Professor Patrick Tam

Professor & NHMRC Senior Principal Research Fellow
Medicine, Children's Medical Research Institute

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 96872800
F: 96872120
E:

Research interests

Dr Tam is internationally recognized for pioneering the application of micromanipulation and embryo culture for analyzing the development of mouse embryos and fate mapping of the mouse germ layers and embryonic gut.

His research focuses on the cellular and molecular mechanisms of body patterning during mouse development. His research includes pioneering the application of micromanipulation and embryo culture for analysing mouse embryos and examining the development of the neural tube and embryonic gut. His other current research is on X-linked diseases.

Current national competitive grants*

2012

Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells and liver progenitor cells
Alexander I, Tam P, Russell D, Yeoh G
NHMRC Project Grants ($770,175 over 3 years)

A molecular paradigm of organ formation during embryonic development: The role of RhoGTPase
Tam P, Loebel D
ARC Discovery Projects ($300,000 over 3 years)

* Grants administered through the University of Sydney

Keywords

Genetics; Embryology; Stem cells; Genetic processes; Birth defects

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013), The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss fof Twist1 function. Developmental Biology. 374(2), 295-307. [Abstract]
  • Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013), Chromatin context and ncRNA highlight targets of MeCP2 in brain. RNA Biology. 10(11), 1741-1757. [Abstract]
  • Ng, H., Tam, P. (2013), The mystique of cellular reprogramming. Current Opinion in Genetics & Development. 23, 501-503. [Abstract]
  • Arkell, R., Fossat, N., Tam, P. (2013), Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output. Current Opinion in Genetics & Development. 23(4), 454-460. [Abstract]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Perkins, A., Tam, P., Pearson, R., Crossley, M. (2013), Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology. 33(15), 2976-2987. [Abstract]
  • Tam, P., Pera, M. (2013), Stem cell science and regenerative medicine. BioEssays. 35, 147-148. [Abstract]
  • Stephensen, R., Rossant, J., Tam, P. (2013), Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages. In: Mammalian Development: Networks, Switches, and Morphogenetic Processes. (pp.167-182).United States: Cold Spring Harbor Laboratory Press.
  • Tam, P., Nelson, W., Rossant, J. (2013), Mammalian Development: Networks, Switches, and Morphogenetic Processes. New York USA: Cold Spring Harbor Laboratory Press.
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013), Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Development. 27(1), 18-23. [Abstract]
  • Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Nishinakamura, R. (2013), Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PloS One. 8(3), e57428. [Abstract]

2012

   
  • Stephenson, R., Rossant, J., Tam, P. (2012), Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology. 4(11), a008235. [Abstract]
  • Arkell, R., Tam, P. (2012), Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology. 2(3), 120030. [Abstract]
  • Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Behringer, R., Tam, P. (2012), Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Developmental biology. 362(2), 132-40. [Abstract]
  • Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi, D., Landsberger, N., Christodoulou, J. (2012), A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics. 131(2), 187-200. [Abstract]
  • Loebel, D., Tam, P. (2012), Rho GTPases in endoderm development and differentiation. Small GTPases. 3(1), 40-44. [Abstract]
  • Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012), Modulation of WNT signaling activity is key to the formation of the embryonic head. Cell Cycle. 11(1), 26-32. [Abstract]

2011

   
  • Tam, P. (2011), Endoderm formation: not so black and white anymore. Developmental Cell. 21(4), e2. [Abstract]
  • Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Robb, L., Tam, P. (2011), Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development. 138(20), 4511-4522. [Abstract]
  • Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., Tam, P. (2011), Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Development, growth & differentiation. 53(7), 843-56. [Abstract]
  • Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, K., Mukhopadhyay, M., Westphal, H., Nolan, P., Arkell, R., Tam, P. (2011), Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development. 138(4), 667-676. [Abstract]
  • Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai, Y., Tam, P., Loebel, D. (2011), Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. The International Journal of Developmental Biology. 55(1), 45-58. [Abstract]
  • Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011), Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. In: Imaging in Developmental Biology: A Laboratory Manual. (pp.311-329).United States: Cold Spring Harbor Laboratory Press.
  • Combes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, A., Little, M., Tam, P., Koopman, P. (2011), Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development. 5(3), 124-130. [Abstract]

2010

   
  • Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010), Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Developmental dynamics : an official publication of the American Association of Anatomists. 239(11), 2851-9. [Abstract]
  • Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, P., Jamieson, R. (2010), Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness. Investigative ophthalmology & visual science. 51(11), 5561-70. [Abstract]
  • Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010), Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Developmental Dynamics. 239(9), 2319-2329. [Abstract]
  • Fath, T., Agnes Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., Khoo, P., Gunning, P. (2010), New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2. European journal of cell biology. 89(7), 489-98. [Abstract]
  • Pera, M., Tam, P. (2010), Extrinsic regulation of pluripotent stem cells. Nature. 465(7299), 713-720. [Abstract]
  • Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. (2010), Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons. The Journal of Neuroscience. 30(4), 1494-1501. [Abstract]
  • Rivera-Pérez, J., Jones, V., Tam, P. (2010), Culture of Whole Mouse Embryos at Early Postimplantation to Organogenesis Stages: Developmental Staging and Methods. In: Methods in Enzymology: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells. (pp.185-203).United States: Elsevier Inc..

2009

   
  • Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J., Tam, P., Grigg, J., Flaherty, M., Gole, G., Jamieson, R. (2009), Novel SOX2 partner-factor domain mutation in a four-generation family. European journal of human genetics : EJHG. 17(11), 1417-22. [Abstract]
  • Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Tam, P. (2009), Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology. 331(2), 176-188. [Abstract]
  • Grassinger, J., Haylock, D., Storan, M., Haines, G., Williams, B., Whitty, G., Vinson, A., Be, C., Li, S., Sørensen, E., Tam, P., Denhardt, D., Sheppard, D., Choong, P., Nilsson, S. (2009), Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood. 114(1), 49-59. [Abstract]
  • Tam, P., Loebel, D. (2009), Specifying mouse embryonic germ cells. Cell. 137(3), 398-400. [Abstract]
  • Rossant, J., Tam, P. (2009), Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development. 136(5), 701-713. [Abstract]

2008

   
  • Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., Robertson, E., Tam, P., Harvey, R. (2008), BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes & development. 22(21), 3037-3049. [Abstract]
  • Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008), Chromosomal rearrangements and novel genes in disorders of eye development, cataract and glaucoma. Twin Research and Human Genetics. 11(4), 412-421. [Abstract]
  • Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, P. (2008), Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development. 125(7), 587-600. [Abstract]
  • Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008), Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression. The European journal of neuroscience. 27(12), 3342-50. [Abstract]
  • Lewis, S., Khoo, P., De Young, R., Steiner, K., Wilcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Tam, P. (2008), Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development (Cambridge). 135(10), 1791-1801. [Abstract]
  • Gabriel, A., Khoo, P., Wong, N., Paul, A., Patrick, P. (2008), Cell grafting and labeling in postimplantation mouse embryos. Methods in Molecular Biology. 461(0), 47-70. [Abstract]
  • Watson, C., Trainor, P., Radziewic, T., Pelka, G., Zhou, S., Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P. (2008), Application of lacZ Transgenic Mice to Cell Lineage Studies. Methods in Molecular Biology. 461, 149-164. [Abstract]