Professor David Winlaw

Paediatric Cardiac Surgeon, Head Kids Heart Research
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 2325
F: +61 2 9845 2163
E:

W: Related website
Related website

Biographical details

Research interests

Pediatric Cardiac Surgery

Genetics of congenital heart disease. Low cardiac output state after cardiac surgery. Brain outcomes after cardiac surgery in children. Human factors in cardiac surgery.

Teaching areas

Prof Winlaw is involved in post graduate teaching through supervision of PhD students and medical students at all stages of their course.

Current national competitive grants*

2012

Genetic Basis of Valvular Heart Disease
Semsarian C, Weintraub R, Winlaw D, Bagnall R
NHMRC Project Grants ($434,255 over 3 years)

* Grants administered through the University of Sydney

Keywords

Genetics; Cardiovascular diseases; Surgery

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Stehn, J., Haass, N., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P., Sequeira, V., Butler, T., Allanson, M., Fath, T., Hill, T., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E., Winlaw, D., Reeve, V., Dixon, I., Weninger, W., Cripe, T., Gunning, P. (2013), A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells. Cancer Research. 73(16), 5169-5182. [Abstract]
  • Mamasoula, C., Prentice, R., Pierscionek, T., Pangilinan, F., Mills, J., Druschel, C., Pass, K., Russell, M., Hall, D., Topf, A., Brown, D., Zelenika, D., Bentham, J., Cosgrove, C., Bhattacharya, S., Riveron, J., Setchfield, K., Brook, J., Bu'Lock, F., Thornborough, C., Rahman, T., Doza, J., Tan, H., O'Sullivan, J., Stuart, A., Blue, G., Winlaw, D., Postma, A., Mulder, B., Zwinderman, A., van Engelen, K., Moorman, A., Rauch, A., Gewillig, M., Breckpot, J., Devriendt, K., Lathrop, G., Farrall, M., Goodship, J., Cordell, H., Brody, L., Keavney, B. (2013), Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls. Circulation. Cardiovascular Genetics. 6(4), 347-353. [Abstract]
  • Cordell, H., Bentham, J., Topf, A., Zelenika, D., Heath, S., Mamasoula, C., Cosgrove, C., Blue, G., Granados-Riveron, J., Setchfield, K., Thornborough, C., Breckpot, J., Soemedi, R., Martin, R., Rahman, T., Hall, D., van Engelen, K., Moorman, A., Zwinderman, A., Barnett, P., Koopmann, T., Adriaens, M., Varro, A., George, A., dos Remedios, C., Bishopric, N., Bezzina, C., O'Sullivan, J., Gewillig, M., Bu'Lock, F., Winlaw, D., Bhattacharya, S., Devriendt, K., Brook, J., Mulder, B., Mital, S., Postma, A., Lathrop, G., Farrall, M., Goodship, J., Keavney, B. (2013), Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nature Genetics. 45(7), 822-824. [Abstract]
  • Cordell, H., Topf, A., Mamasoula, C., Postma, A., Bentham, J., Zelenika, D., Heath, S., Blue, G., Cosgrove, C., Granados Riveron, J., Darlay, R., Soemedi, R., Wilson, I., Ayers, K., Rahman, T., Hall, D., Mulder, B., Zwinderman, A., van Engelen, K., Brook, J., Setchfield, K., Bu'Lock, F., Thornborough, C., O'Sullivan, J., Stuart, A., Parsons, J., Bhattacharya, S., Winlaw, D., Mital, S., Gewillig, M., Breckpot, J., Devriendt, K., Moorman, A., Rauch, A., Lathrop, G., Keavney, B., Goodship, J. (2013), Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Human Molecular Genetics. 22(7), 1473-1481. [Abstract]

2012

   
  • Soemedi, R., Wilson, I., Bentham, J., Darlay, R., Töpf, A., Zelenika, D., Cosgrove, C., Setchfield, K., Thornborough, C., Granados-Riveron, J., Blue, G., Breckpot, J., Hellens, S., Zwolinkski, S., Glen, E., Mamasoula, C., Rahman, T., Hall, D., Rauch, A., Devriendt, K., Gewillig, M., O' Sullivan, J., Winlaw, D., Bu'Lock, F., Brook, J., Bhattacharya, S., Lathrop, M., Santibanez-Koref, M., Cordell, H., Goodship, J., Keavney, B. (2012), Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. American Journal of Human Genetics. 91(3), 489-501. [Abstract]
  • Blue, G., Kirk, E., Sholler, G., Harvey, R., Winlaw, D. (2012), Congenital heart disease: current knowledge about causes and inheritance. Medical Journal of Australia. 197(3), 155-159. [Abstract]
  • Walker, K., Badawi, N., Halliday, R., Stewart, J., Sholler, G., Winlaw, D., Sherwood, M., Holland, A. (2012), Early Developmental Outcomes following Major Noncardiac and Cardiac Surgery in Term Infants: A Population-Based Study. The Journal of Pediatrics. 161(4), 748-752. [Abstract]
  • Soemedi, R., Topf, A., Wilson, I., Darlay, R., Rahman, T., Glen, E., Hall, D., Huang, N., Bentham, J., Bhattacharya, S., Cosgrove, C., Brook, J., Granados-Riveron, J., Setchfield, K., Bu'lock, F., Thornborough, C., Devriendt, K., Breckpot, J., Hofbeck, M., Lathrop, M., Rauch, A., Blue, G., Winlaw, D., Hurles, M., Santibanez-Koref, M., Cordell, H., Goodship, J., Keavney, B. (2012), Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Human Molecular Genetics. 21(7), 1513-1520. [Abstract]
  • Winlaw, D., Badawi, N., Jacobe, S., Kasparian, N., Cooper, S., Murphy, D., Sherwood, M., Roberts, P., Leclair, K., Scarfe, G., Sholler, G. (2012), Hypoplastic left heart syndrome in context. Journal of Paediatrics and Child Health. 48(2), E7-9. [Abstract]

2011

   
  • Sholler, G., Kasparian, N., Pye, V., Cole, A., Winlaw, D. (2011), Fetal and post-natal diagnosis of major congenital heart disease: Implications for medical and psychological care in the current era. Journal of paediatrics and child health. 47(10), 717-22. [Abstract]
  • Esposito, G., Butler, T., Blue, G., Cole, A., Sholler, G., Kirk, E., Grossfeld, P., Perryman, B., Harvey, R., Winlaw, D. (2011), Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of fallot or hypoplastic left heart. American Journal of Medical Genetics. Part A. 155A(10), 2416-2421. [Abstract]
  • Padley, J., Cole, A., Pye, V., Chard, R., Nicholson, I., Jacobe, S., Baines, D., Badawi, N., Walker, K., Scarfe, G., Leclair, K., Sholler, G., Winlaw, D. (2011), Five-year Analysis of Operative Mortality and Neonatal Outcomes in Congenital Heart Disease. Heart, lung & circulation. 20(7), 460-7. [Abstract]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Zheng, Y., Crawley, T., Taghli-Lamallem, O., Semsarian, C., Dunwoodie, S., Winlaw, D., Harvey, R., Fatkin, D., Towbin, J., Molkentin, J., Srivastava, D., Ocorr, K., Bruneau, B., Bodmer, R. (2011), Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology. 193(7), 1181-1196. [Abstract]
  • Au, C., Butler, T., Sherwood, M., Egan, J., North, K., Winlaw, D. (2011), Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy. International journal of experimental pathology. 92(1), 57-65. [Abstract]
  • Winlaw, D., Large, M., Jacobs, J., Barach, P. (2011), Leadership, surgeon well-being and non-technical competencies of pediatric cardiac surgery. Progress in Pediatric Cardiology. 32(2), 129-133.
  • Wang, D., Nykanen, M., Yang, N., Winlaw, D., North, K., Verkman, A., Owler, B. (2011), Altered cellular localisation of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Molecular and cellular neurosciences. 46(4), 318-24. [Abstract]
  • Moradi Marjaneh, M., Kirk, E., Posch, M., Ozcelik, C., Berger, F., Hetzer, R., Otway, R., Butler, T., Blue, G., Griffiths, L., Fatkin, D., Martinson, J., Winlaw, D., Feneley, M., Harvey, R. (2011), Investigation of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4. PloS One. 6(6), e20711-20717. [Abstract]

2010

   
  • Butler, T., Esposito, G., Blue, G., Cole, A., Costa, M., Waddell, L., Walizada, G., Sholler, G., Kirk, E., Feneley, M., Harvey, R., Winlaw, D. (2010), GATA4 Mutations in 357 Unrelated Patients with Congenital Heart Malformation. Genetic testing and molecular biomarkers. 14(6), 797-802. [Abstract]

2009

   
  • Kiely, C., Holland, A., Cole, A., Winlaw, D., Sholler, G. (2009), Transposition of the Great Arteries, Interrupted Inferior Vena Cava and Intestinal Atresia: A New Association?. Heart, lung & circulation. 18(0), 365-7. [Abstract]
  • Butler, T., Egan, J., Graf, F., Au, C., McMahon, A., North, K., Winlaw, D. (2009), Dysfunction induced by ischemia versus edema: does edema matter?. The Journal of Thoracic and Cardiovascular Surgery. 138(1), 141-147. [Abstract]
  • Egan, J., Butler, T., Cole, A., Abraham, S., Murala, J., Baines, D., Street, N., Thompson, L., Biecker, O., Dittmer, J., Cooper, S., Au, C., North, K., Winlaw, D. (2009), Myocardial membrane injury in pediatric cardiac surgery: An animal model. The Journal of Thoracic and Cardiovascular Surgery. 137(5), 1154-1162. [Abstract]

2008

   
  • Egan, J., Butler, T., Cole, A., Aharonyan, A., Baines, D., Street, N., Navaratnam, M., Biecker, O., Zazulak, C., Au, C., Tan, Y., North, K., Winlaw, D. (2008), Myocardial ischemia is more important than the effects of cardiopulmonary bypass on myocardial water handling and postoperative dysfunction: A pediatric animal model. The Journal of Thoracic and Cardiovascular Surgery. 136(5), 1265-1273.e2. [Abstract]
  • Au, C., Butler, T., Egan, J., Cooper, S., Lo, H., Compton, A., North, K., Winlaw, D. (2008), Changes in skeletal muscle expression of AQP1 and AQP4 in dystrophinopathy and dysferlinopathy patients. Acta neuropathologica. 116(3), 235-46. [Abstract]
  • Bhate, S., Rossiter-Thornton, M., Cooper, S., Gillis, J., Cole, A., Sholler, G., Chard, R., Winlaw, D. (2008), Use of sildenafil and nitric oxide in the management of hypoxemia owing to pulmonary arteriovenous fistulas after total cavopulmonary connection. The Journal of thoracic and cardiovascular surgery. 135(2), 446-448. [Abstract]