Combined, Correlative and Integrated Microscopy: Unraveling Biomolecular Structure-Function Activities in Cancer & Transendothelial Transport

Our team seek to understand the spatial and temporal mechanisms involved in the onset and progress of colorectal cancer by using state-of-the-art multidimensional microscopy and 3-D correlative imaging techniques.

In this way, novel ultrastsructural information over micrometre-to-nanometre scales can be gathered to underpin the development and application of new targeted drug delivery strategies of for colorectal cancer.

Other related work focuses on the development of 4-D simulation models of the colorectal tumour's in-vivo microenvironment in relevant organoid and animal models. In this work we explore the structure-function relationship of different subcellular compartments and molecules in various vascular models.