Pathology Honours Projects

Assoc Prof Bob Bao

• Sudden Death in Young Australian CSI (Sydney)
• Inflammatory bowel disease (IBD)

Assoc Prof Stuart Cordwell

• Peptide biomarkers of myocardial ischemia
• The role of calcium overload in myocardial I/R injury

Prof Georges Grau

• Defining the antigen presentation capacity of endothelial cells
• Examining an immunomodulatory role of endothelial microparticles

Assoc Prof Brett Hambly

• Pathogenesis of Marfan Syndrome and related thoracic aortic aneurysm disease

Dr Patric Jansson

• Cancer therapeutics and targeting

Dr Danuta Kalinowski

• Development of New Iron Chelators as Novel Drugs Against Cancer

Prof Nicholas King

• The role of microparticles in the immune response to WNV
• Infiltrating leukocytes in WNV encephalitis - their role in mortality
• Changes in gene expression in neurons and microglia in WNV encephalitis
• The role of mucosal dendritic cells in controlling virus infection in epithelium
• The role of monocyte/dendritic cells in initiating WNV immune responses

Dr Zaklina Kovacevic

• Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer

Prof Jillian Kril

• The quantification of neuronal loss in language variants of frontotemporal dementia
• The role of smoking in neurodegeneration

Dr Darius Lane

• The role of ascorbate in modulating hypoxic signalling in iron metabolism
• The role of GPI-linked ceruloplasmin in astrocyte iron metabolism

Assoc Prof Roger Pamphlett

• Finding the causes of motor neuron disease

Prof Des Richardson

• Transport of Nitric Oxide in Cells and its Interaction with Iron Containing Proteins in Tumour Cells
• The Role of Iron in the Pathogenesis of the Crippling Neurodegenerative Disease, Friedreich's Ataxia
• Investigating cellular response to iron-depletion by examining the mitogen-activated protein kinases (MAPK) signalling pathway
• Molecular Regulation of eIF3a in Cancer Cell Motility and Invasion

Prof Roland Stocker

• Contribution of indoleamine 2,3-dioxygenase to the regulation of vascular tone
• Unravelling the function of heme oxygenase-1 using a genetic approach
• Functional regulating of vascular cells by heme oxygenase-1

Dr Greg Sutherland

• Neurogenesis and alcoholism
• Hepatic encephalopathy and proliferation in the adult human brain
• The PI3K/Akt pathway in Alzheimer’s disease
• The effect of the pre-agonal period on the human brain transcriptome

Assoc Prof Paul Witting

• Characterizing experimental snore vibration damage to cultured human carotid artery endothelial cells as a precursor to carotid artery disease
• Exploring a role for the heme protein neuroglobin in protecting neuronal cells from acute injury
• Investigating the pro-atherogenic action of the acute phase protein serum amyloid A
• Post translational changes to key cardiac proteins in the hearts of diabetic rats after experimental heart attack

Dr Daohai Zhang

• Molecular regulation of ERp29 in epithelial cancer cell plasticity
• Dissecting the role of NDRG-1 in regulating endoplasmic reticulum stress and cancer cell survival

Affiliates

Dr Charles Allan

• Androgen regulation of male germ cell survival and fertility

Dr Rose Boutros

• Phospho-regulation of centrosome proteins in cancer cells

Dr Fabienne Brilot-Turville

• Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) in paediatric multiple sclerosis

Dr Mark Douglas

• Treating hepatitis C virus with cannabinoid antagonists
• Reversing IFN refractoriness to improve HCV treatment

Dr Sue Firth

• IGFBP-3 promotes solid tumour cell survival in adverse microenvironments

Dr Lionel Hebbard

• Cancer stem cells
• Informatics: characterisation of the genetic differences in mouse liver cancer
• Mouse models of fatty liver
• The role of liver-adipose tissue cross talk in liver disease
• Tumour metabolism

Assoc Prof Marina Kennerson

• Gene discovery using next generation genome technologies: family studies to identify genes that cause motor and sensory neuron death

Dr Loretta Lau

• N-MYC/c-MYC-mediated regulation of the telomerase complex in neuroblastoma

Dr Guy Lyons

• Cell-cell interactions in tumour progression

Dr Rita Machaalani

• Nicotinic receptors in the smoking and pre-eclamptic placenta
• Outcomes of sleep studies in infants: Obstructive Sleep Apnea (OSA) and CPAP use

Assoc Prof Susan McLennan

• MicroRNAs in thyroid carcinoma

Dr Heather Medbury

• Redefining the role of monocytes and macrophages in vascular disease

Dr Anastasia Mihailidou

• Regulation of aldosterone/mineralocorticoid receptors in the heart
• Glucagon-Like Peptide-1 agonists, reperfusion injury and type 2 diabetes
• Hyperglycemia removes the gender gap during experimental myocardial infarction

Prof Kathryn North

• A gene for speed: the role of α-actinin-3 in the regulation of skeletal muscle mass

Dr Hilda Pickett

• Telomere maintenance mechanisms in cancer

Prof Phil Robinson

Dr Nick Gorgani (Associate Supervisor):

• Ring Stabilizer, compounds as potential novel tools to control pathogen clearance by phagocytes via the dynamin-actin interaction

Dr Ulla Simanainen

• Androgens and skin cancer
• Cell-specific, androgenic regulation of growth factor signalling in prostate cancer
• Role of androgens in experimental breast cancer

Dr Charmaine Tam

• Matrix remodeling during high fat diet feeding in mice and humans

Dr Kirsty Walters

• Role of androgens in female reproduction

Dr Yiwei Wang

• The role of androgens in cutaneous wound healing

Dr Melanie White

• Why do diabetic hearts behave differently from normal hearts?

Dr Munira Xaymardan

• Role of Platelet Derived Growth Factor Receptor alpha cells in tooth development

Dr Jian Lin Yin

• Biomarkers for predicting graft dysfunction after renal transplantation

Dr Bing Yu

• Gene copy number in sporadic Amyotrophic Lateral Sclerosis

Assoc Prof Hong Zhou

• The role of glucocorticoid receptor in breast cancer and its bone metastasis