Download recordings of seminars held at the Bosch Institute.
Heat Shock Protein 72: A Panacea for Disease Prevention?
SPEAKER - PROFESSOR MARK FEBBRAIO
Professor Mark Febbraio is a Senior Principal Research Fellow of the NHMRC, is the head of the Cellular and Molecular Metabolism Laboratory and Program Leader of Cell Signalling & Metabolism at the Baker IDI Heart & Diabetes Institute. He is also the Chief Scientific Officer and on the Board of Directors of N-Gene Research Laboratories Inc., a USA based Biotechnology company. His research is focussed on understanding cellular and molecular mechanisms associated obesity and type 2 diabetes. He has authored over 180 peer reviewed papers in leading journals such as Nature, Nature Medicine, Cell, Cell Metabolism, The Journal of Clinical Investigation, PNAS and Diabetes. His work is extremely well cited (over 9500 citations, H factor 61). He has won prizes at international, national and institutional levels including the A K McIntyre Prize for significant contributions to Australian Physiological Science (1999), the Colin I Johnson Lectureship by the High Blood Pressure Research Council of Australia (2006) the ESA/ADS Joint Plenary Lecture (2009) and the Sandford Skinner Oration (2011). He is on the Editorial Board of Diabetes, The American Journal of Physiology Endocrinology & Metabolism, Exercise Immunology Reviews and Journal of Applied Physiology. He is a member of seven National or International Professional bodies. He has served on The Council of The Australian Diabetes Society and is a past Honorary Treasurer of this Society (2006-2008). He has served on National Health and Medical Research Grant Review Panels for several years in the areas of Physiology, Cell Biology and Diabetes/Obesity. Professor Febbraio is also dedicated to health and fitness and continues to complete in running races and multi-sport events.
Summary: It is well known that when proteins aggregate, illnesses such as Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis can arise (1), and activation of chaperone proteins can suppress diseases associated with protein misfolding (2). However, the role of chaperone proteins in the treatment of metabolic diseases such as type 2 diabetes (T2D) has been relatively understudied. For the past decade, we (3-5) and others (6) have been examining the role of molecular chaperone proteins in the treatment of metabolic disease. Specifically, we have been studying the role of the inducible form of the 70kDa family of heat shock proteins, namely heat shock protein 72 (HSP72). We have identified an essential role of HSP72 in preventing obesity- induced insulin resistance, using both loss of function and gain of function genetic mouse models and, via the use of small molecule activators of HSP72 currently in human clinical trials for T2D. Moreover, we have demonstrated that activation of HSP72 can preserve muscle function, slow disease progression and increase life span in muscular dystrophy (7). Finally, in unpublished work, we have shown that a small molecule activator of HSP72 improves heart rhythm and function in a mouse model of atrial fibrillation. In this lecture, I will discuss common pathways in these seemingly unrelated diseases that may be regulated by the activation of HSP72.
PODCAST RECORDING DATE
Thursday 31 October, 2013
51:16 minutes Download video (mp4, 365 Mb)
Fueling the Failing Heart: Mitochondrial Function in Heart Disease
SPEAKER - PROFESSOR WILLIAM STANLEY
William C. Stanley is Professor and Chair of Cardiovascular Physiology at the University of Sydney in Australia. He is a native of northern California and attended the University of California, Berkeley. He received postdoctoral training at the Cardiovascular Research Institute at the University of California, San Francisco. In 1989, he joined the faculty of the University of Wisconsin and initiated studies addressing cardiac metabolism in health and disease. In 1992, he left academic research and worked in the pharmaceutical industry in Palo Alto, California, on the discovery and development of drugs for treatment of heart failure and ischemia. He returned to academics in 1996 to join the Department of Physiology and Biophysics at Case Western Reserve University, and established a leading research program addressing metabolic dysfunction in heart disease. In 2007 he joined the Division of Cardiology at the University of Maryland, and in 2013 he moved down under to join the faculty of the University of Sydney. Stanley has broad experience in integrative cardiovascular physiology and pharmacology, nutrition and cardiac metabolism, and has worked with a wide array of experimental systems and approaches, from isolated organelles to humans.
PODCAST RECORDING DATE
Thursday 9 May, 2013
52:23 minutes Download video (mp4, 785.46 Mb)
The Nature of Nutrition: A Unifying Framework from Animal Adaptation to Human Obesity
SPEAKER - PROFESSOR STEPHEN SIMPSON
Professor Stephen Simpson is an Australian Research Council Laureate Fellow in the School of Biological Sciences and Academic Director of the Charles Perkins Centre for the study of obesity, diabetes and cardiovascular disease at the University of Sydney. Stephen returned to Australia in 2005 as an ARC Federation Fellow after 22 years at Oxford where he was Professor of Entomology and Curator of the University Museum of Natural History. Before that he had undertaken his PhD at the University of London, and his undergraduate degree and Honours at the University of Queensland.
Nutrition touches all aspects of biology – indeed the fundamental, interlinked triumvirate in biology is sex, death and nutrition. But nutrition is complex. Animals require numerous nutrients in particular amounts and ratios to maximise fitness. Nutrients come packaged in various ratios and concentrations in foods, which are scattered throughout the environment in time and space and may contain toxins and other non-nutrient compounds. The animal must match its multidimensional, changing nutritional requirements while minimising the costs of locating, ingesting and processing appropriate foods. We have developed a set of state-space models called the Geometric Framework (GF) to capture the multidimensional nature of nutritional requirements, the relative values of foods in relation to these requirements, the behavioural and post-ingestive responses of animals when feeding on diets of varying composition, and the growth and performance consequences of being restricted to particular dietary regimes. We have also derived the necessary theory for defining fitness in relation to nutrient intake, for describing key nutritional traits and assessing trade-offs between life-history responses. I will begin by introducing the models and then show how they have been used to address problems in life-history theory, immunity, human health, collective nutrition and community ecology. Along the way I will use examples spanning slime moulds to humans.
PODCAST RECORDING DATE
Tuesday 25 September, 2012