Pathology Honours / Graduate Diploma Projects

Assoc Prof Bob Bao



Sudden Death in Young Australian CSI (Sydney)
Inflammatory bowel disease (IBD)

Assoc Prof Stuart Cordwell



Peptide biomarkers of myocardial ischemia
The role of calcium overload in myocardial I/R injury

Dr Shelley Forrest



Clinicopathological correlations in Frontotemporal lobar degeneration (FTLD)

Prof Georges Grau



Monocyte subset characterisation in brain complications of infectious diseases
Investigating the roles of extracellular vesicles (EV) in cancer
Extracellular vesicles in the pathogenesis of infectious diseases

Assoc Prof Brett Hambly



Pathogenesis of Marfan Syndrome and related thoracic aortic aneurysm disease

Dr Patric Jansson



Cancer therapeutics and targeting

Dr Danuta Kalinowski



Development of New Iron Chelators as Novel Drugs Against Cancer

Prof Nicholas King



The role of microparticles in the immune response to WNV
Why isn't the foreign embryo rejected by the mother? The role of infection in alerting the mother's immune system to her embryo
Infiltrating leukocytes in WNV encephalitis - their role in mortality
Changes in gene expression in neurons and microglia in WNV encephalitis
The role of mucosal dendritic cells in controlling virus infection in epithelium
The role of monocyte/dendritic cells in initiating WNV immune responses

Dr Zaklina Kovacevic



Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer

Prof Jillian Kril



Clinicopathological correlations in Frontotemporal dementia (FTD)
Understanding alcohol-related brain damage

Dr Darius Lane



Molecular Metabolomics of Cancer

Dr Angelica Merlot



Dissecting the role of NDRG1 in regulating endoplasmic reticulum stress and cancer cell survival

Dr Lenka Munoz



Role of DYRK1A in glioblastoma subtypes
Role of MK2 in glioblastoma chemotherapy resistance

Assoc Prof Roger Pamphlett



Finding the causes of motor neuron disease

Prof Des Richardson



Transport of Nitric Oxide in Cells and its Interaction with Iron Containing Proteins in Tumour Cells
The Role of Iron in the Pathogenesis of the Crippling Neurodegenerative Disease, Friedreich's Ataxia
Investigating cellular response to iron-depletion by examining the mitogen-activated protein kinases (MAPK) signalling pathway
Molecular Regulation of eIF3a in Cancer Cell Motility and Invasion
Dissecting the role of NDRG-1 in regulating endoplasmic reticulum stress and cancer cell survival
Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer

Dr Sumit Sahni



Role of Hypoxia in Cancer Progression

Dr Greg Sutherland



The effect of the agonal period on the human brain transcriptome
The role of microglia in alcohol-related brain damage

Dr Melanie White



Why do diabetic hearts behave differently from normal hearts?

Assoc Prof Paul Witting



Characterizing experimental snore vibration damage to cultured human carotid artery endothelial cells as a precursor to carotid artery disease
Exploring a role for the heme protein neuroglobin in protecting neuronal cells from acute injury
Investigating the pro-atherogenic action of the acute phase protein serum amyloid A
Post translational changes to key cardiac proteins in the hearts of diabetic rats after experimental heart attack

Affiliates

Dr Anthony Ashton



How a baby controls a mother's immune system

Dr Charles Bailey



Functional consequences of mutations in the tumour suppressor CTCF in cancer
Consequences of mutations in the tumour suppressor gene MGA in chronic lymphocytic leukaemia (CLL)

Prof Rob Baxter



Unexpected effects of blocking IGFBP-3-mediated signalling on tumour T cells in breast cancer
A novel approach to enhancing breast cancer chemotherapy by inhibiting DNA damage repair

Dr Kimberley Beaumont



Targeting invadopodia to suppress melanoma metastasis

Dr Holly Bolton



Regulatory T cell therapy in allogeneic stem cell transplantation

Dr Megan Brewer



Modelling inherited peripheral neuropathies in worms

Dr Zac Chatterton



Cell-free DNA methylation analysis in Neurodegenerative disease

Dr Jaesung Choi



Pathogenesis of Cerebral Cavernous Malformations in the brain

Dr Kristina Cook



Cancer Drug Development: Targeting Hypoxia Inducible Factor (HIF)
Developing Novel Cancer Drugs: Do C-terminal HSP90 inhibitors block the HIF hypoxic response?
Understanding the role of obstructive sleep apnoea in cancer growth and spread

Professor Mark Cooper



Role of glucocorticoids in outcome from burn injury

Dr Carol Dobson-Stone



How does the common dementia gene C9orf72 affect DNA methylation in the brain?

Assoc Prof Anthony Don



New Drugs that Enhance Fat Metabolism by Skeletal Muscle
Understanding how age-related myelin loss pre-disposes to Alzheimer's Disease

Honorary Assoc Prof Qihan Dong



Block cell cycle re-entry by quiescent prostate cancer cells

Assoc Prof Kay Double



Interested in brain cancer in kids and its treatment?
Interested in neurodegenerative disease and treatment - Parkinson’s disease, dementia disorders, ALS?

Assoc Prof Mark Gorrell



Roles of a bispecific enzyme in the pathogenesis of chronic liver injury
Regulating extracellular matrix degradation

Prof Glenda Halliday



Investigating the role of ABC genes in frontotemporal dementia pathological processes
Determining the role of COQ2 in multiple system atrophy pathogenesis

Prof Derek Hart



Examining the Role of the Novel C-Type Lectin Receptor CD302 in Dendritic Cell and Macrophage Migration

Dr Sarah Hayes



Proteomics of non-small cell lung cancer: biomarker discovery using cutting-edge mass spectrometry

Prof Sarah Hilmer



What is the effect of chronic polypharmacy on liver, muscle and/or brain?

Assoc Prof Jeff Holst



Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer

Prof Christopher Jackson



Suppression of inflammatory arthritis by Activated Protein C
The contribution of Proteinase Activated Receptors during skin epidermal barrier dysfunction
Targetting Matrix metalloproteinase signaling in RA synovial fibroblasts

Assoc Prof Marina Kennerson



Finding Genes for Motor and Sensory Neuron Degeneration Using Next Generation Sequencing

Assoc Prof John Kwok



Confirmation and functional characterisation of dementia gene variants

Dr Donna Lai



Investigation of cardiomyocyte proliferation and cell metabolism through Neuregulin1/ErbB signalling

Dr Guy Lyons



Genes and cell-cell interactions in tumour progression

Dr Rita Machaalani



Outcomes of sleep studies in infants: Obstructive Sleep Apnea (OSA) and CPAP use

Dr Helen McGuire



Taking on melanoma with personalised immunology

Dr Kelly McKelvey



Inflammation and Combination Therapy to Combat Brain Cancer

Assoc Prof Susan McLennan



The role of hepatocyte microvesicles in NASH progression
The role of macrophage status in development of diabetic complications
The miRNA profile of papillary thyroid cancer

Dr Danqing Min



Monocyte phenotype switching in diabetes: -possible role in the development of complications

Dr Siva Purushothuman



Understanding the common and unique pathomechanisms in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s Disease

Dr Sonia Saad



The role of mitochondrial specific anti-oxidants in chronic kidney disease induced by maternal smoking

Professor Richard Scolyer



An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors

Dr Ulla Simanainen



Androgens and skin cancer
Cell-specific, androgenic regulation of growth factor signalling in prostate cancer
Role of androgens in experimental breast cancer

Dr Kirsty Walters



A potential role for androgens in improving ovarian response to IVF stimulation

Dr Yiwei Wang



The role of androgens in burn wound repair

Macronutrients, metabolism and burn injury

Dr Helen Williams



Does familial hypercholesterolemia promote M1 macrophage formation?

Dr Justin Wong



Do epigenetic changes regulate RNA processing during myeloid cell differentiation?
How does abnormal gene processing lead to leukaemia?
The role of RNA processing during monocyte differentiation

Dr Jian Lin Yin



Biomarkers for Predicting Graft Dysfunction after Renal Transplantation

Assoc Prof Bing Yu



Gene copy number in sporadic Amyotrophic Lateral Sclerosis

Dr Xiangjian Zheng



micro-CT imaging of Cerebral Cavernous Malformation (CCM) in mouse models

Assoc Prof Hong Zhou



The Role of Endogenous Signalling in Age-Associated Changes in Body Composition and Fuel Metabolism
Are Chondrocytes the Target Cells of Glucocorticoid Therapy in Autoimmune Arthritis?
The role of endogenous glucocorticoid signalling in diet-induced bone loss and fuel metabolism

Dr Rachel Tan



Clinical ramifications of mixed pathologies in neurodegenerative dementias