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Professor Ian Alexander

Professor in Paediatrics & Molecular Medicine
Genetic Medicine, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: 9845 3071
F: 9845 1317
E:

Research interests

Dr Alexander's specific expertise and interests include virus-mediated gene transfer with a focus on target organs including the liver and bone marrow, both of which have immense promise as target organs for the treatment of genetic disease in children. His team became the first in Australia to treat a genetic disease (SCID-X1) by gene therapy and are recognised leaders in the establishment of this exciting field in Australia.

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Current national competitive grants*

2012

Analysis and manipulation of the genome-wide integration signatures of gamma-retroviral and lentiviral vectors in human haematopoietic stem cells
Alexander I, Ranganathan S, Cavazzana-Calvo M
NHMRC Project Grants ($591,125 over 3 years)

Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells and liver progenitor cells
Alexander I, Tam P, Russell D, Yeoh G
NHMRC Project Grants ($770,175 over 3 years)

2011

In vivo gene transfer and phenotype correction of normal and urea-cycle deficient primary human hepatocytes in chimeric mouse-human livers: Towards gene therapy for metabolic liver disease
Alexander I, Braet F, Christodoulou J, Kuchel P, Carpenter K
National Health and Medical Research Council Project Grant ($476,706 over 3 years)

Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1)
Little D, Alexander I, Schindeler A
National Health and Medical Research Council Project Grant ($606,732 over 3 years)

2010

Gene therapy, stress haematopoiesis and the risk of malignancy
Alexander I, Alexander S, McCormack M, Thrasher A, Ginn S
NHMRC Project Grant ($595,500 over 3 years)

* Grants administered through the University of Sydney

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Keywords

Gene therapy; Immune system diseases; Virology; Genetic diseases; Hepatology

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Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

2012

   
  • Chung, H., Lin, R., Logan, G., Alexander, I., Sachdev, P., Sidhu, K. (2012), Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles. Stem Cells and Development. 21(2), 206-216. [Abstract]

2011

   
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  • Both, G., Alexander, I., Fletcher, S., Nicolson, T., Rasko, J., Wilton, S., Symonds, G. (2011), Gene therapy: therapeutic applications and relevance to pathology. Pathology. 43(6), 642-56. [Abstract]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2011), A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. (1). [Abstract]
  • Cunningham, S., Kok, C., Dane, A., Carpenter, K., Kizana, E., Kuchel, P., Alexander, I. (2011), Induction and Prevention of Severe Hyperammonemia in the spf(ash) Mouse Model of Ornithine Transcarbamylase Deficiency Using shRNA and rAAV-mediated Gene Delivery. Molecular therapy : the journal of the American Society of Gene Therapy. 19(5), 854-9. [Abstract]

2010

   
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  • Deakin, C., Alexander, I., Kerridge, I. (2010), The ethics of gene therapy: balancing the risks. Current Opinion in Molecular Therapeutics. 12(5), 578-585. [Abstract]
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010), Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery?. Discovery Medicine. 9(49), 519-527. [Abstract]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010), Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. 18(5), 965-76. [Abstract]
  • Logan, G., Wang, L., Zheng, M., Coppel, R., Alexander, I. (2010), Antigen fusion with C3d(3) augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner. Immunology and cell biology. 88(2), 228-32. [Abstract]

2009

   
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  • Deakin, C., Alexander, I., Kerridge, I. (2009), Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?. Molecular Therapy. 17(11), 1842-1848. [Abstract]
  • Dane, A., Cunningham, S., Graf, N., Alexander, I. (2009), Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation With Hepatocellular Proliferation. Molecular therapy : the journal of the American Society of Gene Therapy. 17(9), 1548-54. [Abstract]
  • Cunningham, S., Spinoulas, A., Carpenter, K., Wilcken, B., Kuchel, P., Alexander, I. (2009), AAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spf(ash) Mice. Molecular therapy : the journal of the American Society of Gene Therapy. 17(8), 1340-6. [Abstract]
  • Laurence, J., Allen, R., McCaughan, G., Logan, G., Alexander, I., Bishop, G., Sharland, A. (2009), Gene therapy in transplantation. Transplantation Reviews. 23(3), 159-170. [Abstract]
  • Ginn, S., Cunningham, S., Zheng, M., Spinoulas, A., Carpenter, K., Alexander, I. (2009), In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver. Gene Therapy. 16(6), 820-823. [Abstract]
  • Lee, A., Kahatapitiya, P., Kramer, B., Joya, J., Hook, J., Liu, R., Schevzov, G., Alexander, I., McCowage, G., Montarras, D., Gunning, P., Hardeman, E. (2009), Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. Stem Cells. 27(5), 1098-1108. [Abstract]
  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009), Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene therapy. 16(2), 200-10. [Abstract]
  • Laurence, J., Wang, C., Zheng, M., Cunningham, S., Earl, J., Tay, S., Allen, R., McCaughan, G., Alexander, I., Bishop, G., Sharland, A. (2009), Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation. 15(2), 233-241. [Abstract]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009), Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC musculoskeletal disorders. 10(0), 51. [Abstract]

2008

   
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  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008), Regulatory immune cells in kidney disease. American journal of physiology. Renal physiology. 295(2), F335-42. [Abstract]
  • Cunningham, S., Dane, A., Spinoulas, A., Alexander, I. (2008), Gene delivery to the juvenile mouse liver using AAV2/8 vectors. Molecular therapy : the journal of the American Society of Gene Therapy. 16(6), 1081-1088. [Abstract]
  • Alexander, I., Cunningham, S., Logan, G., Christodoulou, J. (2008), Potential of AAV vectors in the treatment of metabolic disease. Gene Therapy. 15(11), 831-839. [Abstract]
  • Curtin, J., Dane, A., Swanson, A., Alexander, I., Ginn, S. (2008), Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy. 15(5), 384-390. [Abstract]
  • Baoutina, A., Alexander, I., Rasko, J., Emslie, K. (2008), Developing strategies for detection of gene doping. The journal of gene medicine. 10(1), 3-20. [Abstract]

2007

   
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  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007), Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer immunology, immunotherapy : CII. 56(12), 1955-65. [Abstract]
  • Baoutina, A., Alexander, I., Rasko, J., Emslie, K. (2007), Potential Use of Gene Transfer in Athletic Performance Enhancement. Molecular therapy : the journal of the American Society of Gene Therapy. 15(10), 1751-66. [Abstract]
  • Deichmann, A., Hacein-Bey-Abina, S., Schmidt, M., Garrigue, A., Brugman, M., Hu, J., Glimm, H., Gyapay, G., Prum, B., Fraser, C., Fischer, N., Schwarzwaelder, K., Siegler, M., de Ridder, D., Pike-Overzet, K., Howe, S., Thrasher, A., Wagemaker, G., Abel, U., Staal, F., Delabesse, E., Villeval, J., Aronow, B., Hue, C., Prinz, C., Wissler, M., Klanke, C., Weissenbach, J., Alexander, I., Fischer, A., von Kalle, C., Cavazzana-Calvo, M. (2007), Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. The Journal of clinical investigation. 117(8), 2225-2232. [Abstract]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007), Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood. 110(1), 91-8. [Abstract]
  • Kizana, E., Chang, C., Cingolani, E., Ramirez-Correa, G., Sekar, R., Abraham, M., Ginn, S., Tung, L., Alexander, I., Marbán, E. (2007), Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circulation research. 100(11), 1597-604. [Abstract]
  • Yu, Z., McKay, K., van Asperen, P., Zheng, M., Fleming, J., Ginn, S., Kizana, E., Latham, M., Feneley, M., Kirkland, P., Rowe, P., Lumbers, E., Alexander, I. (2007), Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. The journal of gene medicine. 9(6), 429-439. [Abstract]
  • Cooper, S., Kizana, E., Yates, J., Lo, H., Yang, N., Wu, Z., Alexander, I., North, K. (2007), Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis. Neuromuscular disorders : NMD. 17(4), 276-284. [Abstract]
  • Logan, G., Wang, L., Zheng, M., Cunningham, S., Coppel, R., Alexander, I. (2007), AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection. Vaccine. 25(6), 1014-22. [Abstract]

2006

   
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  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006), Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene therapy. 13, 1611-5. [Abstract]
  • Kramer, B., Lemckert, F., Alexander, I., Gunning, P., McCowage, G. (2006), Characterisation of a P140K mutant O(6)-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow. The journal of gene medicine. 8(9), 1071-85. [Abstract]
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006), Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology. 84(3), A29-A29. [Abstract]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Hori, S., Alexander, I., Harris, D., Alexander, S. (2006), Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. Journal of the American Society of Nephrology : JASN. 17(3), 697-706. [Abstract]
  • Trent, R., Alexander, I. (2006), Gene therapy in sport. British journal of sports medicine. 40(1), 4-5. [Abstract]