Assays / Applications

The BMSF caters for a range of analytical equipment including HPLC, UPLC coupled with various detectors such as Diode Array Detection, Florescence and Electrochemical detectors, Single quadruple and Triple quadruple mass spectrometers (each coupled to UV-Vis detectors). Both UV peak based and mass based semi-prep fraction collections are also available.

Assays are currently available at BMSF are as follows (not limited to the list below):

o Cl-Tyrosine analysis in cells and tissues (LC-MS/MS)

o Apolipoproteins and SAA analysis (LC-UV)

o Adenosine analysis (LC-UV; LC-MS/MS)

o Synthesized antifibrotic drugs Px25 and Px64 (LC-MS/MS)

o MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) (LC-MS/MS)

o Arachidonic acid analysis in cells (LC-MS/MS)

o Risperidone analysis in human tissues (LC-MS/MS)

o Platelet-activating factor (PAF) analysis in cells (LC-MS/MS)

o Glutamin analysis in cells (LC-UV)

o Redox-active compounds analysis in Geothrix fermentans (HPLC-EC)

o F2-sioprostane -a wide-used lipid marker in biological system using HPLC-QQQ-MS

o Cocktails of kinetic study of 11 drugs (CYP450 and their metabolites) in human plasma using HPLC-MS/MS

o Quantitative analysis for an anti-cancer drug actinomycin D (LC-MS/MS)

o Phosphatidylcholine, lysophosphatidylcholine and palmitic acid and related metabolites (LC-MS/MS)

o Fatty acids including phytoene, phytofluene, neurosporene, lycopene, gamma-carotene, beta-carotene (HPLC-UV, HPLC-SQ-MS and HPLC-QQQ-MS)

o Drugs with potential inhibition ability to efflux pumps of mycobacterium tuberculosis including Rifapentine, 25-desacetyl rifampicin, Thioridazine hydrochloride, Verapamil hydrochloride, Norverapamil hydrochloride, Rifampicin (LC-MS/MS)

o Capsaicin analysis (LC-MS/MS)

If you would like to set up new assays / applications at BMSF, please contact BMSF Officer. Phone: 02 9036 3460 / M: 0423 335 188; Email: