Epithelial Transport Laboratory
Lab head: David Cook
Location: Medical Foundation Building
This laboratory investigates the transport processes in the cell membrane and the manner in which cells control their membrane transport activity. Particular emphasis has been placed on the mechanisms of sodium ion channel regulation and calcium signalling in epithelial cells.
- The mechanisms by which epithelial sodium (Na+) channels are controlled
- The control of Na+/H+ exchange in epithelial cells
- The mechanisms by which ion transport systems are controlled
- The development of replication-deficient adenoviruses as a tool in studying the role of membrane transport systems in cellular function
Lab members: D Cook (head)
Characterisation of ClC family chloride channels in salivary and other epithelia
Primary supervisor: David Cook
This project will use patch-clamp methods in cultured epithelia to characterise the chloride channels found in their membranes and to investigate the mechanisms by which their activity is controlled.