Dr David Bowen

Senior Lecturer
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

D06 Centenary Institute
The University of Sydney
NSW 2006 Australia

T: +61 2 9565 6264
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Themes | Grants | Keywords | Publications

 

Current national competitive grants*

2011

Deciphering mechanisms of liver allograft tolerance
Bertolino P, Dwyer K, Bowen D, Bishop A
National Health and Medical Research Council Project Grant ($502,983 over 3 years)

* Grants administered through the University of Sydney

Keywords

Transplantation; Immunology; Gastroenterology; Hepatology; Hepatitis

Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

2012

   
  • Alex Bishop, G., Bertolino, P., Bowen, D., McCaughan, G. (2012), Tolerance in liver transplantation. Best Practice & Research. Clinical Gastroenterology. 26(1), 73-84. [Abstract]
  • Bowen, D. (2012), Finding a role for Th17 cells in hepatitis C pathogenesis. Journal of Gastroenterology and Hepatology. 27, 188-191. [Abstract]

2011

   
  • Wood, N., Linn, M., Bowen, D. (2011), Exhausted or just sleeping: Awakening virus-specific responses in chronic hepatitis C virus infection. Hepatology. 54(5), 1879-1882. [Abstract]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., van Rooijen, N., McGuffog, C., Schlitt, H., Bowen, D., McCaughan, G., Bertolino, P. (2011), Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America. 108(40), 16735-40. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]
  • McCaughan, G., Shackel, N., Bowen, D. (2011), Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes?. Liver Transplantation. 17, 219-221. [Abstract]
  • McCaughan, G., Bowen, D. (2011), Pathogenesis of cholestatic hepatitis C. Journal of hepatology. 54(2), 392-4. [Abstract]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011), Role of the hepatic parenchyma in liver transplant tolerance: a paradigm revisited. Digestive Diseases. 29(4), 391-401. [Abstract]

2010

   
  • Bowen, D. (2010), Toward small animal models for the study of human hepatitis viruses. Hepatology (Baltimore, Md.). 52(1), 382-4. [Abstract]
  • Shackel, N., Bowen, D., McCaughan, G. (2010), Snipping away at hepatitis C. Hepatology. 51(2), 703-705. [Abstract]
  • Fuller, M., Shoukry, N., Gushima, T., Bowen, D., Callendret, B., Campbell, K., Hasselschwert, D., Hughes, A., Walker, C. (2010), Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology (Baltimore, Md.). 51(2), 378-87. [Abstract]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010), CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of autoimmunity. 34(1), 15-22. [Abstract]
  • Holz, L., Bowen, D., Bertolino, P. (2010), Mechanisms of T cell death in the liver: to Bim or not to Bim?. Digestive Diseases. 28(1), 14-24. [Abstract]

2009

   
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009), Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation. 87(8), 1105-1111. [Abstract]
  • Velazquez, V., Bowen, D., Walker, C. (2009), Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood. 113(3), 538-545. [Abstract]
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009), Pathology and pathogenesis of hepatitis C. In: Hepatitis C: An Expanding Perspective. (pp.43-75).Australia: IP Communications.

2008

   
  • Ramalingam, R., Meyer-Olson, D., Shoukry, N., Bowen, D., Walker, C., Kalams, S. (2008), Kinetic analysis by real-time PCR of hepatitis C virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV. Journal of Virology. 82(21), 10487-10492. [Abstract]
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., d'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008), Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology. 135(3), 989-97. [Abstract]
  • Bowen, D. (2008), Of mice and molecular mimicry: Modeling autoimmune hepatitis. Hepatology (Baltimore, Md.). 48(3), 1013-5. [Abstract]
  • Bowen, D., Shoukry, N., Grakoui, A., Fuller, M., Cawthon, A., Dong, C., Hasselschwert, D., Brasky, K., Freeman, G., Seth, N., Wucherpfennig, K., Houghton, M., Walker, C. (2008), Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of Virology. 82(10), 5109-5114. [Abstract]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008), Liver tolerance and the manipulation of immune outcomes. Inflammation & Allergy Drug Targets. 7(1), 6-18. [Abstract]
  • Bertolino, P., McCaughan, G., Bowen, D. (2008), Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In: Hepatitis C Virus Disease: Immunobiology and Clinical Applications. (pp.39-70).United States: Springer.

2007

   
  • Bertolino, P., Bowen, D., Benseler, V. (2007), T cells in the liver: there is life beyond the graveyard. Hepatology (Baltimore, Md.). 45(6), 1580-1582. [Abstract]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, G., Bowen, D., Bertolino, P. (2007), The liver: a special case in transplantation tolerance. Seminars in liver disease. 27(2), 194-213. [Abstract]

2006

   
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006), T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology (Baltimore, Md.). 44(5), 1182-90. [Abstract]
  • Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006), Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of hepatology. 44(2), 334-41. [Abstract]