Dr David Bowen

Senior Lecturer
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

D06 Centenary Institute
The University of Sydney
NSW 2006 Australia

T: +61 2 9565 6264
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Themes | Grants | Keywords | Publications

 

Current national competitive grants*

2012

Right Care, Right Time, Right Place: Improving Outcomes for People with Spinal Cord Injury through Early Intervention and Improved Access to Specialised Care
Middleton J, Marshall R, Middleton P, Harrison J, Watt W, Brown D, Cameron P, McClure R, Lyons N, Bowen D
NHMRC Partnership Projects ($1,050,235 over 4 years)

2011

Deciphering mechanisms of liver allograft tolerance
Bertolino P, Dwyer K, Bowen D, Bishop A
National Health and Medical Research Council Project Grant ($502,983 over 3 years)

* Grants administered through the University of Sydney

Keywords

Transplantation; Immunology; Gastroenterology; Hepatology; Hepatitis

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2013

   
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013), Terlipressin Therapy for Moderate to Severe Hyponatremia in Patients with Liver Failure. Internal Medicine Journal. 43(3), 240-246. [Abstract]

2012

   
  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012), Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International. 32(10), 1527-1534. [Abstract]
  • Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012), Naïve CD8 T cells activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology. 57(4), 830-836. [Abstract]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012), Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology. 57(2), 352-358. [Abstract]
  • Bowen, D. (2012), Finding a role for Th17 cells in hepatitis C pathogenesis. Journal of Gastroenterology and Hepatology. 27, 188-191. [Abstract]
  • Alex Bishop, G., Bertolino, P., Bowen, D., McCaughan, G. (2012), Tolerance in liver transplantation. Best Practice & Research. Clinical Gastroenterology. 26(1), 73-84. [Abstract]
  • Bowen, D. (2012), Immune Responses to HCV: Implications for Therapy. In: Advanced Therapy for Hepatitis C. (pp.17-24).United Kingdom: Blackwell Publishing Ltd.

2011

   
  • Wood, N., Linn, M., Bowen, D. (2011), Exhausted or just sleeping: Awakening virus-specific responses in chronic hepatitis C virus infection. Hepatology. 54(5), 1879-1882. [Abstract]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., van Rooijen, N., McGuffog, C., Schlitt, H., Bowen, D., McCaughan, G., Bertolino, P. (2011), Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America. 108(40), 16735-40. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]
  • McCaughan, G., Shackel, N., Bowen, D. (2011), Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes?. Liver Transplantation. 17, 219-221. [Abstract]
  • McCaughan, G., Bowen, D. (2011), Pathogenesis of cholestatic hepatitis C. Journal of hepatology. 54(2), 392-4. [Abstract]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011), Role of the hepatic parenchyma in liver transplant tolerance: a paradigm revisited. Digestive Diseases. 29(4), 391-401. [Abstract]

2010

   
  • Bowen, D. (2010), Toward small animal models for the study of human hepatitis viruses. Hepatology (Baltimore, Md.). 52(1), 382-4. [Abstract]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010), CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of autoimmunity. 34(1), 15-22. [Abstract]
  • Shackel, N., Bowen, D., McCaughan, G. (2010), Snipping away at hepatitis C. Hepatology. 51(2), 703-705. [Abstract]
  • Fuller, M., Shoukry, N., Gushima, T., Bowen, D., Callendret, B., Campbell, K., Hasselschwert, D., Hughes, A., Walker, C. (2010), Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology (Baltimore, Md.). 51(2), 378-87. [Abstract]
  • Holz, L., Bowen, D., Bertolino, P. (2010), Mechanisms of T cell death in the liver: to Bim or not to Bim?. Digestive Diseases. 28(1), 14-24. [Abstract]

2009

   
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009), Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation. 87(8), 1105-1111. [Abstract]
  • Velazquez, V., Bowen, D., Walker, C. (2009), Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood. 113(3), 538-545. [Abstract]
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009), Pathology and pathogenesis of hepatitis C. In: Hepatitis C: An Expanding Perspective. (pp.43-75).Australia: IP Communications.

2008

   
  • Ramalingam, R., Meyer-Olson, D., Shoukry, N., Bowen, D., Walker, C., Kalams, S. (2008), Kinetic analysis by real-time PCR of hepatitis C virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV. Journal of Virology. 82(21), 10487-10492. [Abstract]
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., d'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008), Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology. 135(3), 989-97. [Abstract]
  • Bowen, D. (2008), Of mice and molecular mimicry: Modeling autoimmune hepatitis. Hepatology (Baltimore, Md.). 48(3), 1013-5. [Abstract]
  • Bowen, D., Shoukry, N., Grakoui, A., Fuller, M., Cawthon, A., Dong, C., Hasselschwert, D., Brasky, K., Freeman, G., Seth, N., Wucherpfennig, K., Houghton, M., Walker, C. (2008), Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of Virology. 82(10), 5109-5114. [Abstract]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008), Liver tolerance and the manipulation of immune outcomes. Inflammation & Allergy Drug Targets. 7(1), 6-18. [Abstract]
  • Bertolino, P., McCaughan, G., Bowen, D. (2008), Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In: Hepatitis C Virus Disease: Immunobiology and Clinical Applications. (pp.39-70).United States: Springer.

2007

   
  • Bertolino, P., Bowen, D., Benseler, V. (2007), T cells in the liver: there is life beyond the graveyard. Hepatology (Baltimore, Md.). 45(6), 1580-1582. [Abstract]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, G., Bowen, D., Bertolino, P. (2007), The liver: a special case in transplantation tolerance. Seminars in liver disease. 27(2), 194-213. [Abstract]