Associate Professor Stephen Alexander

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 3430
F: +61 2 9845 3432
E:

On this page

Themes | Grants | Keywords | Publications

 

Current national competitive grants*

2012

TOLERANCE OR REJECTION ? THE ROLE OF INNATE IMMUNITY IN DETERMINNG THE FATE OF A KIDNEY ALLOGRAFT
Chadban S, Wu H, Alexander S
NHMRC Project Grants ($489,255 over 3 years)

Role of purines in renal and transplant injury
Alexander S, Dwyer K, Wang Y
NHMRC Project Grants ($539,610 over 3 years)

Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection
Jones C, Alexander S
NHMRC Project Grants ($581,010 over 3 years)

* Grants administered through the University of Sydney

Keywords

Immunology; Immune tolerance; Child health; Transplantation; Nephrology

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2013

   
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Lahoud, M., Caminschi, I., Harris, D., Alexander, S. (2013), DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International. 83(2), 223-232. [Abstract]
  • Fletcher, J., McDonald, S., Alexander, S. (2013), Prevalence of genetic renal disease in children. Pediatric Nephrology. 28(2), 251-256. [Abstract]

2012

   
  • Wu, H., Noordmans, G., O'Brien, M., Ma, J., Zhao, C., Zhang, G., Kwan, T., Alexander, S., Chadban, S. (2012), Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance. Journal of the American Society of Nephrology. 23(10), 1701-1716. [Abstract]
  • Chapman, J., Alexander, S. (2012), The Candle Illuminating the Pathway to Tolerance?. American Journal of Kidney Diseases. 60, 521-523. [Abstract]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Unwin, R., Harris, D., Dwyer, K., Alexander, S. (2012), Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology. 42(9), 2441-2451. [Abstract]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Sprent, J., Harris, D., Alexander, S., Wang, Y. (2012), IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology. 23(8), 1303-1308. [Abstract]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012), CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology. 23(6), 1058-1067. [Abstract]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012), Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. 81(9), 892-902. [Abstract]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., Kaplan, W., Chapman, J., O'Connell, P., Grey, S. (2012), Human islets express a marked pro-inflammatory molecular signature prior to transplantation. Cell Transplantation. 21(9), 2063-2078. [Abstract]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, L., Saito, M., Sawyer, A., Harris, D., Alexander, S., Durkan, A. (2012), DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine. 5(1), 24-33. [Abstract]

2011

   
  • Bishop, G., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011), Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation. 92(8), e39. [Abstract]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011), IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology : JASN. 22(7), 1229-39. [Abstract]
  • Bishop, G., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011), Approaching the Promise of Operational Tolerance in Clinical Transplantation. Transplantation. 91(10), 1065-1074. [Abstract]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, G. (2011), Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant immunology. 24(3), 149-56. [Abstract]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011), Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron. Experimental nephrology. 117(4), e93-103. [Abstract]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011), Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron. Experimental nephrology. 118(4), e87-99. [Abstract]

2010

   
  • Nankivell, B., Alexander, S. (2010), Rejection of the kidney allograft. New England Journal of medicine. 363(15), 1451-1462. [Abstract]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010), IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology : JASN. 21(6), 933-42. [Abstract]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010), Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. 18(5), 965-76. [Abstract]
  • Sedger, L., Katewa, A., Pettersen, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010), Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood. 115(16), 3258-68. [Abstract]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010), The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(3), 717-30. [Abstract]

2009

   
  • Albaramki, J., Teo, J., Alexander, S. (2009), Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. Pediatric nephrology (Berlin, Germany). 24(9), 1749-52. [Abstract]
  • Fletcher, J., Nankivell, B., Alexander, S. (2009), Chronic allograft nephropathy. Pediatric nephrology (Berlin, Germany). 24(0), 1465-71. [Abstract]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009), Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American journal of pathology. 175(2), 580-91. [Abstract]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009), Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation. 14(4), 357-363. [Abstract]
  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009), CCL2 DNA vaccine to treat renal disease. The international journal of biochemistry & cell biology. 41(0), 729-32. [Abstract]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009), Foxp3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation. 14(1), 40-45. [Abstract]
  • Wang, Y., Alexander, S. (2009), CD8 regulatory T cells: what's old is now new. Immunology and cell biology. 87(3), 192-193. [Abstract]

2008

   
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008), Regulatory immune cells in kidney disease. American journal of physiology. Renal physiology. 295(2), F335-42. [Abstract]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008), Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of immunology (Baltimore, Md. : 1950). 180(10), 6593-6603. [Abstract]
  • Williams, G., Fletcher, J., Alexander, S., Craig, J. (2008), Vesicoureteral reflux. Journal of the American Society of Nephrology : JASN. 19(5), 847-862. [Abstract]
  • Hodson, E., Alexander, S. (2008), Evaluation and management of steroid-sensitive nephrotic syndrome. Current Opinion in Pediatrics. 20(2), 145-150. [Abstract]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008), T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. Journal of Immunology. 180(3), 1556-1564. [Abstract]
  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008), Chimerism and tolerance in a recipient of a deceased-donor liver transplant. The New England Journal of Medicine. 358(4), 369-374. [Abstract]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008), Regulatory T cells in renal disease. International Journal of Clinical and Experimental Medicine. 1(4), 294-304. [Abstract]

2007

   
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007), Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer immunology, immunotherapy : CII. 56(12), 1955-65. [Abstract]
  • Wu, H., Chen, G., Wyburn, K., Yin, J., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007), TLR4 activation mediates kidney ischemia/reperfusion injury. The Journal of clinical investigation. 117(10), 2847-59. [Abstract]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007), Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney international. 72(3), 290-9. [Abstract]
  • Wu, H., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007), Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. Journal of the American Society of Nephrology : JASN. 18(4), 1180-1189. [Abstract]
  • Alexander, S., Fletcher, J., Nankivell, B. (2007), Chronic allograft nephropathy in paediatric renal transplantation. Pediatric nephrology (Berlin, Germany). 22, 17-23. [Abstract]