Laboratory of Blood Cell Development

Lab head: Dr. Stuart Fraser
Location: Room 233, Medical Foundation Building

Our group is interested in the processes that regulate the formation and production of blood cells. This first occurs in the developing embryo. In fact, blood cells are the first mature cell types to form in the embryo. We are interested in how red blood cells form as well as haematopoietic stem cells (HSC), the "master" cells that can give rise to all blood cells.

 

We are interested in;

*Red blood cell formation in the embryo

*Production of HSC in developing embryo

*The processes regulating the condensation and expulsion of the nucleus from developing red blood cells.

*The evolutionary and molecular biology behind red blood cell enucleation.

*Understanding how macrophages regulate blood cell production.

*Relating our findings to human blood diseases. 

Website: http://www.physiol.usyd.edu.au/~fraser/
Lab members: Miss Veronica Antas-Masters Student Dr. Angeles Sanchez-Perez, Senior Research Associate
Research approach equipment: Flow cytometry, cell culture, embryonic stem cells, hematopoietic stem cells, immunohistochemistry

The role of macrophages in red blood cell production.

Primary supervisor: Stuart Fraser

Macrophages and developing red blood cells, or erythroblasts, are found in intimate contact in the bone marrow in structure termed erythroblastic islands. However, our understanding of this cell-cell interaction is very limited. We would like to examine whether erythroblastic island macrophages are a unique population and whether we can isolate these cells for functional and genetic analyses. 


Discipline: Physiology
Keywords: Haematology, Macrophages
Contact: Email Stuart Fraser