Research Publications

Recent publications utilising NSW BTRC tissue -
  • Janeczek, P., Brooker, C.,Dodd, P. R., & Lewohl, J. M. (2015). Differential expression of alpha-synuclein splice variants in the brain of alcohol misusers: Influence of genotype. Drug Alcohol Depend, 155, 284-292. doi:10.1016/j.drugalcdep.2015.05.045
  • Kim, W. S., Kagedal, K., & Halliday, G. M. (2014). Alpha-synuclein biology in Lewy body diseases. Alzheimers Res Ther, 6(5), 73.
  • Beveridge, N. J., Santarelli, D. M., Wang, X., Tooney, P. A., Webster, M. J., Weickert, C. S., & Cairns, M. J. (2014). Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression. Schizophr Bull, 40(2), 399-409. doi:10.1093/schbul/sbs198
  • Bleasel, J. M., Wong, J. H., Halliday, G. M., & Kim, W. S. (2014). Lipid dysfunction and pathogenesis of multiple system atrophy. Acta Neuropathol Commun, 2, 15
  • Don, A. S., Hsiao, J. H., Bleasel, J. M., Couttas, T. A., Halliday, G. M., & Kim, W. S. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathol Commun, 2, 150.
  • Fatima, M., Tan, R., Halliday, G. M., & Kril, J. J. (2015). Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways. Acta Neuropathol Commun, 3(1), 47.
  • Gabery, S., Halliday, G., Kirik, D., Englund, E., & Petersen, A. (2015). Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study. Neuropathol Appl Neurobiol.
    Halliday, G. M., & Murphy, K. E. (2015). Reply: Lysosomal dysfunction in Parkinson's disease. Brain, 138(Pt 4), e340.
  • Henriksson, R., Backman, C. M., Harvey, B. K., Kadyrova, H., Bazov, I., Shippenberg, T. S., & Bakalkin, G. (2014). PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain. Biochim Biophys Acta, 1839(11), 1226-1232.
  • Hunt, N. J., Rodriguez, M. L., Waters, K. A., & Machaalani, R. (2015). Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus. Neurobiol Aging, 36(1), 292-300.
  • Zhang, H., et al., Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. Hum Genet, 2014. 133(11): p. 1383-94.
  • Uhrig, S., et al., Evidence for a Hyperdopaminergic State During Abstinence in Alcohol Dependent Humans and Rats. 2014.
  • Sutherland, G.T., et al., Comorbidities, confounders, and the white matter transcriptome in chronic alcoholism. Alcohol Clin Exp Res, 2014. 38(4): p. 994-1001.
  • Sutherland, G.T., D. Sheedy, and J.J. Kril, Neuropathology of alcoholism, in Handb Clin Neurol. 2014. p. 603-15.
  • Sutherland, G.T., D. Sheedy, and J.J. Kril, Using autopsy brain tissue to study alcohol-related brain damage in the genomic age. Alcohol Clin Exp Res, 2014. 38(1): p. 1-8.
  • Lee, C., R.D. Mayfield, and R.A. Harris, Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. Biol Psychiatry, 2014. 75(10): p. 765-73.
  • Jin, Z., et al., Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. Front Cell Neurosci, 2014. 8: p. 11.
  • Jin, Z., et al., Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics. Front Cell Neurosci, 2014. 8: p. 288.
  • Gorini, G., R.A. Harris, and R.D. Mayfield, Proteomic approaches and identification of novel therapeutic targets for alcoholism. Neuropsychopharmacology, 2014. 39(1): p. 104-30.
  • Farris, S.P. and R.D. Mayfield, RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain. Int Rev Neurobiol, 2014. 116: p. 275-300.
  • Farris, S.P., et al., Transcriptome organization for chronic alcohol abuse in human brain. Mol Psychiatry, 2014.
  • Erdozain, A.M., et al., The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. Addict Biol, 2014.
  • Edenberg, H.J. Genetics of Alcoholism and Substance Dependence: Family Studies. in Molecular Psychiatry Meeting. 2014. San Francisco, CA.
  • Crews, F.T. and R.P. Vetreno, Neuroimmune basis of alcoholic brain damage. Int Rev Neurobiol, 2014. 118: p. 315-57.
  • Bhandage, A.K., et al., GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. Front Cell Neurosci, 2014. 8: p. 415.
  • Wang, J.C., et al., A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. Mol Psychiatry, 2013. 18(11): p. 1218-24.
  • Sutherland, G.T., et al., The effects of chronic alcoholism on cell proliferation in the human brain. Exp Neurol, 2013. 247: p. 9-18.
  • Manzardo, A.M. and M.G. Butler, The Status of Epigenetics and DNA Methylation In Alcoholism, in Introduction to Genetic (DNA Methylation and Gene Methylation and Gene Regulation. 2013, J. Wan, iConcept Press Ltd. p. 1-28.
  • Crews, F.T., et al., High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol Psychiatry, 2013. 73(7): p. 602-12.
  • Booth Depaz, I.M., et al., Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls. Drug Metab Dispos, 2013. 41(6): p. 1187-94.
  • 61. Bazov, I., et al., The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addict Biol, 2013. 18(1): p. 161-9.
  • Sirohi, S., G. Bakalkin, and B.M. Walker, Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. Front Mol Neurosci, 2012. 5: p. 95.
  • Sheedy, D., et al., Influence of liver pathology on markers of postmortem brain tissue quality. Alcohol Clin Exp Res, 2012. 36(1): p. 55-60.
  • Qin, L. and F.T. Crews, NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. J Neuroinflammation, 2012. 9: p. 5.