Professor Ron Trent

Professor of Medical Molecular Genetics
Medicine, Central Clinical School
Sydney Forensic Medicine and Science Network

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9515 7514
F: +61 2 95505412
E:

Research interests

Ron is focussed on understanding the complex interactions that occur between genes and the environment and so lead to the important non-Mendelian genetic disorders that occur in the community.

PhD and Masters' project opportunities

Molecular genetics of complex diseases

Keywords

Motor neuron disease; Bioinformatics; Genetic diseases; Genetic processes

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Hinchcliffe, M., Le, H., Fimmel, A., Molloy, L., Freeman, L., Sullivan, D., Trent, R. (2014), Diagnostic validation of a familial hypercholesterolaemia cohort provides a model for using targeted next generation DNA sequencing in the clinical setting. Pathology. 46(1), 60-68. [Abstract]

2013

   
  • Ramos, E., Latourelle, J., Gillis, T., Mysore, J., Squitieri, F., Di Pardo, A., Di Donato, S., Gellera, C., Hayden, M., Morrison, P., Nance, M., Ross, C., Margolis, R., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M., Hersch, S., Rosas, H., Lucente, D., Harrison, M., Zanko, A., Abramson, R., Marder, K., Gusella, J., Lee, J., Alonso, I., Sequeiros, J., Myers, R., Macdonald, M. (2013), Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset. Neurogenetics. 14(3-4), 173-179. [Abstract]
  • Pamphlett, R., Cheong, P., Trent, R., Yu, B. (2013), Can ALS-Associated C9orf72 Repeat Expansions be Diagnosed on a Blood DNA Test Alone?. PloS One. 8(7), e70007. [Abstract]
  • Cooper, W., Yu, B., Yip, P., Ng, C., Lum, T., Farzin, M., Trent, R., Mercorella, B., Clarkson, A., Kohonen-Corish, M., Horvath, L., Kench, J., McCaughan, B., Gill, A., O'Toole, S. (2013), EGFR mutant-specific immunohistochemistry has high specificity and sensitivity for detecting targeted activating EGFR mutations in lung adenocarcinoma. Journal of Clinical Pathology. 66(9), 744-748. [Abstract]
  • Trent, R., Cheong, P., Chua, E., Kennedy, M. (2013), Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care. Pathology. 45(4), 357-370. [Abstract]
  • Yip, P., Yu, B., Cooper, W., Selinger, C., Ng, C., Kennedy, C., Kohonen-Corish, M., McCaughan, B., Trent, R., Boyer, M., Kench, J., Horvath, L., O'Toole, S. (2013), Patterns of DNA Mutations and ALK Rearrangement in Resected Node Negative Lung Adenocarcinoma. Journal of Thoracic Oncology. 8(4), 408-414. [Abstract]
  • Trent, R. (2013), Direct-to-consumer genetic testing - clinical considerations. The Medical Journal of Australia. 198(9), 496-498. [Abstract]

2012

   
  • Ramos, E., Latourelle, J., Lee, J., Gillis, T., Mysore, J., Squitieri, F., Di Pardo, A., Di Donato, S., Hayden, M., Morrison, P., Nance, M., Ross, C., Margolis, R., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M., Hersch, S., Rosas, H., Lucente, D., Harrison, M., Zanko, A., Marder, K., Gusella, J., Lee, J., Alonso, I., Sequeiros, J., Myers, R., Macdonald, M. (2012), Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset. Human Genetics. 131(12), 1833-1840. [Abstract]
  • Lee, J., Lee, J., Ramos, E., Gillis, T., Mysore, J., Kishikawa, S., Hadzi, T., Hendricks, A., Hayden, M., Morrison, P., Nance, M., Ross, C., Margolis, R., Squitieri, F., Gellera, C., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M., Hersch, S., Rosas, H., Lucente, D., Harrison, M., Zanko, A., Abramson, R., Marder, K., Sequeiros, J., Landwehrmeyer, G., Shoulson, I., Myers, R., MacDonald, M., Gusella, J. (2012), TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochemical and Biophysical Research Communications. 424(3), 404-408. [Abstract]
  • Poursoltan, P., Currey, N., Pangon, L., van Kralingen, C., Selinger, C., Mahar, A., Cooper, W., Kennedy, C., McCaughan, B., Trent, R., Kohonen-Corish, M. (2012), Loss of heterozygosity of the Mutated in Colorectal Cancer gene is not associated with promoter methylation in non-small cell lung cancer. Lung Cancer. 77(2), 272-276. [Abstract]
  • Pamphlett, R., Cheong, P., Trent, R., Yu, B. (2012), Transmission of C9orf72 hexanucleotide repeat expansions in sporadic amyotrophic lateral sclerosis: an Australian trio study. Neuroreport. 23(9), 556-559. [Abstract]
  • Lee, J., Gillis, T., Mysore, J., Ramos, E., Myers, R., Hayden, M., Morrison, P., Nance, M., Ross, C., Margolis, R., Squitieri, F., Griguoli, A., Di Donato, S., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M., Hersch, S., Rosas, H., Lucente, D., Harrison, M., Zanko, A., Abramson, R., Marder, K., Sequeiros, J., MacDonald, M., Gusella, J. (2012), Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. American Journal of Human Genetics. 90(3), 434-444. [Abstract]
  • Lee, J., Ramos, E., Lee, J., Gillis, T., Mysore, J., Hayden, M., Warby, S., Morrison, P., Nance, M., Ross, C., Margolis, R., Squitieri, F., Orobello, S., Di Donato, S., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M., Hersch, S., Rosas, H., Lucente, D., Harrison, M., Zanko, A., Abramson, R., Marder, K., Sequeiros, J., Paulsen, J., Landwehrmeyer, G., Myers, R., MacDonald, M., Gusella, J. (2012), CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 78(10), 690-695. [Abstract]

2011

   
  • Watts, G., Sullivan, D., Poplawski, N., van Bockxmeer, F., Hamilton-Craig, I., Clifton, P., O'Brien, R., Bishop, W., George, P., Barter, P., Bates, T., Burnett, J., Coakley, J., Davidson, P., Emery, J., Martin, A., Farid, W., Freeman, L., Geelhoed, E., Juniper, A., Kidd, A., Kostner, K., Krass, I., Livingston, M., Maxwell, S., O'Leary, P., Owaimrin, A., Redgrave, T., Reid, N., Southwell, L., Suthers, G., Tonkin, A., Towler, S., Trent, R. (2011), Familial hypercholesterolaemia: A model of care for Australasia. Atherosclerosis. Supplements. 12(2), 221¿263. [Abstract]

2010

   
  • Luquin, N., Yu, B., Trent, R., Pamphlett, R. (2010), DHPLC can be used to detect low-level mutations in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis. 11(1-2), 76-82. [Abstract]
  • Trent, R. (2010), Pathology practice and pharmacogenomics. Pharmacogenomics. 11(1), 105-111. [Abstract]
  • Wollstein, A., Lao, O., Becker, C., Brauer, S., Trent, R., Nurnberg, P., Stoneking, M., Kayser, M. (2010), Demographic History of Oceania Inferred from Genome-wide Data. Current Biology. 20(22), 1983-1992. [Abstract]
  • Yu, B., Trent, R. (2010), Genetics of Athletic Performance. In: Encyclopedia of Life Sciences. (pp.1-8).United Kingdom: John Wiley & Sons Ltd..

2009

   
  • Luquin, N., Yu, B., Saunderson, R., Trent, R., Pamphlett, R. (2009), Genetic variants in the promoter of TARDBP in sporadic amyotrophic lateral sclerosis. Neuromuscular Disorders. 19(10), 696-700. [Abstract]
  • Morahan, J., Yu, B., Trent, R., Pamphlett, R. (2009), A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis. 10(5-6), 418-429. [Abstract]
  • Trent, R., Yu, B. (2009), The future of genetic research in exercise science and sports medicine. Medicine and Sport Science. 54, 187-195. [Abstract]

2008

   
  • Luquin, N., Yu, B., Trent, R., Morahan, J., Pamphlett, R. (2008), An analysis of the entire SOD1 gene in sporadic ALS. Neuromuscular disorders : NMD. 18(7), 545-52. [Abstract]
  • Saunderson, R., Yu, B., Trent, R., Pamphlett, R. (2008), A comparison of the lengths of androgen receptor triplet repeats in brain and blood in motor neuron diseases. Journal of the neurological sciences. 267(0), 125-8. [Abstract]
  • Kayser, M., Lao, O., Saar, K., Brauer, S., Wang, X., Nurnberg, P., Trent, R., Stoneking, M. (2008), Genorne-wide analysis indicates more Asian than melanesian ancestry of polynesians. American Journal of Human Genetics. 82(1), 194-198. [Abstract]
  • Le, H., Hinchcliffe, M., Yu, B., Trent, R. (2008), Computer-assisted reading of DNA sequences. Methods in Molecular Medicine. 141, 177-197. [Abstract]
  • Kayser, M., Choi, Y., van Oven, M., Mona, S., Brauer, S., Trent, R., Suarkia, D., Schiefenhovel, W., Stoneking, M. (2008), The impact of the Austronesian expansion: Evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia. Molecular Biology and Evolution. 25(7), 1362-1374. [Abstract]