Associate Professor David Winlaw

Paediatric Cardiac Surgeon, Head Kids Heart Research
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 3063
F: +61 2 9845 2163
E:

Biographical details

A/Prof Winlaw is a clinician and researcher. He completed his MD at St Vincent's Hospital and did further training in transplantation and paediatric cardiac surgery. He now leads this service at The Children's Hospital at Westmead. [More...]

Research interests

Pediatric Cardiac Surgery

Genetics of congenital heart disease.

Low cardiac output state after cardiac surgery.

Brain outcomes after cardiac surgery in children.

Human factors in cardiac surgery.

Teaching areas

A/Prof Winlaw is involved in post graduate teaching through supervision of PhD students and medical students at all stages of their course.

Current national competitive grants*

2012

Genetic Basis of Valvular Heart Disease
Semsarian C, Weintraub R, Winlaw D, Bagnall R
NHMRC Project Grants ($434,255 over 3 years)

* Grants administered through the University of Sydney

Keywords

Genetics; Cardiovascular diseases; Surgery

Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Soemedi, R., Wilson, I., Bentham, J., Darlay, R., Töpf, A., Zelenika, D., Cosgrove, C., Setchfield, K., Thornborough, C., Granados-Riveron, J., Blue, G., Breckpot, J., Hellens, S., Zwolinkski, S., Glen, E., Mamasoula, C., Rahman, T., Hall, D., Rauch, A., Devriendt, K., Gewillig, M., O' Sullivan, J., Winlaw, D., Bu'Lock, F., Brook, J., Bhattacharya, S., Lathrop, M., Santibanez-Koref, M., Cordell, H., Goodship, J., Keavney, B. (2012), Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. American Journal of Human Genetics. 91(3), 489-501. [Abstract]
  • Blue, G., Kirk, E., Sholler, G., Harvey, R., Winlaw, D. (2012), Congenital heart disease: current knowledge about causes and inheritance. Medical Journal of Australia. 197(3), 155-159. [Abstract]
  • Walker, K., Badawi, N., Halliday, R., Stewart, J., Sholler, G., Winlaw, D., Sherwood, M., Holland, A. (2012), Early Developmental Outcomes following Major Noncardiac and Cardiac Surgery in Term Infants: A Population-Based Study. The Journal of Pediatrics. 161(4), 748-752. [Abstract]
  • Soemedi, R., Topf, A., Wilson, I., Darlay, R., Rahman, T., Glen, E., Hall, D., Huang, N., Bentham, J., Bhattacharya, S., Cosgrove, C., Brook, J., Granados-Riveron, J., Setchfield, K., Bu'lock, F., Thornborough, C., Devriendt, K., Breckpot, J., Hofbeck, M., Lathrop, M., Rauch, A., Blue, G., Winlaw, D., Hurles, M., Santibanez-Koref, M., Cordell, H., Goodship, J., Keavney, B. (2012), Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Human Molecular Genetics. 21(7), 1513-1520. [Abstract]
  • Winlaw, D., Badawi, N., Jacobe, S., Kasparian, N., Cooper, S., Murphy, D., Sherwood, M., Roberts, P., Leclair, K., Scarfe, G., Sholler, G. (2012), Hypoplastic left heart syndrome in context. Journal of Paediatrics and Child Health. 48(2), E7-9. [Abstract]

2011

   
  • Esposito, G., Butler, T., Blue, G., Cole, A., Sholler, G., Kirk, E., Grossfeld, P., Perryman, B., Harvey, R., Winlaw, D. (2011), Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of fallot or hypoplastic left heart. American Journal of Medical Genetics. Part A. 155A(10), 2416-2421. [Abstract]
  • Sholler, G., Kasparian, N., Pye, V., Cole, A., Winlaw, D. (2011), Fetal and post-natal diagnosis of major congenital heart disease: Implications for medical and psychological care in the current era. Journal of paediatrics and child health. 47(10), 717-22. [Abstract]
  • Padley, J., Cole, A., Pye, V., Chard, R., Nicholson, I., Jacobe, S., Baines, D., Badawi, N., Walker, K., Scarfe, G., Leclair, K., Sholler, G., Winlaw, D. (2011), Five-year Analysis of Operative Mortality and Neonatal Outcomes in Congenital Heart Disease. Heart, lung & circulation. 20(7), 460-7. [Abstract]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Zheng, Y., Crawley, T., Taghli-Lamallem, O., Semsarian, C., Dunwoodie, S., Winlaw, D., Harvey, R., Fatkin, D., Towbin, J., Molkentin, J., Srivastava, D., Ocorr, K., Bruneau, B., Bodmer, R. (2011), Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology. 193(7), 1181-1196. [Abstract]
  • Au, C., Butler, T., Sherwood, M., Egan, J., North, K., Winlaw, D. (2011), Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy. International journal of experimental pathology. 92(1), 57-65. [Abstract]
  • Wang, D., Nykanen, M., Yang, N., Winlaw, D., North, K., Verkman, A., Owler, B. (2011), Altered cellular localisation of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Molecular and cellular neurosciences. 46(4), 318-24. [Abstract]
  • Winlaw, D., Large, M., Jacobs, J., Barach, P. (2011), Leadership, surgeon well-being and non-technical competencies of pediatric cardiac surgery. Progress in Pediatric Cardiology. 32(2), 129-133.
  • Moradi Marjaneh, M., Kirk, E., Posch, M., Ozcelik, C., Berger, F., Hetzer, R., Otway, R., Butler, T., Blue, G., Griffiths, L., Fatkin, D., Martinson, J., Winlaw, D., Feneley, M., Harvey, R. (2011), Investigation of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4. PloS One. 6(6), e20711-20717. [Abstract]

2010

   
  • Butler, T., Esposito, G., Blue, G., Cole, A., Costa, M., Waddell, L., Walizada, G., Sholler, G., Kirk, E., Feneley, M., Harvey, R., Winlaw, D. (2010), GATA4 Mutations in 357 Unrelated Patients with Congenital Heart Malformation. Genetic testing and molecular biomarkers. 14(6), 797-802. [Abstract]

2009

   
  • Kiely, C., Holland, A., Cole, A., Winlaw, D., Sholler, G. (2009), Transposition of the Great Arteries, Interrupted Inferior Vena Cava and Intestinal Atresia: A New Association?. Heart, lung & circulation. 18(0), 365-7. [Abstract]
  • Butler, T., Egan, J., Graf, F., Au, C., McMahon, A., North, K., Winlaw, D. (2009), Dysfunction induced by ischemia versus edema: does edema matter?. The Journal of Thoracic and Cardiovascular Surgery. 138(1), 141-147. [Abstract]
  • Egan, J., Butler, T., Cole, A., Abraham, S., Murala, J., Baines, D., Street, N., Thompson, L., Biecker, O., Dittmer, J., Cooper, S., Au, C., North, K., Winlaw, D. (2009), Myocardial membrane injury in pediatric cardiac surgery: An animal model. The Journal of Thoracic and Cardiovascular Surgery. 137(5), 1154-1162. [Abstract]

2008

   
  • Egan, J., Butler, T., Cole, A., Aharonyan, A., Baines, D., Street, N., Navaratnam, M., Biecker, O., Zazulak, C., Au, C., Tan, Y., North, K., Winlaw, D. (2008), Myocardial ischemia is more important than the effects of cardiopulmonary bypass on myocardial water handling and postoperative dysfunction: A pediatric animal model. The Journal of Thoracic and Cardiovascular Surgery. 136(5), 1265-1273.e2. [Abstract]
  • Au, C., Butler, T., Egan, J., Cooper, S., Lo, H., Compton, A., North, K., Winlaw, D. (2008), Changes in skeletal muscle expression of AQP1 and AQP4 in dystrophinopathy and dysferlinopathy patients. Acta neuropathologica. 116(3), 235-46. [Abstract]
  • Bhate, S., Rossiter-Thornton, M., Cooper, S., Gillis, J., Cole, A., Sholler, G., Chard, R., Winlaw, D. (2008), Use of sildenafil and nitric oxide in the management of hypoxemia owing to pulmonary arteriovenous fistulas after total cavopulmonary connection. The Journal of thoracic and cardiovascular surgery. 135(2), 446-448. [Abstract]

2007

   
  • Schell, D., Winlaw, D. (2007), Peri-operative management of paediatric patients undergoing cardiac surgery - focus on respiratory aspects of care. Paediatric respiratory reviews. 8(4), 336-347. [Abstract]
  • Winlaw, D. (2007), Congenital heart disease in the 21st century. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. 9(3), 270-274. [Abstract]
  • Kirk, E., Sunde, M., Costa, M., Rankin, S., Wolstein, O., Castro, M., Butler, T., Hyun, C., Guo, G., Otway, R., Mackay, J., Waddell, L., Cole, A., Hayward, C., Keogh, A., Macdonald, P., Griffiths, L., Fatkin, D., Sholler, G., Zorn, A., Feneley, M., Winlaw, D., Harvey, R. (2007), Mutations in Cardiac T-Box Factor Gene TBX20 Are Associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy. American journal of human genetics. 81(2), 280-91. [Abstract]
  • Dimmick, S., Walker, K., Badawi, N., Halliday, R., Cooper, S., Nicholson, I., Sherwood, M., Chard, R., Hawker, R., Lau, K., Jones, O., Grant, P., Sholler, G., Winlaw, D. (2007), Outcomes following surgery for congenital heart disease in low-birthweight infants. Journal of paediatrics and child health. 43(5), 370-375. [Abstract]
  • Blue, G., Mah, J., Cole, A., Lal, V., Wilson, M., Chard, R., Sholler, G., Hawker, R., Sherwood, M., Winlaw, D. (2007), The negative impact of Alagille syndrome on survival of infants with pulmonary atresia. The Journal of thoracic and cardiovascular surgery. 133(4), 1094-1096. [Abstract]