Research Publications

Recent publications utilising NSW BTRC tissue -
  • Wang, F., et al., DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep, 2016. 6: p. 19430. PMCID 4725922
  • Sutherland, G.T., et al., The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research. Alcohol, 2016. 52: p. 33-9.
  • Rubio-Araiz, A., et al., Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model. Addict Biol, 2016.
  • Matosin, N., et al., Molecular evidence of synaptic pathology in the CA1 region in schizophrenia. NPJ Schizophr, 2016. 2: p. 16022.
  • Leyton, C.E., et al., Distinctive pathological mechanisms involved in primary progressive aphasias. Neurobiol Aging, 2016. 38: p. 82-92.
  • Kashem, M.A., et al., Metabolomics of Neurotransmitters and Related Metabolites in Post-Mortem Tissue from the Dorsal and Ventral Striatum of Alcoholic Human Brain. Neurochem Res, 2016. 41(1-2): p. 385-97.
  • Hirth, N., et al., Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proc Natl Acad Sci U S A, 2016. 113(11): p. 3024-9.
  • Hagerty, S.L., et al., An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation. Alcohol Clin Exp Res, 2016. 40(8): p. 1633-40.
  • Davies, K.M., et al., Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics. Clin Sci (Lond), 2016. 130(8): p. 565-74.
  • Chami, B., et al., The rise and fall of insulin signaling in Alzheimer's disease. Metab Brain Dis, 2016. 31(3): p. 497-515.
  • Yang, Y., C. Shepherd, and G. Halliday, Aneuploidy in Lewy body diseases. Neurobiol Aging, 2015. 36(3): p. 1253-60.
  • van Eersel, J., et al., Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration. Neuropathol Appl Neurobiol, 2015. 41(7): p. 906-25.
  • Toselli, F., et al., Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. Xenobiotica, 2015. 45(12): p. 1129-37.
  • Toselli, F., et al., Expression of CYP2E1 and CYP2U1 Proteins in Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. Alcohol Clin Exp Res, 2015. 39(5): p. 790-7.
  • Tan, R.H., et al., Cerebellar neuronal loss in als cases with ATXN2 intermediate repeat expansions. Ann Neurol, 2015.
  • Tan, R.H., et al., TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes. Brain, 2015.
  • Stone, J., et al., The mechanical cause of age-related dementia (Alzheimer's disease): the brain is destroyed by the pulse. J Alzheimers Dis, 2015. 44(2): p. 355-73.
  • Sobczyk, K., et al., Ephrin/Ephrin receptor expression in ammonia-treated rat astrocytes and in human cerebral cortex in hepatic encephalopathy. Neurochem Res, 2015. 40(2): p. 274-83.
  • Norris, S.E., et al., Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. Neurobiol Aging, 2015. 36(4): p. 1659-69.
  • Murphy, K.E., et al., Lysosomal-associated membrane protein 2 Isoforms Are Differentially Affected in Early Parkinson's Disease. Mov Disord, 2015.
  • Moujalled, D., et al., Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43. Hum Mol Genet, 2015. 24(6): p. 1655-69.
  • Mills, J.D., et al., Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy. Neurogenetics, 2015. 16(2): p. 107-22.
  • Mills, J.D., et al., High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation. Mol Brain, 2015. 8: p. 2.
  • Mills, J.D., et al., Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter. Neurogenetics, 2015. 16(3): p. 201-13.
  • Matosin, N., et al., Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment. Neuropharmacology, 2015.
  • Matosin, N., et al., Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. Schizophr Res, 2015. 166(1-3): p. 212-8.
  • Matosin, N., et al., Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation. Acta Neuropathol, 2015.
  • Mamdani, M., et al., Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. PLoS One, 2015. 10(9): p. e0137671.
  • Lourenco, G.F., et al., Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD). Neurobiol Dis, 2015. 82: p. 445-54.
  • Leshchyns'ka, I., et al., Abeta-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease. Nat Commun, 2015. 6: p. 8836.
  • Janeczek, P., et al., Differential expression of alpha-synuclein splice variants in the brain of alcohol misusers: Influence of genotype. Drug Alcohol Depend, 2015. 155: p. 284-92.
  • Hunt, N.J., et al., Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus. Neurobiol Aging, 2015. 36(1): p. 292-300.
  • Huang, Y., et al., SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians. Biomed Res Int, 2015. 2015: p. 135674.
  • Helmfors, L., et al., Protective properties of lysozyme on beta-amyloid pathology: implications for Alzheimer disease. Neurobiol Dis, 2015. 83: p. 122-33.
  • Hancock, S.E., et al., Decreases in Phospholipids Containing Adrenic and Arachidonic Acids Occur in the Human Hippocampus over the Adult Lifespan. Lipids, 2015. 50(9): p. 861-72.
  • Halliday, G.M. and K.E. Murphy, Reply: Lysosomal dysfunction in Parkinson's disease. Brain, 2015. 138(Pt 4): p. e340.
  • Gorg, B., et al., Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy. Glia, 2015. 63(1): p. 37-50.
  • Geevasinga, N., et al., Cortical Function in Asymptomatic Carriers and Patients With C9orf72 Amyotrophic Lateral Sclerosis. The Journal of the American Medical Association Neurology 2015: p. 1268–1274.
  • Gabery, S., et al., Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study. Neuropathol Appl Neurobiol, 2015.
  • Fatima, M., et al., Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways. Acta Neuropathol Commun, 2015. 3(1): p. 47.
  • Farris, S.P., et al., Applying the new genomics to alcohol dependence. Alcohol, 2015. 49(8): p. 825-36.
  • Farris, S.P., et al., Transcriptome organization for chronic alcohol abuse in human brain. Mol Psychiatry, 2015. 20(11): p. 1438-47.
  • Farrawell, N.E., et al., Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions. Sci Rep, 2015. 5: p. 13416.
  • Coupland, K.G., et al., Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer's disease. Curr Alzheimer Res, 2015. 12(8): p. 745-51.
  • Catts, V.S., et al., Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia. NPJ Schizophr, 2015. 1: p. 15037.
  • Abbott, S.K., et al., Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease. J Parkinsons Dis, 2015. 5(1): p. 175-85.
Oral presentations
  • Catts V et al (2015) Evidence for an endogenous deficit in NMDA receptor expression and reduced postsynaptic density NR1 subunit levels in prefrontal cortex of individuals with schizophrenia. Biol Psychiatry Australia, Sydney.
  • Catts V et al (2016) NMDA receptor dysfunction in schizophrenia. Winter Conference on Brain Research, Breckenridge USA.
  • Don A (2015) Defective myelin lipid biosynthesis in pre-clinical Alzheimer's Disease identified through LCxMS/MS analysis. Virtual Symposium on Applied Separation Sciences, online.
  • Edenberg H (2015) Genomics of Alcoholism: GWAS and beyond. World Congress on Psychiatric Genetics Toronto, Canada.
  • Halliday G et al (2016) Dysfunctional lysosomes occur prior to any degenerative changes in the brains of patients with Parkinson's disease. 2016 Annual Conference of the Japanese Neuroscience Society, Yokohama Japan.
  • Hirth N et al (2015) Opioidergic mechanism in alcoholism: Translational studies in rodents and humans. ESBRA meeting, Valencia Spain.
  • King JE et al (2015) Enhancing NGS performance through improvements in template preparation procedure. 2nd Annual Next Generation Sequencing USA Congress, Boston USA.
  • Manzanares J (2015) Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. The European Society for Biomedical Research on Alcoholism 15th ESBRA, Valencia Spain.
  • Manzanares J (2016) Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Socidrogalcohol, Alicante Spain.
  • Mayfield RD (2015) Current approaches to genetic/genomic studies on alcoholism. World Congress of Psychiatric Genetics, Toronto Canada.
  • Purves-Tyson T (2015) Interactions between sex steroid pathways and dopamine-related molecules in rodent midbrain and in the human substantia nigra in schizophrenia. Invited Symposium speaker Symposium: Sex Hormones and their wide-ranging effects on psychopathology. Biological Psychiatry Australia, Sydney.
  • Purves-Tyson T (2015) Sex steroid pathways and dopamine-related molecules in the human substantia nigra in schizophrenia, Invited Symposium speaker. Australia Schizophrenia Conference, Melbourne.
  • Purves-Tyson T et al (2016) A molecular signature of dopamine dysregulation exists in the substantia nigra in schizophrenia IN Symposium: Exciting New Findings about Dopamine. Schizophrenia International Research Society, Florence Italy.
  • Sarkisyan D et al (2015) Epigenome in the brain of human alcoholics: genetically-regulated trajectories. ESBRA meeting, Valencia Spain.
  • Sutherland GT et al (2015) The impact of agonal factors on gene expression in the brains of chronic alcoholics. Research Society on Alcoholism, San Antonio USA.
  • Sytnyk V (2015) The role of the neural cell adhesion molecules in formation and maintenance of excitatory synapses. 4th CADD symposium, UNSW Sydney.
  • Weissleder C et al (2015) Age-related changes in TrkB-TK mRNA expression in the human subependymal zone. Brain Sciences UNSW, Sydney Australia.
  • Zhang H et al (2016) MicroRNA Transcriptome Changes in Multiple Brain Regions ofSubjects with Alcohol Use Disorders. The 13th International Congress of Human Genetics, Kyoto Japan.
Poster presentations
  • Coleman L et al (2016) Alcohol activates TLR7 signaling and releases HMGB1-let 7b complexes in microvesicles. Gordon Research Conference, Galveston TX.
  • Davies D et al (2015) Cofilin-actin aggregates and microglial cell morphology changes in Alzheimer's Disease. Sydney Glia Meeting, Manly.
  • Farg MA et al (2015) DNA damage and repair regulates nuclear translation factors in C9ORF72 patients and in neuronal cell line. Combio, Melbourne.
  • Fatima M et al (2014) Spreading of pathology in motor neuron disease. Inter-university Neuroscience & Mental Health Conference, Sydney.
  • Fatima M et al (2016) Imaging-pathology correlates in the corticospinal tract in motor neuron disease. Australian Society for Medical Research Annual Meeting, Sydney.
  • Kain N et al (2015) Short chain ceramides, associated with insulin resistance, increase with age in the human hippocampus. International Society for Neurochemistry, Cairns.
  • King JE et al (2015) Enhancing NGS performance through improvements in template preparation procedure. EMBL Cancer Genomics Conference, Heidelberg.
  • King JE et al (2015) Enhancing NGS performance through improvements in template preparation procedure. Australian Society for Medical Research Meeting, Adelaide.
  • Lee MR et al (2016) Oxytocin peptide and receptor expression in human post-mortem brain: Effect of alcohol dependence. Intramural Clinical Neurosciences Retreat, National Institutes of Health, NIH campus, Bethesda, MD, USA.
  • Lum JS et al (2015) Current and Potential Antipsychotic Targets: Exploring the Possible Interactions of D2R and mGluR5 in Schizophrenia. Biological Psychiatry Australia, Sydney.
  • McCorkindale A et al (2015) The effects of chronic smoking on Alcohol-related Brain Damage. APSAAR, Sydney.
  • Mathews K et al (2016) Changes to mRNA expression of hippocampal neurogenesis markers over the healthy human life span. Australian Biology of Ageing Conference, Coogee Australia.
  • Sait Hasirci A et al (2015) Alcoholism alters GABAergic neuroactive steroid 3α,5α-THP levels in human amygdala. Research Society on Alcoholism, USA.
  • Truscott RJ et al (2016) In Human, Old Protein Are Everywhere. Australian Biology of Ageing Conference, Coogee Sydney.
  • Weissleder C et al (2015) Neurogenesis Decline in the Subependymal Zone during Aging: Role of EGF-related Transcripts. Biol Psychiatry Australia, Sydney.
  • Youssef P et al (2015) Increased HO-1 activity with no evidence of oxidative stress in the early pathogenesis of Alzheimer’s disease. Societies for Free Radical Research Australasia and Japan (SFRRAJ), Christchurch New Zealand.
  • Wen Liu et al (2016) Death receptor 3 signaling in rat and alcohol human brain. NADIA Consortium Conference, Bethesda MD.
  • Zhang KY et al (2015) Functional Pipeline For Determining Pathogenicity Of Candidate Gene Mutations Causing Motor Neuron Disease. MNDRIA Annual Scientific Meeting, Sydney.
  • Zhang KY et al (2015) Functional Pipeline For Determining Pathogenicity Of Candidate Gene Mutations Causing Motor Neuron Disease. The Asia Pacific FTD/MND Meeting, Sydney.
  • Zhang Y et al (2015) Relationship between oxidative stress, grey matter volume, and inflammatory cytokines in schizophrenia. Biological Psychiatry Australia, Sydney.