Keratoconus is a bilateral progressive, non-inflammatory degenerative ectasia of the cornea that causes loss of visual function, due to a thinning and distortion of the cornea. It is the most common cause for a young patient to require corneal transplantation and occurs in up to 1 in 2000 in the community. At least 10,000 people are living with keratoconus in Australia and around 400 new cases are diagnosed each year. It is the most common indication for corneal transplantation in Australia. The cause of the condition is unknown. The Keratoconus Research Group aims to find out the exact causes of the disease and improve and develop effective diagnosis and treatment methods. We have achieved significant progression on identifying a potential interaction network specific to keratoconus. Validation of this molecular network is ongoing.