Pathology Honours / Graduate Diploma Projects

Assoc Prof Bob Bao



Sudden Death in Young Australian CSI (Sydney)
Inflammatory bowel disease (IBD)

Assoc Prof Stuart Cordwell



Peptide biomarkers of myocardial ischemia
The role of calcium overload in myocardial I/R injury

Prof Georges Grau



Developing novel biomarkers for disease activity in multiple sclerosis
Investigating mechanisms of microparticle production by microvascular endothelial cells and defining clinically useful inhibitors
Assessing microparticles as effectors in the microvascular lesion of cerebral malaria
Defining the antigen presentation capacity of endothelial cells and their microparticles

Assoc Prof Brett Hambly



Pathogenesis of Marfan Syndrome and related thoracic aortic aneurysm disease

Dr Patric Jansson



Cancer therapeutics and targeting

Dr Danuta Kalinowski



Development of New Iron Chelators as Novel Drugs Against Cancer

Prof Nicholas King



The role of microparticles in the immune response to WNV
Why isn't the foreign embryo rejected by the mother? The role of infection in alerting the mother's immune system to her embryo
Infiltrating leukocytes in WNV encephalitis - their role in mortality
Changes in gene expression in neurons and microglia in WNV encephalitis
The role of mucosal dendritic cells in controlling virus infection in epithelium
The role of monocyte/dendritic cells in initiating WNV immune responses

Dr Zaklina Kovacevic



Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer

Prof Jillian Kril



Clinicopathological correlations in Frontotemporal dementia (FTD)
Understanding alcohol-related brain damage

Dr Darius Lane



Molecular Metabolomics of Cancer

Dr Angelica Merlot



Dissecting the role of NDRG1 in regulating endoplasmic reticulum stress and cancer cell survival

Dr Lenka Munoz



Role of DYRK1A in glioblastoma subtypes
Role of MK2 in glioblastoma chemotherapy resistance

Assoc Prof Roger Pamphlett



Finding the causes of motor neuron disease

Prof Des Richardson



Transport of Nitric Oxide in Cells and its Interaction with Iron Containing Proteins in Tumour Cells
The Role of Iron in the Pathogenesis of the Crippling Neurodegenerative Disease, Friedreich's Ataxia
Investigating cellular response to iron-depletion by examining the mitogen-activated protein kinases (MAPK) signalling pathway
Molecular Regulation of eIF3a in Cancer Cell Motility and Invasion
Dissecting the role of NDRG-1 in regulating endoplasmic reticulum stress and cancer cell survival
Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer

Dr Sumit Sahni



Role of Hypoxia in Cancer Progression

Dr Greg Sutherland



The effect of the agonal period on the human brain transcriptome
The role of microglia in alcohol-related brain damage

Dr Melanie White



Why do diabetic hearts behave differently from normal hearts?

Assoc Prof Paul Witting



Characterizing experimental snore vibration damage to cultured human carotid artery endothelial cells as a precursor to carotid artery disease
Exploring a role for the heme protein neuroglobin in protecting neuronal cells from acute injury
Investigating the pro-atherogenic action of the acute phase protein serum amyloid A
Post translational changes to key cardiac proteins in the hearts of diabetic rats after experimental heart attack

Affiliates

Professor Ian Alexander



Repairing genetic mutations in the liver stem cell using recombinant adeno-associated virus (AAV)

Associate Professor Jonathan Arthur



Mining genomic data to understand diseases
Computational approaches to prioritise putative cancer driver mutations and epigenetic mediators
Therapeutically amenable targets from identified genetic alterations in cancer

Dr Anthony Ashton



How a baby controls a mother's immune system

Dr Kimberley Beaumont



Targeting Invadopodia to Suppress Melanoma Invasion and Metastasis

Dr Fabienne Brilot-Turville



Exploring how autoantibodies are pathogenic in multiple sclerosis and demyelinating diseases in humans

Assoc Prof Tracy Bryan



Recruitment of human telomerase to telomeres in cancer cells

Assoc Prof Jennifer Byrne



Identifying targets to improve therapy of high-risk and relapsed paediatric cancer patients
A weighty problem- how the protein TPD52 regulates cellular lipid storage

Dr Anthony Cesare



The telomere deprotection response in cancer

Assoc Prof Megan Chircop



Molecular Mechanism(s) of Action of Anti-Mitotic Compounds and their Anti-Cancer Properties
Molecular Mechanisms of Mitotic Progression and Completion

Professor Mark Cooper



Role of glucocorticoids in outcome from burn injury

Honorary Assoc Prof Qihan Dong



Block cell cycle re-entry by quiescent prostate cancer cells

Dr Mark Douglas



Hepatitis B virus pathogenesis – how does it cause liver cancer

Dr Mark Graham



Neurotransmission gone wrong: disease related proteins involved in nerve cell communication

Prof Derek Hart



mRNA Prostate Cancer Antigen Loaded Blood Dendritic Cell Therapy
LRBA - Investigating the Role of a Novel Protein in Dendritic Cell Function

Dr Sarah Hayes



Proteomics of non-small cell lung cancer: biomarker discovery using cutting-edge mass spectrometry

Prof Christopher Jackson



Suppression of inflammatory arthritis by Activated Protein C
The contribution of Proteinase Activated Receptors during skin epidermal barrier dysfunction
Targetting Matrix metalloproteinase signaling in RA synovial fibroblasts

Assoc Prof Marina Kennerson



Finding Genes for Motor and Sensory Neuron Degeneration Using Next Generation Sequencing

Dr Donna Lai



Investigation of cardiomyocyte proliferation and cell metabolism through Neuregulin1/ErbB signalling

Dr Loretta Lau



Novel treatment of cancers utilising the alternative lengthening of telomeres (ALT) mechanism

Dr David Loebel



Head Development: Intersection of transcriptional and signalling activities
Gene function in gut endoderm development
Control of cell differentiation during mouse embryogenesis and stem cell development

Dr Guy Lyons



Cell-cell interactions in tumour progression

Dr Rita Machaalani



Outcomes of sleep studies in infants: Obstructive Sleep Apnea (OSA) and CPAP use

Prof Nicholas Manolios



The role of Herpes Zoster virus in the aetiopathogenesis of giant cell temporal arteritis

Dr Amy Marshall



Molecular Techniques to Study the Three Dimensional Architecture of the Genome
Unravelling Abnormal Gene Expression to Understand Breast Cancer
How Does Altered Chromatin Organisation Lead to Ovarian Cancer?

Dr Helen McGuire



Taking on melanoma with personalised immunology

Assoc Prof Susan McLennan



The role of hepatocyte microvesicles in NASH progression
The role of macrophage status in development of diabetic complications
The miRNA profile of papillary thyroid cancer

Dr Danqing Min



Phenotypic switching of tissue macrophages in diabetes: possible role in the development of fatty liver disease

Dr Andrew Mitchell



Understanding early immune responses in the spleen to blood-borne pathogens

Professor Kathryn North



A gene for speed: the role of α-actinin-3 in the regulation of skeletal muscle mass

Dr Hilda Pickett



Telomere maintenance mechanisms in cancer

Dr Liang Qiao



Notch signalling plays a key role in determining malignant transformation and cell fate in liver cancer

Dr Sonia Saad



The role of mitochondrial specific anti-oxidants in chronic kidney disease induced by maternal smoking

Dr Aaron Schindeler



New therapeutics for preventing and treating fracture infection

Professor Richard Scolyer



An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors

Dr Ulla Simanainen



Androgens and skin cancer
Cell-specific, androgenic regulation of growth factor signalling in prostate cancer
Role of androgens in experimental breast cancer

Dr Kirsty Walters



A potential role for androgens in improving ovarian response to IVF stimulation

Dr Yiwei Wang



The role of androgens in burn wound repair

Dr Helen Williams



Monocytes in FH: Effect of HDL levels

Dr Justin Wong



Do epigenetic changes regulate RNA processing during myeloid cell differentiation?
How does abnormal gene processing lead to leukaemia?
The role of RNA processing during monocyte differentiation

Dr Munira Xaymardan



Role of Platelet Derived Growth Factor Receptor alpha cells in tooth development

Dr Jian Lin Yin



Biomarkers for Predicting Graft Dysfunction after Renal Transplantation

Assoc Prof Bing Yu



Gene copy number in sporadic Amyotrophic Lateral Sclerosis

Dr Xiangjian Zheng



micro-CT imaging of Cerebral Cavernous Malformation (CCM) in mouse models

Assoc Prof Hong Zhou



The Role of Endogenous Signalling in Age-Associated Changes in Body Composition and Fuel Metabolism
Are Chondrocytes the Target Cells of Glucocorticoid Therapy in Autoimmune Arthritis?