%0 Journal Article
%~ Pubmed
%A Hornberger, Michael
%A Mohamed, Armin
%A Miller, Laurie
%A Watson, John
%A Thayer, Zoe
%A Hodges, John R
%T Focal retrograde amnesia: Extending the clinical syndrome of transient epileptic amnesia.
%B Journal of Clinical Neuroscience
%D 2010
%V 17
%N 10
%P 1319-21
%@ 1532-2653
%X A 44-year-old woman presented with focal retrograde amnesia and complaints of rapid forgetting in the absence of episodes of transient cognitive disturbance. Her MRI and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) were normal. On standard neuropsychological tests she performed within the normal range although a test of autobiographical memory confirmed impoverished recall especially involving recent life events. The electroencephalograph (EEG) recordings were suggestive of temporal lobe epilepsy but no clear diagnosis was established. After 4 years the patient's recurrent brief episodes of disorientation, suggestive of transient epileptic amnesia (TEA), were corroborated by her sister. This diagnosis was confirmed by an ambulatory EEG that revealed ictal activity. Several important points emerge from this study. Focal retrograde amnesia can be a prodromal symptom of TEA which can precede the full-blown syndrome by several years. Moreover, transient attacks might not be reported if patients live alone. The ictal EEG findings further substantiate the epileptic nature of the syndrome.
%Z FOR Codes: 1109



%0 Journal Article
%~ Isi
%A Egan, GF
%A Watson, JDG
%A Amunts, K
%A Schleicher, A
%A Eickhoff, SB
%A Walters, NB
%A Zilles, K
%T Observer-independent analysis of high-resolution MR images of the human cerebral cortex: In vivo delineation of cortical areas
%B HUMAN BRAIN MAPPING
%D 2007
%C United States
%I John Wiley & Sons
%V 28
%N 1
%P 1-8
%@ 1065-9471
%X 
%Z FOR Codes: 110903



%0 Book Section
%A Terpening, Zo?
%A Watson, John
%T Higher visuoperceptual disorders and disorders of spatial cognition
%B Neurology and Clinical Neurosciences
%D 2007
%C United States
%I Mosby Elservier
%V 
%N 
%P 59-71
%@ 9780323033541
%E Schapira, Anthony
%X 
%Z FOR Codes: 110906



%0 Journal Article
%~ Isi
%A Eickhoff, S.
%A Walters, N. B.
%A Schleicher, A.
%A Kril, J.
%A Egan, G. F.
%A Zilles, K.
%A Watson, J. D. G.
%A Amunts, K.
%T High-resolution MRI reflects myeloarchitecture and cytoarchitecture of human cerebral cortex.
%B Human Brain Mapping
%D 2005
%C USA
%I John Wiley & Sons, Inc
%V 24
%N 3
%P 206-215
%@ 1065-9471
%X 
%Z FOR Codes: 110903



%0 Journal Article
%~ Pubmed
%A Podzebenko, Katherine
%A Egan, Gary F
%A Watson, John D G
%T Real and imaginary rotary motion processing: functional parcellation of the human parietal lobe revealed by fMRI.
%B Journal of cognitive neuroscience
%D 2005
%V 17
%N 1
%P 24-36
%@ 0898-929X
%X Functional magnetic resonance imaging was performed in 16 healthy subjects while they undertook orientation discrimination tasks of real rotating and mentally rotating alphanumeric characters. Perception of rotating and stationary abstract characters was also performed. Mental rotation and the perception of alphanumeric characters undergoing real rotation activated equivalent cortical areas, in keeping with the analogue hypothesis of mental rotation. In addition, areas along the dorsal stream, including the V5/middle temporal complex and the intraparietal sulcus (IPS), were activated during both the real and imaginary rotary conditions. Within the parietal lobe there were areas of convergence (i.e., recruited by all three motion conditions) and areas of divergence (i.e., selectively activated by a particular condition). Tasks requiring canonical-mirror orientation discrimination revealed involvement of neural substrates localized to the ventrolateral bank of the IPS. Tasks in which this judgment was not performed and during which the subject viewed rotary motion of abstract stimuli recruited activity in the medial bank of the IPS. These results indicate subspecialization of the human posterior parietal lobe according to function.
%Z FOR Codes: 110903



%0 Journal Article
%~ Isi
%A Chalmers, J.
%A MacMahon, S.
%A Cooper, M.
%A Ferrannini, E.
%A Glasziou, P.
%A Grobbee, D.
%A Hamet, P.
%A Harrap, S.
%A Heller, S.
%A Liu, L. S.
%A Mancia, G.
%A Marre, M.
%A Mogensen, C.
%A Neal, B.
%A Pan, C. Y.
%A Patel, A.
%A Poulter, N.
%A Rodgers, A.
%A Woodward, M.
%A Collins, R.
%A Holman, R.
%A Sandercock, P.
%A Sleight, P.
%A Adams, M.
%A Fulcher, G.
%A Harrisberg, B.
%A Mitchell, P.
%A Pollock, C.
%A Watson, J.
%A Colman, S.
%A Cormack, A.
%A Flynn, S.
%A Jayne, K.
%A Joshi, R.
%A Monaghan, H.
%A Richens, A.
%A Rodeghiero, C.
%A Holloway, T.
%A Gray, B.
%A Milne, A.
%A Adderkin, A.
%A Bobbink, I.
%A de Guise, D.
%A Guertin, M. R.
%A Ma, L. Y.
%A Reid, J.
%A Stolk, R.
%A Wen, W.
%T ADVANCE - Action in Diabetes and Vascular Disease: patient recruitment and characteristics of the study population at baseline.
%B Diabetic Medicine
%D 2005
%C United Kingdom
%I Blackwell Publishing Ltd.
%V 22
%N 7
%P 882-888
%@ 0742-3071
%X 



%0 Journal Article
%A Miller, LA
%A Caine, D
%A Watson, JD
%T A role for the thalamus in memory for unique entities
%B Neurocase
%D 2003
%C P O BOX 825, LISSE, NETHERLANDS, 2160 S
%I Swets Zeitlinger Publishers
%V 9 (6)
%N 
%P 504-514
%@ 1355-4794
%X 



%0 Journal Article
%~ Pubmed
%A Walters, Nathan B
%A Egan, Gary F
%A Kril, Jillian J
%A Kean, Michael
%A Waley, Patricia
%A Jenkinson, Mark
%A Watson, John D G
%T In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation.
%B Proceedings of the National Academy of Sciences
%D 2003
%V 100
%N 5
%P 2981-6
%@ 0027-8424
%X Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even though noninvasive functional imaging techniques such as functional MRI (fMRI) are now commonplace, there is no complementary noninvasive structural technique. We present an in vivo method of examining the detailed neuroanatomy of any individual, which can then be correlated with that individual's own functional results. This method utilizes high-resolution structural MRI to identify distinct cortical regions based on cortical lamination structure. We demonstrate that the observed MR lamination patterns relate to myeloarchitecture through a correlation of histology with MRI. In vivo high-resolution MRI studies identify striate cortex, as well as visual area V5, in four individuals, as defined by using fMRI. The anatomical identification of a cortical area (V5MT) outside of striate cortex is a significant advance, proving it possible to identify extra-striate cortical areas and demonstrating that in vivo structural mapping of the human cerebral cortex is possible.
%Z FOR Codes: 110999



%0 Journal Article
%A Walters, NB
%A Egan, GF
%A Kril, JJ
%A Kean, M
%A Waley, P
%A Jenkinson, M
%A Watson, JDG
%T In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation
%B Proceedings Of The National Academy Of Sciences Of The United States Of America
%D 2002
%C 2101 Constitution Ave Nw, Washington, Dc, 20418
%I Natl Acad Sciences
%V 100
%N 
%P 2981-2986
%@ 0027-8424
%X 



%0 Journal Article
%A Sader, M
%A Miller, LA
%A Caine, D
%A McCredie, RJ
%A Corr, MJ
%A Robertson, M
%A Watson, JDG
%A Celermajer, DS
%T Neuropsychological and psychiatric outcomes following coronary surgery or angioplasty: a comparative study
%B Heart, Lung & Circulation
%D 2002
%C Australia
%I Blackwell Publishing Asia
%V 11
%N 
%P 95-101
%@ 1443-9506
%X 



%0 Journal Article
%A West, MJ
%A White, HD
%A Simes, RJ
%A Kirby, A
%A Anderson, NE
%A Hankey, GJ
%A Simes, S
%A Hunt, D
%A Tonkin, AM
%A Watson, JDG
%T Risk factors for non-haemorraghic stroke in patients with coronary heart disease and the effect of lipid-modifying therapy with pravastatin
%B Journal Of Hypertension
%D 2002
%C 530 Walnut St, Philadelphia, Pa, 19106-3621
%I Lippincott Williams & Wilkins
%V 20
%N 
%P 2513-2517
%@ 0263-6352
%X 



%0 Journal Article
%~ Pubmed
%A Podzebenko, Katherine
%A Egan, Gary F
%A Watson, John D G
%T Widespread dorsal stream activation during a parametric mental rotation task, revealed with functional magnetic resonance imaging.
%B NeuroImage
%D 2002
%V 15
%N 3
%P 547-58
%@ 1053-8119
%X Following a parametrically modulated mental rotation task, in which 10 healthy subjects were instructed to determine whether alphanumeric characters were normal or mirror-reversed, bilateral dorsal stream activations culminating in the intraparietal region were revealed with functional magnetic resonance imaging. Although the parietal activations were bilateral, we observed a right hemispheric dominance for the task, consistent with our previous findings (I. M. Harris et al., 2000). By studying individual activation maps in response to the paradigm, we discerned parcellation of the intraparietal region into discrete subdivisions. In this paper, we address the involvement of structures surrounding the intraparietal sulcus in mental rotation, as well as describing a wider visuospatial attentional network, encompassing neural substrates within the dorsal stream.



%0 Journal Article
%~ Pubmed
%A Miller, L A
%A Caine, D
%A Harding, A
%A Thompson, E J
%A Large, M
%A Watson, J D
%T Right medial thalamic lesion causes isolated retrograde amnesia.
%B Neuropsychologia
%D 2001
%V 39
%N 10
%P 1037-46
%@ 0028-3932
%X Pervasive retrograde amnesia without anterograde memory impairment has rarely been described as a consequence of circumscribed brain damage. We report this phenomenon in a 33 yr-old, right-handed man (JG) in association with the extension in the right thalamus of a previously small, bilateral thalamic lesion. JG presented with a dense amnesia for autobiographical material more than a few years old, with some sparing of recent memories. Furthermore, he was completely unable to recognise famous people or world events. Many other aspects of semantic knowledge were intact and there was no evidence of general intellectual impairment, executive dysfunction or loss of visual imagery. Magnetic resonance imaging revealed an acute lesion in the right thalamus and two small, symmetrical, bilateral non-acute thalamic lesions. Follow-up neuropsychological assessment indicated a stable pattern of impaired retrograde and spared anterograde memory over 18 months and psychiatric assessments yielded no evidence of confabulation, malingering or other symptoms to suggest psychogenic amnesia. JG's profile indicates that the division of declarative memory into just two categories - episodic and semantic - is inadequate. Rather, his case adds to the growing body evidence to suggest that world knowledge pertaining to people and events is stored or accessed similarly to autobiographical information and differently from other types of more general factual knowledge. We hypothesize that the right mediodorsal thalamic nucleus and immediately surrounding regions comprise the central processing mechanism referred to by McClelland (Revue Neurologique, 150 (1994) 570) and Markowitsch (Brain Research Review, 21 (1995) 117) as responsible for inducing and co-ordinating the recall of these sorts of cortically stored memory engrams.



%0 Journal Article
%~ Pubmed
%A Watson, J D
%T 11: disorders of memory and intellect.
%B Medical Journal of Australia
%D 2001
%V 175
%N 8
%P 433-9
%@ 0025-729X
%X The clinical approach to the patient with a suspected disorder of memory and intellect is to establish whether it is dementia, which parts of the brain are affected, what is the cause, what is the prognosis, and what can be done about it. The diagnosis of dementia usually requires the involvement of memory and at least one other cognitive system. Delirium and depression are important differential diagnoses. Patients with dementia should usually have some simple investigations after a careful history-taking and examination to identify "reversible" causes. The commonest cause of dementia is Alzheimer's disease, in which short-term memory disturbance is usually prominent. Other causes of dementia include cerebrovascular disease, Lewy-body disease and Pick's disease. There is now hope for patients with Alzheimer's disease (which can be treated with some success with cholinesterase inhibitors) and patients with vascular dementia, in whom aggressive control of causal risk factors may retard progression.



%0 Journal Article
%A White, HD
%A Simes, RJ
%A Anderson, NE
%A Hankey, GJ
%A Watson, JDG
%A Hunt, D
%A Colquhoun, DM
%A Glasziou, P
%A MacMahon, SW
%A Kirby, AC
%A West, MJ
%A Tonkin, AM
%T Pravastatin therapy and the risk of stroke
%B New England Journal of Medicine
%D 2000
%C 
%I Massachusetts Medical Society
%V 343(5)
%N 
%P 317-326
%@ 0028-4793
%X 



%0 Journal Article
%A Cowell, SF
%A Egan, GF
%A Code, C
%A Harastay, J
%A Watson, JDG
%T The functional neuroanatomy of simple calculation and number repetition: A parametric PET activation study
%B NeuroImage
%D 2000
%C 
%I Academic Press Inc
%V 12
%N 
%P 565-573
%@ 1053-8119
%X 



%0 Journal Article
%A Sheil, AGR
%A Sun, J
%A Wang, LS
%A Rao, N
%A Mears, D
%A Wang, CM
%A Woodman, K
%A Johnston, B
%A Watson, J
%T A Biodialysis system for liver support tested in a porcine hepatic failure model
%B Australian and New Zealand Journal of Surgery
%D 2000
%C 
%I Blackwell Science Asia
%V 70
%N 
%P 127-131
%@ 0004-8682
%X 



%0 Journal Article
%A Wang, LS
%A Sun, J
%A Wang, CM
%A Woodman, K
%A Li, L
%A Wu, L
%A Harbour, C
%A Johnston, B
%A Shi, L
%A Horvat, G
%A Koutalistras, N
%A Lou, X
%A Watson, J
%A Sheil, AGR
%T Analysis of Multivariables during Porcine Liver Digestion to Improve Hepatocyte yield and viability for use in Bioartificial Liver support systems
%B Cell Transplantation
%D 2000
%C 
%I Cognizant Communication Corporation
%V 9
%N 
%P 329-336
%@ 0963-6897
%X