Professor Chris Cowell

Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 3200
F: +61 2 9845 3170
E:

Research interests

Clinical insulin resistance and Type 2 diabetes are new metabolic disorders in children associated with the rise in obesity prevalence. Our group is interested in 1) the relationship between expression of adipocytokines and development of insulin resistance and 2) developing effective interventions by conducting RCT's

Current national competitive grants*

2010

Bisphosphonate Treatment of childhood femoral head avascular necrosis due to Perthes disease
Cowell C, Little D, Munns C, Foster B, Zacharin M
NHMRC Project Grant ($1,305,625 over 5 years)

* Grants administered through the University of Sydney

Keywords

Diabetes; Child health; Endocrinology; Obesity & overweight; Bone health

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Ooi, H., Briody, J., Biggin, A., Cowell, C., Munns, C. (2013), Intravenous Zoledronic Acid Given Every 6 Months in Childhood Osteoporosis. Hormone Research in Paediatrics. 80(3), 179-184. [Abstract]
  • Toelle, B., Garden, F., Ng, K., Belousova, E., Almqvist, C., Cowell, C., Tovey, E., Webb, K., Leeder, S., Marks, G. (2013), Outcomes of the Childhood Asthma Prevention Study at 11.5 years. The Journal of Allergy and Clinical Immunology. 132(5), 1220-1222. [Abstract]
  • Garnett, S., Gow, M., Ho, M., Baur, L., Noakes, M., Woodhead, H., Broderick, C., Burrell, S., Chisholm, K., Halim, J., De, S., Steinbeck, K., Srinivasan, S., Ambler, G., Kohn, M., Cowell, C. (2013), Optimal Macronutrient Content of the Diet for Adolescents With Prediabetes; RESIST a Randomised Control Trial. The Journal of Clinical Endocrinology and Metabolism. 98(5), 2116-2125. [Abstract]
  • Flemming, G., Klammt, J., Ambler, G., Bao, Y., Blum, W., Cowell, C., Donaghue, K., Howard, N., Kumar, A., Sanchez, J., Stobbe, H., Pfäffle, R. (2013), Functional characterization of a heterozygous GLI2 missense mutation in patients with multiple pituitary hormone deficiency. The Journal of Clinical Endocrinology and Metabolism. 98(3), E567-575. [Abstract]
  • Poulton, A., Melzer, E., Tait, P., Garnett, S., Cowell, C., Baur, L., Clarke, S. (2013), Growth and pubertal development of adolescent boys on stimulant medication for attention deficit hyperactivity disorder. The Medical Journal of Australia. 198(1), 29-32. [Abstract]
  • Ho, M., Gow, M., Halim, J., Chisholm, K., Baur, L., Noakes, M., Steinbeck, K., Kohn, M., Cowell, C., Garnett, S. (2013), Effect of a prescriptive dietary intervention on psychological dimensions of eating behavior in obese adolescents. International Journal of Behavioral Nutrition and Physical Activity. 10(1), 119. [Abstract]

2012

   
  • Shrewsbury, V., Garnett, S., Campbell, K., Carver, A., Torvaldsen, S., Steinbeck, K., Cowell, C., Baur, L. (2012), Maternal misconceptions of weight status among Nepean adolescents. Journal of the Academy of Nutrition and Dietetics. 112(12), 2007-2013. [Abstract]
  • Hughes, I., Harris, M., Choong, C., Ambler, G., Cutfield, W., Hofman, P., Cowell, C., Werther, G., Cotterill, A. (2012), Growth Hormone Regimens in Australia: Analysis of the First Three Years of Treatment for Idiopathic Growth Hormone Deficiency and Idiopathic Short Stature. Clinical Endocrinology. 77(1), 62-71. [Abstract]
  • Munns, C., Simm, P., Rodda, C., Garnett, S., Zacharin, M., Ward, L., Geddes, J., Cherian, S., Zurynski, Y., Cowell, C. (2012), Incidence of vitamin D deficiency rickets among Australian children: an Australian Paediatric Surveillance Unit study. Medical Journal of Australia. 196(7), 466-468. [Abstract]
  • Fang, P., Cho, Y., Derr, M., Rosenfeld, R., Hwa, V., Cowell, C. (2012), Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R). Journal of Clinical Endocrinology and Metabolism. 97(2), E243-E247. [Abstract]

2011

   
  • Simm, P., Johannesen, J., Briody, J., McQuade, M., Hsu, B., Bridge, C., Little, D., Cowell, C., Munns, C. (2011), Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2years of treatment in children with secondary osteoporosis. Bone. 49(5), 939-943. [Abstract]
  • Garnett, S., Baur, L., Cowell, C. (2011), The prevalence of increased central adiposity in Australian school children 1985 to 2007. Obesity reviews : an official journal of the International Association for the Study of Obesity. 12(11), 887-96. [Abstract]
  • Tam, C., Heilbronn, L., Henegar, C., Wong, M., Cowell, C., Cowley, M., Kaplan, W., Clément, K., Baur, L. (2011), An early inflammatory gene profile in visceral adipose tissue in children. International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity. 6(2-2), e360-3. [Abstract]
  • Hughes, I., Choong, C., Harris, M., Ambler, G., Cutfield, W., Hofman, P., Cowell, C., Werther, G., Cotterill, A., Davies, P. (2011), Growth hormone treatment for Turner syndrome in Australia reveals that younger age and increased dose interact to improve response. Clinical Endocrinology. 74(4), 473-480. [Abstract]
  • Bridge, P., Pocock, N., Nguyen, T., Munns, C., Cowell, C., Forwood, N., Thompson, M. (2011), Validation of Longitudinal DXA Changes in Body Composition From Pre- to Mid-Adolescence Using MRI as Reference. Journal of Clinical Densitometry. 14(3), 340-347. [Abstract]
  • Tran, F., Vu, D., Nguyen, H., Bui, T., Huynh, L., Nguyen, K., Nguyen, V., Tran, H., Tran, D., Hoang, T., Harkin, N., Armstrong, K., Jameson, K., Pham, A., Chris, C., Maria, C. (2011), Glycaemic control in children with neonatal diabetes and type 1 diabetes in Vietnam. International Health. 3(3), 188-192.
  • Xiong, F., Garnett, S., Cowell, C., Biesheuvel, C., Zeng, Y., Long, C., Wang, Q., Wang, D., Luo, Y., Luo, S. (2011), Waist circumference and waist-to-height ratio in Han Chinese children living in Chongqing, south-west China. Public health nutrition. 14(1), 20-6. [Abstract]

2010

   
  • Crawford, B., Cowell, C., Emder, P., Learoyd, D., Chua, E., Sinn, J., Jack, M. (2010), Iodine toxicity from soy milk and seaweed ingestion is associated with serious thyroid dysfunction. The Medical Journal of Australia. 193(7), 413-415. [Abstract]
  • Quinn, S., Baur, L., Garnett, S., Cowell, C. (2010), Treatment of clinical insulin resistance in children: a systematic review. Obesity reviews : an official journal of the International Association for the Study of Obesity. 11(10), 722-30. [Abstract]
  • Garnett, S., Srinivasan, S., Birt, S., Ambler, G., Lawrie, E., Cowell, C., Craig, M. (2010), Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?. Clinical endocrinology. 72(4), 475-80. [Abstract]
  • Garnett, S., Baur, L., Noakes, M., Steinbeck, K., Woodhead, H., Burrell, S., Chisholm, K., Broderick, C., Parker, R., De, S., Shrinivasan, S., Hopley, L., Hendrie, G., Ambler, G., Kohn, M., Cowell, C. (2010), Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers - RESIST. A randomised control trial investigating the effects of two different diets on insulin sensitivity in young people with insulin resistance and/or pre-diabetes. BMC Public Health. 10, 575. [Abstract]
  • Denney-Wilson, E., Cowell, C., Okely, A., Hardy, L., Aitken, R., Dobbins, T. (2010), Associations between insulin and glucose concentrations and anthropometric measures of fat mass in Australian adolescents. BMC Pediatrics. 10(1), 58. [Abstract]
  • Tam, C., Garnett, S., Cowell, C., Heilbronn, L., Lee, J., Wong, M., Baur, L. (2010), IL-6, IL-8 and IL-10 levels in healthy weight and overweight children. Hormone Research in Paediatrics. 73(2), 128-134. [Abstract]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010), Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics. 4(6), 507–517.

2009

   
  • Johannesen, J., Briody, J., McQuade, M., Little, D., Cowell, C., Munns, C. (2009), Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone. 45(5), 898-902. [Abstract]
  • Bridge, P., Pocock, N., Nguyen, T., Munns, C., Cowell, C., Thompson, M. (2009), Prediction of appendicular skeletal and fat mass in children: excellent concordance of dual-energy X-ray absorptiometry and magnetic resonance imaging. Journal of Pediatric Endocrinology & Metabolism. 22(9), 795-804. [Abstract]
  • Steinbeck, K., Baur, L., Cowell, C., Pietrobelli, A. (2009), Clinical research in adolescents: challenges and opportunities using obesity as a model. International journal of obesity (2005). 33(0), 2-7. [Abstract]
  • Booth, M., Dobbins, T., Aitken, R., Denney-Wilson, E., Hardy, L., Okely, A., George, J., Sullivan, D., Cowell, C. (2009), Costs of managing conditions associated with obesity among Australian teenagers. Journal of paediatrics and child health. 45(0), 448-56. [Abstract]

2008

   
  • Gleeson, H., Wiley, V., Wilcken, B., Elliott, E., Cowell, C., Thonsett, M., Byrne, G., Ambler, G. (2008), Two-year pilot study of newborn screening for congenital adrenal hyperlasia in New South Wales compared with nationwide case surveillance in Australia. Journal of Paediatrics and Child Health. 44(10), 554-559. [Abstract]
  • Maguire, A., Craig, M., Cowell, C. (2008), Management of adrenal insufficiency during the stress of medical illness and surgery.Comment. The Medical journal of Australia. , 350. [Abstract]
  • Kim, L., Holland, A., Srinivasan, S., Cowell, C., Benn, D., Robinson, B. (2008), Paediatric bilateral adrenal phaeochromocytomas in association with a novel mutation in the von Hippel Lindau gene. Journal of paediatrics and child health. 44(9), 514-516. [Abstract]
  • Garnett, S., Baur, L., Cowell, C. (2008), Waist-to-height ratio: a simple option for determining excess central adiposity in young people. International journal of obesity (2005). 32(6), 1028-30. [Abstract]
  • Högler, W., Blimkie, C., Cowell, C., Inglis, D., Rauch, F., Kemp, A., Wiebe, P., Duncan, C., Farpour-Lambert, N., Woodhead, H. (2008), Sex-specific developmental changes in muscle size and bone geometry at the femoral shaft. Bone. 42(5), 982-989. [Abstract]
  • Wiebe, P., Blimkie, C., Farpour-Lambert, N., Briody, J., Marsh, D., Kemp, A., Cowell, C., Howman-Giles, R. (2008), Effects of single-leg drop-landing exercise from different heights on skeletal adaptations in prepubertal girls: a randomized controlled study. Pediatric Exercise Science. 20(2), 211-228. [Abstract]
  • Maguire, A., Biesheuvel, C., Ambler, G., Moore, B., McLean, M., Cowell, C. (2008), Evaluation of adrenal function using the human corticotrophin-releasing hormone test, low dose Synacthen test and 9am cortisol level in children and adolescents with central adrenal insufficiency. Clinical endocrinology. 68(0), 683-91. [Abstract]
  • Gleeson, H., Wiltshire, E., Briody, J., Hall, J., Chaitow, J., Sillence, D., Cowell, C., Munns, C. (2008), Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. The Journal of Rheumatology. 35(4), 707-712. [Abstract]
  • Zhu, K., Greenfield, H., Zhang, Q., Du, X., Ma, G., Foo, L., Cowell, C., Fraser, D. (2008), Growth and bone mineral accretion during puberty in Chinese girls: a five-year longitudinal study. Journal of Bone and Mineral Research. 23(2), 167-172. [Abstract]
  • Högler, W., Blimkie, C., Rauch, F., Woodhead, H., Cowell, C. (2008), Scaling and adjusting growth-related data and sex-differences in the muscle-bone relation: a perspective. Journal of musculoskeletal & neuronal interactions. 8(1), 25-28. [Abstract]