Associate Professor Stephen Alexander

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 3430
F: +61 2 9845 3432
E:

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Themes | Grants | Keywords | Publications

 

Current national competitive grants*

2012

Role of purines in renal and transplant injury
Alexander S, Dwyer K, Wang Y
NHMRC Project Grants ($539,610 over 3 years)

Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection
Jones C, Alexander S
NHMRC Project Grants ($581,010 over 3 years)

TOLERANCE OR REJECTION ? THE ROLE OF INNATE IMMUNITY IN DETERMINNG THE FATE OF A KIDNEY ALLOGRAFT
Chadban S, Wu H, Alexander S
NHMRC Project Grants ($489,255 over 3 years)

* Grants administered through the University of Sydney

Keywords

Immunology; Immune tolerance; Child health; Transplantation; Nephrology

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Lahoud, M., Caminschi, I., Harris, D., Alexander, S. (2013), DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International. 83(2), 223-232. [Abstract]
  • Wyld, M., Clayton, P., Jesudason, S., Chadban, S., Alexander, S. (2013), Pregnancy outcomes for kidney transplant recipients. American Journal of Transplantation. 13(12), 3173-3182. [Abstract]
  • Fernandez, M., Yu, U., Zhang, G., White, R., Sparwasser, T., Alexander, S., Jones, C. (2013), Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology. 447(1-2), 9-20. [Abstract]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013), Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation. 22(10), 1929-1941. [Abstract]
  • Fletcher, J., McDonald, S., Alexander, S. (2013), Prevalence of genetic renal disease in children. Pediatric Nephrology. 28(2), 251-256. [Abstract]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Sparwasser, T., Bishop, G., Sharland, A., Alexander, S. (2013), Infiltrating Foxp3(+) Regulatory T Cells From Spontaneously Tolerant Kidney Allografts Demonstrate Donor-Specific Tolerance. American Journal of Transplantation. 13(11), 2819-2830. [Abstract]
  • Wang, Y., Alexander, S. (2013), IL-2/Anti-IL-2 Complex: A Novel Strategy of In Vivo Regulatory T Cell Expansion in Renal Injury. Journal of the American Society of Nephrology. 24, 1503-1504. [Abstract]
  • Ingelfinger, J., Alexander, S. (2013), One step closer to "rejectostix". The New England Journal of Medicine. 369, 84-85. [Abstract]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Alexander, S., Harris, D., Wang, Y. (2013), Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International. 84(4), 745-755. [Abstract]
  • Hu, M., Fletcher, J., McCahon, E., Catchpoole, D., Zhang, G., Wang, Y., Algar, E., Alexander, S. (2013), Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein. The Journal of Pediatrics. 163(1), 224-229. [Abstract]
  • Kui Tan, T., Zheng, G., Hsu, T., Ra Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Min Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Thompson, E., Harris, D. (2013), Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation. 93(4), 434-449. [Abstract]
  • Wyburn, K., Chadban, S., Kwan, T., Alexander, S., Wu, H. (2013), Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. American Journal of Physiology. Renal physiology. 304(1), F68-76. [Abstract]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013), Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology. 6(3), 326-333. [Abstract]

2012

   
  • Wu, H., Noordmans, G., O'Brien, M., Ma, J., Zhao, C., Zhang, G., Kwan, T., Alexander, S., Chadban, S. (2012), Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance. Journal of the American Society of Nephrology. 23(10), 1701-1716. [Abstract]
  • Chapman, J., Alexander, S. (2012), The Candle Illuminating the Pathway to Tolerance?. American Journal of Kidney Diseases. 60, 521-523. [Abstract]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Unwin, R., Harris, D., Dwyer, K., Alexander, S. (2012), Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology. 42(9), 2441-2451. [Abstract]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Sprent, J., Harris, D., Alexander, S., Wang, Y. (2012), IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology. 23(8), 1303-1308. [Abstract]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012), CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology. 23(6), 1058-1067. [Abstract]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012), Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. 81(9), 892-902. [Abstract]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., Kaplan, W., Chapman, J., O'Connell, P., Grey, S. (2012), Human islets express a marked pro-inflammatory molecular signature prior to transplantation. Cell Transplantation. 21(9), 2063-2078. [Abstract]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, L., Saito, M., Sawyer, A., Harris, D., Alexander, S., Durkan, A. (2012), DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine. 5(1), 24-33. [Abstract]

2011

   
  • Bishop, G., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011), Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation. 92(8), e39. [Abstract]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011), IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology : JASN. 22(7), 1229-39. [Abstract]
  • Bishop, G., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011), Approaching the Promise of Operational Tolerance in Clinical Transplantation. Transplantation. 91(10), 1065-1074. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011), Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron. Experimental nephrology. 117(4), e93-103. [Abstract]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011), Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron. Experimental nephrology. 118(4), e87-99. [Abstract]

2010

   
  • Nankivell, B., Alexander, S. (2010), Rejection of the kidney allograft. New England Journal of medicine. 363(15), 1451-1462. [Abstract]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010), IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology : JASN. 21(6), 933-42. [Abstract]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010), Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. 18(5), 965-76. [Abstract]
  • Sedger, L., Katewa, A., Pettersen, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010), Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood. 115(16), 3258-68. [Abstract]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010), The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(3), 717-30. [Abstract]

2009

   
  • Albaramki, J., Teo, J., Alexander, S. (2009), Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. Pediatric nephrology (Berlin, Germany). 24(9), 1749-52. [Abstract]
  • Fletcher, J., Nankivell, B., Alexander, S. (2009), Chronic allograft nephropathy. Pediatric nephrology (Berlin, Germany). 24(0), 1465-71. [Abstract]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009), Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American journal of pathology. 175(2), 580-91. [Abstract]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009), Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation. 14(4), 357-363. [Abstract]
  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009), CCL2 DNA vaccine to treat renal disease. The international journal of biochemistry & cell biology. 41(0), 729-32. [Abstract]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009), Foxp3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation. 14(1), 40-45. [Abstract]
  • Wang, Y., Alexander, S. (2009), CD8 regulatory T cells: what's old is now new. Immunology and cell biology. 87(3), 192-193. [Abstract]

2008

   
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008), Regulatory immune cells in kidney disease. American journal of physiology. Renal physiology. 295(2), F335-42. [Abstract]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008), Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of immunology (Baltimore, Md. : 1950). 180(10), 6593-6603. [Abstract]
  • Williams, G., Fletcher, J., Alexander, S., Craig, J. (2008), Vesicoureteral reflux. Journal of the American Society of Nephrology : JASN. 19(5), 847-862. [Abstract]
  • Hodson, E., Alexander, S. (2008), Evaluation and management of steroid-sensitive nephrotic syndrome. Current Opinion in Pediatrics. 20(2), 145-150. [Abstract]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008), T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. Journal of Immunology. 180(3), 1556-1564. [Abstract]
  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008), Chimerism and tolerance in a recipient of a deceased-donor liver transplant. The New England Journal of Medicine. 358(4), 369-374. [Abstract]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008), Regulatory T cells in renal disease. International Journal of Clinical and Experimental Medicine. 1(4), 294-304. [Abstract]