Geriatric Pharmacology Research Team
Lab head: A/Prof Sarah Hilmer
Location: Royal North Shore Hospital
Pharmacokinetics and pharmacodynamics of fentanyl in old age and frailty
Primary supervisor: Sarah Hilmer
This project aims to improve our understanding of clinical pharmacology in old age and frailty. The target drug, fentanyl, is administered intravenously to patients undergoing upper gastrointestinal endoscopies and colonoscopies. It is a marker of hepatic blood flow and of CYP3A clearance. The student will recruit young, older robust and older frail participants, take 3-4 blood samples for measurement of fentanyl concentrations, and observe participants for respiratory depression. The student will use software to analyse the roles of age, frailty, sex, co-medications, co-morbidities and body composition on pharmacokinetics and pharmacodynamics of fentanyl.