Our research laboratories
Macromolecular Structure, Associate Professor Brett Hambly
The research programme in this Unit has two strands: (i) determination of the molecular structure and function of proteins, using the contractile proteins as a model system, and (ii) understanding cardiovascular disease at a molecular and cellular level.
Molecular Immunopathology, Professor Nick Hunt
The chief areas of research currently in the Unit are the immunopathology of infectious disease (especially malaria), and the regulation of inflammatory responses. We are interested in expression of host genes, in particular cytokines, chemokines and haem enzymes. Some of our work is done with experimental models in mice, some with cultured cell systems and some with material obtained post-mortem from victims of malaria.
Molecular Pharmacology and Pathology Program (MPP), Professor Des Richardson
Iron is essential for life and growth. While it is well known that iron deficiency can lead to anaemia it is generally not appreciated that iron is critical for the growth of all cells, particularly cancer cells. The Iron Metabolism and Chelation Program is concerned with understanding the basic processes of how tumour cells utilise and transport iron. This knowledge will lead to the development of therapies that can selectively starve tumour cells of iron and inhibit their growth.
Mucosal Immunology, Associate Professor Bob Bao
The main research interest of this Unit focuses on mucosal immunity, at both molecular and cellular levels.
Neuropathology, Professor Jillian Kril, Dr Greg Sutherland, Dr Michael Buckland (Honorary Associate)
The main research interests of this Unit are the pathogenesis of neurological psychiatric disorders. We have research projects studying neurodegenerative disease, such as Alzheimer's disease, frontotemporal dementia (FTD), motor neuron disease (MND) and Lewy body diseases, as well as alcohol-related brain damage, schizophrenia and brain tumours. Using a variety of histological and molecular techniques we aim to understand the clinicopathological correlations of central nervous system diseases and the role of genes in the causation of these diseases.
Redox Biology Group, Associate Professor Paul Witting
The main research interest is in exploring the relationship between oxidative stress and the evolution of tissue damage in the acute setting of stroke and myocardial infarct.
The Stacey Motor Neuron Disease Laboratory, Associate Professor Roger Pamphlett
This laboratory investigates the causes of motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), in an attempt for find effective treatments for these patients. Epidemiological studies looking for risk factors for MND are undertaken using data from the Australian MND DNA Bank, which is run by this unit. Neurogenetic studies are undertaken using blood DNA from this bank, as well as tissue DNA, in collaboration with the Genome Center as Washington University, St Louis. Toxicological studies assessing the role of environmental toxins are undertaken using both human tissue and animal models.
Vascular Immunology, Professor Georges Grau
Understanding better the mechanisms of microvessel pathology in cerebral malaria and other inflammatory diseases. On this basis, proposing new therapeutic approaches.
Viral Immunopathology, Professor Nicholas King
The main interest of this Unit is the immunobiology of the cell membrane surface. The main areas of research include the control of modulation of cell membrane architecture and cell surface molecules important in immune cell interactions.