%0 Journal Article
%~ PubMed
%A Tan, King
%A Brewer, Janice
%A Rowe, Dominic B
%A Jenkins, Bronwyn
%A Powers, James M
%A Buckland, Michael E
%T Adult onset leucodystrophy with neuroaxonal spheroids and pigmented glia (ALSP): report of a new kindred.
%B Neuropathology and Applied Neurobiology
%D 2012
%C United Kingdom
%I Wiley-Blackwell Publishing Ltd.
%V 38
%N 1
%P 95-100
%@ 1365-2990
%X 
%Z FOR Codes: 110999


%0 Journal Article
%~ PubMed
%A Salim, Alaa A
%A Wilson, Peter J
%A Cherukuri, Ravi K
%A McKenzie, Sandra
%A Buckland, Michael E
%T An unusual association of calcifying pseudoneoplasm of the neuraxis with interhemispheric lipoma and agenesis of corpus callosum.
%B Pathology
%D 2012
%C United Kingdom
%I Informa Healthcare
%V 44
%N 7
%P 657-659
%@ 0031-3025
%X 
%Z FOR Codes: 1109 1112


%0 Journal Article
%~ PubMed
%A Matthews, Slade
%A Succar, Petter
%A Jelinek, Herbert
%A McParland, Brent
%A Buckland, Michael
%A McLachlan, Craig S
%T Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century.
%B Asia-Pacific Journal of Clinical Oncology
%D 2012
%C United Kingdom
%I Wiley-Blackwell Publishing Ltd.
%V 8
%N 3
%P 213-216
%@ 1743-7563
%X Advances in molecular genetics are currently challenging the traditional morphological categorization of gliomas. Recurrent molecular and cytogenetic aberrations add prognostic and predictive information over and above that provided by standard histomorphological techniques and may influence decisions to re-operate or observe, to deliver radiation or not, or to administer chemotherapy to glioma patients. The importance of routine hematoxylin and eosin (H-E pathological stains cannot be underestimated, especially in resource-poor areas and developing countries where there is likely to be a significant economic opportunity cost for molecular diagnosis services. New research tools for image analyses of histological H-E slides, such as the precise measures of cell area, curvature and nuclear roundness, may provide an increased ability to provide an accurate classification for an inherently subjective process of histological assessment. We discuss the current trends, limitations and impact of molecular classification in this mini review.
%Z FOR Codes: 10401 111202


%0 Conference Proceedings
%A Jelinek, Herbert F
%A Ahammer, Helmut
%A Matthews, Slade
%A Succar, Peter
%A McLachlan, Craig S
%A Buckland, Michael
%T Establishing a Reference Range for Oligondendroglioma Classification using Higuchi Dimension Analysis
%B Ninth IASTED International Conference on Biomedical Engineering
%D 2012
%C Innsbruck, Austria Feb 15-17
%I ACTA Press
%V 
%N 
%P 
%@ 9780889869097
%E Hamza, MH
%E Simsik, D
%X 
%Z FOR Codes: 90302


%0 Journal Article
%~ PubMed
%A Simon, Neil G
%A Parratt, John D
%A Barnett, Michael H
%A Buckland, Michael E
%A Gupta, Ruta
%A Hayes, Michael W
%A Masters, Lynette T
%A Reddel, Stephen W
%T Expanding the clinical, radiological and neuropathological phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
%B Journal of neurology, neurosurgery, and psychiatry
%D 2012
%C United Kingdom
%I BMJ Group
%V 83
%N 1
%P 15-22
%@ 1468-330X
%X Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of the CNS with a predilection for the hindbrain and responsive to immunotherapy. Five further cases are described with detailed pathology and long term evaluation. CLIPPERS does not represent a benign condition, and without chronic immunosuppression the disease may relapse. The radiological distribution is focused not only in the pons but also in the brachium ponti and cerebellum. Pontocerebellar atrophy occurred early, even in cases treated promptly. Significant cognitive impairment was seen in some cases and was associated with additional cerebral atrophy. The pathology included distinctive histiocytic as well as lymphocytic components and evidence of neuro-axonal injury. Additional subclinical systemic findings on investigation were identified. Relapse was associated with withdrawal of corticosteroids, and disability was least marked in cases where both the presentation and relapses were treated promptly. We propose that the title of the syndrome be amended to chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids to more accurately reflect the distribution of the radiological findings.
%Z FOR Codes: 110903


%0 Journal Article
%~ PubMed
%A Karina, Aivazian
%A Jonker, Benjamin P
%A Morey, Adrienne
%A Selinger, Christina
%A Gupta, Ruta
%A Buckland, Michael E
%T Glioblastoma with primitive neuroectodermal tumour-like components.
%B Pathology
%D 2012
%C United Kingdom
%I Informa Healthcare
%V 44
%N 3
%P 270-273
%@ 0031-3025
%X 
%Z FOR Codes: 110316


%0 Journal Article
%~ PubMed
%A Barnett, Mh
%A Prineas, Jw
%A Buckland, Me
%A Parratt, Jde
%A Pollard, Jd
%T Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy.
%B Multiple Sclerosis
%D 2012
%C United Kingdom
%I Sage Publications Ltd.
%V 18
%N 1
%P 108-112
%@ 1477-0970
%X Auto-antibody mediated astrocyte injury is implicated as a primary event in neuromyelitis optica (NMO) by biomarker, post-mortem and experimental studies that differentiate the condition from multiple sclerosis. We describe the clinical, radiological and neuropathological features of a severe cerebral attack in a natalizumab-treated patient with relapsing myelitis and serum aquaporin-4 antibodies. Our findings support autopsy evidence that abrupt astrocyte destruction precedes demyelination in NMO, and emphasize the importance of serological testing in patients with limited disease. Adherence to current NMO diagnostic criteria may delay treatment, or lead to inappropriate therapy with beta-interferon or natalizumab.
%Z FOR Codes: 110904


%0 Journal Article
%~ PubMed
%A Flanagan, Simon
%A Lee, Maggie
%A Li, Cheryl C Y
%A Suter, Catherine M
%A Buckland, Michael E
%T Promoter Methylation Analysis of IDH Genes in Human Gliomas.
%B Frontiers in Oncology
%D 2012
%C Switzerland
%I Frontiers Research Foundation
%V 2
%N 
%P 193
%@ 2234-943X
%X 
%Z FOR Codes: 1112


%0 Journal Article
%~ PubMed
%A Hurelbrink, Carrie B
%A Barnett, Yael
%A Buckland, Michael E
%A Wilkinson, Mark
%A Leicester, Jon
%A Anderson, Craig
%A Brennan, Jeffrey
%A Barnett, Michael
%T Revisiting cerebral thromboangiitis obliterans.
%B Journal of the Neurological Sciences
%D 2012
%C Netherlands
%I Elsevier BV
%V 317
%N 1-2
%P 141-145
%@ 0022-510X
%X We describe a 56-year-old patient with progressive cognitive decline in the context of heavy tobacco use and migraine, and imaging evidence of an occlusive terminal cerebral vasculopathy. The results of brain biopsy recapitulated the pathological features described by Lindenberg and Spatz in their classic 1939 treatise on cerebral thromboangiitis obliterans, or cerebral Buerger''s disease. Although the condition is associated with heavy smoking, the identification of a hypercoagulable state in our patient suggests a multifactorial pathogenesis. The diagnosis of cerebral thromboangiitis obliterans in life is facilitated by modern neuroimaging and should prompt immediate cessation of smoking and a search for an underlying prothrombotic tendency.
%Z FOR Codes: 110904


%0 Journal Article
%~ PubMed
%A Ahmed, Rebekah
%A Buckland, Michael
%A Davies, Leo
%A Halmagyi, G Michael
%A Rogers, Shannon L
%A Oberste, Steven
%A Barnett, Michael H
%T Enterovirus 71 meningoencephalitis complicating rituximab therapy.
%B Journal of the neurological sciences
%D 2011
%C Netherlands, United Kingdom
%I Elsevier BV
%V 305
%N 
%P 149–151
%@ 0022-510X
%X We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin''s lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions.
%Z FOR Codes: 110903


%0 Journal Article
%~ PubMed
%A Chang, F C F
%A Berman, Y
%A Buckland, M E
%A Mackinlay, N
%A McGlade, A
%A Collins, S
%A Ng, K
%T Genetic prion disease-associated myelodysplasia and SIADH in siblings.
%B European Journal of Neurology
%D 2011
%C United States
%I Wiley-Blackwell Publishing Ltd.
%V 18
%N 12
%P e149-50
%@ 1468-1331
%X 
%Z FOR Codes: 1109


%0 Journal Article
%~ PubMed
%A Lee, Lianne
%A Sevastos, Jacob
%A Rainer, Stephen
%A Buckland, Michael E
%T Giant cell tubulitis and tubular basement membrane immune deposits.
%B Pathology
%D 2011
%C United Kingdom, Australia
%I Informa Healthcare
%V 43
%N 4
%P 383-386
%@ 0031-3025
%X 
%Z FOR Codes: 110316


%0 Journal Article
%~ PubMed
%A Gupta, R
%A Webb-Myers, R
%A Flanagan, S
%A Buckland, M E
%T Isocitrate dehydrogenase mutations in diffuse gliomas: clinical and aetiological implications.
%B Journal of clinical pathology
%D 2011
%C United Kingdom
%I BMJ Group
%V 64
%N 10
%P 835-44
%@ 1472-4146
%X The discovery of isocitrate dehydrogenase (IDH) mutations in gliomas is one example of the large impact that next-generation sequencing is having on the understanding of tumour biology and human disease in general. IDH mutations are early and common events in the development of astrocytomas, oligodendrogliomas and oligoastrocytomas. IDH mutations are also found in some myeloid malignancies and soft tissue tumours, but are rare in other malignancies. IDH mutation detection can be incorporated into routine pathology practice via immunohistochemistry and/or standard sequencing techniques and has great diagnostic value. An emerging theme is that IDH mutation status in gliomas is of great prognostic relevance, and there are proposals to include IDH mutation status in the next iteration of the WHO classification of gliomas. The mechanisms of action(s) of mutant IDH are not fully understood, but the understanding is progressing rapidly, and may provide a mechanism to link diverse proneoplastic processes such as oxidative damage and epigenetic dysregulation. There are exciting prospects of novel therapies for glioma patients emerging from the elucidation of these mechanisms. Given the diagnostic and prognostic implications of IDH mutation, and the potential for new therapies, all gliomas should be assessed for IDH mutation status in the future.
%Z FOR Codes: 110316 111202 110903


%0 Journal Article
%~ PubMed
%A Tan, King L
%A Parkinson, Jonathon F
%A McGee-Collett, Martin G
%A Buckland, Michael E
%T Spinal intradural malignant peripheral nerve sheath tumour.
%B Pathology
%D 2011
%C United Kingdom, Australia
%I Informa Healthcare
%V 43
%N 3
%P 278-280
%@ 0031-3025
%X 
%Z FOR Codes: 111202


%0 Journal Article
%~ PubMed
%A Parkinson, Jonathon F
%A Afaghi, Vahid
%A Payne, Cathy A
%A Buckland, Michael E
%A Brewer, Janice M
%A Biggs, Michael T
%A Little, Nicholas S
%A Wheeler, Helen R
%A Cook, Raymond J
%A McDonald, Kerrie L
%T The impact of molecular and clinical factors on patient outcome in oligodendroglioma from 20 years' experience at a single centre.
%B Journal of Clinical Neuroscience
%D 2011
%C United Kingdom
%I Churchill Livingstone
%V 18
%N 3
%P 329-333
%@ 1532-2653
%X The increased chemosensitivity of oligodendroglial tumours has been associated with loss of heterozygosity (LOH) of the p arm of chromosome 1 and the q arm of chromosome 19 (LOH 1p/19q). Other clinical and molecular factors have also been identified as being prognostic and predictive of treatment outcome. We reviewed 105 patients with oligodendroglioma treated at a single centre over 20 years. Median survival in oligodendroglioma patients with LOH 1p/19q was significantly longer (10.9 vs. 2.0 years). In the anaplastic oligodendroglioma group, univariate analysis demonstrated decreased patient age, presentation with seizures, use of adjuvant chemotherapy and LOH 1p/19q as predictors of improved survival. Multivariate analysis confirmed LOH 1p/19q as a significant predictor of improved survival (hazard ratio, 3.4; p=0.015). Median survival in patients with anaplastic oligodendroglioma with LOH 1p/19q was 15.4 years vs. 1.2 years for those without LOH 1p/19q. This study confirms the utility of LOH 1p/19q as a prognostic marker in oligodendroglioma.
%Z FOR Codes: 111202


%0 Journal Article
%~ PubMed
%A Li, Dianna
%A Brennan, Jeffrey W
%A Buckland, Michael
%A Parkinson, Jonathon F
%T Bronchogenic carcinoid metastasis to the intramedullary spinal cord.
%B Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
%D 2010
%C United Kingdom, Aus
%I Churchill Livingstone
%V 17
%N 9
%P 1196-8
%@ 1532-2653
%X Carcinoid tumours are malignant tumours of neuroendocrine origin. Spinal-cord compression from carcinoid metastasis is uncommon, and intradural spinal carcinoid is rare. We report an instance of intramedullary carcinoid metastasis of the conus medullaris in the context of stable, asymptomatic systemic disease. To our knowledge this is the first reported case of intramedullary carcinoid metastasis.
%Z FOR Codes: 111209 110903


%0 Journal Article
%~ PubMed
%A Shingde, M V
%A Buckland, M
%A Busam, K J
%A McCarthy, S W
%A Wilmott, J
%A Thompson, J F
%A Scolyer, R A
%T Primary cutaneous Ewing sarcoma/primitive neuroectodermal tumour: a clinicopathological analysis of seven cases highlighting diagnostic pitfalls and the role of FISH testing in diagnosis.
%B Journal of Clinical Pathology
%D 2009
%C United Kingdom
%I BMJ Group
%V 62
%N 10
%P 915-919
%@ 1472-4146
%X AIMS: To perform a clinicopathological analysis of a series of primary cutaneous Ewing sarcomas/primitive neuroectodermal tumours (ES/PNET) to highlight the pathological features, discuss the differential diagnosis, emphasise the role of molecular testing (particularly fluorescence in situ hybridisation, FISH) in diagnosis and outline the patients'' clinical course. METHODS: Seven cases of primary cutaneous ES/PNET were identified from the authors'' consultation files. RESULTS: The patients were aged 16-61 years (median 25). Five were female and two were male. Five cases involved the limbs and two the trunk. Five were initially misdiagnosed (three as carcinoma and two as melanoma). All cases were characterised histologically by sheet-like growth of small round cells with little cytoplasm and showed strong membranous staining for CD99 and positive but variable staining for FLI-1. Six patients showed an EWS rearrangement (five on FISH analysis and one on RT-PCR). All tumours were completely excised. Three patients received adjuvant chemotherapy, one of whom also received radiotherapy. Follow-up was available in all cases (range 11-57 months; median 41). No recurrences or metastases occurred. CONCLUSIONS: Although rare, primary cutaneous ES/PNET should be considered in the differential diagnosis of cutaneous "small blue cell tumours". Immunostaining for FLI-1 and molecular testing for evidence of an EWS rearrangement are useful ancillary investigations to confirm the diagnosis. The prognosis of primary cutaneous ES/PNET appears to be more favourable than extracutaneous ES/PNET.
%Z FOR Codes: 302


%0 Journal Article
%~ PubMed
%A Bobryshev, Yuri
%A Tran, Dinh
%A Killingsworth, Murray
%A Buckland, Michael
%A Lord, Reginald
%T Dendritic Cell-Associated Immune Inflammation of Cardiac Mucosa: A Possible Factor in the Formation of Barrett's Esophagus.
%B Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
%D 2008
%C United States
%I Springer
%V 13
%N 3
%P 442-50
%@ 1873-4626
%X The development of Barrett''s esophagus is poorly understood, but it has been suggested that cardiac mucosa is a precursor of intestinal type metaplasia and that inflammation of cardiac mucosa may play a role in the formation of Barrett''s esophagus. The present study was undertaken to examine the presence and distribution of immune-inflammatory cells in cardiac mucosa, specifically focusing on dendritic cells because of their importance as regulators of immune reactions.
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Newland, L R
%A Walsh, A
%A Gilbert, D R
%A Buckland, M E
%T Selective internal radiation therapy: a case of SIR-Sphere associated duodenal ulceration.
%B Pathology
%D 2007
%C Rankine Rd, Basingst
%I Carfax Publishing
%V 39
%N 5
%P 526-528
%@ 0031-3025
%X 
%Z FOR Codes: 110399


%0 Journal Article
%~ PubMed
%A Buckland, Michael
%A Leahy, Belinda
%A Lukeis, Robyn
%A Suter, Mary
%A Turner, Jenny
%A Morey, Adrienne
%T Molecular testing for paraffin embedded material.
%B Pathology
%D 2006
%C United Kingdom
%I Carfax Publishing
%V 38
%N 6
%P 602
%@ 0031-3025
%X 
%Z FOR Codes: 60199