Burns research & reconstructive surgery

Identifying the diffusible factor(s) produced by skin cells grown on tropoelastin scaffolds

Almine J., Li Z., Maitz P.K.M. and Weiss, A.S.

The main aim of this project is to study the cell-scaffold interaction and identify the diffusible factor(s) produced by skin cells cultured on the scaffold, which promotes cell proliferation and possible keratinocyte differentiation.

Identifying the diffusible factor(s) responsible for the proliferation of keratinocytes and fibroblasts would be important progress in the treatment of burns and the development of a suitable skin graft. The treatment of burns patients involves the rapid coverage and closure of the wounds, which is dependent on cell proliferation and differentiation, ultimately re-establishing the epidermis and dermis. This process can be facilitated by the addition of a diffusible factor(s); consequently achieving rapid wound closure, reducing the chance of infection and re-forming skin with minimal scarring.