student profile: Mr Phillip Munoz


Map

Thesis work

Thesis title: Effects of High-Intensity Exercise Training on Heart, Lung, Muscle and Physical Activity Among Patients with Early-Onset Type 2 Diabetes or Gestational Diabetes

Supervisors: Alison HARMER , Jennifer ALISON , Susan MCLENNAN , Edmund LAU

Thesis abstract:

Diabetes prevalence in Australia is amongst the highest in the developed world and increasingly affects younger people. This thesis will examine two groups of patients: those with a particularly aggressive diabetes phenotype�br /� - early-onset type 2 diabetes (EOT2D) and people at high risk of developing type 2 diabetes�br /� – women with previous gestational diabetes mellitus (pGDM).�br /� �br /� Early onset type 2 diabetes mellitus is a very aggressive form of diabetes evidenced by poor metabolic control, the appearance of severe cardiovascular disease about three decades earlier than in later onset type 2 diabetes and early mortality – primarily from cardiovascular causes. Given that the only study that has investigated effects of exercise among people with EOT2D demonstrated that moderate-intensity continuous exercise had no effect on maximum oxygen uptake, it may be that the exercise intensity was insufficient to stimulate measurable adaptation. To date, no studies have examined the effects of aerobic interval training among young patients with EOT2D.�br /� �br /� Women with previous gestational diabetes mellitus have an exceptionally high (at least a 7 fold higher) risk of developing type 2 diabetes mellitus compared with women without pGDM. Previous GDM is associated with subclinical atherosclerosis prior to the development of the metabolic syndrome or T2D. There may also be subclinical heart dysfunction, however this has rarely been examined and responses to exercise training have not been investigated.�br /� The aim of our study is to investigate the effects of a novel exercise intervention, high intensity�br /� aerobic interval training, on aerobic fitness, heart volumes and function, vascular stiffness, metabolic control, substrate utilization and cardiovascular risk factors among patients with EOT2D or pGDM.�br /� �br /� 20 participants with EOT2D (5 completed) and 16 women with pGDM will be recruited for this pilot study, and will be randomized to either usual care (exercise advice) or exercise advice plus high intensity aerobic interval training. Our major hypotheses are that aerobic interval training will improve:�br /� 1. Aerobic fitness�br /� 2. Heart volumes (stroke volume) and function (ventricular relaxation)�br /� And among those with EOT2D, will not adversely affect metabolic control (HbA1c, glycosylated haemoglobin).�br /�

Selected publications

Download citations: PDF RTF Endnote

Journals

  • O'Meagher, S., Ganigara, M., Munoz, P., Tanous, D., Chard, R., Celermajer, D., Puranik, R. (2014). Right Ventricular Outflow Tract Enlargement Prior to Pulmonary Valve Replacement is Associated with Poorer Structural and Functional Outcomes, in Adults with Repaired Tetralogy of Fallot. Heart, Lung and Circulation, 23(5), 482-488. [More Information]
  • O'Meagher, S., Munoz, P., Alison, J., Young, I., Tanous, D., Celermajer, D., Puranik, R. (2012). Exercise capacity and stroke volume are preserved late after tetralogy repair, despite severe right ventricular dilatation. Heart, 98(21), 1595-1599. [More Information]
  • King, G., Brown, N., Diba, C., Thorpe, C., Munoz, P., Marks, G., Toelle, B., Ng, K., Berend, N., Salome, C. (2005). The effects of body weight on airway calibre. European Respiratory Journal, 25(5), 896-901. [More Information]

2014

  • O'Meagher, S., Ganigara, M., Munoz, P., Tanous, D., Chard, R., Celermajer, D., Puranik, R. (2014). Right Ventricular Outflow Tract Enlargement Prior to Pulmonary Valve Replacement is Associated with Poorer Structural and Functional Outcomes, in Adults with Repaired Tetralogy of Fallot. Heart, Lung and Circulation, 23(5), 482-488. [More Information]

2012

  • O'Meagher, S., Munoz, P., Alison, J., Young, I., Tanous, D., Celermajer, D., Puranik, R. (2012). Exercise capacity and stroke volume are preserved late after tetralogy repair, despite severe right ventricular dilatation. Heart, 98(21), 1595-1599. [More Information]

2005

  • King, G., Brown, N., Diba, C., Thorpe, C., Munoz, P., Marks, G., Toelle, B., Ng, K., Berend, N., Salome, C. (2005). The effects of body weight on airway calibre. European Respiratory Journal, 25(5), 896-901. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.