Executive Director - Professor Jonathan Stone BSc(Med), PhD (Sydney)

Biographical Details

Prof. Jonathan Stone

Professor Stone completed a BSc (Med) and PhD (1966) in P.O. Bishop's group at the University of Sydney, beginning life-long interest in the function, structure and diseases of the visual system. After postdoctoral work in JC Eccles' group in Chicago and O. Creutzfeld's and H. Holländer's groups in Münich, he rejoined Bishop's group, at the John Curtin School of Medical Research (ANU), in 1970, as a Research Fellow. He moved to Anatomy at the University of New South Wales (1976-1986), and then to the Challis Chair of Anatomy (Sydney, 1987-2003). From 2003-2007 he served as Director, Research School of Biological Sciences, before rejoining the University of Sydney (2007 -) as Professor of Retinal and Cerebral Neurobiology. He served as Director of the then Institute for Biomedical Research, the predecessor of the Bosch Insititute from 2000-2003.

Professor Stone is a Fellow of the Australian Academy of Science and served as its Secretary (Biological Sciences) from 1986-90. He has served as Managing Trustee of the Sir Zelman Cowen Universities Fund, a private charitable trust committed to the support of medical research, since 1995.

Research Interests

Jonathan has contributed to understanding of the structure and function of the visual pathways, including the concept of parallel processing in the visual system and retinal development, angiogenesis and degeneration. His recent work concerns neuroprotective approaches to the treatment of age-related degenerations of the retina and brain

Current national competitive grants

ARC Centre of Excellence in Vision Science (2006 - 13), total funding $14.5m

Publications 2001-2013

  • Moro, C., Torres, N., El Massri, N., Ratei, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A.L., 2013. Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. Biomed Central Under review/accepted.
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J., 2013. Cerebral haemorrhage leads to plaque formation: experimental evidence. PLoS Under review.
  • Stone, J., Johnstone, D., Mitrofanis, J., 2013. The helmet experiment in Parkinson’s disease: an observation of the mechanism of action of near infra-red light. WALT 2012 Proceedings. Under review
  • Purushothuman, S., Nandasena, C., Peoples, C., El Masri, N., Johnstone, D., Mitrofanis, J., Stone, J., 2013. Saffron pre-treatment offers neuroprotection to nigral and retinal dopaminergic cells of MPTP-treated mice. Journal of Parkinson's Disease Under re-review.
  • Shaw, V.E., Peoples, C., Spana, S., Ashkan, K., Benabid, A.L., Stone, J., Baker, G.E., Mitrofanis, J., 2012. Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease 2012, 296875.
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A.L., Stone, J., Baker, G.E., Mitrofanis, J., 2012. Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism Relat Disord 18, 469-476.
  • Peoples, C., Shaw, V., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J., 2012. Survival of dopaminergic amacrine cells in MPTP-treated mice after near-infrared light treatment. ISRN Neurology 2012, 8 pages.
  • Natoli, R., Valter, K., Chrysostomou, V., Stone, J., Provis, J., 2011. Morphological, functional and gene expression analysis of the hyperoxic mouse retina. Exp Eye Res 92, 306-314.
  • Zhu, Y., Valter, K., Stone, J., 2010. Environmental damage to the retina and preconditioning: contrasting effects of light and hyperoxic stress. Invest Ophthalmol Vis Sci 51, 4821-4830.
  • Zhu, Y., Natoli, R., Valter, K., Stone, J., 2010. Microarray analysis of hyperoxia stressed mouse retina: differential gene expression in the inferior and superior region. Adv Exp Med Biol 664, 217-222.
  • Zhu, Y., Natoli, R., Valter, K., Stone, J., 2010. Differential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia. Mol Vis 16, 740-755.
  • Shaw, V.E., Spana, S., Ashkan, K., Benabid, A.L., Stone, J., Baker, G.E., Mitrofanis, J., 2010. Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. J Comp Neurol 518, 25-40.
  • Natoli, R., Zhu, Y., Valter, K., Bisti, S., Eells, J., Stone, J., 2010. Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Mol Vis 16, 1801-1822.
  • Falsini, B., Piccardi, M., Minnella, A., Savastono, C., Fiorani, L., Maccarone, R., Romeo, S., Silva, R., Stone, J., Bisti, S., 2010. Saffron as a retinal neuroprotectant: preclinical studies and early clinical results. Proceedings of the 8th International Symposium on Ocular Pharmacology and Therapeutics.
  • Chrysostomou, V., Stone, J., Valter, K., 2010. Differences in Photoreceptor Sensitivity to Oxygen Stress Between Long Evans and Sprague-Dawley Rats, in: Anderson, R., LaVail, M., Hollyfield, J., Mandal, M. (Eds.), Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations, pp. 473-479.
  • Valter, K., Kirk, D.K., Stone, J., 2009. Optimising the structure and function of the adult P23H-3 retina by light management in the juvenile and adult. Exp Eye Res 89, 1003-1011.
  • Stone, J., Heckenlively, J., 2009. Animal Models of Inherited Retinal Degenerations, in: Squire, L. (Ed.), The Encyclopaedia of Neuroscience. Academic Press, Oxford, pp. 437-447.
  • Chrysostomou, V., Valter, K., Stone, J., 2009. Cone-rod dependence in the rat retina: variation with the rate of rod damage. Invest Ophthalmol Vis Sci 50, 3017-3023.
  • Chrysostomou, V., Stone, J., Valter, K., 2009. Life history of cones in the of the rhodopsin-mutant P23H-3 rat: evidence of long term survival. Invest Ophthalmol Vis Sci 50, 2407-2416.
  • Valter, K., Kirk, D., Stone, J., 2008. The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina., in: Anderson, E., LaVail, MM., Hollyfield, JG. (Ed.), Advances in Experimental medicine and Biology, Vol.613, Recent Advances in Retinal Degeneration. Springer, pp. 193-199.
  • Stone, J., van Driel, D., Valter, K., Rees, S., Provis, J., 2008. The locations of mitochondria in mammalian photoreceptors: relation to retinal vasculature. Brain Res 1189, 58-69.
  • Stone, J., Valter, K., 2008. Roles Of Oxygen In The Stability Of Photoreceptors: Evidence From Mouse And Other Models Of Human Disease, in: Chalupa, L. (Ed.), Eye, Retina, and Visual System of the Mouse. MIT Press, pp. 559-572.
  • Stone, J., 2008. What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages. Medical Hypotheses 71, 347-359.
  • Stone, J., 2008. Into a Maelstrom: One Man’s Arrival in Mid-20th Century Australia. National Library of Australia Newsletter 19, 18-21.
  • Stone, J., 2008. The Roles of Universities: Views of a Scholar of the Last Century, in: Walton, K. (Ed.), Julius Stone Centenary. Federation Press, Sydney.
  • Natoli, R., Provis, J., Valter, K., Stone, J., 2008. Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study. Mol Vis 14, 1983-1994.
  • Natoli, R., Provis, J., Valter, K., Stone, J., 2008. Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina. Invest Ophthalmol Vis Sci 49, 4561-4567.
  • Eells, J., DeSmet, K., Kirk, D., Wong-Riley, M., Whelan, H., Ver Hoeve, J., Nork, T., Stone, J., Valter, K., 2008. Photobiomodulation for the Treatment of Retinal Injury and Retinal Degenerative Diseases, in: Waynant, R., Tata, D. (Eds.), Proceeding of Light- Assisted Tissue Regeneration and Therapy Conference. Springer, New York, pp. 39-51.
  • Chrysostomou, V., Stone, J., Stowe, S., Barnett, N.L., Valter, K., 2008. The status of cones in the rhodopsin mutant P23H-3 retina: light-regulated damage and repair in parallel with rods. Invest Ophthalmol Vis Sci 49, 1116-1125.
  • Bravo-Nuevo, A., Williams, N.K., Valter, K., Stone, J., 2007. Mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed an normal and degenerative rat. Mitochondrion 7, 340-346.
  • Stone, J., Sandercoe, T.M., Provis, J., 2006. Mechanisms of the Formation and Stability of Retinal Blood Vessels, in: Tombran-Tink, J., Barnstable, C. (Eds.), Ocular Angiogenesis: Diseases, Mechanisms and Therapeutics. Humana Press, Totowa, NJ, pp. 101-126.
  • Jozwick, C., Valter, K., Stone, J., 2006. Reversal of functional loss in the P23H-3 rat retina by management of ambient light. Exp Eye Res 83, 1074-1080.
  • Geller, S., Krowka, R., Valter, K., Stone, J., 2006. Toxicity of hyperoxia to the retina: evidence from the mouse. Adv Exp Med Biol 572, 425-437.
  • Cullen, K.M., Kocsi, Z., Stone, J., 2006. Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging 27, 1786-1796.
  • Wellard, J., Lee, D., Valter, K., Stone, J., 2005. Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia. Vis Neurosci 22, 501-507.
  • Valter, K., Bisti, S., Gargini, C., Di Loreto, S., Maccarone, R., Cervetto, L., Stone, J., 2005. Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Invest Ophthalmol Vis Sci 46, 1748-1754.
  • Stone, J., Mervin, K., Walsh, N., Valter, K., Provis, J., Penfold, P., 2005. Photoreceptor stability and degeneration in mammalian retina: lessons from the edge, in: Penfold, P., Provis, J. (Eds.), Macular Degeneration: Science and Medicine in Practice. Springer Verlag, pp. 149-165.
  • Geller, S., Krowka, R., Valter, K., Stone, J., 2005. Toxicity of hyperoxia to the retina: evidence from the mouse, in: Hollyfield, J., Anderson, G., LaVail, M. (Eds.), Retinal Degenerative Disease. Springer, pp. 425-438.
  • Cullen, K.M., Kocsi, Z., Stone, J., 2005. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. J Cereb Blood Flow Metab 25, 1656-1667.
  • Yu, D.Y., Cringle, S., Valter, K., Walsh, N., Lee, D., Stone, J., 2004. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci 45, 2013-2019.
  • Walsh, N., Van Driel, D., Lee, D., Stone, J., 2004. Multiple vulnerability of photoreceptors to mesopic ambient light in the P23H transgenic rat. Brain Research 1013, 194-203.
  • Walsh, N., Bravo-Nuevo, A., Geller, S., Stone, J., 2004. Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALB/cj mouse strains to oxygen stress: Evidence of an oxygen phenotype. Current Eye Research 29, 441-448.
  • Gargini, C., Bisti, S., Demontis, G., Valter, K., Stone, J., Cervetto, L., 2004. ERG changes associated with retinal upregulation of trophic factors: observations following optic nerve section. Neuroscience 126, 775-783.
  • Bravo-Nuevo, A., Walsh, N., Stone, J., 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C(2J) mouse. Invest Ophthalmol Vis Sci 45, 2005-2012.
  • Valter, K., Bisti, S., Stone, J., 2003. Location of CNTFR on outer segments: evidence of the site of action of CNTF in rat retina. Brain Res 985, 169 - 175.
  • Stone, J., Valter, K., 2003. Roles of retinal macroglia in maintaining the stability of the retina, in: Hertz, L. (Ed.), Non-neuronal cell of the nervous system: function and dysfunction. Elsevier, Amsterdam, pp. 295 - 314.
  • Sandercoe, T.M., Geller, S.F., Hendrickson, A.E., Stone, J., Provis, J.M., 2003. VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: evidence of developmental hypoxia. J Comp Neurol 462, 42-54.
  • Lee, D., Geller, S., Walsh, N., Valter, K., Yasumura, D., Matthes, M., LaVail, M., Stone, J., 2003. Photoreceptor degeneration in Pro23His and S334ter transgenic rats. Adv Exp Med Biol 533, 297-302.
  • Geller, S.F., Stone, J., 2003. Quantitative PCR analysis of FosB mRNA expression after short duration oxygen and light stress. Adv Exp Med Biol 533, 249-257.
  • Bravo-Nuevo, A., Williams, N., Geller, S., Stone, J., 2003. Mitochondrial deletions in normal and degenerating rat retina. Adv Exp Med Biol 533, 241-248.
  • Valter, K., Driel, D.V., Bisti, S., Stone, J.S., 2002. FGFR1 Expression and FGFR1-FGF-2 Colocalisation in Rat Retina: Sites of FGF-2 on Rat Photoreceptors. Growth Factors 20, 177-188.
  • Mervin, K., Stone, J., 2002. Regulation by oxygen of photoreceptor death in the developing and adult C57BL/6J mouse. Experimental Eye Research. 75, 715-722.
  • Mervin, K., Stone, J., 2002. Developmental death of photoreceptors in the C57BL/6Jmouse: association with retinal function and self-protection. Experimental Eye Research. 75, 703-713.
  • Lee, D., Geller, S., Walsh, N., Valter, K., Yasumura, D., Matthes, M., LaVail, M., Stone, J., 2002. Photoreceptor degeneration in Pro23His and S334ter transgenic rats, in: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (Eds.), 10th International Symposium on Retinal Degenerations (RD2002). Kluwer Academic/Plenum Publ, Burgenstock, Switzerland, pp. 297-302.
  • Walsh, N., Valter, K., Stone, J., 2001. Cellular and subcellular patterns of expression of bFGF and CNTF in the normal and light stressed adult rat retina. Experimental Eye Research, 72, 495-501.
  • Walsh, N., Stone, J., 2001. Timecourse of bFGF and CNTF expression in light-induced photoreceptor degeneration in the rat retina, New Insights into Retinal Degenerative Diseases. Kluwer Academic Plenum Publishers, New York, pp. 111-118.
  • Stone, J., Maslim, J., Fawsi, A., Lancaster, P., Heckenlively, J., 2001. The role of perinatal stress in retinitis pigmentosa: evidence from surveys in Australia and the USA. Canadian Journal of Ophthalmology, 315-322.
  • Stone, J., 2001. Art Macabre: is anatomy necessary? Australian and New Zealand Journal of Surgery 71, 1-000.
  • Fisher, S.K., Stone, J., Rex, T.S., Linberg, K.A., Lewis, G.P., 2001. Experimental retinal detachment: a paradigm for understanding the effects of induced photoreceptor degeneration. Prog Brain Res 131, 679-698.
  • Bowers, F., Valter, K., Chan, S., Walsh, N., Maslim, J., Stone, J., 2001. Effects of oxygen and bFGF on the vulnerability of photoreceptors to light damage. Invest Ophthal & Visual Science, 42, 804-815.