Epithelial Transport Laboratory

Lab head: David Cook
Location: Medical Foundation Building

This laboratory investigates the transport processes in the cell membrane and the manner in which cells control their membrane transport activity.  Particular emphasis has been placed on the mechanisms of sodium ion channel regulation and calcium signalling in epithelial cells.

Current research:


  • The mechanisms by which epithelial sodium (Na+) channels are controlled

  • The control of Na+/H+ exchange in epithelial cells

  • The mechanisms by which ion transport systems are controlled

  • The development of replication-deficient adenoviruses as a tool in studying the role of membrane transport systems in cellular function

Lab members: D Cook (head)

Use of replication-deficient adenoviruses and retroviruses to investigate control of epithelial sodium channels in epithelia

Primary supervisor: David Cook

Use of replication-deficient adenoviruses and retroviruses to investigate control of epithelial sodium channels in epithelia.

There are several different aspects of this project, each of which would be suitable for an honours project. One aspect will be to examine to mechanism by which pathogens and particularly viruses regulate sodium channel activity. Another is to investigate the role of the sgkkinase in regulating sodium channel activity. The third is to examine the mechanisms by which extracellular nucleotides such as ATP regulate sodium channel activity. Each of these projects combines molecular biology with electrical measurements of sodium transport across epithelia.


Discipline: Physiology
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