Dr Devanshi Seth

Principal Scientist; Group Head (alcoholic liver disease); NIH Project Leader (GenomALC); Clinical Senior Lecturer;
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 95157201
F: +61 2 9515 5779
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Biographical details

Dr Seth, BSc (Hons), MSc (Agriculture), MPH, PhD (Genetics), is a Principal Scientist and Clinical Senior Lecturer at the (i) Drug Health Services (DHS), (ii) Centenary Institute (CI) at RPAH; and at the University of Sydney (USYD), Clinical and Addiction Medicine. Dr Devanshi Seth has more than 25 years of training and experience as Molecular Biologist in Biotechnology industry and more recently in Public Health, with 10 years of contribution towards alcohol research. Dr Seth has several publications in peer reviewed high impact journals in this area. Her work is recognised internationally through invitations to chair and present at international meetings and has generated several national and international collaborations. She also has long term collaboration with Prof Geoff McCaughan, Director AW Morrow Gastroenterology & Liver Clinic, RPAH and Prof Paul Haber, Medical Director, DHS, Sydney South West Area Health Service (SSWAHS). [More...]

Research interests

Dr Devanshi Seth has an international profile in alcohol research: to understand the molecular pathogenesis, genetics and associated risk factors, prevention and treatment of alcoholic liver disease (ALD) through novel therapeutic agents.

Areas of research: Clinical; in vitro and in vivo models of alcohol; Chronic Alcohol; Alcohol related tissue injury; Alcoholism/Addiction; Liver; Cirrhosis/Fibrosis

Opportunities for Honours and PhD: All current research listed above have opportunity for students as honours and/or PhD projects.

Current national competitive grants*

2011

Genetic risk factors for alcoholic cirrhosis - genome wide case control study
Seth D, Haber P, Nalpas B, Stickel F, Day C, Lumeng L, Morgan T, Whitfield J
NIH Research Support ($525,920 over 5 years)

* Grants administered through the University of Sydney

Keywords

Genomics; Cell & Molecular Biology; Alcohol; Inflammation; Liver

International links

Switzerland. (University of Bern, Switzerland) Felix Stickel, M.D. is an Associate Professor and GI specialist at the University of Heidelberg and University of Eirlangen, Germany and Head, Dept. of Visceral Surgery and Medicine, University of Bern. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
United States. (University of California-Irvine VA Medical Center, Long Beach CA) Timothy R, MORGAN, MD is Professor of Medicine, University of California, Irvine and Chief, Hepatology at the VA Medical Centre. He is the lead US Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
France. (University Paris XII, France) Bertrand Nalpas, M.D, PhD, is Director of research at the University Paris VII, France. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
Germany. (Salem Medical Center, Heidelberg Centre of Alcohol Research Liver Disease and Nutrition, University of Heidelberg) Helmut Karl Seitz, M.D., PhD, AGAF is Professor, Medical Director, Department of Medicine, Salem Medical Center, Heidelberg; Head, Centre of Alcohol Research Liver Disease and Nutrition. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
United States. (University of California, LA Indiana school of Medicine, Indianpolis) Prof Tatiana Foroud, B.s, M.S, PhD is Professor of Medical & Molecular Genetics. She is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Dr Seth and Prof Foroud have jointly organised symposium on GWAS at the ISBRA 2008 meeting..
United States. (Indiana University, Bloomington, IN) Lawrence Lumeng, M.D. is a Professor, Physician/Scientist at the Indiana University, Bloomington, IN. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
Australia. (Queensland Institute of Medical Research, Brisbane) John B Whitfield, BSc, MSC, PhD, MRCPath, FRCPath is the Director a Senior Principal Research Fellow at the Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Drs Whitfield and Seth have had ~8 years of collaboration and held joint grants during this period..
United Kingdom. (University of Newcastle, UK) DAY, Christopher Paul, MD, MRCP, PhD, FRCP is Pro Vice Chancellor of Medical Sciences & Professor of Liver Medicine at the University of Newcastle, UK. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Prof Day and Dr Seth have also published together recently in Hepatology..

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2008

2014

   
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S., Hennessy, A., Prins, J., Twigg, S., McLennan, S., McCaughan, G., Bachovchin, W., Gorrell, M. (2014), Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio. 4, 43-54. [Abstract]

2013

   
  • Lakshman, M., Amdur, R., Shah, R., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K. (2013), CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism. (pp.199-234).Germany: Springer Science+Business Media.

2012

   
  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012), Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology. 18(26), 3389-3399. [Abstract]

2011

   
  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011), Pathogenesis of Alcohol-induced Liver Disease - classical concepts and recent advances. Journal of gastroenterology and hepatology. 26(7), 1089-105. [Abstract]

2010

   
  • Seth, D., Daly, A., Haber, P., Day, C. (2010), Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology. 51(4), 1463-1465. [Abstract]
  • Seth, D., D'Souza El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., de Villiers, W., Vonlaufen, A., Xu, Z., Phillips, P., Yang, S., Goldstein, D., Pirola, R., Wilson, J., Moles, A., Fernández, A., Colell, A., García-Ruiz, C., Fernández-Checa, J., Meyer, C., Meindl-Beinker, N. (2010), Alcohol, Signaling, and ECM Turnover. Alcoholism, clinical and experimental research. 34(1), 4-18. [Abstract]

2008

   
  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshman, M. (2008), Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: Clinical and Experimental. 57(12), 1663-1668. [Abstract]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., Leo, M., Lieber, C., Voiculescu, M., Buzatu, E., Ionescu, C., Dudas, J., Saile, B., Ramadori, G. (2008), Inflammation and repair in viral hepatitis C. Digestive Diseases and Sciences. 53(6), 1468-1487. [Abstract]
  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2008), Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. Journal of hepatology. 48(4), 614-627. [Abstract]