Vascular Immunology Laboratory
Lab head: Professor Georges Grau
Location: K25 - Medical Foundation Building
This laboratory seeks to decipher the fine interactions between microvascular endothelial cells and circulating blood cells, by studying the biology and pathophysiology of microvascular endothelial cells. Diseases such as cerebral malaria, multiple sclerosis and viral encephalitis are being modelled using brain-derived endothelium, while lung-derived cell-lines are being used to study adult respiratory distress syndrome, asthma, and other pulmonary illnesses. In addition to functional studies, the latest imaging technology is being used to visualise the diverse players involved in inflammation. Using these integrated approaches, the cellular, molecular and genetic features of microvascular biology will be explored.
Improved understanding of pathophysiological mechanisms will lead not only to significant advances in fundamental knowledge of biology, but also will identify new targets for the development of drugs intended to treat the many diseases caused by inflammatory processes.
Examining an immunomodulatory role for endothelial microparticles
Primary supervisor: Julie Wheway
This project aims to extend on new data obtained in our lab demonstrating a novel immunomodulatory role for brain endothelial microparticles (EMP) in T cell activation. EC-MP will be co-cultured with both CD4+ and CD8+ T cells and their ability to modulate T cell activation assessed. Properties of the EMP will be examined to determine the means by which this modulation occurs.
Techniques used will include cell culture, flow cytometry and fluorescence microscopy and western blotting.
Co-supervisors: Georges Grau
Keywords: Brain, T-cells, Immunology