Preventing the superbug apocalypse
Wednesday 16 October 2013, 6–7.30pm
Professor Jon Iredell, Professor Centre for Infectious Diseases and Microbiology at Westmead Millennium Institute for Medical Research and the Westmead Clinical School
Associate Professor Tom Gottlieb, Clinical Associate Professor and Senior Specialist, Concord Hospital
Dr Vicky Sheppeard, Director of Communicable Diseases, NSW Health (Chair)
Antibiotics – the great medical discovery of the 20th century – have produced a monster. While the highly-publicised golden staph threat is being addressed in Australia, the emerging issue is with gram-negative bacteria – bacteria that doesn't survive well in external environments but spreads from person to person.
The interconnectedness of everybody’s microflora means that gut microbes are shared very effectively. It’s not just humans who share them - even migratory water birds transmit them around the world. E. coli from a hospital dump in Europe might be ultimately deposited in South America, Asia or Australia. It is a global ecological problem with potentially catastrophic effects. Associate Professor Gottlieb will describe the worst case scenario and analyse the causes and responses. Professor Iredell will then outline the various solutions his research team are investigating in an attempt to avert disaster. Dr Vicky Sheppeard, Director of Communicable Diseases, NSW Health, is chairing the talks.
VENUE: PricewaterhouseCoopers Sydney Room, Level 10, 201 Sussex St, Sydney
A 21st Century Medicine Lecture, presented by the Sydney Medical School, the University of Sydney in conjunction with Sydney Ideas and the Westmead Millennium Institute and the Marie Bashir Institute
Missed the presentation?
LISTEN: "Preventing the superbug apocalypse " audio of the presentation
SLIDES: "The Antibiotic Paradox", Associate Professor Tom Gottlieb; "Antibiotic Resistance - an ecological problem", John Iredell
READ: Radius magazine’s interview with Professor Jon Iredell – October 2013
- Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection
- Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora
- Bacteriophage adhering to mucus provide a non–host-derived immunity
- Contradicted and Initially Stronger Effects in Highly Cited Clinical Research
- Why Most Published Research Findings Are False
- NHMRC Evidence Hierarchy: designations of 'levels of evidence' according to type of research question
- Persistence of Contradicted Claims in the Literature
- Limited diversity in the gene pool allows prediction of third-generation cephalosporin and aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae
- Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
- The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels