Professor Steven Meikle
Grants
2012-2014, Roger Fulton, Steven Meikle. Advanced computational algorithms for brain imaging studies of freely moving animals, Australian Research Council/Discovery Projects (DP). $916,791.00
2011-2013, Mark Ian Reinhard, Andrew G Weisenberger, Steven Meikle. Novel imaging technologies for continuous measurement of tracer kinetics in awake animals, Australian Research Council/Discovery Projects (DP). $555,740.00
2011 - 2013. Mark Reinhard, Andrew G Weisenberger, Steven Meikle. Novel imaging technologies for continuous measurement of tracer kinetics in awake animals, Australian Research Council/Discovery Projects (DP). $350,000
2010 - 2010. Arthur Conigrave, David Day, Simon Fleming, Claire Goldsbury, Jurgen Gotz, Georges Grau, Thomas Grewal, Trevor Hambley, Jan Marc, Steven Meikle, Paul Munroe, Christopher Murphy, Timoth Newsome, Rpbyn Overall, Ramzan Iqbal, Lilian Soon, Marion, Stevens-Kalceff, Daniela Triani, Peter Waterhouse, Anthony Weiss, Wolfgang Weninger, Sabine Wimmer-Kleikamp, Paul Young, Cristobel dos Remedios, Filip Guiller Braet. A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy, Australian Research Council/Linkage Infrastructure, Equipment and Facilities (LIEF). $720,000
2009 - 2011. Richard Banati, Roger Fulton, Steven Meikle. Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals, Australian Research Council/Discovery Projects (DP). $330,000
2009 - 2009. Steven Meikle. Intra- and inter-laboratory variability of dopaminergic receptor binding measurements in the rat brain using quantitative microPET, Australian Institute of Nuclear Science and Engineering/Awards. $23,500
2006 - 2008. Richard Banati, Steven Meikle, Roger Fulton. Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals, Australian Research Council/Discovery Projects (DP). $408,000
2006 - 2009. Dale Bailey, Richard Banati, Steven Meikle. New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo, Australian Research Council/Discovery Projects (DP). $526,753
2006 - 2007. Steven Meikle, Peter Kench. The development and evaluation of a novel multi-pinhole imaging technique for small animal SPECT, Australian Institute of Nuclear Science and Engineering/Awards. $16,000
2005 - 2009. Richard Banati, Steven Meikle. Novel Transmission Scanning and Computational Strategies for Quantitative Functional Imaging, Australian Research Council/Linkage Projects (LP). $90,000
2004 - 2009. Stefan Eberl, Michael Fulham, Roger Fulton, Steven Meikle, Dagan Feng. Smart information use for PET-CT quantitative molecular imaging, Australian Research Council/Discovery Projects (DP). $700,000
Publications
2011
Meikle, S R, Kench, P L, Lin, J 2011, Design considerations of small-animal SPECT cameras, Multimodality Molecular Imaging of Small-Animals: Instrumentation and Applications, Springer, London
Kench, P L, Lin, J, Gregoire, M, Meikle, S R 2011, An investigation of inconsistent projections and artefacts in multi-pinhole SPECT with axially aligned pinholes , Physics in Medicine and Biology, 56, 7487-7503
Lehnert, W, Gregoire, M, Reilhac, A, Meikle, S R 2011, Analytical positron range modelling in heterogeneous media for PET Monte Carlo simulation, Physics in Medicine and Biology, 56(11), 3313-3335
Zhou, W V, Kyme, A, Meikle, S R, Fulton, R R 2011, Event-based motion correction for PET transmission measurements with a rotating point source, Physics in Medicine and Biology, 56(9), 2651-2665
Naidoo (Naidoo-Variawa), S, Lehnert, W, Banati, R B, Meikle, S R 2011, Scatter correction for large non human primate brain imaging using microPET, Physics in Medicine and Biology, 56(7), 2131-2143
Naidoo (Naidoo-Variawa), S, Lehnert, W, Banati, R B, Meikle, S R 2011, Scatter correction for large non-human primate brain imaging using microPET, Physics in Medicine and Biology, 56(7), 2131-2143
Lin, J, Meikle, S R 2011, SPECT using asymmetric pinholes with truncated projections, Physics in Medicine and Biology, 56(13), 4103-4118
Moussa, I A, Banister, S D, Giboureau, N, Meikle, S R, Kassiou, M 2011, Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent, Bioorganic & Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 21(22), 6820-6823
Moussa, I A, Banister, S D, Giboureau, N, Meikle, S R, Kassiou, M 2011, Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N′-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ 1 receptor PET imaging agent, Bioorganic & Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, in press
Stoodley, PW, Richards, D, Meikle, S R, Clarke, J L, Hui, R, Thomas, L 2011, The potential role of echocardiographic strain imaging for evaluating cardiotoxicity due to cancer therapy, Heart, Lung and Circulation (Print), 20, 3-9
Stoodley, PW, Richards, D, Meikle, S R 2011, Two-dimensional myocardial strain imaging detects changes in left ventricular systolic function immediately after anthracycline chemotherapy, European Journal of Echocardiography, in press
Dobeli, K, Lewis, S J, Meikle, S R, Thiele, D, Brennan, P C 2011, Optimization of hepatic lesion detection with computed tomography (CT): Is randomization of lesion location necessary?, SPIE, International Society for optical Engineers, USA
Dobeli, K, Lewis, S J, Meikle, S R, Thiele, D, Brennan, P C 2011, Optimization of hepatic lesion detection with computer tomography (CT): Is randomization of lesion location necessary?, SPIE Medical Imaging, SPIE - International Society for Optical Engineering
Kyme, A, Zhou, V, Meikle, S R, Baldock, C, Fulton, R R 2011, Optimised Motion Tracking for Positron Emission Tomography Studies of Brain Function in Awake Rats, PLoS One, 6(7), e21727-1-e21727-16
2010
Fulton, R R, Meikle, S R, Kyme, A, Zhou, W V, Akhtar, M, Kassiou, M, Popovic, K, Karlsson, I J 2010, Imaging the awake rat brain with microPET, head tracking and motion correction, 5th International Conference on Imaging Technologies in Biomedical Sciences (ITBS 2009)
Fulton, R R, Meikle, S R, Kyme, A, Zhou, W V, Popovic, K, Kassiou, M, Akhtar, M 2010, Motion-corrected microPET brain imaging of conscious rats, 2009 World Molecular Imaging Conference, Online, USB drive/online
Naidoo (Naidoo-Variawa), S, Lehnert, W, Kassiou, M, Banati, R B, Meikle, S R 2010, Attenuation correction for the large non-human primate brain imaging using microPET, Physics in Medicine and Biology, 55(8), 2351-2363
2009
Kyme, A., Zhou, W. V., Meikle, S. R., Popovic, K., Akhtar, M., and Fulton, R. R., 2009, Motion Tracking of Fully Conscious Small Animals in PET, IEEE Nuclear Science Symposium and Medical Imaging Conference, Orlando, Florida, United States of America, 2009-10-28 , 2009-10-31
Meikle, S. R., 2009, A non-local post-filtering algorithm for PET incorporating anatomical knowledge, 2009 IEEE Nuclear Science Symposium, 2728-2732, Orlando, Florida, USA
Meikle, S. R., Kyme, A., Baldock, C., and Fulton, R. R., 2009, Understanding and compensating for refraction errors in stero-optical tracking during small animal PET/SPECT, 2009 IEEE Nuclear Science Symposium Conference Record, Orlando, Florida, USA
Fulton, R. R., Meikle, S. R., Kyme, A., Zhou, W. V., Akhtar, M., Kassiou, M., Popovic, K., and Karlsson, I. J., 2009, Imaging the awake rat brain with microPET, head tracking and motion correction., 5th International Conference on Imaging Technologies in Biomedical Sciences, Milos, Greece, 2009-09-13 , 2009-09-16
Fulton, R. R., Meikle, S. R., Kyme, A., Zhou, W. V., Popovic, K., Kassiou, M., and Akhtar, M., 2009, Motion corrected microPET rain imaging of conscious rats, 2009 World Molecular Imaging Conference, Montreal, Canada, 2009-09-23 , 2009-09-26
Kyme, A., Zhou, W. V., Meikle, S. R., Popovic, K., Karlsson, I. J., Lehnert, W., and Fulton, R. R., 2009, Motion correction for PET brain imaging of awake rats, The Inaugural Sydney International Workshop on Synergies in Astronomy and Medicine, Sydney, Australia, 2009-12-14 , 2009-12-16
Kassiou, M., Banati, R. B., Holsinger, R. M., and Meikle, S. R., 2009, Challenges in molecular imaging of Parkinson's disease: A brief overview, Brain Research Bulletin, 78[2-3], 105-108
Zhou, W. V., Kyme, A., Meikle, S. R., and Fulton, R. R., 2009, A Scheme for PET Data Normalisation in Event-based Motion Correction, Physics in Medicine and Biology, 54[17], 5321-5339
Zhou, W. V., Kyme, A., Meikle, S. R., and Fulton, R. R., 2009, A scheme for PET data normalization in event-based motion correction;, Physics in Medicine and Biology, 54[17], 5321-5339
Chan, C., Fulton, R. R., Feng, D. D., and Meikle, S. R., 2009, Regularized image reconstruction with an anatomically adaptive prior for positron emission tomography, Physics in Medicine and Biology, 54[24], 7379-7400
2008
Barnes, P J, Baldock, C, Meikle, S R, Fulton, R R 2008, Benchmarking of a motion sensing system for medical imaging and radiotherapy, Physics in Medicine and Biology, 53, 5845-5857
Kyme, A, Zhou, W V, Meikle, S R, Fulton, R R 2008, Real-time 3D motion tracking for small animal brain PET, Physics in Medicine and Biology, 53, 2651-2666
Zhou, V, Kyme, A, Meikle, S R, Fulton, R R 2008, An event-driven motion correction method for neurological PET studies of awake laboratory animals, Molecular Imaging and Biology, 10, 315-324
Lehnert, W, Meikle, S R, Newport, D 2008, Count rate performance of the microPET Focus 220 animal scanner in singles transmission scanning mode, IEEE Transactions on Nuclear Science, 55(5), 2493-2500
2007
Liu, X, Banister, S D, Christie, M J, Banati, R B, Meikle, S R, Coster, M, Kassiou, M 2007, Trishomocubanes: Novel sigma ligands modulate cocaine-induced behavioural effects, European Journal of Pharmacology, 555(1), 37-42
Chan, C, Fulton, R R, Cai, W T, Feng, D D, Meikle, S R 2007, Minimum Cross-entropy Reconstruction of PET Images with Anatomically Based Anisotropic Median-Diffusion Filtering, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Institute of Electrical and Electronics Engineers, Inc, USA, 6527-6530
Naidoo-Variawa, S, Hey Cunningham, AJ, Lehnert, W, Kench, P L, Kassiou, M, Banati, R B, Meikle, S R 2007, High-resolution imaging of the large non-human primate brain using microPET: a feasibility study, Physics in Medicine and Biology, 52(22), 6627-6638
Zaidi, H, Montandon, M, Meikle, S R 2007, Strategies for attenuation compensation in neurological PET studies, NeuroImage, 34(2), 518-541
Cagnin, A, Kassiou, M, Meikle, S R, Banati, R B 2007, Positron emission tomography imaging of neuroinflammation, Neurotherapeutics, 4(3), 443-452
2006
Meikle, S R, Beekman, F, Rose, S 2006, Complementary molecular imaging technologies: High Resolution SPECT, PET and MRI, Drug Discovery Today: Technologies, 3(2), 187-194
Liu, X, Banister, S D, Christie, M J, Banati, R B, Meikle, S R, Coster, M, Kassiou, M 2006, Trishomocubanes: Novel Sigma ligands modulate cocaine-induced behavioural effects, European Journal of Pharmacology, 555(1), 37-42
Lehnert, W, Meikle, S R, Siegel, S, Newport, D, Banati, R B, Rosenfeld, A 2006, Evaluation of transmission methodologyand attenuation correction for the microPET Focus 220 animal scanner, Physics in Medicine and Biology, 51(16), 4003-4016
Cagnin, A, Kassiou, M, Meikle, S R, Banati, R B 2006, In vivo evidence for microglial activation in neurodegenerative dementia, Acta Neurologica Scandinavica, 114(Supplement 185), 107-114