Associate Professor Brett Hambly

Associate Professor
Pathology, School of Medical Sciences
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 3059
F: +61 2 9351 3429
E:
W: Related website

Biographical details

1980-81 Intern and Resident Medical Officer, Royal Prince Alfred Hospital, Sydney 1982-84 Relief Staff - Medical, Royal Prince Alfred Hospital, Sydney 1982-84 Life Insurance Medical Research Fund of Australia & New Zealand Research Scholar (Candidate for Ph.D.), Department of Anatomy, University of Sydney 1984-86 Temporary Lecturer, Department of Anatomy, University of Sydney 1987-88 NHMRC CJ Martin Post-doctoral Research Fellow, Department of Biochemistry and Biophysics, University of California, San Francisco 1989-90 NHMRC CJ Martin Post-doctoral Research Fellow, Dept of Anatomy, Univ Sydney 1991 NHMRC Senior Research Officer, Department of Anatomy, University of Sydney 1992-93 Lecturer, Department of Pathology, University of Sydney 1994-02 Senior Lecturer, Department of Pathology, University of Sydney 2003- Associate Professor, School Medical Science - Pathology Discipline, Univ Sydney 2003- Adjunct Assoc Professor, Biology (Molec Biophysics), Florida State Univ, Tallahassee

Research interests

My research focuses on cardiovascular disease, in particular familial hypertrophic cardiomyopathy, atherosclerosis and Genetic thoracic aortic aneurysm

Teaching areas

Cardiovascular and cancer pathology

Keywords

Atherosclerosis; Cardiovascular diseases; Genetic diseases; Proteomics; Molecular biology

International links

China. (Department of Plastic Surgery, Shanghai Third Peoples Hospital, School of Medicine, Shanghai Jiaotong University) Collaborative research with Prof Yong Fang.
United States. (Florida State University) Adjunct Assoc Professor, Biology (Molec Biophysics), Florida State Univ, Tallahassee.

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Ng, E., Lu, Y., Hambly, B., Jelinek, H., Yu, B., Matthews, S., McLachlan, C. (2013), Angiotensin-converting enzyme gene DD genotype is associated with increased systolic blood pressure in an Australian Rural Type 2 Diabetic Cohort. Hypertension Research. 36(4), 381-382. [Abstract]
  • Ko, H., Yin, J., Wyburn, K., Wu, H., Eris, J., Hambly, B., Chadban, S. (2013), Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction. Nephrology, Dialysis, Transplantation. 28(2), 327-336. [Abstract]
  • Ocsan, R., Lai, Y., Prabhu, K., Hambly, B., McLachlan, C. (2013), Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. Journal of Physiology and Pharmacology. 64(6), 727-736. [Abstract]
  • Jeremy, R., Robertson, E., Lu, Y., Hambly, B. (2013), Perturbations of mechanotransduction and aneurysm formation in heritable aortopathies. International Journal of Cardiology. 169(1), 7-16. [Abstract]
  • Zhang, X., Lai, D., Bao, S., Hambly, B., Gillies, M. (2013), Triamcinolone Acetonide Inhibits p38MAPK Activation and Neuronal Apoptosis in Early Diabetic Retinopathy. Current Molecular Medicine. 13(6), 946-958. [Abstract]
  • Buljan, V., Damian Holsinger, R., Brown, D., Bohorquez-Florez, J., Hambly, B., Delikatny, E., Ivanova, E., Banati, R. (2013), Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos. 23(2), 023120. [Abstract]
  • Buljan, V., Damian Holsinger, R., Hambly, B., Banati, R., Ivanova, E. (2013), Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface. Journal of Biological Physics. 39(1), 81-98. [Abstract]

2012

   
  • Yao, M., Xie, C., Constantine, M., Hua, S., Hambly, B., Jardine, G., Sved, P., Dong, Q. (2012), How can food extracts consumed in the Mediterranean and East Asia suppress prostate cancer proliferation?. British Journal of Nutrition. 108(3), 424-430. [Abstract]
  • Wu, B., Li, S., Sheng, L., Zhu, J., Gu, L., Shen, H., La, D., Hambly, B., Bao, S., Di, W. (2012), Metformin inhibits the development and metastasis of ovarian cancer. Oncology Reports. 28(3), 903-908. [Abstract]
  • Tavakoli, N., Harris, A., Sullivan, D., Hambly, B., Bao, S. (2012), Interferon-γ deficiency reduces neointimal formation in a model of endoluminal endothelial injury combined with atherogenic diet. International Journal of Molecular Medicine. 30(3), 545-552. [Abstract]
  • Cordwell, S., Edwards, A., Liddy, K., Moshkanbaryans, L., Solis, N., Parker, B., Yong, A., Wong, C., Kritharides, L., Hambly, B., White, M. (2012), Release of tissue-specific proteins into coronary perfusate as a model for biomarker discovery in myocardial ischemia / reperfusion injury. Journal of Proteome Research. 11(4), 2114-2126. [Abstract]
  • Wu, B., Hu, K., Li, S., Zhu, J., Gu, L., Shen, H., Hambly, B., Bao, S., Di, W. (2012), Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer. Oncology Reports. 27(1), 101-108. [Abstract]
  • Ng, E., Hambly, B., Matthews, S., McLachlan, C., Jelinek, H. (2012), WEKA machine learning classification in identifying autonomic dysfunction parameters associated with ACE insertion/deletion genotypes. Proceedings of the IASTED International Conference: Biomedical Engineering.

2011

   
  • Parker, B., Palmisano, G., Edwards, A., White, M., Engholm-Keller, K., Lee, A., Scott, N., Kolarich, D., Hambly, B., Packer, N., Larsen, M., Cordwell, S. (2011), Quantitative N-linked glycoproteomics of myocardial ischemia / reperfusion injury reveals early remodeling in the extracellular environment. Molecular & Cellular Proteomics. 10(8), M110.006833. [Abstract]

2010

   
  • McLachlan, C., Ocsan, R., Spence, I., Hambly, B., Matthews, S., Wang, L., Jelinek, H. (2010), Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia. Baylor University Medical Center Proceedings. 23(4), 368-370. [Abstract]
  • Singh, J., Xie, C., Yao, M., Hua, S., Vignarajan, S., Jardine, G., Hambly, B., Sved, P., Dong, Q. (2010), Food extracts consumed in Mediterranean countries and East Asia reduce protein concentrations of androgen receptor, phospho-protein kinase B, and phospho-cytosolic phospholipase A(2)alpha in human prostate cancer cells. Journal of Nutrition. 140(4), 786-791. [Abstract]
  • Fang, Y., Shen, J., Yao, M., Beagley, K., Hambly, B., Bao, S. (2010), Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines. The British journal of dermatology. 162(3), 478-86. [Abstract]
  • Hardy, J., Hambly, B., Ko, H., Wyburn, K., Eris, J., Yin, J. (2010), Stimulation of Mesangial Cells by Angiotensin II and Lipopolysaccharide Increases Expression of Interleukin-18, but Not IL-18 Receptor. Nephron. Experimental nephrology. 116(4), e63-71. [Abstract]

2009

   
  • Zhang, X., Bao, S., Hambly, B., Gillies, M. (2009), Vascular endothelial growth factor-A: A multifunctional molecular player in diabetic retinopathy. The international journal of biochemistry & cell biology. 41(12), 2368-71. [Abstract]
  • Harris, A., Shen, J., Radford, J., Bao, S., Hambly, B. (2009), GM-CSF deficiency delays neointima formation in a normolipidemic mouse model of endoluminal endothelial damage. Immunology and cell biology. 87(2), 122-30. [Abstract]

2008

   
  • Eng, P., Chua, W., Suk Peng Chew, V., Wong, P., Yin, J., Hambly, B., McLachlan, C. (2008), Chronic angiotensin-converting enzyme inhibition up-regulates mouse kidney growth arrest specific-6 protein and the AXL subfamily of receptor tyrosine kinases. Journal of the Renin-angiotensin-Aldosterone System. 9(4), 238-241. [Abstract]
  • Wu, H., Craft, M., Wang, P., Wyburn, K., Chen, G., Ma, J., Hambly, B., Chadban, S. (2008), IL-18 Contributes to Renal Damage after Ischemia-Reperfusion. Journal of the American Society of Nephrology : JASN. 19(12), 2331-41. [Abstract]
  • Ko, H., Hambly, B., Eris, J., Levidiotis, V., Wyburn, K., Wu, H., Chadban, S., Yin, J. (2008), Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transplant immunology. 20(0), 99-105. [Abstract]
  • Hambly, B., Oakley, C., Fajer, P. (2008), Protein comparative sequence analysis and computer modeling. Methods in molecular medicine. 141, 245-256. [Abstract]
  • Stefani, M., Tsubakihara, M., Allen, P., Macdonald, P., dos Remedios, C. (2008), Actin and its binding proteins in heart failure. In: Actin-binding proteins and disease. (pp.318-334).United Kingdom: Springer.
  • Hambly, B., Oakley, C., Fajer, P. (2008), Protein Comparative Sequence Analysis and Computer Modeling. In: Clinical Bioinformatics. (pp.245-256).New Jersey, USA: Humana Press Inc..
  • Tavakoli, N., Hambly, B., Sullivan, D., Bao, S. (2008), Forkhead box protein 3: Essential immune regulatory role. The international journal of biochemistry & cell biology. 40(0), 2369-73. [Abstract]