Professor Emeritus Brian J. Morris

Professor Emeritus
Physiology, School of Medical Sciences
Bosch Institute

F13 - Anderson Stuart Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 3688
F: +61 2 9351 2227
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W: Related website
Curriculum vitae

Biographical details

Brian Morris was appointed to the academic staff of the Department (now Discipline) of Physiology in 1978 after 3 years of postdoctoral studies in the USA as a CJ Martin Fellow, then an Advanced Fellow of the American Heart Association, firstly at the University of Missouri, Columbia, in 1975-1976, then at the University of California, San Francisco, from 1976-1978. He has been a Professor since 1999. In Sep 2013 the University of Sydney Senate appointed him as Professor Emeritus. His research has been mostly in the realm of molecular biology and molecular genetics, with a particular interest in hypertension. He won the Edgeworth David Medal in 1985 from the Royal Society of New South Wales, the 2006 Faculty of Medicine Award for Excellence in Postgraduate Research Supervision, a Scroll of Honour Australia Day Award for community service from The Waverley Council in 2007. In 2010 Brian Morris was conferred the Lewis K. Dahl Memorial Award and Lecture by the American Heart Association's Council for High Blood Pressure Research, presenting his Lecture on his lifetime hypertension discoveries at HBPR2010 in Washington, DC. He has served the High Blood Pressure Research Council of Australia as a member of the Executive Committee for 3 six-year terms, being Treasurer from 2005-2010 and is currently Editor for 2014-2019. He was a foundation member of the editorial board of Hypertension from 1979-1981, and has been a board member in recent years since 2002. He was a member of the Editorial Board of the Journal of Hypertension from 2003-2007. Brian Morris has over 344 academic publications. His publications have been cited over 6,400 times to early 2014. His H-index is 43.

Research interests

Brian Morris is involved in research in several different fields. His long-term interest has been the molecular genetics of hypertension, over recent years having a particular focus on genome-wide alterations in gene and microRNA expression in human essential hypertension and rodent models of this condition. He is a co-CI on a NHMRC grant for 2013-2015 with Eugenie Lumbers and colleagues at University of Newcastle on the expression of the various components of the (pro)renin-angiotensin system and other genes in fetal and maternal tissues to determine whether these have a role in premature labour. A major current research involvement is the molecular genetics of longevity. This followed a sabbatical (Special Studies Program) in the Department of Geriatric Medicine, Kuakini Medical Center, University of Hawaii, Honolulu for 2 months in 2012-13 leading to multiple first-author publications. This adds to his long-term interest and publications on molecular mechanisms of ageing, longevity and the influences of dietary factors on health. Other work includes the publication of completed work from his Lab on the molecular biology of factors involved in alternative splicing of pre-mRNAs, a process that results in the generation of multiple proteins from most of the genes in the genome. Brian was the first in the world to patent the use of PCR for cervical screening (priority date Feb 1987). This test was devised to detect the cancer-causing types of human papillomavirus. His work in the cervical cancer field led him to become interested in promoting the health and medical benefits of male circumcision (www.circinfo.net and www.circumcisionaustralia.org), a field in which he has developed a strong international reputation, with over 60 academic publications.

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Morris, B., Tobian, A., Hankins, C., Klausner, J., Banerjee, J., Bailis, S., Moses, S., Wiswell, T. (2014), Veracity and rhetoric in paediatric medicine: a critique of Svoboda and Van Howe's response to the AAP policy on infant male circumcision. Journal of Medical Ethics. 40, 463-470. [Abstract]
  • Morris, B., Donlon, T., He, Q., Grove, J., Masaki, K., Elliott, A., Willcox, D., Willcox, B. (2014), Association Analyses of Insulin Signaling Pathway Gene Polymorphisms With Healthy Aging and Longevity in Americans of Japanese Ancestry. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 69(3), 270-273. [Abstract]
  • Morris, B., Bailis, S., Wiswell, T. (2014), Circumcision Rates in the United States: Rising or Falling? What Effect Might the New Affirmative Pediatric Policy Statement Have?. Mayo Clinic Proceedings. 89(5), 677-686. [Abstract]
  • Morris, B., Tobian, A. (2014), Circumcision is a religious/cultural procedure, not a medical procedure-reply. JAMA Pediatrics. 168(3), 294. [Abstract]
  • He, Q., Morris, B., Grove, J., Petrovitch, H., Ross, W., Masaki, K., Rodriguez, B., Chen, R., Donlon, T., Willcox, D., Willcox, B. (2014), Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry. PloS One. 9(5), e94385. [Abstract]
  • He, Q., Morris, B., Grove, J., Petrovitch, H., Ross, W., Masak, K., Rodriguez, B., Chen, R., Donlon, T., Willcox, D., Willcox, B. (2014), Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry. PLoS One. 9(5), e94385.
  • Morris, B., Hankins, C., Tobian, A., Krieger, J., Klausner, J. (2014), Does Male Circumcision Protect against Sexually Transmitted Infections? Arguments and Meta-Analyses to the Contrary Fail to Withstand Scrutiny. ISRN Urology. 2014, Article ID 684706.
  • Morris, B., Green, E. (2014), Circumcision, Male. In: The Wiley Blackwell Encyclopedia of Health, Illness, Behavior, and Society. (pp.1-4).United Kingdom: John Wiley & Sons, Ltd..
  • Morris, B. (2014), Reply to "Circumcision: A bioethical challenge" by Svoboda. Journal of Medical Ethics. 40, 16791.
  • Morris, B., Tobian, A., Hankins, C., Klausner, J., Banerjee, J., Bailis, S., Moses, S., Wiswell, T., Zoloth, L. (2014), Unethical not to recommend circumcision. Journal of Medical Ethics. , 16815.

2013

   
  • Morris, B., Wiswell, T. (2013), Circumcision and Lifetime Risk of Urinary Tract Infection: A Systematic Review and Meta-analysis. Journal of Urology. 189(6), 2118-2124. [Abstract]
  • Morris, B. (2013), Seven sirtuins for seven deadly diseases of aging. Free Radical Biology & Medicine. 56, 133-171. [Abstract]
  • Jackson, K., Marques, F., Watson, A., Palma-Rigo, K., Nguyen-Huu, T., Morris, B., Charchar, F., Davern, P., Head, G. (2013), A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice. Hypertension. 62(4), 775-781. [Abstract]
  • Bates, M., Ziegler, J., Kennedy, S., Mindel, A., Wodak, A., Zoloth, L., Tobian, A., Morris, B. (2013), Recommendation by a law body to ban infant male circumcision has serious worldwide implications for pediatric practice and human rights. BMC Pediatrics. 13(1), 136. [Abstract]
  • Morris, B., Tobian, A. (2013), Legal Threat to Infant Male Circumcision. JAMA Pediatrics. 167(10), 890-891. [Abstract]
  • Morris, B., Krieger, J. (2013), Does Male Circumcision Affect Sexual Function, Sensitivity, or Satisfaction?-A Systematic Review. Journal of Sexual Medicine. 10, 2644-2657. [Abstract]
  • Yang, Y., Markus, M., Mangs, A., Raitskin, O., Sperling, R., Morris, B. (2013), ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome. Molecular Biology Reports. 40, 5381-5395. [Abstract]
  • Morris, B., Krieger, J., Kigozi, G. (2013), Male circumcision decreases penile sensitivity as measured in a large cohort. BJU International. 111(5), E269-E270. [Abstract]
  • Morris, B. (2013), Science supports infant circumcision, so should skeptics. The Skeptic (UK). 24, 30-33.

2012

   
  • Marques, F., Morris, B. (2012), Neurogenic hypertension: revelations from genome-wide gene expression profiling. Current Hypertension Reports. 14(6), 485-491. [Abstract]
  • Bates, B., Morris, B. (2012), Legal arguments opposing infant male circumcision are flawed. Internal Medicine Journal. 42(11), 1281-1282. [Abstract]
  • Morris, B., Wodak, A., Mindel, A., Schrieber, L., Duggan, K., Dilley, A., Willcourt, R., Lowy, M., Cooper, D. (2012), Reply. Internal Medicine Journal. 42(11), 1279-1280. [Abstract]
  • Dilley, A., Morris, B. (2012), Reply. Internal Medicine Journal. 42(11), 1277-1278. [Abstract]
  • Morris, B. (2012), Boyle and hill's circumcision 'phallusies'. BJU International. , E153-154. [Abstract]
  • Morris, B., Wodak, A., Mindel, A., Schrieber, L., Duggan, K., Dilley, A., Willcourt, R., Lowy, M., Cooper, D. (2012), The 2010 Royal Australasian College of Physicians' policy statement 'Circumcision of infant males' is not evidence based. Internal Medicine Journal. 42(7), 822-828. [Abstract]
  • Morris, B., Waskett, J. (2012), Circumcision reduces prostate cancer risk. Asian Journal of Andrology. 14(5), 661-662. [Abstract]
  • Morris, B., Bailey, R., Klausner, J., Leibowitz, A., Wamai, R., Waskett, J., Banerjee, J., Halperin, D., Zoloth, L., Weiss, H., Hankins, C. (2012), Review: A critical evaluation of arguments opposing male circumcision for HIV prevention in developed countries. AIDS Care. 24(12), 1565-1575. [Abstract]
  • Morris, B., Wodak, A., Mindel, A., Schrieber, L., Duggan, K., Dilley, A., Willcourt, R., Lowy, M., Cooper, D., Lumbers, E., Russell, C., Leeder, S. (2012), Infant male circumcision: An evidence-based policy statement. Open Journal of Preventive Medicine. 2(1), 79-92.
  • Morris, B., Wamai, R. (2012), Biological basis for the protective effect conferred by male circumcision against HIV infection. International Journal of STD & AIDS. 23(3), 153-159. [Abstract]
  • Marques, F., Morris, B. (2012), Letter by Marques and Morris Regarding Article, "Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection". Circulation. 125(5), e337. [Abstract]
  • Morris, B., Waskett, J., Gray, R. (2012), Does sexual function survey in Denmark offer any support for male circumcision having an adverse effect?. International Journal of Epidemiology. 41(1), 310-314. [Abstract]
  • Klausner, J., Morris, B. (2012), Benefits of male circumcision. Journal of the American Medical Association. , 455-456. [Abstract]
  • Wamai, R., Morris, B., Waskett , J., Green, E., Banerjee, J., Bailey, R., Klausner , J., Sokal, D., Hankins, C. (2012), Criticisms of African trials fail to withstand scrutiny: Male circumcision does prevent HIV infection. Journal of Law and Medicine. 20(1), 93-123.
  • Morris, B. (2012), Die medizinischen vorteile der beschneidung [The medical benefits of circumcision]. W+N. Kulturpolitische Nachrichten des Fachverbandes "Werte und Normen" in Niedersachen e.V. [Cultural Policy News of the Association "Values and Norms" in Lower Saxony eV]. 2012/2, 6-21.
  • Morris, B., Mindel, A., Tobian, A., Hankins, C., Gray, R., Bailey, R., Bosch, X., Wodak, A. (2012), Should Male Circumcision be Advocated for Genital Cancer Prevention?. Asian Pacific Journal of Cancer Prevention. 13(9), 4839-4842. [Abstract]
  • Morris, B., Waskett, J. (2012), Claims That Circumcision Increases Alexithymia and Erectile Dysfunction Are Unfounded: A Critique of Bollinger and Van Howe's "Alexithymia and Circumcision Trauma: A Preliminary Investigation". International Journal of Men's Health. , 177-181.
  • Morris, B. (2012), Re: Technical Report on Male Circumcision- Time to accept the evidence in favor!. Pediatrics. , e756-e785.
  • Morris, B., Waskett, J., Banerjee, J., Wamai, R., Tobian, A., Gray, R., Bailis, S., Bailey, R., Klausner, J., Willcourt, R., Halperin, D., Wiswell, T., Mindel, A. (2012), A 'snip' in time: what is the best age to circumcise?. BMC Pediatrics. 12(1), 20. [Abstract]
  • Morris, B., Castellsague, X., Wiswell, T., Gray, R., Bailey, R., Hankins, C., Tobian, A., Weiss, H., Klausner, J., Halperin, D., Quinn, T. (2012), New Circumcision Policy Welcomed. Pediatrics. 130(3), e756-e785.
  • Wang, Y., Pringle, K., Sykes, S., Marques, F., Morris, B., Zakar, T., Lumbers, E. (2012), Fetal sex affects expression of renin-angiotensin system components in term human decidua. Endocrinology. 153(1), 462-468. [Abstract]
  • Morris, B., Cox, G. (2012), Current Medical Evidence Supports Male Circumcision. In: Surgical Guide to Circumcision. (pp.201-231).Germany: Springer-Verlag.
  • Cox, G., Morris, B. (2012), Why Circumcision: From Prehistory to the Twenty-First Century. In: Surgical Guide to Circumcision. (pp.243-260).Germany: Springer-Verlag.

2011

   
  • Morris, B. (2011), A "SNP in time" for SCNN1G to join the "highly likely" list of genes for essential hypertension. Hypertension. 58(6), 996-997. [Abstract]
  • Marques, F., Campain, A., Tomaszewski, M., Zukowska-Szczechowska, E., Yang, Y., Charchar, F., Morris, B. (2011), Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. Hypertension. 58(6), 1093-1098. [Abstract]
  • Wamai, R., Morris, B. (2011), 'How to contain generalized HIV epidemics' article misconstrues the evidence. International Journal of STD & AIDS. , 415-416. [Abstract]
  • Marques, F., Campain, A., Davern, P., Yang, Y., Head, G., Morris, B. (2011), Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. Physiological genomics. 43(12), 766-771. [Abstract]
  • Marques, F., Pringle, K., Conquest, A., Hirst, J., Markus, M., Sarris, M., Zakar, T., Morris, B., Lumbers, E. (2011), Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section. Placenta. 32(3), 214-221. [Abstract]
  • Morris, B. (2011), Renin, genes, and beyond: 40 years of molecular discoveries in the hypertension field. Hypertension. 57(3), 538-548. [Abstract]
  • Banerjee, J., Klausner, J., Halperin, D., Wamai, R., Schoen, E., Moses, S., Morris, B., Bailis, S., Venter, F., Martinson, N., Coates, T., Gray, G., Bowa, K. (2011), Circumcision denialism unfounded and unscientific. American Journal of Preventive Medicine. , e11-12; author reply e13-4. [Abstract]
  • Wamai, R., Morris, B., Bailis, S., Sokal, D., Klausner, J., Appleton, R., Sewankambo, N., Cooper, D., Bongaarts, J., de Bruyn, G., Wodak, A., Banerjee, J. (2011), Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa. Journal of the International AIDS Society. 14(1), 49. [Abstract]
  • Marques, F., Campain, A., Davern, P., Yang, Y., Head, G., Morris, B. (2011), Genes influencing circadian differences in blood pressure in hypertensive mice. PloS One. 6(4), e19203. [Abstract]
  • Morris, B., Gray, R., Castellsague, X., Bosch, F., Halperin, D., Waskett, J., Hankins, C. (2011), The strong protective effect of circumcision against cancer of the penis. Advances in Urology. 2011, 812368. [Abstract]
  • Morris, B., Eley, C. (2011), Male circumcision: An appraisal of current instrumentation. In: Biomedical Engineering -From Theory to Applications. (pp.315-354).Croatia: InTech.
  • Cooper, D., Wodak, A., Morris, B. (2011), The case for boosting infant male circumcision in the face of rising heterosexual transmission of HIV – In Reply. (Invited). Medical Journal of Australia. 194(2), 101.
  • Morris, B., Waskett, J., Gray, R., Halperin, D., Wamai, R., Auvert, B., Klausner, J. (2011), Exposé of misleading claims that male circumcision will increase HIV infections in Africa. Journal of Public Health Africa. 2(e28), 117-122.
  • Morris, B., Castellsague, X. (2011), The role of circumcision in preventing STIs. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. (pp.715-740).Germany: Springer.
  • Markus, M., Marques, F., Morris, B. (2011), Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PloS One. 6(12), e28926. [Abstract]

2010

   
  • Morris, B., Wodak, A. (2010), Circumcision survey misleading. Australian and New Zealand Journal of Public Health. , 636-637. [Abstract]
  • Marques, F., Morris, B. (2010), Commentary on resveratrol and hormesis: resveratrol--a hormetic marvel in waiting?. Human & Experimental Toxicology. 29(12), 1026-1028. [Abstract]
  • Cooper, D., Wodak, A., Morris, B. (2010), The case for boosting infant male circumcision in the face of rising heterosexual transmission of HIV. The Medical Journal of Australia. 193(6), 318-319. [Abstract]
  • Marques, F., Campain, A., Yang, Y., Morris, B. (2010), Meta-Analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. Hypertension. 56(2), 319-324. [Abstract]
  • Gray, R., Bailey, R., Morris, B. (2010), Keratinization of the adult male foreskin and implications for male circumcision. AIDS. , 1381. [Abstract]
  • Morris, B. (2010), Sympathetic meta-analysis of adrenoceptor gene variants in hypertension. American Journal of Hypertension. 23(3), 225. [Abstract]
  • Marques, F., Markus, M., Morris, B. (2010), The molecular basis of longevity, and clinical implications. Maturitas. 65(2), 87-91. [Abstract]
  • Everitt, A., Heilbronn, L., Morris, B., Brown-Borg, H., Merry, B., Simpson, S., Varady, K., Masoro, E., Redman, L., Le Couteur, D. (2010), Conclusion: Human Calorie Restriction and Anti-Aging Therapy. In: Calorie Restriction, Ageing and Longevity. (pp.311-318).Germany, United Stat: Springer Science + Business Media B.V..
  • Morris, B. (2010), Calorie restriction mimetics and aging. In: Calorie Restriction, Ageing and Longevity. (pp.141-176).Germany, United Stat: Springer Science + Business Media B.V..

2009

   
  • Marques, F., Markus, M., Morris, B. (2009), Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. The International Journal of Biochemistry & Cell Biology. 41(11), 2125-2128. [Abstract]
  • Morris, B., Bailis, S., Waskett, J., Wiswell, T., Halperin, D. (2009), Medicaid coverage of newborn circumcision: a health parity right of the poor. American Journal of Public Health. , 969-971. [Abstract]
  • Morris, B. (2009), Might a leptin gene variant affect blood pressure in obese brazilians?. American Journal of Hypertension. 22(5), 467. [Abstract]
  • Loughlin, F., Mansfield, R., Vaz, P., McGrath, A., Setiyaputra, S., Gamsjaeger, R., Chen, E., Morris, B., Guss, J., Mackay, J. (2009), The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proceedings of the National Academy of Sciences of the United States of America. 106(14), 5581-5586. [Abstract]
  • Pönighaus, C., Speirs, H., Morris, B., Kuhn, J., Kleesiek, K., Götting, C. (2009), Xylosyltransferase gene variants and their role in essential hypertension. American Journal of Hypertension. 22(4), 432-436. [Abstract]
  • Markus, M., Morris, B. (2009), RBM4: A multifunctional RNA-binding protein. The International Journal of Biochemistry & Cell Biology. 41(4), 740-743. [Abstract]
  • Waskett, J., Morris, B., Weiss, H. (2009), Errors in meta-analysis by Van Howe. International Journal of STD & AIDS. , 216-218; author reply 218-20. [Abstract]
  • Morris, B. (2009), GRK4 genetics and response to beta-blocker. American Journal of Hypertension. 22, 235-236. [Abstract]
  • Marques, F., Markus, M., Morris, B. (2009), Hormesis as a pro-healthy aging intervention in human beings?. Dose-response : a publication of International Hormesis Society. 8(1), 28-33. [Abstract]

2008

   
  • Morris, B. (2008), Fluorescence activated cell sorting of transiently transfected As4.1 cells shows renin enhancer directs on/off switching of renin promoter in vitro. Clinical and Experimental Pharmacology & Physiology. 35(4), 367-371. [Abstract]
  • Martin, S., Markus, M., Morris, B., Davisson, R., Lawrence, A., van den Buuse, M. (2008), Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?. Neuropharmacology. 54(2), 399-404. [Abstract]
  • Morris, B. (2008), How Xenohormetic Compounds Confer Health Benefits. In: Mild Stress and Healthy Aging. (pp.115-138).Netherlands: Springer Science+Business Media.
  • Halperin, D., Wamai, R., Weiss, H., Hankins, C., Agot, K., Abdool Karim, Q., Shisana, O., Bailey, R., Betukumesu, B., Bongaarts, J., Bowa, K., Cash, R., al, E., Morris, B. (2008), Male circumcision is an efficacious, lasting and cost-effective strategy for combating HIV in high-prevalence AIDS epidemics. Future HIV Therapy. , 399-405.
  • Abete, P., Calabrese, E., Ji, L., Kristensen, T., Le Bourg, E., Loeschcke, V., Morris, B., Rengo,, F., Rattan, S., Safwat, A., Sarup, P., Sørensen, J., Vaiserman, A. (2008), Mild Stress and Healthy Aging: Perspectives for Human Beings. In: Mild Stress and Healthy Aging. (pp.171-183).Netherlands: Springer Science+Business Media.
  • Morris, B., Halperin, D., Klausner, J. (2008), Cut!. New Scientist. 2670, 20-21.
  • Waskett, J., Morris, B. (2008), Re: 'RS Van Howe, FM Hodges. The carcinogenicity of smegma: debunking a myth.' An example of myth and mythchief making?. Journal of the European Academy of Dermatology and Venereology. 22(1), 131. [Abstract]
  • Mangs, A., Morris, B. (2008), ZRANB2: Structural and functional insights into a novel splicing protein. The International Journal of Biochemistry & Cell Biology. 40(0), 2353-2357. [Abstract]
  • Markus, M., Morris, B. (2008), Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical Interventions in Aging. 3(2), 331-339. [Abstract]