Publications

CONTENTS

Selected Publications

Major Collaborations
Cover Photos
Images


Selected Publications

Angiogenesis/Vascular Biology

  1. Chan-Ling T, Halasz P and Stone J, “Development of retinal vasculature in the cat: processes and mechanisms” (1990) 9 Current Eye Research 459-478. (1.113) [82]
  2. Chan-Ling T, Gock B and Stone J, “The effect of oxygen on vasoformative cell division: Evidence that 'Physiological hypoxia' is the stimulus for normal retinal vasculogenesis” (1995) 36 Investigative Ophthalmology and Visual Science 1201-1214. (Highest ranking journal for ophthalmology: IF: 4.148) [93] (e-publication at http://www.iovs.org/cgi/content/abstract/36/7/1201)
  3. Stone J, Itin A, Alon T, Pe’er Y, Gnessin H, Chan-Ling T and Keshet E, “Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia” (1995) 15 Journal of Neuroscience 4738-4747. (8.306) [389] (e-publication at http://www.jneurosci.org/cgi/content/abstract/15/7/4738)
  4. Contribution by personal invitation: Chan-Ling T, “Glial, neuronal and vascular cytogenesis in whole-mounted cat retina” (1997) 36(1) A special issue of Microscopy Research and Technique on retinal histology 1-16. (2.307) [58] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/55932/ABSTRACT)
  5. Hughes S, Yang H, and Chan-Ling T, “Vascularisation of the human fetal retina: Roles of vasculogenesis and angiogenesis” (2000) 41(5) Investigative Ophthalmology and Visual Science 1217-1228. (4.148) [57] (e-publication at: http://www.iovs.org/cgi/reprint/41/5/1217?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=hughes&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=41&resourcetype=HWCIT)
  6. Hughes S and Chan-Ling T, “Roles of endothelial cell migration and apoptosis in vascular remodelling during development of the central nervous system” (2000) 7 Microcirculation 317-333. (2.911) [20] (e-publication at http://taylorandfrancis.metapress.com/(iy2kt1ipdb2jhauo4gxeu445)/app/home/contribution.asp?referrer=parent&backto=issue,3,6;journal,43,55;linkingpublicationresults,1:111039,1)
  7. Morcos Y, Hosie MJ, Bauer HC and Chan-Ling T, “Immunolocalisation of occludin and claudin-1 to tight junctions in intact CNS vessels of mammalian retina” (2001) 30(2) Journal of Neurocytology 107-123. (0.880) [23] (e-publication at http://www.springerlink.com/content/u4742p7175r65603/)
  8. Chan-Ling T, McLeod S, Hughes S, Chu Y, Baxter L, Hasegawa T and Lutty G, “Astrocyte-endothelial cell relationships during human retinal vascular development” (2004) 45(6) Investigative Ophthalmology and Visual Science 2020-2032. (Highest ranking journal for ophthalmology: IF: 4.148) [27]. (e-publication at http://www.iovs.org/cgi/content/abstract/45/6/2020)
  9. Hughes S and Chan-Ling T, “Characterisation of smooth muscle cells and pericyte differentiation in the rat retina in vivo” (2004) 45(8) Investigative Ophthalmology and Visual Science 2795-2806. (Highest ranking journal for ophthalmology: IF: 4.148) [36] (e-publication at http://www.iovs.org/cgi/content/abstract/45/8/2795)
  10. Chan-Ling T, Koina M, McColm JR, Dahlstrom JE, Bean E, Adamson S, Baxter L “CD44+ stem cells have a role in mural cell formation in the human choroid, while choroidal vessels have limited pericyte ensheathment”. Investigative Ophthalmology and Visual Science. (2011) 52 (1) Investigative Ophthalmology and Visual Science 399-410 (http://www.iovs.org/content/52/1/399.abstract?related-urls=yes&legid=iovs;52/1/399) (Impact Factor 3.431)
  11. Chan-Ling T, Dahlstrom JE, Koina M, McColm JR, Sterling RA, Bean EG, Adamson S, Hughes S and Baxter LC, “Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels” (2011) 92 (5) Experimental Eye Research 361-376 (http://www.sciencedirect.com/science/article/pii/S0014483511000431) (Impact Factor 2.538)


Astrocyte Biology

  1. Chan-Ling T and Stone J, “Factors determining the migration of astrocytes into the developing retina: Migration does not depend on intact axons or patent vessels” (1991) 303(3) Journal of Comparative Neurology 375-386. (3.672) [57] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/109691551/ABSTRACT)
  2. Chan-Ling T and Stone J, “Factors determining the morphology and distribution of astrocytes in the cat retina: A ‘contact-spacing’ model of astrocyte interaction” (1991) 303(3) Journal of Comparative Neurology 387-399. (3.672) [43] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/109691552/ABSTRACT)
  3. Holländer H, Makarov F, Dreher Z, van Driel D, Chan-Ling T, Stone J, “Structure of the macroglia of the retina: the sharing and division of labour between astrocytes and Muller cells” (1991) 313 Journal of Comparative Neurology 587-603. (3.672) [109] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/109692051/ABSTRACT)
  4. Tout S, Dreher Z, Chan-Ling T and Stone J, “Contact-Spacing among astrocytes is independent of neighbouring structures In vivo and In vitro evidence” (1993) 332 Journal of Comparative Neurology 433-443. (3.672) [9] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/109692953/ABSTRACT)
  5. Tout S, Chan-Ling T, Höllander H and Stone J, “The role of Müller cells in the formation of the blood-retinal barrier” (1993) 55 Neuroscience 291-301. (3.601) [73] (e-publication at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0F-485GF0K-6W&_coverDate=07%2F31%2F1993&_alid=502428315&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4861&_sort=d&view=c&_acct=C000008818&_version=1&_urlVersion=0&_userid=115085&md5=dfbce7a57beb9010ab9a642135bde470)
  6. Morcos Y and Chan-Ling T, “Identification of oligodendrocyte precursors in the myelinated streak of the adult rabbit retina in vivo” (1997) 21(2) GLIA 163-182. (4.677) [9] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/53774/ABSTRACT)
  7. Morcos Y, Shorey CDS and Chan-Ling T, “Contribution of O4+ oligodendrocyte precursors and astrocytes to the glial ensheathment of vessels in the rabbit myelinated streak” (1999) 27 GLIA 1-14. (4.677) [3] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/62003526/ABSTRACT)
  8. Morcos Y and Chan-Ling T, “Concentration of astrocytic filaments at the retinal optic nerve junction is coincident with the absence of intra-retinal myelination: comparative and developmental evidence” (2000) 29 Journal of Neurocytology 665-678. (0.880) [13] (e-publication at http://www.springerlink.com/content/v7vhu6418850r850/)
  9. Chu Y, Hughes S, and Chan-Ling T, “Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma” (2001) 15(11) FASEB Journal 2013. (14.6) [30] (Please note the content of this 3-page summary is different to the full report that appeared on line.) (e-publication at http://www.fasebj.org/cgi/content/short/15/11/2013)
  10. Kuo IY, Chan-Ling T, Wojcikiewicz RJ, and Hill CE, “Limited intravascular coupling in the rodent brainstem and retina supports a role for glia in regional blood flow”. (2008) 511 The Journal of Comparative Neurology 773-787. (Impact Factor: 3.915) (e-publication at: http://www3.interscience.wiley.com/cgi-bin/fulltext/121454717/PDFSTART)
  11. Chan-Ling T, Baxter L, Weible II MW and Hughes S, “In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae; differentiation, proliferation and apoptosis”. (2009) 57 Glia 39-53. Impact Factor: 5.380)(Plus Cover Photo) (e-publication at: http://www3.interscience.wiley.com/cgi-bin/fulltext/120853974/PDFSTART)
  12. Contribution by personal invitation: Chan-Ling T, “Glial, neuronal and vascular interactions in the mammalian retina” Progress in Retinal Research. Eds N. Osborne & G. Chader. Pergamon Press, Oxford. Vol 13, 357-389 1994.[39]


Neuropathology

  1. Chan-Ling T, Neill AL and Hunt N, “Early microvascular changes in murine cerebral malaria detected in retinal wholemounts” (1992) 140 American Journal of Pathology 1121-1130. (6.946) [50]
  2. Medana L, Chan-Ling T and Hunt NH, “Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: relationship to disruption of the blood-retinal barrier” (1996) 16 GLIA 51-64. (Plus Cover Photo) (4.677) [30] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/70755/ABSTRACT)
  3. Ma N, Hunt N, Madigan M and Chan-Ling T, “Correlation between enhanced vascular permeability, up-regulation of cellular adhesion molecules and monocyte adhesion in the retina during fatal murine cerebral malaria” (1996) 149 American Joruanl of Pathology 1745-1762. (6.946) [36] (e-publication at http://ajp.amjpathol.org/cgi/content/abstract/149/5/1745)
  4. Ma N. Madigan M, Chan-Ling T and Hunt N, “Compromised blood-nerve barrier, astrogliosis, and myelin disruption in optic nerves during fatal murine cerebral malaria” (1997) 19(2) GLIA 135-151. (4.677) [20] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/53693/ABSTRACT)
  5. Medana L, Hunt N and Chan-Ling T, “Early activation of microglia in the pathogenesis of fatal murine cerebral malaria” (1997) 19(2) GLIA 91-103. (Plus cover photo) (4.677) [51] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/53689/ABSTRACT)
  6. Hu P, Pollard J, Hunt N, Taylor J, and Chan-Ling T, “Microvascular and cellular responses in the optic nerve of rats with acute experimental allergic encephalomyelitis (EAE)” (1998) 8(3) Brain Pathology 475-486. (8.512) [21]
  7. Hu P, Pollard J, Hunt N and Chan-Ling T, “Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE)” (1998) 8(3) Brain Pathology 487-498. (8.512) [11]
  8. Medana I, Chan-Ling T and Hunt NH, “Reactive changes of retinal microglia during fatal murine cerebral malaria: effects of dexamethasone and experimental permeabilisation of the blood-brain barrier” (2000) 156(3) American Journal of Pathology 1055-1065. (6.946) [14] (e-publication at http://ajp.amjpathol.org/cgi/content/full/156/3/1055)
  9. Hughes S, Yang H, and Chan-Ling T, “Vascularisation of the human fetal retina: Roles of vasculogenesis and angiogenesis” (2000) 41(5) Investigative Ophthalmology and Visual Science 1217-1228. (4.148) [57] (e-publication at: http://www.iovs.org/cgi/reprint/41/5/1217?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=hughes&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=41&resourcetype=HWCIT)
  10. Potter SM, Chan-Ling T, Rosinova E, Ball HJ, Mitchell A, Hunt NH, “A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria” (2006) 173(1-2) Journal of Neuroimmunology 96-107. (IF: 2.880)[12] (e-publication at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T03-4J2M46R-1&_coverDate=04%2F30%2F2006&_alid=502358152&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4851&_sort=d&view=c&_acct=C000008818&_version=1&_urlVersion=0&_userid=115085&md5=b32b113438eb7a356f9a28dbb0e1ffe0)
  11. Potter SM, Chan-Ling T, Ball HJ, Mitchell A, Maluish L, Mansour H, Hunt NH, “Perforin mediated apoptosis of cerebral Microvascular endothelial cells during experimental cerebral malaria” (2006) 36 International Journal of Parasitology 485-496. (IF: 3.337)[13] (e-publication at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7F-4J2VXXT-1&_coverDate=04%2F30%2F2006&_alid=502363882&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5057&_sort=d&view=c&_acct=C000008818&_version=1&_urlVersion=0&_userid=115085&md5=ffda534149f6e9fdcc7e539fcb8ba2f0)
  12. Medana, IM, Chaudhri, G Chan-Ling, T & Hunt, NH, “The central nervous system in cerebral malaria: "innocent bystander" or active participant in the induction of pathology?” (2001) 79(2) Immunology and Cell Biology 101-120. (2.531) [21] (e-publication at http://www.blackwell-synergy.com/doi/abs/10.1046/j.1440-1711.2001.00995.x)
  13. Hunt NH, Golenser J, Chan-Ling T, Parekh S, Rae C, Potter S, Medana IM, Miu J, Ball HJ, “Immunopathogenesis of cerebral malaria. (Review)” (2006) 36 International Journal of Parasitology 569-582. (Rank 9 out of 20 in the field of Parasitology IF: 3.092) [26] (e-publication at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7F-4JHMH45-2&_coverDate=05%2F31%2F2006&_alid=502360141&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5057&_sort=d&view=c&_acct=C000008818&_version=1&_urlVersion=0&_userid=115085&md5=8263e564017a769227cebd12a5067e5e


Retinopathy of Prematurity

  1. Chan-Ling T, Tout S, Holländer H and Stone J, “Vascular changes and their mechanisms in the feline model of Retinopathy of prematurity” (1992) 33 Investigative Ophthalmology and Visual Science 2128-2147. (Highest ranking journal for ophthalmology: IF: 4.148) [56] (e-publication at http://www.iovs.org/cgi/content/abstract/33/7/2128)
  2. Chan-Ling T and Stone J, “Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier” (1992) 33 Investigative Ophthalmology and Visual Science 2148-2159. (Highest ranking journal for ophthalmology: IF: 4.148) [41] (e-publication at http://www.iovs.org/cgi/content/abstract/33/7/2148)
  3. Chan-Ling T, Gock B and Stone J, “Supplemental oxygen therapy: Basis for non-invasive treatment of retinopathy of prematurity” (1995) 36 Investigative Ophthalmology and Visual Science 1215-1230. (Highest ranking journal for ophthalmology: IF: 4.148) [37] (e-publication at http://www.iovs.org/cgi/content/abstract/36/7/1215)
  4. Stone J, Chan-Ling T, Pe'er J, Itin A, Gnessin H and Keshet E, “Roles of VEGF and astrocyte degeneration in the genesis of retinopathy of prematurity” (1996) 37 Investigative Ophthalmology and Visual Science 290-299. (Highest ranking journal for ophthalmology: IF: 4.148) [140] (e-publication at http://www.iovs.org/cgi/content/abstract/37/2/290)
  5. Chan-Ling T and Hughes S, “Cell-cell interactions in the formation of the human retinal vasculature. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery (November 2003, Anaheim, California)” (2006) Molecular Vision. (e-publication at http://www.molvis.org/molvis/v12/a63/) (2.777) [2]
  6. Flynn JT & Chan-Ling T: “Retinopathy of prematurity: two distinct mechanisms that underlie zone 1 and zone 2 disease” (2006) 142(1) American Journal of Ophthalmology 46-59. (Ranked 9 out of 42 in the field of ophthalmology with IF: 2.3) [10] (e-publication at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VK5-4K9JB47-6&_coverDate=07%2F31%2F2006&_alid=502357525&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6113&_sort=d&view=c&_acct=C000008818&_version=1&_urlVersion=0&_userid=115085&md5=c8126669335f463e83edab0e9376043c) [2]
  7. Hughes S, Gardiner T, Baxter L, Chan-Ling T, “Smooth muscle cell and pericyte changes underlie pathogenesis of Plus Disease in Retinopathy of Prematurity” (2006) Nature Biotech Winter symposium on Angiogenesis, Miami Feb, 2006 Short report, web-based at www.med.miami.edu/mnbws/06Chan-Ling.pdf.
  8. Hughes S, Gardiner T, Baxter L, Chan-Ling T, “Changes in pericytes and smooth muscle cells in the kitten model of Retinopathy of Prematurity (ROP): Implications for plus disease” (2007) 48 Investigative Ophthalmology and Visual Science 1368-1379. (IF: 4.418) [2] (e-publication at: http://www.iovs.org/cgi/reprint/48/3/1368?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=hughes+s&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT)
  9. Invited review as the 1994 Australian Life Sciences Research awardee: Chan-Ling T, “From Kittens to Babies: The gift of sight” (1995) 7 Today's Life Science 26. (n/a) [n/a]


Stem Cell Biology

  1. Chan-Ling T, Baxter L, Afzal A, Sengupta N, Caballero S, Rosinova E and Grant MB, “Hematopoietic stem cells provide repair functions after laser-induced Bruch’s membrane rupture model of choroidal neovascularisation” (2006) 168(3) American Journal of Pathology 1031-1044. (Highest ranking journal in pathology with impact factors of 8.51) [20] (e-publication at http://ajp.amjpathol.org/cgi/content/abstract/168/3/1031)
  2. Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, and Grant MB, “IGF Binding Protein-3 Regulates Hematopoietic Stem and Endothelial Precursor Cell Differentiation, Migration and Retinal Development” (2007) 104 Proceedings of the National Academy of Sciences (PNAS) 10595(Impact Factor: 15.053) [14]. (e-publication at: http://www.pnas.org/cgi/reprint/104/25/10595)
  3. Weible MW II and Chan-Ling T, “Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes” (2007) 55(11) Glia 1156-68 (Impact Factor: 5.500)(Plus Cover photo) [5] (e-publication at: http://www3.interscience.wiley.com/cgi-bin/fulltext/114284388/PDFSTART)
  4. Kielczewski JL, McFarland EL, Jarajapu Y, Afzal A, Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Cai J, Boulton ME, Mames RN, Gardiner T, Chan-Ling T, and Grant MB, “Insulin-like growth factor binding protein-3 (IGFBP-3) mediates vascular repair by enhancing nitric oxide generation”. (2009) 105 Circulation Research 897-905 Note: Kielczewski and McFarland and the two senior authors Chan-Ling and Grant contributed equally to this manuscript. J Circulation Research (IF: 12.755)
  5. Howitt J, Putz U, Lackovic J, Doan A, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S and Tan SS. Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. (2009) 106(36) Proceedings of the National Academy of Sciences (PNAS )15489-15494
  6. Kielczewski JL, Hu P, Shaw LC, Li Calzi S, Mames RN, Gardiner TA, McFarland E, Chan-Ling T, Grant MB “Novel Protective Properties of IGFBP-3 Result in Enhanced Pericyte Ensheathment, Reduced Microglial Activation, Increased Microglial Apoptosis, and Neuronal Protection after Ischemic Retinal Injury” (2011) The American Journal of Pathology 178 (4) 1517-1528 (http://www.sciencedirect.com/science/article/pii/S0002944011000198) (Impact Factor 5.673) [Please note that TCL and Grant are equal senior authors]
  7. Kielczewski J, Li Calzi S, Shaw L, Cai . Qi X, Ruan Q, Wu L, L Li, Hu, P, Chan-Ling T, Mames R; Firth S, Baxter R, Turowski P, Busik J, Boulton, M; Grant, M “Free Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase)” (2011) Investigative Ophthalmology and Visual Science 52(11):8278-86


Ageing

  1. Hughes S, Gardiner T, Hu P, Baxter E, Rosinova E and Chan-Ling T, “Altered pericyte-endothelial relations in the aging rat retina: Implications for vessel stability” (2006) 27(12) Neurobiology of Aging 1838-1847. [11] (Highest impact factor under gerontology: 5.55) E article, available, Nov 2005. http://www.neurobiologyofaging.org/article/PIIS0197458005003490/abstract
  2. Chan-Ling T, Hughes S, Baxter L, Rosinova E, McGregor I, Morcos Y, van Nieuwenhuyzen, PS and Hu P, “Inflammation and breakdown of the blood-retinal barrier during ‘physiological aging’ in the rat retina: a model for CNS aging” (2007) 14(1) Microcirculation 63. (IF: 2.955) [13] (e-publication at http://www.informaworld.com.ezproxy2.library.usyd.edu.au/smpp/content~content=a769178550~db=all~order=page)
  3. Mansour H, Chamberlain CG, Weible II MW, Hughes S, Chu Y and Chan-Ling T, “Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces availability of astrocytes to neurons”. (2008) 7(4) Aging Cell 526-540. (Impact Factor: 5.854) (e-publication at: http://www3.interscience.wiley.com/cgi-bin/fulltext/119879262/PDFSTART)
  4. Hunt GE, Nieuwenhuijzen PSV, Chan-Ling T and McGregor IS, “When an old rat smells a cat': a decline in defense-related, but not accessory olfactory, Fos expression in aged rats” 2009 Neurobiology of Aging 25th March 2009 In Press [IF: 5.999]
  5. Braidy, N; Guillemin, G; Mansour, H; Chan-Ling, T; Grant, R “Age related Changes in NAD+ Metabolism Oxidative stress and Sirt1 activity in Wistar Rats” (2011) PLoS ONE 6 (4) e19194 (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019194) (Impact Factor 4.351)
  6. Braidy, N; Guillemin, G; Mansour, H; Chan-Ling, T; Grant, R “Changes in Kynurenine Pathway Metabolism During Aging” (2011) FEBS Journal 278 4425–4434


Book Chapters

  1. Contribution by personal invitation: Chan-Ling T: The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface. In: Dermietzel, R., Spray, D. C., Nedergaard, M. (Eds.): Blood-Brain Barriers - From Ontogeny to Artificial Interfaces. Wiley-VCH, Weinheim, p. 701-724. 2006.
  2. Contribution by personal invitation: Chan-Ling T: Vasculogenesis and angiogenesis in formation of the retinal vasculature: cell-cell interactions and molecular cues. In Penn, J (Ed): Retinal and Choroidal Angiogenesis.Springer, The Netherlands, Chapter 6 p. 119-138, 2008.
  3. Chan-Ling T: “Vascular biology: Development of the Retinal Vasculaure”. In D’Amore P (Section Ed.). Encyclopedia of the Eye, Academic Press, London, 2010

Major Collaborations

  • Professor Maria Grant - Department of Pharmacology & Therapeutics, University of Florida
    Collaborative studies to maximise the repair functions of hematopoietic stem cells in stemming vision loss. This work is funded by the Department of Educations, Science and Technology’s International Science Linkages Program.
  • Professor John Flynn – Harkness Eye Institute, Columbia University
    Understanding Retinopathy of Prematurity: The Gift of Sight. Professor Chan-Ling currently holds the appointment of Adjunct Professor of Ophthalmic Science(Ophthalmology) at the Harkness Eye Institute of the Columbia University Medical Center ,New York
  • Dr. Tom Gardiner – Department of Ophthalmology & Visual Science, Queens University, Belfast
    Collaborative studies utilising transmission electron microscopy to characterise changes in pericyte and smooth muscle cell ensheathment of retinal and choroidal blood vessels during normal development, in disease and in aging
  • Professor Jane Dahlstrom/Dr Mark Koina – Histopathology, Canberra Hospital, ACT
    Collaborative studies on the cellular and molecular mechanisms of formation of the human choroidal and retinal vasculature.
  • Professor Ming (Shih-Chang) Wang Parker-Hughes Chair of Diagnostic Radiology Discipline of Medical Imaging, Westmead Hospital. Sydney Medical School
    Use of iron-labelled nanoparticles for tracking neural precursor cells in an experimental model of stroke.

Cover Photos

Glia cover - Tail Loi Chan-Ling - Retinal Biology Lab

Medana L, Chan-Ling T and Hunt NH, “Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: relationship to disruption of the blood-retinal barrier” (1996) 16 GLIA 51-64. (Plus Cover Photo) (4.677) [30] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/70755/ABSTRACT)

Glia cover 2 - Tail Loi Chan-Ling - Retinal Biology Lab

Medana L, Hunt N and Chan-Ling T, “Early activation of microglia in the pathogenesis of fatal murine cerebral malaria” (1997) 19(2) GLIA 91-103. (Plus cover photo) (4.677) [51] (e-publication at http://www3.interscience.wiley.com/cgi-bin/abstract/53689/ABSTRACT)

American Journal of Pathology cover- Tail Loi Chan-Ling - Retinal Biology Lab

Hu P, Pollard J and Chan-Ling T, “Breakdown of the blood-retinal barrier induced by activated T cells of nonneural specificity” (2000) 156(4) American Journal of Pathology 1139-1149. (Plus Cover Photo) (6.946) [14] (e-publication at http://ajp.amjpathol.org/cgi/content/full/156/4/1139)

Glia Cover 3 - Tail Loi Chan-Ling - Retinal Biology Lab

Weible MW II and Chan-Ling T, “Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes” (2007) 55(11) Glia 1156-68 (Impact Factor: 5.500) (Plus Cover photo) [5] (e-publication at: http://www3.interscience.wiley.com/cgi-bin/fulltext/114284388/PDFSTART)


Images

graphic

Retina Astrocytes Technique: Confocal, 40x Objective Winner – Olympus Bioscapes Competition 2005 - Mr. Hussein Mansour Retinal & Developmental Neurobiology Laboratory Department of Anatomy and Histology, The University of Sydney Sydney, Australia Specimen

This photo by Hussein Mansour, PhD student at the Retinal and Developmental Neurobiology Laboratory, shows how aging can affect the eye and brain. Blood vessels look blue, and astrocytes (so-called “helper” cells of the nervous system) are mostly red, creating a graceful branching pattern. But the beauty belies a darker truth. As rats (and people) age, their astrocytes change; some scientists believe that understanding astrocyte changes is part of the core of understanding age-related brain disease and degeneration.