ELECTROPHYSIOLOGY AND GLAUCOMA RESEARCH

Group leader

Group Members

Professor Stuart Graham PhD MBBS MS FRANZCO FRACS
Professor John Grigg MBBS FRANZCO FRACS
A/Professor Hema Arvind MBBS FRANZCO FRACS
Dr Yuyi You Post-Doc Fellow
Dr Nonna Saakova Electrophysiology Technician
Chenyu Tim Wang PhD Student

Research Activity

This research group continues to conduct research into new techniques for electrodiagnosis and imaging of the visual system. The group conducted severall electrophysiological studies aimed at the early detection of glaucoma. In close collaboration with the Brain and Mind Centre and North Shore Hospital Department of Neurology, the group is conducted research aimed at studying mechanisms of de/remyelination and axonal loss in multiple sclerosis using the visual system as a model.

Projects

Development of a Blue/Yellow Multifocal Visual Evoked Potential

Martins, Klistorner, Graham, Arvind

Research is also continues into use of blue-yellow stimuli for presenting the multifocal Visual Evoked Potential (mVEP) in an attempt to detect glaucoma at an earlier stage. The rationale for this is that in subjective perimetry blue/yellow testing has been shown to be more effective at detecting early disease. To date, the mVEP technique has used a black and white stimulus to demonstrate abnormal visual field defects in glaucoma cases. A study was completed in 2009 investigating the power of Blue-on-Yellow mfVEP in detecting pre-perimetric glaucoma. The technique demonstrated high sensitivity in cases where subjective perimetry was still normal. Longitudinal (5 years) research is now underway to investigate the predictive power of Blue-on-Yellow mfVEP in glaucoma as compared to other structural and functional methods.

Multi-focal VEP and OCT in MS optic neuritis and NMO patients

This project studies electrophysiological and structural features of MS and NMO optic neuritis.

Chronic demyelination and axonal loss in MS

Effect of chronic demyelination on axonal neurodegeneration in MS is studies using visual system as a model.

Mechanisms of axonal loss in MS

This project investigates potential role of trans-synaptic degeneration in MS.