Selected publications:



Sean Lal, Amy Li and Cris dos Remedios. Limitations in translating animal
studies to humans in cardiovascular disease. (2016) Journal of Cardiovascular
Translational Research April 9(2): 165-6

James McNamara, Amy Li, Nicola Smith, Sean Lal, Bob Graham, KB Kooiker,
Jenny Van Diik, Cris dos Remedios, Samantha Harris and Roger Cooke. Ablation
of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in
murine cardiomyocytes. (2016) Journal of Molecular and Cellular Cardiology
March 26(94): 65-71

Sean Lal, Lisa Nguyen, Rhenan Tezone, Fredrik Ponten, Jacob Odeberg, Amy Li
and Cristobal dos Remedios. Tissue MicroArray (TMA) Profiling in Human Heart
Failure. (2016) Proteomics September 16(17): 2319-26.

Sean Lal, Lisa Turner, Catherine Powell, Michael Wilson and Paul Bannon.
Improvements in Left Ventricular Ejection Fraction and Quality of Life in
Patients with Heart Failure who undergo Coronary Artery Bypass Surgery. (2016)
International Journal of Cardiology Volume 222 (1), Pages 671–673

Nelson Wang and Sean Lal. Post-dilation in Transcatheter Aortic Valve
Replacement: A Systematic Review and Meta-analysis. (2017) Journal of
Interventional Cardiology Mar 21

Crossman DJ, Shen X, Jüllig M, Munro M, Hou Y, Middleditch M, Shrestha
D, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C.
Increased collagen within the transverse tubules in human heart failure. (2017)
Cardiovasc Research. 2017 Apr 20

McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ,
Cooke R, Dos Remedios CG. MYBPC3 Mutations are associated with a reduced
Super-relaxed State in patients with Hypertrophic Cardiomyopathy. (2017) PLoS
One Jun 28;12(6):e0180064.

C. G. dos Remedios, S. P. Lal, A. Li, J. McNamara, A. Keogh, P. S. Macdonald,
R. Cooke, E. Ehler, R. Knöll, S. B. Marston, J. Stelzer, H. Granzier, C. Bezzina,
van Dijk, F. De Man, G. J. M. Stienen, J. Odeberg, F. Pontén, W. Linke, J. van
Velden. The Sydney Heart Bank: improving translational research while
eliminating or reducing the use of animal models of human heart disease. (2017)
Biophysical Reviews 14th August

Jim Ge and Sean Lal. Human Cardiac Regeneration: New Cells in Old Hearts
Revisited. (2017) Cardiology Today 2017; 7(2): 17-19.

Ranganath Mamidi, Jiayang Li, Kenneth S. Gresham, Chang Yoon Doh, Amy Li,
Sean Lal, Cristobal G. dos Remedios and Julian E. Stelzer. Dose-dependent
effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and
force generation in failing human myocardium. (2017) in press Circulation Heart

Nelson Wang, Jordan Fulcher, Nishan Abeysuryia, Mark Adams, Sean Lal.
Predictors of Successful Chronic Total Occlusion Percutaneous Coronary
Interventions: A systematic review and meta-analysis. (2017) in press British
Medical Journal Heart

Sean Lal, Irina Kotchetikova, Jacob Cao, Daniel Jackson, Rachael Cordina and
David S Celermajer. Heart failure admissions and poor subsequent outcomes in
adults with congenital heart disease. (2017) in press European Journal of Heart

Petr Vikhorev, Natalia Smoktunowicz, Alex Munster, O’Neal Copeland. Sawa
Kostin, Cecile Montgiraudi, Andrew Messer, Mohammad Toliat, Amy Li,
Cristoboal dose Remedios, Sean Lal, Cheavar Blair, Kenneth Campbell, Maya
Guglin, Ralph Lnoll, Steven Marston. Abnormal contractility in human heart
myofibrils from patients with dilated cardiomyopathy due to mutations in TTN
and contractile protein genes. (2017) in press Nature Scientific Reports



1.         Penninger J, Haubner B, dos Remedios C, Sangita C, Bennet D, Walsh S, Ganapathy B, Polizzotti B, Ammanarmanchi N. (submitted) Stimulation of cardiomyocyte regeneration in neonatal mice and in human myocardium with neuregulin reveals a therapeutic window. Science Translational Medicine (#5171) Accepted April 1, 2015.

2.         Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, Szewczykowska M,  dos Remedios C, Malm T, Nyengaard R, Possnert G, Jovinge S, Klinikapediatrii K, Sjos S, Jashari R, Druid H, Andrae M, Frisen J. Dynamics of cell generation and turnover in the human heart. Cell (in press) -D-15-00115R2.    

3.         Dwyer J, Pluess M, Iskratsch T, dos Remedios CG, Ehler E. (2015) The formin FHOD1 in cardiomyocytes. Anatomical Record 297: 1560-1570.

4.         Li A, dos Remedios CG (2015) Special Issue on human heart failure (Editorial). Biophysical Review 7: 1-3.

5.         McNamara JW, Li A, dos Remedios CG, Cooke R. (2015) The role of super-relaxed myosin in skeletal and cardiac muscle. Biophysical Reviews 7: 5-14.

6.         Kagemoto T, Li, A, dos Remedios CG, Ishiwata S. Spontaneous oscillatory contraction (SPOC) in cardiomyocytes. Biophysical Reviews 7: 15-24.

7.         Pleuss M, Daeubler G, dos Remedios CG, Ehler E. (2015) Adaptations of cytoarchitecture in human dilated cardiomyopathy. Biophysical Reviews 7: 25-32. DOI 10.1007/s12551-014-0146-2.

8.         Ge Z, Lal S, Le TYL, dos Remedios CG, Chong JJH (2015) Cardiac stem cells: translation to human studies. Biophysical Reviews 7: 127-139. DOI 10.1007/s12551-014-0148-0



7.         Kosobrodova E, Mohamed A, Su Y, Kondyurin A, dos Remedios CG, McKenzie DR, Bilek MMM. (2014) Cluster of differentiation antibody microarrays on plasma ion immersion implanted polycarbonate. Materials Science and Engineering: C 35: 434-440. Conference. AIP Conference Proceedings, vol. 1525, 2013, pp. 364–369,

8.         Saba A, Donzelli R, Colligiani D, Raffaelli A, Nannipien M, Kusmic C, dos Remedios C, Simonides WS, Iervasi G, Zucchi R. (2014) Quantification of thyroxine and 3,5,3’-triiodothyronine in human and animal heart by a novel liquid chromatography - tandem mass spectrometry method. Hormone and Metabolic Research 46: 1-7.

9.         Manders E, Bogaard H-J, Handoko ML, van de Veerdonk M, Keogh A, Westerhof N, Stienen GJM, dos Remedios CG, Humbert M, Dorfmüller P, Fadel E, Guignabert C, van der Velden J, Vonk-Noordegraaf  A, de Man FS, Ottenheijm CAC. (2014) Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension. Journal of the American College of Cardiology 64: 28-37.

10.      Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, can der Velden J. (2014) Phosphorylation of protein kinase C sites Ser42/44 decreases Ca2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. Archives of Biochemistry and Biophysics 554: 11-21.

11.      Rain S, Denielli, Bos D, Handoko ML, Westerhof N, Ger Stienen G, Ottenheijm C, Goebel, Dorfmüller P, Guignabert C, Humbert M, Bogaard HJ, dos Remedios C, Saripalli C, Hidalgo CG, Henk L. Granzier, Vonk-Noordegraaf A, van der Velden J, de Man FS. (2014) Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension. Journal of the American Heart Association 3: e000716. (doi: 10.1161/JAHA.113.000716).

12.      Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AMC, Christiaans I, Wilde AAM, dos Remedios C, Lammertsma AA. van Rossum AC, Stienen GJM, van Slegtenhorst M, Schinkel AF, Michels M, Ho CY, Poggesi C, van der Velden J. (2014) Gene-specific increase in energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations. Cardiovascular Research 103: 248-257.

13.      Walweel K, J. Li J, Molenaar P, Imtiaz1 MS, Quail A, dos Remedios CG, Beard NA, Dulhunty AF, van Helden1 DF, Laver DR. (2014) Regulation of human RyR2 by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.  Journal of General Physiology 144: 263-271.

14.      Chahine MN, Mioulane M, Sikkel MB, O’Gara P, dos Remedios CG, Pierce GN, Lyon AR, Foldes G, Harding SE. (2014) Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. Cardiovascular Research 105: 31-43.

15.      Koopmann T, Adriaens M, Moerland P, Marsman R, Westerveld M, Lal S, Zhang T, Simmons C, Baczko I, dos Remedios C, Bishopric N, Varro A, George A, Lodder E, Bezzina C. (submitted to PLoS ONE 9: (e97380. doi: 10.1371/journal.pone.0097380. eCollection 2014



16.      Sequeira V, Wijnker PJM, Nijenkamp LAM, Najafi A, Rosalie Witjas-Paalberends R, Regan JA, Boontje N, ten Cate F, Carrier L, Sadayappan S, van Slegtenhorst M, Zaremba R, Foster DB, Murphy A, Poggesi C, dos Remedios C, Stienen GJM, Michels M, van der Velden J. (2013) Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins. Circulation Research 112: 1491-1505.

17.      Bayliss CR, Jacques AM, Leung MC, Ward DG, Redwood CS, Gallon CE, Copeland O, McKenna WJ, dos Remedios C, Marston SB, Messer AE. (2013) Myofibrillar Ca2+-sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T. Cardiovascular Research 97: 500-508. Hamdani N, Krysiak J, Kreusser M, Neef S, dos Remedios C, Maier L, Krüger M, Backs J, Linke W. (2013) Crucial role for Ca2+/calmodulin dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circulation Research 112: 664-674.

18.      Lin M-W, Ho JWK, Harrison L, dos Remedios CG, Adelstein S. (2013) An antibody-based leukocyte-capture microarray for the diagnosis of Systemic Lupus Erythematosus. PLoS ONE 4: 179-189.

19.      Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, dos Remedios CG, Graham D, Colan S, Kühn B. (2013) Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Science USA. 110: 1446-1451. Memo M, Leung MC, Ward DG, dos Remedios C, Morimoto S, Zhang L, Ravenscroft G, McNamara E, Nowak KJ, Marston SB, Messer AE. (2013) Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes In myofibrillar Ca2+-sensitivity. Cardiovascular Research 99: 65-73.

20.      Witjas-Paalberends P, Tencate FJ, Michels M, Niessen JWM, Poggesi C, Piroddi N, Ferrara C, Scellini B, Hazebroek M, Heymans S, Tesi C, Stienen GJM, Vanslegtenhorst M, van Dijk S, Olivera S, dos Remedios CG, van der (2013)  J. (2013) Cellular dysfunction in hypertrophic cardiomyopathy. Cardiovascular Research 99: 432-441.

21.      VelonasVM, Woo HH, dos Remedios CG, Assinder SJ (2013) Current status of biomarkers for prostate cancer. International Journal of Molecular Sciences (accepted May 14, 2013).

22.      Li A, Estigoy C, Raftery M, Cameron D, Odeberg J, Ponten F, Lal S, dos Remedios CG (2013) Heart research advances using database search engines, Human Protein Atlas and the Sydney Heart Bank. Heart Lung Circulation 22: 819-826.

23.      Rain S, Handoko ML, Westerhof N, Stienen GJM, Paulus WJ, Ottenheijm CAC, Marcus JT, Dorfmuller P, Guignabert C, Humbert M, McDonald P, dos Remedios CG, Postmus PE, Vonk-Noordegraaf A, Van der Velden J, De Man FS. (2013) Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation 128: 2016-2025.

24.      Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD. (2013) Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nature Genetics 45: 822-824. Koetter S, Gout L, Van Frieling-Selawsky M, Müller AE, Helling S, Marcus K, dos Remedios C., Linke W, Krüger M. (2013) Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. Cardiovascular Research 99: 648-656.

25.      Kooij V, Zhang P, Piersma SR, Sequeira V, Boontje NM, Wijnker PJM, Jiménez KE, dos Remedios C, Murphy AM, Van Eyk JE, van der Velden J, Stienen GJM. (2013) PKCα-specific phosphorylation of the troponin complex in human myocardium: A functional and proteomics analysis. PLoS ONE 8: e74847 (doi: 10.1371/journal.pone.0074847).

26.      Marsman RFJ, Bezzina C, Freiberg F, Verkerk A, Adriaens M, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann T. Baczko I, dos Remedios CG, George A Jr, Bishopric N, Lodder EM, de Bakker J, Fischer R, Coronel R, Wilde A, Gotthardt M, Remme CA. (2013) Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Journal of Molecular and Cellular Cardiology 63: 549-559.

27.      Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J (2014) Phosphorylation of protein kinase C sites Ser42/44 decreases Ca2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. Archives of Biochemistry and Biophysics 554: 11-21.

28.      Kuster DW, Mulders J, Ten Cate FJ, Michels M, dos Remedios CG, da Costa Martins PA, van der Velden J, Oudejans CB. (2013) MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations. Journal of Molecular and Cellular Cardiology 65: 59-66.

29.      van Dijk SJ, Boontje NM, Heymans MW, ten Cat FJ, Michels M,dos Remedios C, Dooijes D, van Slegtenhorst MA, van der Velden J, Stienen GJM. (2013) Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations. Pflügers Archiv - European Journal of Physiology 466: 1619-1633.



30.      van Dijk SJ, Paalberends RE, Najafi A, Michels M, Sadayappan S, Carrier L, Boontje NM, Kuster D, van Slegtenhorst M, Dooijes D, dos Remedios CG, ten Cate FJ, Stienen GJM, van der Velden J. (2012) Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation Heart Failure 5: 36-46.

31.      Li A, Ponten F, dos Remedios CG. (2012) The interactome of LIM domain proteins: The contributions of LIM domain proteins to heart failure and heart development. Proteomics 12: 203–225.

32.      Wriggers W, Olson W, dos Remedios CG. (2012) Computational opportunities for remote collaboration and capacity building afforded by web 2.0 and Cloud computing. Biophysical Reviews 4: 152-160.

33.      dos Remedios CG, Nakamura H (2012) Editorial: Special Issue on computational biophysics. Biophysical Reviews 4: 149-152.

34.      Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell BW, Natarajan R, dos Remedios C, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee JW, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF. (2012) Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy due to pulmonary arterial hypertension. Circulation: Heart Failure 6: 136-144.

35.      Liang LH, Khammy O, Byrne M, Amirahmadi F, Foster A, Li G, Zhang L, dos Remedios C, Chen C, Kaye DM. (2012) Irregular rhythm adversely influences calcium handling in ventricular myocardium: Implications for the interaction between heart failure and atrial fibrillation. Circulation Heart Failure 5:786-793.

36.      Wijnker P, Foster D, Allison D, Tsao A, Frazier A, dos Remedios C, Murphy A, Stienen G, van der Velden J. (2013) Impact of site-specific phosphorylation of the protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes. American Journal of Physiology Heart and Circulatory 304: H260-H268.

37.      Zhang P, Kirk JA, Ji W, dos Remedios CG, Kass DA, Van Eyk JE, Murphy AM. (2012) Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation 126: 828-1837.

38.      Kuster D, Sequeira V, Najafi A, Boontje N, Wijnker P, Paalberends E, Marston S, dos Remedios C, Carrier L, Demmers J, Redwood C, Sadayappan S, van Der Velden J. (2012) GSK3β phosphorylates newly identified site in the Pro-Ala rich region of cardiac myosin binding protein C and alters cross-bridge cycling kinetics in humans. Circulation Research 112: 633-639.



39.      Foreman AL, Phillips L, Kanellis VG, Hammoudeh D, Naumann C, Wong H, Chisari R, Hibbert DB, Lee GCH, Patra R, Julli M, Chapman J, Cooke AR, dos Remedios CG. (2011) A DNA-based assay for toxic chemicals in wastewater. Environmental Toxicology and Chemistry 30: 1810-1818.

40.      Maeder M, Khammy O, dos Remedios C, Kaye D. (2011) Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. Journal of the American College of Cardiology. 58: 474-480.

41.      Wolfe JE, Ishiwata S, Braet F, Whan R, Su Y, Lal S, dos Remedios CG. (2011) SPontaneous Oscillatory Contraction (SPOC): Auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews 3: 53-62.

42.      Changsirivathanathamrong D, Wang Y, Rajbhandari D, Maghzal GJ, Mak WM, Woolfe C, Anzaca FF, Duflou J, Gebski V, dos Remedios CG, Celermajer DS, Stocker R. (2011) Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Critical Care Medicine 39: 2679-2683.

43.      Bilek M, Bax D, Kondyurin A, Yin Y, Nosworthy N, Fisher K, Waterhouse A, Weiss A, dos Remedios C, McKenzie D. (2011) Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Science USA 108: 14405-14410.

44.      Morales M, dos Remedios CG. (2011) Biophysical educational experiment: Science and goodwill in Latin America and Africa.  Biophysical Reviews 3: 101-106.

45.      Polden J, McManus CA, dos Remedios C, Dunn MJ. (2011) A 2-D gel reference map of the basic human heart proteome.  Proteomics 11: 3582-3586.

46.      Hirsh SL, Nosworthy NJ, Kondyurin A, dos Remedios CG, McKenzie DR, Bilek MM (2011) Linker-free covalent thermophilic β-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry 21: 17832-17841.

Wijnker PJM, Bolnik P, Gergs U, Muller F, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJM, van der Velden J, Kirchhefer U. (2011) Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing myocardium. Journal of Muscle Research Cell Motility 32: 221-223.