Publications

CONTENTS

Text Book Publication

Publications


Text Book Publication

Development of the Ocular Lens
Edited by Frank J. Lovicu, Michael L. Robinson
Published November 2004
ISBN:0521838193


'Development of the Ocular Lens' provides a current view of research in lens developmental biology, emphasising recent technical and molecular breakthroughs.

Elucidation of the mechanisms that govern lens development has enabled us to understand how the normal lens forms and how developmental processes, namely cell proliferation and differentiation, are involved in the maintenance of its normal structure, function and growth throughout life. This knowledge is fundamental to our understanding of many lens disorders.

The ocular lens has also become a model for understanding the developmental biology of more complex organ systems. In this book, leading experts in lens cell biology and development discuss lens evolution, induction, morphology, the regulation of the lens cell cycle and fiber cell differentiation, as well as lens regeneration.

This book is a broad and authoritative treatment of the subject that will serve as a reference for graduate students and research scientists in developmental biology and in the visual sciences, as well as for ophthalmologists.

Publications

2011

  • Lovicu FJ, McAvoy JW, de Iongh RU. 2011. Understanding the role of growth factors in embryonic development: insights from the lens. Phil. Trans. R. Soc. B. 366:1204-1218.
  • Kallifatidis G, Boros J, Shin E-H, McAvoy JW, Lovicu FJ. 2011. The fate of dividing cells during lens morphogenesis, differentiation and growth. Exp. Eye Res. 92:502-511.
  • Sugiyama Y, Lovicu FJ, McAvoy JW. 2011. Planar cell polarity in the mammalian eye lens. Organogenesis. 7:191-201.
  • Lovicu FJ, McAvoy JW, de Iongh RU. 2011. Understanding the role of growth factors in embryonic development: insights from the lens. Phil Trans R Soc B. 2011; in press.

2010

  • West-Mays JA, Pino G, Lovicu FJ. 2010. Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis. Prog Ret Eye Res. 29:135-143.
  • Alibardi L, Lovicu FJ. 2010. Immunolocalization of FGF1 and FGF2 in the regenerating tail of the lizard Lampropholis guichenoti: implications for FGFs as trophic factors in lizard tail regeneration. Acta Histochemica. 112:459-473.
  • Sugiyama Y, Stump RJ, Nguyen A, Wen L, Chen Y, Wang Y, Murdoch JN, Lovicu FJ, McAvoy JW. 2010. Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.
    Dev Biol. 2010;338:193-201.
  • Newitt P, Boros J, Madakashira BP, Robinson ML, Reneker LW, McAvoy JW, Lovicu FJ. 2010. Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation. 2010;80:53-67.
  • Wang Q, McAvoy JW, Lovicu FJ. 2010. Growth factor signaling in vitreous humor-induced lens fiber differentiation. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3599-610.

2009

  • Chong CC, Stump RJ, Lovicu FJ, McAvoy JW. 2009. TGFß promotes Wnt expression during cataract development. Exp Eye Res. 88:307-313.
  • Wang Q, Stump R, McAvoy JW, Lovicu FJ. 2009. MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Exp Eye Res. 88: 293-306.
  • Iyengar L, Patkunanathan B, McAvoy JW, Lovicu FJ. 2009. Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors. 27:50-62.

2008

  • O'Connor MD, Wederell ED, de Iongh R, Lovicu FJ, McAvoy JW. 2008. Generation of transparency and cellular organization in lens explants. Exp Eye Res. 86:734-745.
  • Chen Y, Stump RJW, Lovicu FJ, Shimono A, McAvoy JW. 2008. Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology. 324:161-176.

2007

  • Pennisi DJ, Wilkinson L, Kolle G, Sohaskey ML, Gillinder K, Piper MJ, McAvoy JW, Lovicu FJ, Little MH. 2007. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Dev Dyn. 236:502-11.
  • Iyengar L, Wang Q, Rasko JEJ, McAvoy JW, Lovicu FJ. 2007. The duration of MAPK/ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation. 75:662-668.
  • Jamieson RV, Farrar N, Stewart K, Perveen R, Mihelec M, Carette M, Grigg JR, McAvoy JW, Lovicu FJ, Tam PPL, Scambler P, Lloyd IC, Donnai D, Black GCM. 2007. Characterisation of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation. 28:968-977.
  • Markus MA, Goy C, Adams DJ, Lovicu FJ, Morris BJ. 2007.Renin Enhancer is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension (in press, August 6, 2007).
    Lovicu FJ, and McAvoy, JW. 2001. FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development. 128. 5075-5084.

2006

  • Symonds JG, Lovicu FJ, Chamberlain CG. 2006. Posterior capsule opacification-like changes in rat lens explants cultured with TGFβ and FGF: Effects of cell coverage and regional differences. Exp. Eye Res. 82:693-699.
  • Iyengar L, Patkunanathan B, Lynch OT, McAvoy JW, Rasko JEJ, Lovicu FJ. 2006. Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Exp. Eye Res. 83:667-78.
  • Symonds JG, Lovicu FJ, Chamberlain CG. 2006. Differing effects of dexamethasone and diclofenac on posterior capsule opacification-like changes in a rat lens explant model. Exp. Eye Res. 83:771-82.
  • Stump RJW, Lovicu FJ, Ang S, Pandey SK, McAvoy JW. 2006. Lithium stabilises the polarised lens epithelial phenotype and inhibits proliferation, migration and epithelial mesenchymal transition. J. Pathology. 210:249-57.
  • Adams DJ, Head GA, Markus MA, Lovicu FJ, van der Weyden L, Köntgen F, Arends MJ, Thiru S, Mayorov DN, Morris BJ. 2006. Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem. 281:31753-61.
  • Chen Y, Stump RJW, Lovicu FJ, McAvoy JW. 2006. A role for Wnt/Planar Cell Polarity signaling during lens fiber cell differentiation? Semin Cell Dev Biol. 17:712-25.
  • Boros J, Newitt P, Wang Q, McAvoy JW, Lovicu FJ. 2006. Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation. Semin Cell Dev Biol. 17:741-52.
  • Lovicu FJ. 2006. Cell Signaling in Lens Development. Semin Cell Dev Biol. 17:675.
  • Thompson J, Lovicu FJ, Ziman M. 2006. Pax7 regulation of superior collicular topography: insights from Pax6 (Sey) mutant mice. Exp Brain Res. 178:316-25.

2005

  • de Iongh RU, Wederell E, Lovicu FJ, McAvoy JW. 2005. Transforming growth factor-ß-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs. 179:43-55.
  • Lovicu FJ, McAvoy JW. 2005. Growth Factor Regulation Of Lens Development. Dev. Biol. 280:1-14.

2004

  • Ang SJ, Stump RJW, Lovicu FJ, McAvoy JW. 2004. Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Expression Patterns, 4: 289–295.
  • Lovicu FJ, Steven P, Saika S,. McAvoy JW. 2004. Aberrant lens fiber differentiation contributes to anterior subcapsular cataract formation in vivo: a process dependent on reduced levels of Pax6. Invest Ophthal Vis Sci. 45:1946-1953.
  • Thompson J., Lovicu F., Ziman M. 2004.The role of Pax7 in determining the cytoarchitecture of the superior colliculus. Dev Growth Differ. 46:213-218.
  • Chen Y, Stump RJW, Lovicu FJ, McAvoy JW. 2004. Expression of Frizzleds and secreted frizzled-related proteins (sFRPs) during rodent lens development. Int J Dev Biol. 48:867-877.
  • Robinson ML, Lovicu FJ. 2004. The Lens: Historical and Comparative Perspectives. In “Development of the Ocular Lens”. Eds. Lovicu FJ and Robinson ML. Cambridge University Press. New York.
  • Lang RA, McAvoy JW. 2004. Growth factors in lens development. In “Development of the Ocular Lens”. Eds. Lovicu FJ and Robinson ML. Cambridge University Press. New York.
  • de Iongh RU, Chen Y, Kokkinos MI, McAvoy JW. 2004. BMP and activin receptor expression in lens development. Mol Vis. 10:566-576.
  • Tanaka T, Saika S, Ohnishi Y, Ooshima A, McAvoy JW, Liu CY, Azhar M, Doetschman T, Kao WW. 2004. Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury. Mol Vis. 10:462-7.
  • Lovicu FJ, Ang S, Chorazyczewska M, McAvoy JW. 2004. Deregulation of Lens Epithelial Cell Proliferation and Differentiation during the Development of TGFß-induced Anterior Subcapsular Cataract. Dev. Neurosci. 26:446-455.
  • Lovicu FJ, McAvoy JW. 2004. Growth Factor Regulation Of Lens Development. Dev. Biol. 280:1-14.

2003

  • Stump RJW, Ang S, Chen Y, von Bahr T, Lovicu FJ, Pinson K, de Iongh RU, Yamaguchi TP, Sasoon DA, McAvoy JW. (2003) A role for Wnt/ß-catenin signalling in lens epithelial differentiation. Dev Biol. 259:48-61.
  • Yager M, Hughes JAI, Lovicu FJ, Gunning PW, Weinberger RP, O'Neill, GM. 2003. Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma. Br J Cancer. 89:860-863.

2002

  • Lovicu FJ, Schulz M, Hales AM, Vincent L, Overbeek PA, Chamberlain CG, and McAvoy JW. 2002. TGFß induces the morphological and molecular changes similar to human anterior subcapsular cataract. Brit J Ophthal. 86, 220-226.
  • Kok A, Lovicu FJ, Chamberlain CG and McAvoy JW. 2002. PDGF influences proliferation and potentiates FGF-induced fibre differentiation in lens epithelial explants. Growth Factors. 20:27-34.
  • Maruno K, Lovicu FJ , Chamberlain CG and McAvoy JW. 2002. Apoptosis is a feature of TGFß-induced cataract. Clin Exp Optom. 85:76-82.
  • Bradbury RA, Cropley J, Kifor O, Lovicu FJ, de Iongh RU, Kable E, Brown EM, Seely EW, Peat BB, Conigrave AD. 2002. Localization of the extracellular Ca2+-sensing receptor in the human placenta. Placenta. 2002. 23:192-200.
  • Saika S, Miyamoto T, Ishida I, Shirai K, Ohnishi Y, Ooshima A, McAvoy JW. TGFbeta-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol. 2002. 86:1428-33.

2001

  • Saika S, Okada Y,Miyamoto T, Oshnishi Y, Ooshima A, McAvoy JW. Smad translocation and growth supression in lens epithelial cells by endogenous TGFß. Exp Eye Res. 2001;72:679-686.
  • de Iongh RU, Gordon-Thomson C, Hales AM, Chamberlain CG, McAvoy JW. TGF-ß receptor expression in the lens: implications for differentiation and cataractogenesis. Exp Eye Res. 2001;72:649-659
  • de Iongh, RU., Lovicu, FJ, Overbeek, P. A., Schneider, MD., Joya, J., Hardeman, E. and McAvoy, JW. (2001). Requirement for TGFß receptor signaling during terminal lens fiber differentiation. Development. 128:3995-4010.
  • Zhao S, Hung F-C, Colvin J. S, White, A., Dai, W., Lovicu FJ, Ornitz, D.M., and Overbeek P.A. 2001. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 128, 5051-5060.
  • Saika S, Okada Y, Miyamoto T, Ohnishi Y, Ooshima A, McAvoy JW. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair. Exp Eye Res. 2001. 72:679-86.
  • Lovicu FJ, and McAvoy, JW. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development. 128. 5075-5084.

2000

  • Adams DJ, van der Weyden L, Kovacic A, Lovicu FJ, Copeland NG, Gilbert DJ, Jenkins NA, Ioannou PA and Morris BJ. 2000. Chromosomal localization and characterization of the mouse human zinc finger protein 265 gene. Cytogenet Cell Genet. 88:68-73.
  • Hales AM, Chamberlain CG, McAvoy JW. Susceptibility to TGFß-induced cataract increases with ageing in the rat. Invest Ophthalmol Vis Sci. 2000;41:3544-3551.
  • Ueda Y, Chamberlain CG, Satoh K McAvoy JW. Inhibition of FGF-induced _A-crystallin promoter activity in lens epithelial explants by TGFß. Invest Ophthalmol Vis Sci. 2000;41:1833-1839.
  • Lovicu FJ, Kolle G, Yamada T, Little MH, McAvoy JW. Ocular expression of Crim1 during murine development. Mech Develop. 2000;94:261-5.
  • McAvoy JW, Chamberlain CG, de Iongh RU, Hales AM, Lovicu FJ. Peter Bishop Lecture: growth factors in lens development and cataract: key roles for FGF and TGFß. Clin Exp Ophthalmol. 2000;28:133-139.

1999

  • Shang F, Gong X, McAvoy JW, Chamberlain C Nowell Jr TR, Taylor A. Ubiquitin-dependent pathway is up-regulated in differentiating lens cells. Exp Eye Res. 1999;68:179-192.
  • Lovicu FJ McAvoy JW. Spatial and temporal expression of p57KIP2 during murine lens development. Mech Develop. 1999; 86:65-69.
  • McAvoy JW, Chamberlain CG, de Iongh RU, Hales AM, Lovicu FJ. Lens development, Eye. 1999;13:425-437.
  • Hales AM, Chamberlain CG, Dreher B, McAvoy JW. Intravitreal injection of TGFß induces cataract in rats. Invest Ophthalmol Vis Sci. 1999;40:3231-3236.
  • Lovicu FJ, Kao W-K, Overbeek PA. 1999. Ectopic gland induction by lens-specific expression of keratinocyte growth factor (FGF-7) in transgenic mice. Mech Develop. 88:43-53

1998

  • Lovicu FJ, Overbeek PA. 1998. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development. 125: 3365-3377.
  • Srinivasan, Y., Lovicu FJ, Overbeek PA. 1998. Lens-specific expression of Transforming Growth Factor ß1 in Transgenic Mice Causes Anterior Subcapsular Cataracts. J Clin Invest. 101: 625-634.
  • Gordon -Thomson C, de Iongh RU, Hales AM, Chamberlain CG, McAvoy JW. Differential cataractogenic potency of TGF-ß1, TGF-ß2 and TGF-ß3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci. 1998;39:1399-1409.
  • Klok EJ, Chamberlain CG, Lubsen NH, McAvoy JW. Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-I. Exp Eye Res. 1998;67:425-431.

1997

  • Hales AM, Chamberlain CG, Murphy CR, McAvoy JW. Estrogen protects lenses against cataract induced by TGFß. J Exp Med. 1997;185:273-280.
  • Schulz MW, Chamberlain CG, McAvoy JW. Binding of FGF-1 and FGF-2 to heparan sulphate proteoglycans of the mammalian lens capsule. Growth Factors 1997;14:1-13.
  • Chamberlain CG, McAvoy JW. Fibre differentiation and polarity in the mammalian lens: A key role for FGF. Prog Ret Eye Res. 1997;16:443-478.
  • Lovicu FJ, de Iongh RU, McAvoy JW Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth. Curr Eye Res. 1997;16:222-230.
  • Wang DZM, Hammond VE, Abud HE, Bertoncello I, McAvoy JW, Bowtell DDL. Genetic interaction between Sos1 and weak EGF receptor mutations demonstrates a requirement for Sos1 in growth factor signalling and a strategy for analysing mammalian signalling proteins. Genes Develop 1997;11:309-320.
  • de Iongh RU, Lovicu FJ, Chamberlain CG, McAvoy JW. Differential expression of FGF receptors during rat lens morphogenesis and growth. Invest Ophthalmol Vis Sci. 1997;38:1688-1699.

1996

  • Schulz MW, Chamberlain CG, McAvoy JW. Inhibition of TGFß-induced cataractous changes in lens explants by ocular media and _2-macroblobulin. Invest Ophthalmol Vis Sci. 1996; 37:1509-1519.
  • de Iongh RU, Lovicu FJ, Hanneken A, Baird A, McAvoy JW. FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Develop Dynam 1996; 206:412-426.
  • Sussman MA, McAvoy JW, Rudisill M, Swanson B, Lyons GE, Kedes L, Blanks J. Lens tropomodulin: developmental expression during differentiation. Exp Eye Res. 1996; 63:223-232.
  • Liu J, Chamberlain CG, McAvoy JW. IGF enhancement of IGF-induced fiber differentiation and DNA synthesis in lens explants. Exp Eye Res. 1996; 63:621-629.

1995

  • Lovicu FJ, Chamberlain CG, McAvoy JW. Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants. Invest Ophthalmol Vis Sci. 1995; 36:1459-1469.
  • Hales AM, Chamberlain CG, McAvoy JW. Cataract induction in lenses cultured with transforming growth factor-ß. Invest Ophthalmol Vis Sci. 1995; 36:1709-1713.

1994

  • Liu J, Hales AM, Chamberlain CG, McAvoy JW. Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor-ß. Invest Ophthalmol Vis Sci. 1994; 35: 388-401.
  • Chamberlain CG, Hales AM, Liu J, McAvoy JW. TGF-ß induced cataract-like changes in lens epithelia. Letter to the Editor. Invest Ophthalmol Vis Sci. 1994; 35:3787-3788.
  • Hales AM, Schulz MW, Chamberlain CG, McAvoy JW. TGF-ß1 induces lens cells to accumulate _-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res. 1994; 13:885-890.

1993

  • de Iongh RU, McAvoy JW. Cellular localisation of aFGF during early lens development by a triple fluorescent labelling technique. J Comput Assist Microsc. 1993; 5:31-36.
  • Lovicu FJ, McAvoy JW. A structural analysis of fibroblast growth factor (FGF)-induced lens fibre differentiation in vitro. J Comput Assist Microsc. 1993; 5:57-63.
  • Schulz MW, Chamberlain CG, de Iongh RU, McAvoy JW. Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns. Development 1993;118:117-126.
  • Lovicu FJ, McAvoy JW. Localisation of aFGF, bFGF and HSPG in rat lens: implications for lens polarity and growth patterns. Invest Ophthalmol Vis Sci. 1993; 34:3355-3365.
  • Richardson NA, Chamberlain CG, McAvoy JW. IGF-I enhancement of FGF-induced lens fibre differentiation in rats of different ages. Invest Ophthalmol Vis Sci. 1993; 34:3303-3312.
  • de Iongh RU, McAvoy JW. Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in lens morphogenesis. Develop Dynam 1993; 198:190-202.

1992

  • de Iongh R, McAvoy JW. Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye: implications for lens development. Growth Factors 1992;6:159-177.
  • Richardson NR, McAvoy JW, Chamberlain CG. Age of rats affects response of lens epithelial explants to fibroblast growth factor. Exp Eye Res. 1992;55:649-656.
  • Lovicu FJ, McAvoy JW. Age of rats affects response of lens epithelial explants to FGF: an ultrastructural study. Invest Ophthalmol Vis Sci. 1992;33:2269-2278.
  • Hales AM, Chamberlain CG, McAvoy JW. Measurement of lens cell migration on a laminum substratum using image analysis. J Comput Assist Microsc. 1992; 4:135-139.
  • Peek R, McAvoy JW, Lubsen NH, Schoenmakers JGG. Rise and fall of crystallin gene messenger levels during fibroblast growth factor induced terminal differentiation of lens cells. Dev Biol. 1992;

1991

  • Chamberlain CG, McAvoy JW, Richardson NA. The effects of insulin and basic fibroblast growth factor on fibre differentiation in rat lens epithelial explants. Growth Factors 1991;4:183-188.
  • Parmigiani CM, McAvoy JW. The roles of laminin and fibronectin in the development of the lens capsule. Curr Eye Res. 1991;10:501-511.
  • McAvoy JW, Chamberlain CG, de Iongh RU, Richardson NA, Lovicu FJ. The role of fibroblast growth factor in eye lens development. Ann NY Acad Sci. 1991; 638:256-274.
  • McAvoy JW, Chamberlain CG, Richardson NA, Lovicu FJ. Fibroblast growth factor, a lens-inducing molecule from the retina In 'New Frontiers in Ophthalmology'. Editor CY Khoo Elsevier Science Publishers, Amsterdam 1991; 627-631.

1990

  • McAvoy JW, Chamberlain CG. Growth factors in the eye. Prog Growth Factor Res. 1990;2:29-43.
  • Richardson NA, McAvoy JW. Age-related changes in fibre differentiation of rat lens epithelial explants exposed to fibroblast growth factor. Exp Eye Res. 1990;50:203-211.

1989

  • Chamberlain CG, McAvoy JW. Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF). Growth Factors 1989;1:125-134.
  • Lovicu FJ, McAvoy JW. Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF). Exp Eye Res. 1989;49:479-494.
  • McAvoy JW, Chamberlain CG. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development 1989;107:221-228.
  • Parmigiani CM, McAvoy JW. A morphometric analysis of the development of the rat lens capsule. Curr Eye Res. 1989;8:1271-1277.
  • Richardson NA, McAvoy JW. An enzyme-linked immunosorbent assay for the quantitation of DNA. J Immunol Meth. 1989;125:287-289.