus
The University of Sydney

Telephone 61 2 9351 2745
Fax 61 2 9351 3329

Website Research Group Website
Contact Details

Biographical details

Michael received his PhD in Organic Chemistry in 1992 from the University of NSW. Following this he took up a position as research scientist within the Biomedicine and Health Program at the Australian Nuclear Science and Technology Organisation (ANSTO). In 1993 he was appointed as a visiting scientist at the CEA-Service Hospitalier Frédéric Joliot Life Sciences group in France looking at methods for studying the living brain. Shortly after that Michael took up a postdoctoral position at the Johns Hopkins Medical Institutes in Baltimore USA. In 1996 he was awarded a Fogerty Fellowship that saw him take up a position at the NIH National Institute of Drug Abuse (NIDA) USA. He then moved back to Sydney to the Department of PET and Nuclear Medicine at the Royal Prince Alfred Hospital as a Principal Hospital Scientist and in 2006 took up a position at the University of Sydney in which he is currently Professor of Medicinal Chemistry. He is a Fellow of the Royal Australian Chemical Institute (FRACI C.Chem) and current chair of the Medicinal Chemistry & Chemical Biology Division of RACI. He is a thematic editor for Current Pharmaceutical Design and the Editor for the Journal of Labelled Compounds and Radiopharmaceuticals. In addition, he serves on 11 journal editorial advisory boards concerned with medicinal chemistry and drug design.

Research interests

  • Medicinal Chemistry and Drug Discovery
  • Structure-activity relationships of CNS bioactive molecules
  • Rationale CNS drug design and evaluation
  • Heterocyclic Chemistry

Research in my group is interdisciplinary and built around the key themes of medicinal chemistry and drug discovery. Our research group utilises modern organic chemistry techniques to rationally design and synthesise novel compounds for a range of CNS targets which are associated with neuropathologie ssuch as Parkinson’s disease, schizophrenia, anxiety and depression. In this domain understanding drug-protein and drug-binding site interactions is a key component which allows us to obtain structure-activity relationships of bioactive CNS molecules. In addition by using molecular imaging techniques within these fields we are able to better understand the living brain in normal and diseased states through in vivo studies.

Current projects

For current research activities and opportunities please visit our home page: http://www.chem.usyd.edu.au/~kassiou

Selected grants

2015

  • Novel therapeutics for the remediation of social deficits in psychiatric illness; McGregor I, Kassiou M, Hunt G, Cornish J; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).
  • Development of small molecule inhibitors of LRRK2 for treatment of Parkinson's disease; Kassiou M, Munoz L; Parkinson's New South Wales Incorporated/Research Support.
  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • HPLC-MS for high throughput drug and protein analysis; Payne R, Kassiou M, Cordwell S, Hibbs D, Groundwater P, Shepherd N; DVC Research/Equipment Grant.

2012

  • A flexible high throughput analytical system for psychopharmacology and drug discovery; McGregor I, Simpson S, Shannon Weickert C, Kassiou M, Copeland J, Solowij N, Codd R, Arnold J, Karl T, Long L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • A unique class of tumour-specific drugs for the trearment of advanced metastatic cancer; Rendina L, Kassiou M; National Breast Cancer Foundation/Novel Concept Awards.
  • New Strategies in the Treatment and Imaging of Neurodegenerative Diseases; Kassiou M; National Health and Medical Research Council (NHMRC)/International Collaborations: Australian-European Union Health Research Grants.

2011

  • Imaging of neuroinflammation in neurodegenerative disease (INMiND); Jacobs A, Maggi A, Aigner L, Guilloteau D, Aime S, Planas A, Van Der Linden A, Tavitian B, Herholz K, Boutin H, Perani D, Halldin C, Nordberg A, Van Laere K, Baekelandt V, Knudsen G, Pappata S, Rinne J, Holmes C, Roncaroli F, Brooks D, Kassiou M, Kellermayer M, Heneka M, Biserni A, Perk I, Cavallotti C, Alavijeh M, Mathe D, Ronn L; European Commission (Belgium)/Seventh Framework Network of Excellence Programme.
  • Preclinical validation of oxytocin as a novel treatment for alcohol dependence; McGregor I, Hunt G, Kassiou M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Development of Carboranes as New Agents in the Diagnosis and Treatment of Brain Disease; Kassiou M, Rendina L; Australian Research Council (ARC)/Discovery Projects (DP).
  • Preparative High-Performance Liquid Chromatography (HPLC); Payne R, Jolliffe K, Hambley T, Kassiou M, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Molecular targets of amino acid/neurotransmitter conjugates of fatty acids; Connor M, Vaughan C, Kassiou M, McIntyre P; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Purinergic P2X7 Receptor as a Target for Antidepressant Drug Discovery; Kassiou M, McGregor I, Bennett M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The translocator protein (TSPO) as a novel target for the treatment of Alzheimers Disease; Ittner L, Kassiou M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Radiolabelled MMP Binding Agents for the Identification, Quantification, and Targeting of MMPs in CNS Disorders and Tumours; Hambley T, Kassiou M; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Motion Menura multimodal mouse testing apparatus (MMTA): (Turnkey system comprising 6 testing chambers with associated control and tracking software).; Kemp A, Hermens D, McGregor I, Einfeld S, Kassiou M, Arnold J, Hunt G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Selective Targeting of Breast Tumours for Boron Neutron Capture Therapy; Rendina L, Kassiou M; National Breast Cancer Foundation/Novel Concept Awards.
  • Hidex Chameleon V Multi-Technology plate reader; Ittner L, Goetz J, MacDonald C, Kassiou M, Connor M, Holsinger D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • RES: Contract Research Agreement with Bayer Schering Pharma; Kassiou M; Bayer Schering Pharma AG/Research Support.
  • Development of Novel Radiolabelled Molecular Probes for Studying Diseases of the Brain; Kassiou M; Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education (Fed)/International Science Linkages (ISL) Competitive Grants.
  • Research Infrastructure (Major Equipment) Scheme 2008; Ittner L, Goetz J, Christie M, Bennett M, Kassiou M, Connor M, Holsinger D, Bagley E; Faculty of Medicine/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The Targeting of Brain Tumours by a New Class of Agents for Boron Neutron Capture Therapy; Rendina L, Kassiou M; Cure Cancer Australia Foundation/Research Support.

2007

  • Automatic Gamma Counter; Meikle S, Banati R, Kassiou M, Bailey D, Baldock C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Evaluation of a selective NMDA NR1A/2B receptor antagonist as a drug treatment in an animal model of Parkinsons disease; Henderson J, Kassiou M; Australian Rotary Health Research Fund/Research Grant.
  • Characterisation - Imaging; Meikle S, Kassiou M, Banati R; Office for Science and Medical Research (NSW)/National Collaborative Research Infrastructure Strategy Program.
  • Development of Novel Radiolabelled Molecular Probes for Studying Diseases of the Brain; Meikle S, Banati R, Kassiou M; DEST/International Science Linkages Competitive Grants.
  • Establishment of a National Imaging Facility; Banati R, Meikle S, Kassiou M; Department of Education, Science and Training (DEST)/National Collaborative Research Infrastructure Strategy (Australia).

2006

  • Functionalised MMP Inhibitors as Radiodiagnostic, Radiotherapeutic, and Radiation-Sensitising Agents for Metastatic Cancer; Hambley T, Kassiou M; Australian Research Council (ARC)/Discovery Projects (DP).

2005

  • Glial and neuroinflammatory mechanisms of neuronal degeneration and regeneration: The functional states of microglia in central nervous system and macrophages in the peripheral nervous system.; Pollard J, Kassiou M, Prineas J, Banati R, Bennett M; NSW Ministry of Science and Medical Research/Spinal Cord Injury Research Grants.
  • Evaluation of a selective NMDA NR1A/2B receptor antagonist as a drug treatment in an animal model of Parkinsons disease.; Henderson J, Kassiou M; Australian Rotary Health Research Fund/Parkinsons Disease.

2004

  • Functional in vivo imaging of neurodegenerative disorders of the brain using PET & SPECT; Kassiou M, Guilloteau D; DEST/Innovation Access Program.
  • 1295 - Comparison of structurally diverse SPECT radioligands for the peripheral benzodiazepine receptor; Kassiou M; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Development and evaluation of a SPECT radioligand for imaging the sigma receptor; Kassiou M; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.

2003

  • Development of radioligands for imaging the NMDA receptor using Positron Emission Tomography (PET); Kassiou M; Embassy of France in Australia/Research Grant.
  • Trishomocubanes: Potential neuroprotective drug therapies for Parkinsons disease; Henderson J, Kassiou M; Brain Foundation of Australia/Research Grants.

2002

  • Not known; Kassiou M; DVC Research/Research and Development Scheme: Research and Development (R&D).

Selected publications

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Book Chapters

  • Barron, M., Werry, E., McGregor, I., Kassiou, M. (2014). P2X7 in Bipolar and Depressive Disorders. In Norbert Weiss, Alexandra Koschak (Eds.), Pathologies of Calcium Channels, (pp. 635-661). Berlin: Springer-Verlag.
  • Guenther, K., Hambley, T., Kassiou, M. (2008). Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET). In Nicola Antonio Colabufo (Eds.), Multidrug Resistance: Biological and Pharmaceutical Advances in Antitumour Treatment, (pp. 291-320). India: Research Signpost.

Journals

  • Medran-Navarrete, V., Bernards, N., Kuhnast, B., Damont, A., Pottier, G., Schollhorn-Peyronneau, M., Kassiou, M., Marguet, F., Puech, F., Boisgard, R., et al (2014). [18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET. Journal of Labelled Compounds and Radiopharmaceuticals, 57(6), 410-418. [More Information]
  • Liang, V., Ullrich, M., Lam, H., Chew, Y., Banister, S., Song, X., Zaw, T., Kassiou, M., Goetz, J., Nicholas, H. (2014). Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71(17), 3339-3361. [More Information]
  • Ullrich, M., Liang, V., Chew, Y., Banister, S., Song, X., Zaw, T., Lam, H., Berber, S., Kassiou, M., Nicholas, H., Goetz, J. (2014). Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9(9), 2237-2255. [More Information]
  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Ribeiro, M., Vercouillie, J., Debiais, S., Cottier, J., Bonnaud, I., Camus, V., Banister, S., Kassiou, M., Arlicot, N., Guilloteau, D. (2014). Could 18F-DPA-714 PET imaging be interesting to use in the early post-stroke period? European Journal of Nuclear Medicine and Molecular Imaging, 4(28), 1-8. [More Information]
  • Zavitsanou, K., Lim, C., Purves-Tyson, T., Karl, T., Kassiou, M., Banister, S., Guillemin, G., Shannon Weickert, C. (2014). Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition. Brain, Behavior, and Immunity, 41(2014), 173-181. [More Information]
  • Beinat, C., Reekie, T., Hibbs, D., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Tsanaktsidis, J., Kassiou, M. (2014). Investigations of amide bond variation and biaryl modification in analogues of alpha7 nAChR agonist SEN12333. European Journal of Medicinal Chemistry, 84, 200-205. [More Information]
  • Gent, Y., Weijers, K., Molthoff, C., Windhorst, A., Huisman, M., Kassiou, M., Jansen, G., Lammertsma, A., van der Laken, C. (2014). Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis. Arthritis Research and Therapy, 16(2), 1-9. [More Information]
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo[1,4]diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55, 4568-4571. [More Information]
  • Coughlin, J., Wang, Y., Ma, S., Yue, C., Kim, P., Adams, A., Roosa, H., Gage, K., Stathis, M., et al, Kassiou, M. (2014). Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected by HIV. Journal of neurovirology, 20(3), 219-232. [More Information]
  • Beinat, C., Banister, S., Hoban, J., Tsanaktsidis, J., Metaxas, A., Windhorst, A., Kassiou, M. (2014). Structure-activity relationships of N-substituted 4-(trifluoromethoxyl)benzamidines with affinity for GluN2B-containing NMDA receptors. Bioorganic & Medicinal Chemistry Letters, 24(3), 828-830. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Chua, S., Kassiou, M., Ittner, L. (2014). The translocator protein as a drug target in Alzheimer's disease. Expert Review of Neurotherapeutics, 14(4), 439-448. [More Information]
  • Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A., Smigova, A., Cawthorne, C., Julyan, P., Wilkinson, S., Banister, S., Kassiou, M., et al (2013). [(18)F]DPA-714: Direct comparison with [(11)C]PK11195 in a model of cerebral ischemia in rats. PLoS One, 8673 (2), 1-9. [More Information]
  • Beinat, C., Banister, S., McErlean, C., Kassiou, M. (2013). A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane. Tetrahedron Letters, 54(39), 5345-5347. [More Information]
  • Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., McGregor, I. (2013). Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the VI(A) Receptor. Neuropsychopharmacology, 38(11), 2249-2259. [More Information]
  • Ribeiro, M., Vercouillie, J., Corcia, P., Arlicot, N., Erra, B., Maia, S., Bonnaud, I., Debiais, S., Kassiou, M., Guilloteau, D. (2013). Cerebral biodistribution of the PET TSPO radioligand, (18)F-DPA-714, in acute and chronic brain diseases. Journal of Labelled Compounds and Radiopharmaceuticals, 56(S1), P219-P219.
  • Wilkinson, S., Price, J., Kassiou, M. (2013). Improved accessibility to the desoxy analogues of delta(9)-tetrahydrocannabinol and cannabidiol. Tetrahedron Letters, 54(1), 52-54. [More Information]
  • Schollhorn-Peyronneau, M., Saba, W., Goutal, S., Damont, A., Dolle, F., Kassiou, M., Bottlaender, M., Valette, H. (2013). Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand. Drug Metabolism and Disposition, 41(1), 122-131. [More Information]
  • Santiago-Ribeiro, M., Vercouillie, J., Cottier, J., Debiais, S., Bonnaud, I., Arlicot, N., Erra, B., Maia, S., Kassiou, M., Guilloteau, D. (2013). Microglia activation after acute stroke demonstrated using 18F-DPA-714 PET. Correlation with MRI. European Journal of Nuclear Medicine and Molecular Imaging, 40(S2), S208-S208. [More Information]
  • Banister, S., Manoli, M., Barron, M., Werry, E., Kassiou, M. (2013). N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as sigma receptor ligands with potential neuroprotective effects. Bioorganic and Medicinal Chemistry, 21(19), 6038-6052. [More Information]
  • Reekie, T., Kavanagh, M., Longworth, M., Kassiou, M. (2013). Synthesis of Biologically Active Seven-Membered-Ring Heterocycles. Synthesis: journal of synthetic organic chemistry, 45(23), 3211-3227. [More Information]
  • Kavanagh, M., Doddareddy, M., Kassiou, M. (2013). The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorganic & Medicinal Chemistry Letters, 23(13), 3690-3696. [More Information]
  • Banister, S., Manoli, M., Kassiou, M. (2013). The development of radiotracers for imaging sigma receptors in the central nervous system (CNS) using positron emission tomography (PET). Journal of Labelled Compounds and Radiopharmaceuticals, 56(3-4), 215-224. [More Information]
  • Kahlert, J., Austin, C., Kassiou, M., Rendina, L. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry: an international journal for chemical science, 66(10), 1118-1123. [More Information]
  • Banister, S., Wilkinson, S., Longworth, M., Stuart, J., Apetz, N., English, K., Brooker, L., Goebel, C., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2013). The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience, 4(7), 1081-1092. [More Information]
  • Austin, C., Kahlert, J., Kassiou, M., Rendina, L. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology, 45(7), 1212-1216. [More Information]
  • Banister, S., Rendina, L., Kassiou, M. (2012). 7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (sigma-2) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(12), 4059-4063. [More Information]
  • Banister, S., Wilkinson, S., Hanani, R., Reynolds, A., Hibbs, D., Kassiou, M. (2012). A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7-dimethylpy-razolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands. Tetrahedron Letters, 53(29), 3780-3783. [More Information]
  • Banister, S., Manoli, M., Doddareddy, M., Hibbs, D., Kassiou, M. (2012). A σ1 receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDS). Bioorganic & Medicinal Chemistry Letters, 22(19), 6053-6058. [More Information]
  • Beinat, C., Banister, S., Prehn, S., Doddareddy, M., Hibbs, D., Sako, M., Collins, M., Tran, T., Al-Muhtasib, N., Xiao, Y., Kassiou, M. (2012). Consequences of linker length alteration of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(7), 2380-2384. [More Information]
  • Leaver, K., Reynolds, A., Bodard, S., Guilloteau, D., Chalon, S., Kassiou, M. (2012). Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum. ACS Chemical Neuroscience, 3(2), 114-119. [More Information]
  • Scarf, A., Luus, C., Da Pozzo, E., Selleri, S., Guarino, C., Martini, C., Ittner, L., Kassiou, M. (2012). Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa). Current Molecular Medicine, 12(4), 488-493. [More Information]
  • Moussa, I., Banister, S., Manoli, M., Doddareddy, M., Cui, J., Mach, R., Kassiou, M. (2012). Exploration of ring size in a series of cyclic vicinal diamines with sigma(1) receptor-affinity. Bioorganic & Medicinal Chemistry Letters, 22(17), 5493-5497. [More Information]
  • Gilmore, A., Heblinski, M., Reynolds, A., Kassiou, M., Connor, M. (2012). Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. British Journal of Pharmacology, 167(5), 1076-1088. [More Information]
  • Arlicot, N., Vercouillie, J., Ribeiro, M., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Corcia, P., Stabin, M., Reynolds, A., Kassiou, M., et al (2012). Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation. Nuclear Medicine and Biology, 39(4), 570-578. [More Information]
  • Scarf, A., Aumann, K., Kassiou, M. (2012). Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)? Current Molecular Medicine, 12(4), 387-397. [More Information]
  • Corcia, P., Tauber, C., Vercoullie, J., Arlicot, N., Prunier, C., Praline, J., Nicolas, G., Venel, Y., Hommet, C., Baulieu, J., Kassiou, M., et al (2012). Molecular imaging of microglial activation in amyotrophic lateral sclerosis. PLoS One, 7(12), 1-7. [More Information]
  • Endres, C., Coughlin, J., Gage, K., Watkins, C., Kassiou, M., Pomper, M. (2012). Radiation dosimetry and biodistribution of the TSPO ligand (11)C-DPA-713 in humans. The Journal of Nuclear Medicine, 53(2), 330-335. [More Information]
  • Gosling, J., Baker, S., Haynes, J., Kassiou, M., Pouton, C., Warfe, L., White, P., Scammells, P. (2012). Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N6-Substituents as Adenosine A1 Receptor Agonists. ChemMedChem: chemistry enabling drug discovery, 7(7), 1191-1201. [More Information]
  • Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C., Kassiou, M., Hunt, G., McGregor, I. (2012). The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor-Binding Profile, Prosocial Effects and Distribution of c-Fos Expression in Adolescent Rats. Journal of Neuroendocrinology, 24(7), 1012-1029. [More Information]
  • Banister, S., Kassiou, M. (2012). The Therapeutic Potential of Sigma (sigma) Receptors for the Treatment of Central Nervous System Diseases: Evaluation of the Evidence. Current Pharmaceutical Design, 18(7), 884-901. [More Information]
  • Dolle, F., Kuhnast, B., Damont, A., van Camp, N., Kassiou, M., Tavitian, B., Boisgard, R. (2011). [18F]DPA-716 as a candidate for imaging the TSPO 18 kDa with PET: Radiosynthesis and comparative evaluation ([11C]DPA-713/[18F]DPA-714) in a rat model of neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S275-S275.
  • Vercouillie, J., Ribeiro, M., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Reynolds, A., Kassiou, M., Guilloteau, D., Corcia, P. (2011). Biodistribution of the TSPO radioligand (18)F-DPA-714 in healthy volunteers. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S255-S255.
  • Issa, F., Kassiou, M., Rendina, L. (2011). Boron in drug discovery: Carboranes as unique pharmacophores in biologically active compounds. Chemical Reviews, 111(9), 5701-5722. [More Information]
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Kassiou, M., et al (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity, 25(6), 1113-1122. [More Information]
  • Dolle, F., Le Helleix, S., Schollhorn-Peyronneau, M., Saba, W., Banister, S., Tournier, N., Valette, H., Kassiou, M. (2011). Carbon-11-labelling of a novel, trishomocubane-derived, high affinity and selectivity DAT ligand. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S276-S276.
  • Moussa, I., Banister, S., Akladios, F., Chua, S., Kassiou, M. (2011). Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazine sigma(1) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(19), 5707-5710. [More Information]
  • Banister, S., Moussa, I., Jorgensen, W., Chua, S., Kassiou, M. (2011). Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (σ) receptor ligands modulates off-target activity and subtype selectivity. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(12), 3622-3626. [More Information]
  • Banister, S., Yoo, D., Chua, S., Cui, J., Mach, R., Kassiou, M. (2011). N-arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (sigma) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(18), 5289-5292. [More Information]
  • Ribeiro, M., Vercouillie, J., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Reynolds, A., Kassiou, M., Guilloteau, D., Corcia, P. (2011). P-167 The potential interest of the PET radioligand (18)F-DPA-714 in neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S256-S256.
  • Martin, A., Boisgard, R., Kassiou, M., Dolle, F., Tavitian, B. (2011). Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [(18)F]DPA-714. Molecular Imaging and Biology, 13(1), 10-15. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Crossley, E., Issa, F., Scarf, A., Kassiou, M., Rendina, L. (2011). Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells. Chemical Communications, 47(44), 12179-12181. [More Information]
  • Moussa, I., Banister, S., Giboureau, N., Meikle, S., Kassiou, M. (2011). Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(22), 6820-6823. [More Information]
  • Damont, A., Boisgard, R., Kuhnast, B., Lemee, F., Raggiri, G., Scarf, A., Da Pozzo, E., Selleri, S., Martini, C., Tavitian, B., Kassiou, M., et al (2011). Synthesis of 6-[(18)F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(16), 4819-4822. [More Information]
  • Scarf, A., Kassiou, M. (2011). The translocator protein. The Journal of Nuclear Medicine, 52(5), 677-680. [More Information]
  • Banister, S., Moussa, I., Beinat, C., Reynolds, A., Schiavini, P., Jorgensen, W., Kassiou, M. (2011). Trishomocubane as a Scaffold for the Development of Selective Dopamine Transporter (DAT) Ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(1), 38-41. [More Information]
  • Banister, S., Clegg, J., Hanani, R., Kassiou, M. (2010). 11-{[2-(3-fluorophenyl)ethyl](methyl)-amino}pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]-undecan-8-one. Acta Crystallographica. Section E: Structure Reports Online, 66(10), o2693-o2693.
  • Naidoo (Naidoo-Variawa), S., Lehnert, W., Kassiou, M., Banati, R., Meikle, S. (2010). Attenuation correction for the large non-human primate brain imaging using microPET. Physics in Medicine and Biology, 55(8), 2351-2363. [More Information]
  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Moussa, I., Banister, S., Beinat, C., Giboureau, N., Reynolds, A., Kassiou, M. (2010). Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands. Journal of Medicinal Chemistry, 53(16), 6228-6239. [More Information]
  • Giboureau, N., Aumann, K., Beinat, C., Kassiou, M. (2010). Development of vesicular acetylcholine transporter ligands: Molecular probes for Alzheimer's disease. Current Bioactive Compounds, 6(3), 129-155.
  • Abraham, M., Boisgard, R., Theze, B., Van Camp, N., Kuhnast, B., Damont, A., Kassiou, M., Dolle, F., Tavitian, B. (2010). Evaluation of the PBR/TSPO radioloigand [18F]DPA-714 in a rat model of focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 30(1), 230-241. [More Information]
  • Banister, S., Roeda, D., Dolle, F., Kassiou, M. (2010). Fluorine-18 chemistry for PET: A concise introduction. Current Radiopharmaceuticals, 3(2), 68-80.
  • Beinat, C., Banister, S., Moussa, I., Reynolds, A., McErlean, C., Kassiou, M. (2010). Insights into structure-activity relationships and CNS therapeutic applications of NR2B selective antagonists. Current Medicinal Chemistry, 17(34), 4166-4190. [More Information]
  • Banister, S., Moussa, I., Jordan, M., Coster, M., Kassiou, M. (2010). Oxo-bridged isomers of aza-trishomocubane sigma (o) receptor ligands: Synthesis, in vitro binding, and molecular modeling. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 20(1), 145-148. [More Information]
  • Gunosewoyo, H., Kassiou, M. (2010). P2X purinergic receptor ligands: Recently patented compounds. Expert Opinion on Therapeutic Patents, 20(5), 625-646. [More Information]
  • Giboureau, N., Mat Som, I., Boucher, A., Guilloteau, D., Kassiou, M. (2010). PET Radioligands for the Vesicular Acetylcholine Transporter (VAChT). Current Topics in Medicinal Chemistry, 10(15), 1569-1583. [More Information]
  • Reynolds, A., Hanani, R., Hibbs, D., Damont, A., Da Pozzo, E., Selleri, S., Dolle, F., Martini, C., Kassiou, M. (2010). Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 20(19), 5799-5802. [More Information]
  • Luus, C., Hanani, R., Reynolds, A., Kassiou, M. (2010). The development of PET radioligands for imaging the translocator protein (18 kDa): What have we learned? Journal of Labelled Compounds and Radiopharmaceuticals, 53(7), 501-510. [More Information]
  • Valette, H., Xiao, Y., Schollhorn-Peyronneau, M., Damont, A., Kosikowski, A., Wei, Z., Kassiou, M., Kellar, K., Dolle, F., Bottlaender, M. (2009). 18F-ZW-104: A New Radioligand for Imaging Neuronal Nicotinic Acetylcholine Receptors-In Vitro Binding Properties and PET Studies in Baboons. The Journal of Nuclear Medicine, 50(8), 1349-1355. [More Information]
  • Doorduin, J., Klein, H., Dierckx, R., James, M., Kassiou, M., De Vries, E. (2009). [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: A comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Molecular Imaging and Biology, 11(6), 386-398. [More Information]
  • Damont, A., van Camp, N., Kuhnast, B., Hinnen, F., Boisgard, R., Chauveau, F., Boutin, H., Probst, K., Clark, J., Katsifis, A., Kassiou, M. (2009). [18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106 as potent PBR pet-imaging candidates: Radiosynthesis and comparative studies. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S122-S122.
  • Truong, L., Allbutt, H., Coster, M., Kassiou, M., Henderson, J. (2009). Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+ parafascicular lesions. Brain Research Bulletin, 78(2-3), 91-96. [More Information]
  • Kassiou, M., Banati, R., Holsinger, D., Meikle, S. (2009). Challenges in molecular imaging of Parkinson's disease: A brief overview. Brain Research Bulletin, 78(2-3), 105-108. [More Information]
  • Chauveau, F., Van Camp, N., Dolle, F., Kuhnast, B., Hinnen, F., Damont, A., Boutin, H., James, M., Kassiou, M., Tavitian, B. (2009). Comparative evaluation of the translocator protein radioligands (11)C-DPA-713, (18)F-DPA-714, and (11)C-PK11195 in a rat model of acute neuroinflammation. The Journal of Nuclear Medicine, 50(3), 468-476.
  • Warraich, S., Allbutt, H., Billing, R., Radford, J., Coster, M., Kassiou, M., Henderson, J. (2009). Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model. Brain Research Bulletin, 78(2-3), 85-90. [More Information]
  • Edington, A., McKinzie, A., Reynolds, A., Kassiou, M., Ryan, R., Vandenberg, R. (2009). Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. Journal of Biological Chemistry, 284(52), 36424-36430. [More Information]
  • Endres, C., Pomper, M., James, M., Uzuner, O., Hammoud, D., Watkins, C., Reynolds, A., Hilton, J., Dannals, R., Kassiou, M. (2009). Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans. The Journal of Nuclear Medicine, 50(8), 1276-1282. [More Information]
  • Leaver, K., Allbutt, H., Creber, N., Kassiou, M., Henderson, J. (2009). Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection. Brain Research Bulletin, 80(6), 397-402. [More Information]
  • Gunosewoyo, H., Coster, M., Bennett, M., Kassiou, M. (2009). Purinergic P2X(7) receptor antagonists:Chemistry and fundamentals of biological screening. Bioorganic and Medicinal Chemistry, 17(14), 4861-4865. [More Information]
  • Dolle, F., Luus, C., Reynolds, A., Kassiou, M. (2009). Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Current Medicinal Chemistry, 16(22), 2899-2923. [More Information]
  • Reynolds, A., Kassiou, M. (2009). Recent advances in the Mitsunobu reaction: Modifications and applications to biologically active molecules. Current Organic Chemistry, 13(16), 1610-1632.
  • Scarf, A., Ittner, L., Kassiou, M. (2009). The translocator protein (18 kDa): Central nervous system disease and drug design. Journal of Medicinal Chemistry, 52(3), 581-592. [More Information]
  • Ioppolo, J., Kassiou, M., Rendina, L. (2009). Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane(12). Tetrahedron Letters, 50(47), 6457-6461. [More Information]
  • Dolle, F., Damont, A., Valette, H., Hinnen, F., Kuhnast, B., Saba, W., Schollhorn-Peyronneau, M., Kozikowski, A., Bottlaender, M., Kassiou, M. (2009). ZW-102 and ZW-104, two novel fluorine-18 labelled radioligands for imaging nicotinic acetylcholine receptors with PET. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S364-S364.
  • van Dijk, A., Johnston, C., Allbutt, H., Kassiou, M., Henderson, J. (2008). Behavioural effects of trishomocubanes in rats with unilateral 6-hydroxydopamine lesions. Behavioural Brain Research, 190(1), 14-21. [More Information]
  • Gunosewoyo, H., Liu, G., Bennett, M., Coster, M., Kassiou, M. (2008). Cubyl amides: Novel P2X(7) receptor antagonists. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(13), 3720-3723. [More Information]
  • Besret, L., Dolle, F., Herard, A., Guillermier, M., Demphel, S., Hinnen, F., Coulon, C., Ottaviani, M., Bottlaender, M., Hantraye, P., Kassiou, M. (2008). Dopamine D1 Receptor Imaging in the Rodent and Primate Brain Using the Isoquinoline (+)-[(11)C]A-69024 and Positron Emission Tomography. Journal of Pharmaceutical Sciences, 97(7), 2811-2819. [More Information]
  • James, M., Fulton, R., Vercoullie, J., Henderson, D., Garreau, L., Chalon, S., Dolle, F., Selleri, S., Guilloteau, D., Kassiou, M. (2008). DPA-714, a New Translocator Protein-Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization. The Journal of Nuclear Medicine, 49(5), 814-822. [More Information]
  • Leaver, K., Allbutt, H., Creber, N., Kassiou, M., Henderson, J. (2008). Neuroprotective effects of a selective N-methyl-D-aspartate NR2B receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease. Clinical and Experimental Pharmacology and Physiology, 35(11), 1388-1394. [More Information]
  • Henderson, J., Lanciego, J., Smith, Y., Gundlach, A., Kassiou, M. (2008). Proceedings of the 2007 International Brain Research Organisation Satellite Meeting "Movement Disorders: Focus on the Thalamus and Basal Ganglia" held in Sydney, Australia, 10-11 July, 2007. Brain Research Bulletin, 78(2-3), 53-54. [More Information]
  • Damont, A., Hinnen, F., Kuhnast, B., Schollhorn-Peyronneau, M., James, M., Luus, C., Tavitian, B., Kassiou, M., Dolle, F. (2008). Radiosynthesis of [(18)F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) PET. Journal of Labelled Compounds and Radiopharmaceuticals, 51(7-8), 286-292. [More Information]
  • Dolle, F., Langle, S., Roger, G., Fulton, R., Lagnel, B., Henderson, D., Hinnen, F., Paine, T., Coster, M., Valette, H., Kassiou, M., et al (2008). Synthesis and In-Vivo Evaluation of [(11)C]p-PVP-MEMA as a PET Radioligand for Imaging Nicotinic Receptors. Australian Journal of Chemistry: an international journal for chemical science, 61(6), 438-445.
  • Banister, S., Clegg, J., Coster, M., Jolliffe, K., Kassiou, M. (2007). (1R,2S,3R,6S,7R,8S)-Tricyclo[6.2.1.02,7]-undeca-4,9-diene-3,6-diol. Acta Crystallographica. Section E: Structure Reports Online, E63, o92-o93.
  • Emond, P., Mavel, S., Zea-Ponce, Y., Kassiou, M., Garreau, L., Bodard, S., Drossard, M., Chalon, S., Guilloteau, D. (2007). (E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter. Nuclear Medicine and Biology, 34(8), 967-971.
  • Boutin, H., Chauveau, F., Thominiaux, C., Gregoire, M., James, M., Trebossen, R., Hantraye, P., Dolle, F., Tavitian, B., Kassiou, M. (2007). 11C-DPA-713: A novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. The Journal of Nuclear Medicine, 48(4), 573-581.
  • Kozikowski, A., Chellappan, S., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., Wei, Z., Guilloteau, D., Emond, P., Dolle, F., Kassiou, M., et al (2007). Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem: chemistry enabling drug discovery, 2, 54-57. [More Information]
  • Quinlivan, M., Chalon, S., Vergote, J., Henderson, J., Katsifis, A., Kassiou, M., Guilloteau, D. (2007). Decreased vesicular acetylcholine transporter and alpha-4beta-2 nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neuroscience Letters, 415, 97-101. [More Information]
  • Giboureau, N., Emond, P., Fulton, R., Henderson, D., Chalon, S., Garreau, L., Roselt, P., Eberl, S., Mavel, S., Bodard, S., Fulham, M., Kassiou, M., et al (2007). Ex vivo and in vivo evaluation of (2R,3R)-5-[18F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter. Synapse (New York), 61(12), 962-670. [More Information]
  • Naidoo (Naidoo-Variawa), S., Hey Cunningham, A., Lehnert, W., Kench, P., Kassiou, M., Banati, R., Meikle, S. (2007). High-resolution imaging of the large non-human primate brain using microPET: a feasibility study. Physics in Medicine and Biology, 52(22), 6627-6638. [More Information]
  • Collier, T., Waterhouse, R., Kassiou, M. (2007). Imaging sigma receptors: Applications in drug development. Current Pharmaceutical Design, 13, 51-72. [More Information]
  • Kassiou, M. (2007). Molecular imaging in drug development (EDITORIAL). Current Pharmaceutical Design, 13(1), 1-1.
  • Gunosewoyo, H., Coster, M., Kassiou, M. (2007). Molecular probes for P2X7 receptor studies. Current Medicinal Chemistry, 14(14), 1505-1523. [More Information]
  • Cagnin, A., Kassiou, M., Meikle, S., Banati, R. (2007). Positron emission tomography imaging of neuroinflammation. Neurotherapeutics, 4(3), 443-452. [More Information]
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2007). Trishomocubanes: Novel sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42.
  • Truong, L., Allbutt, H., Kassiou, M., Henderson, J. (2006). Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesions. Behavioural Brain Research, 169(1), 1-9. [More Information]
  • James, M., Selleri, S., Kassiou, M. (2006). Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry, 13(17), 1991-2001. [More Information]
  • Thominiaux, C., Dolle, F., James, M., Bramoulle, Y., Boutin, H., Besret, L., Gregoire, M., Valette, H., Bottlaender, M., Tavitian, B., Kassiou, M., et al (2006). Improved synthesis of the peripheral benzodiazepine receptor ligand C-11 DPA-713 using C-11 methyl triflate. Applied Radiation and Isotopes, 64(5), 570-573. [More Information]
  • Cagnin, A., Kassiou, M., Meikle, S., Banati, R. (2006). In vivo evidence for microglial activation in neurodegenerative dementia. Acta Neurologica Scandinavica, 114(Supplement 185), 107-114.
  • Thominiaux, C., de Bruin, B., Bramoulle, Y., Hinnen, F., Demphel, S., Valette, H., Bottlaender, M., Besret, L., Kassiou, M., Dolle, F. (2006). Radiosynthesis of (E)-N-(2- C-11 methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist. Applied Radiation and Isotopes, 64(3), 348-354. [More Information]
  • Assaad, T., Mavel, S., Parsons, S., Kruse, S., Galineau, L., Allouchi, H., Kassiou, M., Chalon, S., Guilloteau, D., Emond, P. (2006). Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 16(10), 2654-2657. [More Information]
  • Vercouillie, J., Mavel, S., Galineau, L., Ragusa, T., Innis, R., Chalon, S., Kassiou, M., Dolle, F., Besnard, J., Guilloteau, D., et al (2006). Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 16(5), 1297-1300. [More Information]
  • Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry: an international journal for chemical science, 59(1), 53-58.
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2006). Trishomocubanes: Novel Sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42. [More Information]
  • Kassiou, M. (2005). Capabilities of PET and SPECT in pre-clinical and clinical research. Current Pharmaceutical Design, 11(25), 3201-3201.
  • Liu, X., Mattner, F., Katsifis, A., Christie, M., Kassiou, M. (2005). Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin- 4-yl)-4-[123I]iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 1(1), 31-38. [More Information]
  • Kassiou, M., Meikle, S., Banati, R. (2005). Ligands for peripheral benzodiazepine binding sites in glial cells. Brain Research Reviews, 48(2), 207-210. [More Information]
  • Mohamed, A., Eberl, S., Fulham, M., Kassiou, M., Zaman, A., Henderson, D., Beveridge, S., Constable, C., Lo, S. (2005). Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and F-18-FDG PET imaging). European Journal of Nuclear Medicine and Molecular Imaging, 32(2), 180-185. [More Information]
  • Meikle, S., Kench, P., Kassiou, M., Banati, R. (2005). Small animal SPECT and its place in the matrix of molecular imaging technologies. Physics in Medicine and Biology, 50(22), R45-R61. [More Information]
  • Zea-Ponce, Y., Mavel, S., Assaad, T., Kruse, S., Parsons, S., Emond, P., Chalon, S., Giboureau, N., Kassiou, M., Guilloteau, D. (2005). Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter. Bioorganic and Medicinal Chemistry, 13(3), 745-753. [More Information]
  • Kassiou, M., Dannals, R., Liu, X., Wong, D., Ravert, H., Scheffel, U. (2005). Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors. Bioorganic and Medicinal Chemistry, 13(11), 3623-3626. [More Information]
  • James, M., Fulton, R., Henderson, D., Eberl, S., Meikle, S., Thomson, S., Allan, R., Dolle, F., Fulham, M., Kassiou, M. (2005). Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand. Bioorganic and Medicinal Chemistry. [More Information]
  • Henderson, D., Eberl, S., Thomson, S., Smith, A., Allan, R., Fulham, M., Loiacono, R., Kassiou, M. (2004). 3-Pyridyl Ethers As Spect Radioligands For Imaging Nicotinic Acetylcholine Receptors. Applied Radiation and Isotopes, 60(5), 669-676. [More Information]
  • Katsifis, A., Kassiou, M. (2004). Development Of Radioligands For In Vivo Imaging Of Gaba(A)-Benzodiazepine Receptors. Mini - Reviews in Medicinal Chemistry, 4(8), 909-921.
  • Dolle, F., Valette, H., Demphel, S., Coulon, C., Ottaviani, M., Bottlaender, M., Kassiou, M. (2004). Radiosynthesis And In Vivo Evaluation Of [11C]Ro-547312: A Novel Nr1/2B Subtype Selective Nmda Receptor Radioligand. Journal of Labelled Compounds and Radiopharmaceuticals, 47(13), 911-920. [More Information]
  • Roger, G., Dolle, F., de Bruin, B., Liu, X., Besret, L., Bramoulle, Y., Coulon, C., Ottaviani, M., Bottlaender, M., Valette, H., Kassiou, M. (2004). Radiosynthesis And Pharmacological Evaluation Of [11C]Emd-95885: A High Affinity Ligand For Nr2B-Containing Nmda Receptors. Bioorganic and Medicinal Chemistry, 12(12), 3229-3237. [More Information]
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  • Kassiou, M., Katsifis, A. (2003). PET radiochemistry in drug development and evaluation. Chemistry in Australia, 70(5), 10-12.
  • Katsifis, A., Mardon, K., Mattner, F., Loc'h, C., McPhee, M., Dikic, B., Kassiou, M., Ridley, D. (2003). Pharmacological evaluation of (S)-8-[123I]iodobretazenil: a radioligand for in vivo studies of central benzodiazepine receptors. Nuclear Medicine and Biology, 30(2), 191-198.
  • Quinlivan, M., Mattner, F., Papazian, V., Zhou, J., Katsifis, A., Emond, P., Chalon, S., Kozikowski, A., Guilloteau, D., Kassiou, M. (2003). Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear Medicine and Biology, 30(7), 741-746.
  • Roger, G., Lagnel, B., Besret, L., Bramoulle, Y., Coulon, C., Ottaviani, M., Kassiou, M., Bottlaender, M., Valette, H., Dolle, F. (2003). Synthesis, radiosynthesis and In Vivo evaluation of 5-[3-(4-Benzylpiperidin-1-yl) prop-1-ynyl]-1, 3-dihydrobenzoimidazol-2-[11C] one, as a potent NR 1A/2B subtype selective NMDA PET radiotracer. Bioorganic and Medicinal Chemistry, 11, 5401-5408. [More Information]
  • Kassiou, M., Loc'h, C., Bottlaender, M., Mardon, K., Ottaviani, M., Coulon, C., Katsifis, A., Maziere, B. (2002). (+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET. Nuclear Medicine and Biology, 29(3), 295-302.
  • Kassiou, M., Bottlaender, M., Loc'h, C., Dolle, F., Musachio, J., Coulon, C., Ottaviani, M., Dannals, R., Maziere, B. (2002). Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors. Synapse (New York), 45(2), 95-104. [More Information]
  • Kassiou, M., Loc'h, C., Dolle, F., Musachio, J., Dolci, L., Crouzel, C., Dannals, R., Maziere, B. (2002). Preparation of a bromine-76 labelled analogue of epibatidine: a potent ligand for nicotinic acetylcholine receptor studies. Applied Radiation and Isotopes, 57(5), 713-717.
  • Kassiou, M., Eberl, S., Meikle, S., Birrell, A., Constable, C., Fulham, M., Wong, D., Musachio, J. (2001). In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT. Nuclear Medicine and Biology, 28, 165-175.
  • Kassiou, M., Mardon, K., Mattner,, F., Katsifis, A., Dikic, B. (2001). Pharmacological evaluation of (+)-2-[123I]A-69024: A radioligand for in vivo studies of dopamine D1 receptors. Life Sciences, 69, 669-675.
  • Liu, X., Christie, M., Kassiou, M., Nuwayhid, S., Werling, L. (2001). Trishomocubanes: Novel sigma-ligands modulate amphetamine-stimulated [3H]dopamine release. European Journal of Pharmacology, 422, 39-45.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.

Conferences

  • Fulham, M., Kassiou, M., Greguric, I., Thomson, S., Eberl, S., Tiam, P., Mattner, F., Henderson, D., Fulton, R., Katsifis, A., et al (2012). Synthesis and in vivo evaluation of arylalkyl 4-benzyl piperidines as radioligands for sigma receptors. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • Fulton, R., Meikle, S., Kyme, A., Zhou, W., Popovic, K., Kassiou, M., Akhtar, M. (2010). Motion-corrected microPET brain imaging of conscious rats. 2009 World Molecular Imaging Conference, USB drive/online: Online.
  • Banister, S., Coster, M., Kassiou, M. (2009). A versatile polycyclic scaffold for the discovery of selective sigma (sigma) receptor ligands. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Kassiou, M. (2009). Discovery of new therapeutic immunomodulator drugs as a pathway for treating brain disease. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Kassiou, M. (2009). Imaging immune response in the CNS - Applications for therapeutic development. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Moussa, I., Coster, M., Kassiou, M. (2009). Synthesis and pharmacological evaluation of novel sigma receptor ligands. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Fulton, R., Kyme, A., Zhou, V., Leaver, K., Kassiou, M., Lehnert, W., Meikle, S. (2008). Progress towards microPET imaging of small, awake laboratory animals. 2008 World Molecular Imaging Congress, Europe: World Molecular Imaging Congress.
  • Doorduin, J., Klein, H., James, M., Kassiou, M., Dierckx, R., Vries, E. (2007). (18F)DPA-714 as a novel PET tracer for PBR: A comparison with (11C)PK11195 in a rat model of HSV encephalitis. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • James, M., Fulton, R., Vercouille, J., Henderson, D., Garreau, L., Eberl, S., Chalon, S., Selleri, S., Dolle, F., Guilloteau, D., Kassiou, M. (2007). DPA-714 A new translocator protein (18kDa) ligand: Synthesis, radiofluorination and pharmacological characterisation. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Mavel, S., Zea-Ponce, Y., Garreau, L., Chalon, S., Kassiou, M., Guilloteau, D., Emond, P. (2007). E-((R,R) and (S,S))-5-(125I)-AOIBV: Potential SPECT tracers in vivo studies of the vesicular AcetylCholine Transporter (VACht). 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Kassiou, M., Chellappan, S., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., Wei, Z., Guilloteau, D., Emond, P., Dolle, F., et al (2007). Radiosynthesis and preliminary evaluation of ZW-90 and ZW-110, two novel acetylenic pyridines for imaging nicotonic receptors. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Giboureau, N., Chalon, S., Garreau, L., Kassiou, M., Emond, P., Guilloteau, D. (2007). Rat distribution of (18F)-Fuoropropoxy- and (18F)-Fluoroethoxybenzovesamicol, as PET radioligands for the vesicular acetylcholine transporter (VACht). 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Creelman, A., Thominiaux, C., Chauveau, F., Fulton, R., Kuhnast, B., Henderson, D., Boutin, H., Selleri, S., McGregor, I., Hantraye, P., Kassiou, M., et al (2007). Synthesis and evaluation of the translocator protein (18kDa) (TSPO) ligand (11C)DPA0715 in rat and non-human primate. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Langley, S., Roger, G., Fulton, R., Lagnel, B., Henderson, D., Hinnen, F., Bottlaender, M., Dolle, F., Kassiou, M. (2007). Synthesis and in vivo evaluation of (11c)P-PVP-MEMA as a PET radioligand for Imaging nicotonic receptors. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Kassiou, M., Bruin, B., Demphel, S., Besret, L., Hinnen, F., Dolle, F., Bramoulle, Y., Thominiaux, C., Bottlaender, M. (2005). Radiosynthesis of (E)-N-(2-[11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor ligand. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • Fulham, M., Kassiou, M., Dolle, F., Thomson, S., Henderson, D., James, M., Eberl, S., Fulton, R., Allan, R. (2005). Synthesis and In Vivo Evaluation of a Novel Peripheral Benzodiazepine Receptor PET Radioligand. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • Feng, D., Kassiou, M., Fulham, M., Wong, K., Elberl, S. (2003). Quantification of 5-[123I]iodo-A-85380 in nonhuman primates using spect: parameter identifiability and stabilitty. Modelling and Control in Biomedical Systems 2003 (Including Biological Systems), UK: Pergamon.

Patents

  • Kassiou, M., James, M., Luus, C. (2013). Oxazepines derived ligands for the TSPO (FILED UNDER: PYRIDAZEINES AND OXAZEPINE AS TSPO LIGANDS). Patent No. 8492379.
  • Kassiou, M., James, M. (2010). 2-Arylpyrazolo[L,5-a]Pyrimidin-3-yl Acetamide Deriv As Ligands For Translocator Protein. Patent No. 2008/10473. South Africa.
  • Kassiou, M., James, M., Luus, C. (2009). Patent No. WO2009079683 (A1).

2014

  • Medran-Navarrete, V., Bernards, N., Kuhnast, B., Damont, A., Pottier, G., Schollhorn-Peyronneau, M., Kassiou, M., Marguet, F., Puech, F., Boisgard, R., et al (2014). [18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET. Journal of Labelled Compounds and Radiopharmaceuticals, 57(6), 410-418. [More Information]
  • Liang, V., Ullrich, M., Lam, H., Chew, Y., Banister, S., Song, X., Zaw, T., Kassiou, M., Goetz, J., Nicholas, H. (2014). Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71(17), 3339-3361. [More Information]
  • Ullrich, M., Liang, V., Chew, Y., Banister, S., Song, X., Zaw, T., Lam, H., Berber, S., Kassiou, M., Nicholas, H., Goetz, J. (2014). Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9(9), 2237-2255. [More Information]
  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Ribeiro, M., Vercouillie, J., Debiais, S., Cottier, J., Bonnaud, I., Camus, V., Banister, S., Kassiou, M., Arlicot, N., Guilloteau, D. (2014). Could 18F-DPA-714 PET imaging be interesting to use in the early post-stroke period? European Journal of Nuclear Medicine and Molecular Imaging, 4(28), 1-8. [More Information]
  • Zavitsanou, K., Lim, C., Purves-Tyson, T., Karl, T., Kassiou, M., Banister, S., Guillemin, G., Shannon Weickert, C. (2014). Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition. Brain, Behavior, and Immunity, 41(2014), 173-181. [More Information]
  • Beinat, C., Reekie, T., Hibbs, D., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Tsanaktsidis, J., Kassiou, M. (2014). Investigations of amide bond variation and biaryl modification in analogues of alpha7 nAChR agonist SEN12333. European Journal of Medicinal Chemistry, 84, 200-205. [More Information]
  • Barron, M., Werry, E., McGregor, I., Kassiou, M. (2014). P2X7 in Bipolar and Depressive Disorders. In Norbert Weiss, Alexandra Koschak (Eds.), Pathologies of Calcium Channels, (pp. 635-661). Berlin: Springer-Verlag.
  • Gent, Y., Weijers, K., Molthoff, C., Windhorst, A., Huisman, M., Kassiou, M., Jansen, G., Lammertsma, A., van der Laken, C. (2014). Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis. Arthritis Research and Therapy, 16(2), 1-9. [More Information]
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo[1,4]diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55, 4568-4571. [More Information]
  • Coughlin, J., Wang, Y., Ma, S., Yue, C., Kim, P., Adams, A., Roosa, H., Gage, K., Stathis, M., et al, Kassiou, M. (2014). Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected by HIV. Journal of neurovirology, 20(3), 219-232. [More Information]
  • Beinat, C., Banister, S., Hoban, J., Tsanaktsidis, J., Metaxas, A., Windhorst, A., Kassiou, M. (2014). Structure-activity relationships of N-substituted 4-(trifluoromethoxyl)benzamidines with affinity for GluN2B-containing NMDA receptors. Bioorganic & Medicinal Chemistry Letters, 24(3), 828-830. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Chua, S., Kassiou, M., Ittner, L. (2014). The translocator protein as a drug target in Alzheimer's disease. Expert Review of Neurotherapeutics, 14(4), 439-448. [More Information]

2013

  • Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A., Smigova, A., Cawthorne, C., Julyan, P., Wilkinson, S., Banister, S., Kassiou, M., et al (2013). [(18)F]DPA-714: Direct comparison with [(11)C]PK11195 in a model of cerebral ischemia in rats. PLoS One, 8673 (2), 1-9. [More Information]
  • Beinat, C., Banister, S., McErlean, C., Kassiou, M. (2013). A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane. Tetrahedron Letters, 54(39), 5345-5347. [More Information]
  • Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., McGregor, I. (2013). Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the VI(A) Receptor. Neuropsychopharmacology, 38(11), 2249-2259. [More Information]
  • Ribeiro, M., Vercouillie, J., Corcia, P., Arlicot, N., Erra, B., Maia, S., Bonnaud, I., Debiais, S., Kassiou, M., Guilloteau, D. (2013). Cerebral biodistribution of the PET TSPO radioligand, (18)F-DPA-714, in acute and chronic brain diseases. Journal of Labelled Compounds and Radiopharmaceuticals, 56(S1), P219-P219.
  • Wilkinson, S., Price, J., Kassiou, M. (2013). Improved accessibility to the desoxy analogues of delta(9)-tetrahydrocannabinol and cannabidiol. Tetrahedron Letters, 54(1), 52-54. [More Information]
  • Schollhorn-Peyronneau, M., Saba, W., Goutal, S., Damont, A., Dolle, F., Kassiou, M., Bottlaender, M., Valette, H. (2013). Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand. Drug Metabolism and Disposition, 41(1), 122-131. [More Information]
  • Santiago-Ribeiro, M., Vercouillie, J., Cottier, J., Debiais, S., Bonnaud, I., Arlicot, N., Erra, B., Maia, S., Kassiou, M., Guilloteau, D. (2013). Microglia activation after acute stroke demonstrated using 18F-DPA-714 PET. Correlation with MRI. European Journal of Nuclear Medicine and Molecular Imaging, 40(S2), S208-S208. [More Information]
  • Banister, S., Manoli, M., Barron, M., Werry, E., Kassiou, M. (2013). N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as sigma receptor ligands with potential neuroprotective effects. Bioorganic and Medicinal Chemistry, 21(19), 6038-6052. [More Information]
  • Reekie, T., Kavanagh, M., Longworth, M., Kassiou, M. (2013). Synthesis of Biologically Active Seven-Membered-Ring Heterocycles. Synthesis: journal of synthetic organic chemistry, 45(23), 3211-3227. [More Information]
  • Kavanagh, M., Doddareddy, M., Kassiou, M. (2013). The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorganic & Medicinal Chemistry Letters, 23(13), 3690-3696. [More Information]
  • Banister, S., Manoli, M., Kassiou, M. (2013). The development of radiotracers for imaging sigma receptors in the central nervous system (CNS) using positron emission tomography (PET). Journal of Labelled Compounds and Radiopharmaceuticals, 56(3-4), 215-224. [More Information]
  • Kahlert, J., Austin, C., Kassiou, M., Rendina, L. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry: an international journal for chemical science, 66(10), 1118-1123. [More Information]
  • Banister, S., Wilkinson, S., Longworth, M., Stuart, J., Apetz, N., English, K., Brooker, L., Goebel, C., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2013). The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience, 4(7), 1081-1092. [More Information]
  • Austin, C., Kahlert, J., Kassiou, M., Rendina, L. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology, 45(7), 1212-1216. [More Information]
  • Kassiou, M., James, M., Luus, C. (2013). Oxazepines derived ligands for the TSPO (FILED UNDER: PYRIDAZEINES AND OXAZEPINE AS TSPO LIGANDS). Patent No. 8492379.

2012

  • Banister, S., Rendina, L., Kassiou, M. (2012). 7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (sigma-2) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(12), 4059-4063. [More Information]
  • Banister, S., Wilkinson, S., Hanani, R., Reynolds, A., Hibbs, D., Kassiou, M. (2012). A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7-dimethylpy-razolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands. Tetrahedron Letters, 53(29), 3780-3783. [More Information]
  • Banister, S., Manoli, M., Doddareddy, M., Hibbs, D., Kassiou, M. (2012). A σ1 receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDS). Bioorganic & Medicinal Chemistry Letters, 22(19), 6053-6058. [More Information]
  • Beinat, C., Banister, S., Prehn, S., Doddareddy, M., Hibbs, D., Sako, M., Collins, M., Tran, T., Al-Muhtasib, N., Xiao, Y., Kassiou, M. (2012). Consequences of linker length alteration of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(7), 2380-2384. [More Information]
  • Leaver, K., Reynolds, A., Bodard, S., Guilloteau, D., Chalon, S., Kassiou, M. (2012). Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum. ACS Chemical Neuroscience, 3(2), 114-119. [More Information]
  • Scarf, A., Luus, C., Da Pozzo, E., Selleri, S., Guarino, C., Martini, C., Ittner, L., Kassiou, M. (2012). Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa). Current Molecular Medicine, 12(4), 488-493. [More Information]
  • Moussa, I., Banister, S., Manoli, M., Doddareddy, M., Cui, J., Mach, R., Kassiou, M. (2012). Exploration of ring size in a series of cyclic vicinal diamines with sigma(1) receptor-affinity. Bioorganic & Medicinal Chemistry Letters, 22(17), 5493-5497. [More Information]
  • Gilmore, A., Heblinski, M., Reynolds, A., Kassiou, M., Connor, M. (2012). Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. British Journal of Pharmacology, 167(5), 1076-1088. [More Information]
  • Arlicot, N., Vercouillie, J., Ribeiro, M., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Corcia, P., Stabin, M., Reynolds, A., Kassiou, M., et al (2012). Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation. Nuclear Medicine and Biology, 39(4), 570-578. [More Information]
  • Scarf, A., Aumann, K., Kassiou, M. (2012). Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)? Current Molecular Medicine, 12(4), 387-397. [More Information]
  • Corcia, P., Tauber, C., Vercoullie, J., Arlicot, N., Prunier, C., Praline, J., Nicolas, G., Venel, Y., Hommet, C., Baulieu, J., Kassiou, M., et al (2012). Molecular imaging of microglial activation in amyotrophic lateral sclerosis. PLoS One, 7(12), 1-7. [More Information]
  • Endres, C., Coughlin, J., Gage, K., Watkins, C., Kassiou, M., Pomper, M. (2012). Radiation dosimetry and biodistribution of the TSPO ligand (11)C-DPA-713 in humans. The Journal of Nuclear Medicine, 53(2), 330-335. [More Information]
  • Gosling, J., Baker, S., Haynes, J., Kassiou, M., Pouton, C., Warfe, L., White, P., Scammells, P. (2012). Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N6-Substituents as Adenosine A1 Receptor Agonists. ChemMedChem: chemistry enabling drug discovery, 7(7), 1191-1201. [More Information]
  • Fulham, M., Kassiou, M., Greguric, I., Thomson, S., Eberl, S., Tiam, P., Mattner, F., Henderson, D., Fulton, R., Katsifis, A., et al (2012). Synthesis and in vivo evaluation of arylalkyl 4-benzyl piperidines as radioligands for sigma receptors. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C., Kassiou, M., Hunt, G., McGregor, I. (2012). The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor-Binding Profile, Prosocial Effects and Distribution of c-Fos Expression in Adolescent Rats. Journal of Neuroendocrinology, 24(7), 1012-1029. [More Information]
  • Banister, S., Kassiou, M. (2012). The Therapeutic Potential of Sigma (sigma) Receptors for the Treatment of Central Nervous System Diseases: Evaluation of the Evidence. Current Pharmaceutical Design, 18(7), 884-901. [More Information]

2011

  • Dolle, F., Kuhnast, B., Damont, A., van Camp, N., Kassiou, M., Tavitian, B., Boisgard, R. (2011). [18F]DPA-716 as a candidate for imaging the TSPO 18 kDa with PET: Radiosynthesis and comparative evaluation ([11C]DPA-713/[18F]DPA-714) in a rat model of neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S275-S275.
  • Vercouillie, J., Ribeiro, M., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Reynolds, A., Kassiou, M., Guilloteau, D., Corcia, P. (2011). Biodistribution of the TSPO radioligand (18)F-DPA-714 in healthy volunteers. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S255-S255.
  • Issa, F., Kassiou, M., Rendina, L. (2011). Boron in drug discovery: Carboranes as unique pharmacophores in biologically active compounds. Chemical Reviews, 111(9), 5701-5722. [More Information]
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Kassiou, M., et al (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity, 25(6), 1113-1122. [More Information]
  • Dolle, F., Le Helleix, S., Schollhorn-Peyronneau, M., Saba, W., Banister, S., Tournier, N., Valette, H., Kassiou, M. (2011). Carbon-11-labelling of a novel, trishomocubane-derived, high affinity and selectivity DAT ligand. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S276-S276.
  • Moussa, I., Banister, S., Akladios, F., Chua, S., Kassiou, M. (2011). Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazine sigma(1) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(19), 5707-5710. [More Information]
  • Banister, S., Moussa, I., Jorgensen, W., Chua, S., Kassiou, M. (2011). Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (σ) receptor ligands modulates off-target activity and subtype selectivity. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(12), 3622-3626. [More Information]
  • Banister, S., Yoo, D., Chua, S., Cui, J., Mach, R., Kassiou, M. (2011). N-arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (sigma) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(18), 5289-5292. [More Information]
  • Ribeiro, M., Vercouillie, J., Tauber, C., Venel, Y., Baulieu, J., Maia, S., Reynolds, A., Kassiou, M., Guilloteau, D., Corcia, P. (2011). P-167 The potential interest of the PET radioligand (18)F-DPA-714 in neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 54(1), S256-S256.
  • Martin, A., Boisgard, R., Kassiou, M., Dolle, F., Tavitian, B. (2011). Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [(18)F]DPA-714. Molecular Imaging and Biology, 13(1), 10-15. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Crossley, E., Issa, F., Scarf, A., Kassiou, M., Rendina, L. (2011). Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells. Chemical Communications, 47(44), 12179-12181. [More Information]
  • Moussa, I., Banister, S., Giboureau, N., Meikle, S., Kassiou, M. (2011). Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(22), 6820-6823. [More Information]
  • Damont, A., Boisgard, R., Kuhnast, B., Lemee, F., Raggiri, G., Scarf, A., Da Pozzo, E., Selleri, S., Martini, C., Tavitian, B., Kassiou, M., et al (2011). Synthesis of 6-[(18)F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(16), 4819-4822. [More Information]
  • Scarf, A., Kassiou, M. (2011). The translocator protein. The Journal of Nuclear Medicine, 52(5), 677-680. [More Information]
  • Banister, S., Moussa, I., Beinat, C., Reynolds, A., Schiavini, P., Jorgensen, W., Kassiou, M. (2011). Trishomocubane as a Scaffold for the Development of Selective Dopamine Transporter (DAT) Ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(1), 38-41. [More Information]

2010

  • Banister, S., Clegg, J., Hanani, R., Kassiou, M. (2010). 11-{[2-(3-fluorophenyl)ethyl](methyl)-amino}pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]-undecan-8-one. Acta Crystallographica. Section E: Structure Reports Online, 66(10), o2693-o2693.
  • Kassiou, M., James, M. (2010). 2-Arylpyrazolo[L,5-a]Pyrimidin-3-yl Acetamide Deriv As Ligands For Translocator Protein. Patent No. 2008/10473. South Africa.
  • Naidoo (Naidoo-Variawa), S., Lehnert, W., Kassiou, M., Banati, R., Meikle, S. (2010). Attenuation correction for the large non-human primate brain imaging using microPET. Physics in Medicine and Biology, 55(8), 2351-2363. [More Information]
  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Moussa, I., Banister, S., Beinat, C., Giboureau, N., Reynolds, A., Kassiou, M. (2010). Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands. Journal of Medicinal Chemistry, 53(16), 6228-6239. [More Information]
  • Giboureau, N., Aumann, K., Beinat, C., Kassiou, M. (2010). Development of vesicular acetylcholine transporter ligands: Molecular probes for Alzheimer's disease. Current Bioactive Compounds, 6(3), 129-155.
  • Abraham, M., Boisgard, R., Theze, B., Van Camp, N., Kuhnast, B., Damont, A., Kassiou, M., Dolle, F., Tavitian, B. (2010). Evaluation of the PBR/TSPO radioloigand [18F]DPA-714 in a rat model of focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 30(1), 230-241. [More Information]
  • Banister, S., Roeda, D., Dolle, F., Kassiou, M. (2010). Fluorine-18 chemistry for PET: A concise introduction. Current Radiopharmaceuticals, 3(2), 68-80.
  • Beinat, C., Banister, S., Moussa, I., Reynolds, A., McErlean, C., Kassiou, M. (2010). Insights into structure-activity relationships and CNS therapeutic applications of NR2B selective antagonists. Current Medicinal Chemistry, 17(34), 4166-4190. [More Information]
  • Fulton, R., Meikle, S., Kyme, A., Zhou, W., Popovic, K., Kassiou, M., Akhtar, M. (2010). Motion-corrected microPET brain imaging of conscious rats. 2009 World Molecular Imaging Conference, USB drive/online: Online.
  • Banister, S., Moussa, I., Jordan, M., Coster, M., Kassiou, M. (2010). Oxo-bridged isomers of aza-trishomocubane sigma (o) receptor ligands: Synthesis, in vitro binding, and molecular modeling. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 20(1), 145-148. [More Information]
  • Gunosewoyo, H., Kassiou, M. (2010). P2X purinergic receptor ligands: Recently patented compounds. Expert Opinion on Therapeutic Patents, 20(5), 625-646. [More Information]
  • Giboureau, N., Mat Som, I., Boucher, A., Guilloteau, D., Kassiou, M. (2010). PET Radioligands for the Vesicular Acetylcholine Transporter (VAChT). Current Topics in Medicinal Chemistry, 10(15), 1569-1583. [More Information]
  • Reynolds, A., Hanani, R., Hibbs, D., Damont, A., Da Pozzo, E., Selleri, S., Dolle, F., Martini, C., Kassiou, M. (2010). Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 20(19), 5799-5802. [More Information]
  • Luus, C., Hanani, R., Reynolds, A., Kassiou, M. (2010). The development of PET radioligands for imaging the translocator protein (18 kDa): What have we learned? Journal of Labelled Compounds and Radiopharmaceuticals, 53(7), 501-510. [More Information]

2009

  • Valette, H., Xiao, Y., Schollhorn-Peyronneau, M., Damont, A., Kosikowski, A., Wei, Z., Kassiou, M., Kellar, K., Dolle, F., Bottlaender, M. (2009). 18F-ZW-104: A New Radioligand for Imaging Neuronal Nicotinic Acetylcholine Receptors-In Vitro Binding Properties and PET Studies in Baboons. The Journal of Nuclear Medicine, 50(8), 1349-1355. [More Information]
  • Doorduin, J., Klein, H., Dierckx, R., James, M., Kassiou, M., De Vries, E. (2009). [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: A comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Molecular Imaging and Biology, 11(6), 386-398. [More Information]
  • Damont, A., van Camp, N., Kuhnast, B., Hinnen, F., Boisgard, R., Chauveau, F., Boutin, H., Probst, K., Clark, J., Katsifis, A., Kassiou, M. (2009). [18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106 as potent PBR pet-imaging candidates: Radiosynthesis and comparative studies. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S122-S122.
  • Banister, S., Coster, M., Kassiou, M. (2009). A versatile polycyclic scaffold for the discovery of selective sigma (sigma) receptor ligands. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Truong, L., Allbutt, H., Coster, M., Kassiou, M., Henderson, J. (2009). Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+ parafascicular lesions. Brain Research Bulletin, 78(2-3), 91-96. [More Information]
  • Kassiou, M., Banati, R., Holsinger, D., Meikle, S. (2009). Challenges in molecular imaging of Parkinson's disease: A brief overview. Brain Research Bulletin, 78(2-3), 105-108. [More Information]
  • Chauveau, F., Van Camp, N., Dolle, F., Kuhnast, B., Hinnen, F., Damont, A., Boutin, H., James, M., Kassiou, M., Tavitian, B. (2009). Comparative evaluation of the translocator protein radioligands (11)C-DPA-713, (18)F-DPA-714, and (11)C-PK11195 in a rat model of acute neuroinflammation. The Journal of Nuclear Medicine, 50(3), 468-476.
  • Kassiou, M. (2009). Discovery of new therapeutic immunomodulator drugs as a pathway for treating brain disease. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Warraich, S., Allbutt, H., Billing, R., Radford, J., Coster, M., Kassiou, M., Henderson, J. (2009). Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model. Brain Research Bulletin, 78(2-3), 85-90. [More Information]
  • Edington, A., McKinzie, A., Reynolds, A., Kassiou, M., Ryan, R., Vandenberg, R. (2009). Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. Journal of Biological Chemistry, 284(52), 36424-36430. [More Information]
  • Kassiou, M. (2009). Imaging immune response in the CNS - Applications for therapeutic development. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Endres, C., Pomper, M., James, M., Uzuner, O., Hammoud, D., Watkins, C., Reynolds, A., Hilton, J., Dannals, R., Kassiou, M. (2009). Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans. The Journal of Nuclear Medicine, 50(8), 1276-1282. [More Information]
  • Leaver, K., Allbutt, H., Creber, N., Kassiou, M., Henderson, J. (2009). Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection. Brain Research Bulletin, 80(6), 397-402. [More Information]
  • Kassiou, M., James, M., Luus, C. (2009). Patent No. WO2009079683 (A1).
  • Gunosewoyo, H., Coster, M., Bennett, M., Kassiou, M. (2009). Purinergic P2X(7) receptor antagonists:Chemistry and fundamentals of biological screening. Bioorganic and Medicinal Chemistry, 17(14), 4861-4865. [More Information]
  • Dolle, F., Luus, C., Reynolds, A., Kassiou, M. (2009). Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Current Medicinal Chemistry, 16(22), 2899-2923. [More Information]
  • Reynolds, A., Kassiou, M. (2009). Recent advances in the Mitsunobu reaction: Modifications and applications to biologically active molecules. Current Organic Chemistry, 13(16), 1610-1632.
  • Moussa, I., Coster, M., Kassiou, M. (2009). Synthesis and pharmacological evaluation of novel sigma receptor ligands. 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Scarf, A., Ittner, L., Kassiou, M. (2009). The translocator protein (18 kDa): Central nervous system disease and drug design. Journal of Medicinal Chemistry, 52(3), 581-592. [More Information]
  • Ioppolo, J., Kassiou, M., Rendina, L. (2009). Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane(12). Tetrahedron Letters, 50(47), 6457-6461. [More Information]
  • Dolle, F., Damont, A., Valette, H., Hinnen, F., Kuhnast, B., Saba, W., Schollhorn-Peyronneau, M., Kozikowski, A., Bottlaender, M., Kassiou, M. (2009). ZW-102 and ZW-104, two novel fluorine-18 labelled radioligands for imaging nicotinic acetylcholine receptors with PET. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S364-S364.

2008

  • van Dijk, A., Johnston, C., Allbutt, H., Kassiou, M., Henderson, J. (2008). Behavioural effects of trishomocubanes in rats with unilateral 6-hydroxydopamine lesions. Behavioural Brain Research, 190(1), 14-21. [More Information]
  • Gunosewoyo, H., Liu, G., Bennett, M., Coster, M., Kassiou, M. (2008). Cubyl amides: Novel P2X(7) receptor antagonists. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(13), 3720-3723. [More Information]
  • Besret, L., Dolle, F., Herard, A., Guillermier, M., Demphel, S., Hinnen, F., Coulon, C., Ottaviani, M., Bottlaender, M., Hantraye, P., Kassiou, M. (2008). Dopamine D1 Receptor Imaging in the Rodent and Primate Brain Using the Isoquinoline (+)-[(11)C]A-69024 and Positron Emission Tomography. Journal of Pharmaceutical Sciences, 97(7), 2811-2819. [More Information]
  • James, M., Fulton, R., Vercoullie, J., Henderson, D., Garreau, L., Chalon, S., Dolle, F., Selleri, S., Guilloteau, D., Kassiou, M. (2008). DPA-714, a New Translocator Protein-Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization. The Journal of Nuclear Medicine, 49(5), 814-822. [More Information]
  • Leaver, K., Allbutt, H., Creber, N., Kassiou, M., Henderson, J. (2008). Neuroprotective effects of a selective N-methyl-D-aspartate NR2B receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease. Clinical and Experimental Pharmacology and Physiology, 35(11), 1388-1394. [More Information]
  • Henderson, J., Lanciego, J., Smith, Y., Gundlach, A., Kassiou, M. (2008). Proceedings of the 2007 International Brain Research Organisation Satellite Meeting "Movement Disorders: Focus on the Thalamus and Basal Ganglia" held in Sydney, Australia, 10-11 July, 2007. Brain Research Bulletin, 78(2-3), 53-54. [More Information]
  • Fulton, R., Kyme, A., Zhou, V., Leaver, K., Kassiou, M., Lehnert, W., Meikle, S. (2008). Progress towards microPET imaging of small, awake laboratory animals. 2008 World Molecular Imaging Congress, Europe: World Molecular Imaging Congress.
  • Guenther, K., Hambley, T., Kassiou, M. (2008). Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET). In Nicola Antonio Colabufo (Eds.), Multidrug Resistance: Biological and Pharmaceutical Advances in Antitumour Treatment, (pp. 291-320). India: Research Signpost.
  • Damont, A., Hinnen, F., Kuhnast, B., Schollhorn-Peyronneau, M., James, M., Luus, C., Tavitian, B., Kassiou, M., Dolle, F. (2008). Radiosynthesis of [(18)F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) PET. Journal of Labelled Compounds and Radiopharmaceuticals, 51(7-8), 286-292. [More Information]
  • Dolle, F., Langle, S., Roger, G., Fulton, R., Lagnel, B., Henderson, D., Hinnen, F., Paine, T., Coster, M., Valette, H., Kassiou, M., et al (2008). Synthesis and In-Vivo Evaluation of [(11)C]p-PVP-MEMA as a PET Radioligand for Imaging Nicotinic Receptors. Australian Journal of Chemistry: an international journal for chemical science, 61(6), 438-445.

2007

  • Doorduin, J., Klein, H., James, M., Kassiou, M., Dierckx, R., Vries, E. (2007). (18F)DPA-714 as a novel PET tracer for PBR: A comparison with (11C)PK11195 in a rat model of HSV encephalitis. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Banister, S., Clegg, J., Coster, M., Jolliffe, K., Kassiou, M. (2007). (1R,2S,3R,6S,7R,8S)-Tricyclo[6.2.1.02,7]-undeca-4,9-diene-3,6-diol. Acta Crystallographica. Section E: Structure Reports Online, E63, o92-o93.
  • Emond, P., Mavel, S., Zea-Ponce, Y., Kassiou, M., Garreau, L., Bodard, S., Drossard, M., Chalon, S., Guilloteau, D. (2007). (E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter. Nuclear Medicine and Biology, 34(8), 967-971.
  • Boutin, H., Chauveau, F., Thominiaux, C., Gregoire, M., James, M., Trebossen, R., Hantraye, P., Dolle, F., Tavitian, B., Kassiou, M. (2007). 11C-DPA-713: A novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. The Journal of Nuclear Medicine, 48(4), 573-581.
  • Kozikowski, A., Chellappan, S., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., Wei, Z., Guilloteau, D., Emond, P., Dolle, F., Kassiou, M., et al (2007). Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem: chemistry enabling drug discovery, 2, 54-57. [More Information]
  • Quinlivan, M., Chalon, S., Vergote, J., Henderson, J., Katsifis, A., Kassiou, M., Guilloteau, D. (2007). Decreased vesicular acetylcholine transporter and alpha-4beta-2 nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neuroscience Letters, 415, 97-101. [More Information]
  • James, M., Fulton, R., Vercouille, J., Henderson, D., Garreau, L., Eberl, S., Chalon, S., Selleri, S., Dolle, F., Guilloteau, D., Kassiou, M. (2007). DPA-714 A new translocator protein (18kDa) ligand: Synthesis, radiofluorination and pharmacological characterisation. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Mavel, S., Zea-Ponce, Y., Garreau, L., Chalon, S., Kassiou, M., Guilloteau, D., Emond, P. (2007). E-((R,R) and (S,S))-5-(125I)-AOIBV: Potential SPECT tracers in vivo studies of the vesicular AcetylCholine Transporter (VACht). 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Giboureau, N., Emond, P., Fulton, R., Henderson, D., Chalon, S., Garreau, L., Roselt, P., Eberl, S., Mavel, S., Bodard, S., Fulham, M., Kassiou, M., et al (2007). Ex vivo and in vivo evaluation of (2R,3R)-5-[18F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter. Synapse (New York), 61(12), 962-670. [More Information]
  • Naidoo (Naidoo-Variawa), S., Hey Cunningham, A., Lehnert, W., Kench, P., Kassiou, M., Banati, R., Meikle, S. (2007). High-resolution imaging of the large non-human primate brain using microPET: a feasibility study. Physics in Medicine and Biology, 52(22), 6627-6638. [More Information]
  • Collier, T., Waterhouse, R., Kassiou, M. (2007). Imaging sigma receptors: Applications in drug development. Current Pharmaceutical Design, 13, 51-72. [More Information]
  • Kassiou, M. (2007). Molecular imaging in drug development (EDITORIAL). Current Pharmaceutical Design, 13(1), 1-1.
  • Gunosewoyo, H., Coster, M., Kassiou, M. (2007). Molecular probes for P2X7 receptor studies. Current Medicinal Chemistry, 14(14), 1505-1523. [More Information]
  • Cagnin, A., Kassiou, M., Meikle, S., Banati, R. (2007). Positron emission tomography imaging of neuroinflammation. Neurotherapeutics, 4(3), 443-452. [More Information]
  • Kassiou, M., Chellappan, S., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., Wei, Z., Guilloteau, D., Emond, P., Dolle, F., et al (2007). Radiosynthesis and preliminary evaluation of ZW-90 and ZW-110, two novel acetylenic pyridines for imaging nicotonic receptors. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Giboureau, N., Chalon, S., Garreau, L., Kassiou, M., Emond, P., Guilloteau, D. (2007). Rat distribution of (18F)-Fuoropropoxy- and (18F)-Fluoroethoxybenzovesamicol, as PET radioligands for the vesicular acetylcholine transporter (VACht). 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Creelman, A., Thominiaux, C., Chauveau, F., Fulton, R., Kuhnast, B., Henderson, D., Boutin, H., Selleri, S., McGregor, I., Hantraye, P., Kassiou, M., et al (2007). Synthesis and evaluation of the translocator protein (18kDa) (TSPO) ligand (11C)DPA0715 in rat and non-human primate. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Langley, S., Roger, G., Fulton, R., Lagnel, B., Henderson, D., Hinnen, F., Bottlaender, M., Dolle, F., Kassiou, M. (2007). Synthesis and in vivo evaluation of (11c)P-PVP-MEMA as a PET radioligand for Imaging nicotonic receptors. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2007). Trishomocubanes: Novel sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42.

2006

  • Truong, L., Allbutt, H., Kassiou, M., Henderson, J. (2006). Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesions. Behavioural Brain Research, 169(1), 1-9. [More Information]
  • James, M., Selleri, S., Kassiou, M. (2006). Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry, 13(17), 1991-2001. [More Information]
  • Thominiaux, C., Dolle, F., James, M., Bramoulle, Y., Boutin, H., Besret, L., Gregoire, M., Valette, H., Bottlaender, M., Tavitian, B., Kassiou, M., et al (2006). Improved synthesis of the peripheral benzodiazepine receptor ligand C-11 DPA-713 using C-11 methyl triflate. Applied Radiation and Isotopes, 64(5), 570-573. [More Information]
  • Cagnin, A., Kassiou, M., Meikle, S., Banati, R. (2006). In vivo evidence for microglial activation in neurodegenerative dementia. Acta Neurologica Scandinavica, 114(Supplement 185), 107-114.
  • Thominiaux, C., de Bruin, B., Bramoulle, Y., Hinnen, F., Demphel, S., Valette, H., Bottlaender, M., Besret, L., Kassiou, M., Dolle, F. (2006). Radiosynthesis of (E)-N-(2- C-11 methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist. Applied Radiation and Isotopes, 64(3), 348-354. [More Information]
  • Assaad, T., Mavel, S., Parsons, S., Kruse, S., Galineau, L., Allouchi, H., Kassiou, M., Chalon, S., Guilloteau, D., Emond, P. (2006). Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 16(10), 2654-2657. [More Information]
  • Vercouillie, J., Mavel, S., Galineau, L., Ragusa, T., Innis, R., Chalon, S., Kassiou, M., Dolle, F., Besnard, J., Guilloteau, D., et al (2006). Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 16(5), 1297-1300. [More Information]
  • Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry: an international journal for chemical science, 59(1), 53-58.
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2006). Trishomocubanes: Novel Sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42. [More Information]

2005

  • Kassiou, M. (2005). Capabilities of PET and SPECT in pre-clinical and clinical research. Current Pharmaceutical Design, 11(25), 3201-3201.
  • Liu, X., Mattner, F., Katsifis, A., Christie, M., Kassiou, M. (2005). Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin- 4-yl)-4-[123I]iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 1(1), 31-38. [More Information]
  • Kassiou, M., Meikle, S., Banati, R. (2005). Ligands for peripheral benzodiazepine binding sites in glial cells. Brain Research Reviews, 48(2), 207-210. [More Information]
  • Kassiou, M., Bruin, B., Demphel, S., Besret, L., Hinnen, F., Dolle, F., Bramoulle, Y., Thominiaux, C., Bottlaender, M. (2005). Radiosynthesis of (E)-N-(2-[11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor ligand. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • Mohamed, A., Eberl, S., Fulham, M., Kassiou, M., Zaman, A., Henderson, D., Beveridge, S., Constable, C., Lo, S. (2005). Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and F-18-FDG PET imaging). European Journal of Nuclear Medicine and Molecular Imaging, 32(2), 180-185. [More Information]
  • Meikle, S., Kench, P., Kassiou, M., Banati, R. (2005). Small animal SPECT and its place in the matrix of molecular imaging technologies. Physics in Medicine and Biology, 50(22), R45-R61. [More Information]
  • Zea-Ponce, Y., Mavel, S., Assaad, T., Kruse, S., Parsons, S., Emond, P., Chalon, S., Giboureau, N., Kassiou, M., Guilloteau, D. (2005). Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter. Bioorganic and Medicinal Chemistry, 13(3), 745-753. [More Information]
  • Kassiou, M., Dannals, R., Liu, X., Wong, D., Ravert, H., Scheffel, U. (2005). Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors. Bioorganic and Medicinal Chemistry, 13(11), 3623-3626. [More Information]
  • Fulham, M., Kassiou, M., Dolle, F., Thomson, S., Henderson, D., James, M., Eberl, S., Fulton, R., Allan, R. (2005). Synthesis and In Vivo Evaluation of a Novel Peripheral Benzodiazepine Receptor PET Radioligand. 16th International Symposium on Radiopharmaceutical Chemistry, United Kingdom: Wiley.
  • James, M., Fulton, R., Henderson, D., Eberl, S., Meikle, S., Thomson, S., Allan, R., Dolle, F., Fulham, M., Kassiou, M. (2005). Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand. Bioorganic and Medicinal Chemistry. [More Information]

2004

  • Henderson, D., Eberl, S., Thomson, S., Smith, A., Allan, R., Fulham, M., Loiacono, R., Kassiou, M. (2004). 3-Pyridyl Ethers As Spect Radioligands For Imaging Nicotinic Acetylcholine Receptors. Applied Radiation and Isotopes, 60(5), 669-676. [More Information]
  • Katsifis, A., Kassiou, M. (2004). Development Of Radioligands For In Vivo Imaging Of Gaba(A)-Benzodiazepine Receptors. Mini - Reviews in Medicinal Chemistry, 4(8), 909-921.
  • Dolle, F., Valette, H., Demphel, S., Coulon, C., Ottaviani, M., Bottlaender, M., Kassiou, M. (2004). Radiosynthesis And In Vivo Evaluation Of [11C]Ro-547312: A Novel Nr1/2B Subtype Selective Nmda Receptor Radioligand. Journal of Labelled Compounds and Radiopharmaceuticals, 47(13), 911-920. [More Information]
  • Roger, G., Dolle, F., de Bruin, B., Liu, X., Besret, L., Bramoulle, Y., Coulon, C., Ottaviani, M., Bottlaender, M., Valette, H., Kassiou, M. (2004). Radiosynthesis And Pharmacological Evaluation Of [11C]Emd-95885: A High Affinity Ligand For Nr2B-Containing Nmda Receptors. Bioorganic and Medicinal Chemistry, 12(12), 3229-3237. [More Information]
  • Roselt, P., Meikle, S., Kassiou, M. (2004). The Role Of Positron Emission Tomography In The Discovery And Development Of New Drugs; As Studied In Laboratory Animals. European Journal of Drug Metabolism and Pharmacokinetics, 29(1), 1-6.

2003

  • Kassiou, M., Katsifis, A. (2003). PET radiochemistry in drug development and evaluation. Chemistry in Australia, 70(5), 10-12.
  • Katsifis, A., Mardon, K., Mattner, F., Loc'h, C., McPhee, M., Dikic, B., Kassiou, M., Ridley, D. (2003). Pharmacological evaluation of (S)-8-[123I]iodobretazenil: a radioligand for in vivo studies of central benzodiazepine receptors. Nuclear Medicine and Biology, 30(2), 191-198.
  • Feng, D., Kassiou, M., Fulham, M., Wong, K., Elberl, S. (2003). Quantification of 5-[123I]iodo-A-85380 in nonhuman primates using spect: parameter identifiability and stabilitty. Modelling and Control in Biomedical Systems 2003 (Including Biological Systems), UK: Pergamon.
  • Quinlivan, M., Mattner, F., Papazian, V., Zhou, J., Katsifis, A., Emond, P., Chalon, S., Kozikowski, A., Guilloteau, D., Kassiou, M. (2003). Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear Medicine and Biology, 30(7), 741-746.
  • Roger, G., Lagnel, B., Besret, L., Bramoulle, Y., Coulon, C., Ottaviani, M., Kassiou, M., Bottlaender, M., Valette, H., Dolle, F. (2003). Synthesis, radiosynthesis and In Vivo evaluation of 5-[3-(4-Benzylpiperidin-1-yl) prop-1-ynyl]-1, 3-dihydrobenzoimidazol-2-[11C] one, as a potent NR 1A/2B subtype selective NMDA PET radiotracer. Bioorganic and Medicinal Chemistry, 11, 5401-5408. [More Information]

2002

  • Kassiou, M., Loc'h, C., Bottlaender, M., Mardon, K., Ottaviani, M., Coulon, C., Katsifis, A., Maziere, B. (2002). (+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET. Nuclear Medicine and Biology, 29(3), 295-302.
  • Kassiou, M., Bottlaender, M., Loc'h, C., Dolle, F., Musachio, J., Coulon, C., Ottaviani, M., Dannals, R., Maziere, B. (2002). Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors. Synapse (New York), 45(2), 95-104. [More Information]
  • Kassiou, M., Loc'h, C., Dolle, F., Musachio, J., Dolci, L., Crouzel, C., Dannals, R., Maziere, B. (2002). Preparation of a bromine-76 labelled analogue of epibatidine: a potent ligand for nicotinic acetylcholine receptor studies. Applied Radiation and Isotopes, 57(5), 713-717.

2001

  • Kassiou, M., Eberl, S., Meikle, S., Birrell, A., Constable, C., Fulham, M., Wong, D., Musachio, J. (2001). In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT. Nuclear Medicine and Biology, 28, 165-175.
  • Kassiou, M., Mardon, K., Mattner,, F., Katsifis, A., Dikic, B. (2001). Pharmacological evaluation of (+)-2-[123I]A-69024: A radioligand for in vivo studies of dopamine D1 receptors. Life Sciences, 69, 669-675.
  • Liu, X., Christie, M., Kassiou, M., Nuwayhid, S., Werling, L. (2001). Trishomocubanes: Novel sigma-ligands modulate amphetamine-stimulated [3H]dopamine release. European Journal of Pharmacology, 422, 39-45.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.

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