Cancer Biology Group

Lab head: Qihan Dong
Location: Room 371, Blackburn Building

Mechanism of cell cycle re-entry by quiescent prostate cancer cells

Primary supervisor: Qihan Dong

Background:
Cancers are made up of both actively dividing and "resting" cancer cells. These resting or quiescent cancer cells are thought to be central to relapse, after actively dividing cancer cells are eliminated by chemo- or radio-therapy. One can envisage if cell cycle re-entry by these quiescent cancer cells is blocked, cancer recurrence can be prevented or delayed. However, the regulatory signals required for quiescent cancer cells to re-enter the cell cycle have not been determined. Identification of these signals will provide needed molecular targets for preventing cancer recurrence. We have found a list of genes that are over-expressed in advanced form of prostate cancer compared with either normal prostate or organ-confined prostate cancer. The role these gene products play in promoting cell cycle re-entry by quiescent prostate cancer cells is unclear.
 
Aim of Study:
To determine the effect of gene products that are over-expressed in advanced form of prostate cancer in cell cycle re-entry by quiescent prostate cancer cells.
 
Methods:
Honours students will learn cell culture and immunoblot and use these techniques to determine the identified gene product (proteins) in cell cycle re-entry by quiescent cancer cells.
 
Ethics Application Requirements:
Not required as all are in vitro studies.
 
Key References:
Desoize B, Jardillier J. Multicellular resistance: a paradigm for clinical resistance? Crit Rev Oncol Hematol 2000;36:193-207.


Discipline: Pathology
Co-supervisors: Brett Hambly
Keywords: Cell biology, Cancer
Contact: Email Qihan Dong