Lab head: Prof David J Handelsman
Location: ANZAC Research Institute (Concord Hospital)
Role of androgens in experimental breast cancer
Primary supervisor: Ulla Simanainen
Breast cancer is the most common invasive cancer in Australian women. Yet for such a common fatal disease, the causes and mechanisms in breast cancer remain speculative. While estrogens have a widely understood involvement, the role of androgens via androgen receptor (AR) remains controversial. AR is expressed in normal mammary cells and in 70-90% of breast cancers and based on our preliminary data AR functions as a tumor suppressor in experimental breast cancer.
The Honours project(s) aim to 1) identify androgen signalling in the breast cancer 2) determine modifying factors for androgen signalling in breast cancer and 3) determine the role of AR in transplants of human breast cancer cells. The Honours students will get experience in mouse models, cell culture, siRNA technique, techniques of molecular biology (qRT-PCR), cell biology (histology/immunohistochemistry) and biochemistry (hormone assays).
Co-supervisors: Yan Ru (Ellen) Gao, Yu Zheng
Keywords: Breast cancer, Andrology, Endocrinology