%0 Journal Article
%~ PubMed
%A Edelman, J J B
%A Sherrah, A G
%A Wilson, M K
%A Bannon, P G
%A Brereton, R J
%A Ross, D E
%A Vallely, M P
%T Anaortic, total-arterial, off-pump coronary artery bypass surgery-Why bother?
%B Heart, Lung & Circulation
%D 2013
%C Australia
%I Elsevier Australia
%V 22
%N 3
%P 161-170
%@ 1444-2892
%X 
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Edelman, J James B
%A Fung, Yoke Lin
%A Pennings, Gabrielle J
%A Reddel, Caroline J
%A Bannon, Paul G
%A Bayfield, Matthew S
%A Kritharides, Leonard
%A Fraser, John F
%A Vallely, Michael P
%T Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology.
%B Shock
%D 2013
%C United States
%I Lippincott Williams & Wilkins
%V 39
%N 2
%P 149-154
%@ 1540-0514
%X 
%Z FOR Codes: 110201 110323 111601


%0 Journal Article
%~ PubMed
%A Edelman, J James B
%A Wilson, Michael K
%A Bannon, Paul G
%A Vallely, Michael P
%T Cardiac surgery versus stenting: what is better for the patient?
%B ANZ Journal of Surgery
%D 2012
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 82
%N 11
%P 792-798
%@ 1445-2197
%X 
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Ramponi, Fabio
%A Puranik, Rajesh
%A Wilson, Michael K
%A Bannon, Paul G
%T Intraluminal mass of the ascending aorta.
%B European Journal of Cardio-Thoracic Surgery
%D 2012
%C Netherlands
%I Oxford University Press
%V 42
%N 5
%P 904
%@ 1873-734X
%X 
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Edelman, J James B
%A Bannon, Paul G
%A Vallely, Michael P
%T Letter by edelman et Al regarding article, "second internal thoracic artery versus radial artery in coronary artery bypass grafting: a long-term, propensity score-matched follow-up study".
%B Circulation
%D 2012
%C United States
%I Lippincott Williams & Wilkins
%V 125
%N 17
%P e630
%@ 0009-7322
%X 
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Padang, Ratnasari
%A Bagnall, Richard D
%A Richmond, David R
%A Bannon, Paul G
%A Semsarian, Christopher
%T Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease.
%B Journal of Molecular and Cellular Cardiology
%D 2012
%C United Kingdom
%I Academic Press
%V 53
%N 2
%P 277-281
%@ 1095-8584
%X Bicuspid aortic valve (BAV) is the commonest congenital heart disease and a highly heritable trait; however, only the NOTCH1 gene has been linked to limited cases of BAV in humans. Recently, the transcription factor GATA5 has been shown to have an essential role in aortic valve development, and targeted deletion of Gata5 in mice is associated with partially penetrant BAV formation. Here, we investigated the relationship between GATA5 gene variants and BAV with its associated aortopathy. One hundred unrelated individuals with confirmed BAV were prospectively recruited. Following collection of clinical information and DNA extraction, the coding regions and splice signal sequences of the GATA5 gene were screened for sequence variations. The clinical characteristics of the cohort included a male predominance (77%), mean age of diagnosis 29??22years, associated aortopathy in 59% and positive family history for BAV in 13%. Genetic analysis identified the presence of 4 rare non-synonymous variations within the GATA5 transcriptional activation domains, namely Gln3Arg, Ser19Trp, Tyr142His and Gly166Ser, occurring in one patient each. Gln3Arg and Tyr142His substitutions affect highly conserved and functionally relevant residues, and are likely to impact on the transcriptional activation of GATA5 target regions. A novel Ser19Trp variation was identified at a highly conserved amino acid residue in one patient, while the Gly166Ser variant was found in a familial case of BAV and associated aortopathy. Rare non-synonymous variations in the functionally important GATA5 transcriptional activation domains may be important in the pathogenesis of BAV disease in humans.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Seco, Michael
%A Edelman, J James B
%A Wilson, Michael K
%A Bannon, Paul G
%A Vallely, Michael P
%T Serum Biomarkers of Neurologic Injury in Cardiac Operations.
%B Annals of Thoracic Surgery
%D 2012
%C United States
%I Elsevier Inc.
%V 94
%N 3
%P 1026-1033
%@ 0003-4975
%X Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Wise, Steven G
%A Byrom, Michael J
%A Waterhouse, Anna
%A Bannon, Paul G
%A Ng, Martin K C
%A Weiss, Anthony S
%T A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties.
%B Acta biomaterialia
%D 2011
%C Netherlands
%I Elsevier BV
%V 7
%N 1
%P 295-303
%@ 1878-7568
%X Small-diameter synthetic vascular graft materials fail to match the patency of human tissue conduits used in vascular bypass surgery. The foreign surface retards endothelialization and is highly thrombogenic, while the mismatch in mechanical properties induces intimal hyperplasia. Using recombinant human tropoelastin, we have developed a synthetic vascular conduit for small-diameter applications. We show that tropoelastin enhances endothelial cell attachment (threefold vs. control) and proliferation by 54.7 ?? 1.1% (3 days vs. control). Tropoelastin, when presented as a monomer and when cross-linked into synthetic elastin for biomaterials applications, had low thrombogenicity. Activation of the intrinsic pathway of coagulation, measured by plasma clotting time, was reduced for tropoelastin (60.4 ?? 8.2% vs. control). Platelet attachment was also reduced compared to collagen. Reductions in platelet interactions were mirrored on cross-linked synthetic elastin scaffolds. Tropoelastin was subsequently incorporated into a synthetic elastin/polycaprolactone conduit with mechanical properties optimized to mimic the human internal mammary artery, including permeability, compliance, elastic modulus and burst pressure. Further, this multilayered conduit presented a synthetic elastin internal lamina to circulating blood and demonstrated suturability and mechanical durability in a small scale rabbit carotid interposition model.
%Z FOR Codes: 100404


%0 Journal Article
%~ PubMed
%A Rahnavardi, Mohammad
%A Yan, Tristan D
%A Bannon, Paul G
%A Wilson, Michael K
%T Aortic valve-sparing operations in aortic root aneurysms: remodeling or reimplantation?
%B Interactive cardiovascular and thoracic surgery
%D 2011
%C Switzerland
%I European Association for Cardio-Thoracic Surgery
%V 13
%N 2
%P 189-97
%@ 1569-9285
%X A best evidence topic was written according to a structured protocol. The question addressed was whether the reimplantation (David) technique or the remodeling (Yacoub) technique provides the optimum event free survival in patients with an aortic root aneurysm suitable for an aortic valve-sparing operation. In total, 392 papers were found using the reported search criteria, of which 14 papers provided the best evidence to answer the clinical question. A total of 1338 patients (Yacoub technique in 606 and David technique in 732) from 13 centres were included. In most series, cardiopulmonary bypass time and aortic cross-clamp time were longer for the David technique compared to the Yacoub technique. Early mortality was comparable between the two techniques (0-6.9% for the Yacoub technique and 0-6% for the David technique). There is a tendency for a higher freedom from significant long-term aortic insufficiency in the David group than the Yacoub group, which does not necessarily result in a higher reoperation rate in the Yacoub group. In the largest series reported, freedom from a moderate-to-severe aortic insufficiency at 12 years was 82.6 ?? 6.2% in the Yacoub and 91.0 ?? 3.8% in the David group (P=0.035). Freedom from reoperation at the same time point was 90.4 ?? 4.7% in the Yacoub group and 97.4 ?? 2.2% in the David group (P=0.09). In another series, freedom from reoperation at a follow-up time of about four years was 89 ?? 4% in the Yacoub group and 98 ?? 2% in the David group. Although some authors merely preferred the Yacoub technique for a bicuspid aortic valve, the accumulated evidence in the current review indicates comparable results for both techniques in a bicuspid aortic valve. Current evidence is in favour of the David rather than the Yacoub technique in pathologies such as Marfan syndrome, acute type A aortic dissection, and excessive annular dilatation that may impair aortic root integrity. Careful selection of patients for each technique and successful restoration of normal cusp geometry are the keys to success in aortic valve-sparing operations.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Cao, Christopher
%A Yan, Tristan D
%A Kennedy, Catherine
%A Hendel, Nick
%A Bannon, Paul G
%A McCaughan, Brian C
%T Bronchopulmonary carcinoid tumors: long-term outcomes after resection.
%B The Annals of Thoracic Surgery
%D 2011
%C United States
%I Elsevier Inc.
%V 91
%N 2
%P 339-343
%@ 0003-4975
%X Bronchopulmonary carcinoid tumors are considered as a relatively uncommon and less malignant group of lung cancers. However, patients with histologically atypical disease are known to have a worse prognosis. The present study aims to evaluate the long-term outcomes after resection of bronchopulmonary carcinoid tumors according to the new tumor, nodes, metastasis (TNM) staging system.
%Z FOR Codes: 111204


%0 Journal Article
%~ PubMed
%A Edelman, J James
%A Yan, Tristan D
%A Bannon, Paul G
%A Wilson, Michael K
%A Vallely, Michael P
%T Coronary artery bypass grafting with and without manipulation of the ascending aorta - a meta-analysis.
%B Heart, Lung & Circulation
%D 2011
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 20
%N 5
%P 318-324
%@ 1444-2892
%X The main criticism of surgery in the SYNTAX trial was increased rate of stroke when compared to percutaneous coronary intervention. We aimed to determine whether avoiding aortic manipulation would decrease the rate of stroke.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Padang, Ratnasari
%A Poh, Chin
%A Cao, Christopher
%A Wilson, Michael K
%A Bannon, Paul G
%A Vallely, Michael P
%T Drug-eluting stents versus coronary artery bypass grafting for the treatment of coronary artery disease: A meta-analysis of randomized and nonrandomized studies.
%B The Journal of thoracic and cardiovascular surgery
%D 2011
%C United States
%I Mosby, Inc.
%V 141
%N 5
%P 1134-44
%@ 1097-685X
%X We performed the present systematic review and meta-analysis of randomized and nonrandomized comparative studies in an attempt to compare the safety and efficacy of drug-eluting stents with coronary artery bypass grafting for patients with coronary artery disease.
%Z FOR Codes: 1102 1103


%0 Journal Article
%~ PubMed
%A Davies, Reece A
%A Black, Deborah
%A Jeremy, Richmond W
%A Bannon, Paul G
%A Bayfield, Matthew S
%A Hendel, P Nicholas
%A Hughes, Clifford F
%A Wilson, Michael K
%A Vallely, Michael P
%T Evolution in the Techniques and Outcomes of Aortic Arch Surgery: A 22 Year Single Centre Experience.
%B Heart, lung & circulation
%D 2011
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 20
%N 11
%P 704-11
%@ 1444-2892
%X Aortic arch replacement is a complicated and high risk procedure. There have been many advances over recent years. We review the changes in our unit''s techniques and outcomes over the past 22 years.
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Edelman, James J B
%A Ramponi, Fabio
%A Bannon, Paul G
%A Jeremy, Richmond
%T Familial aortic aneurysm and dissection due to transforming growth factor-{beta} receptor-2 mutation.
%B Interactive cardiovascular and thoracic surgery
%D 2011
%C Switzerland
%I European Association for Cardio-Thoracic Surgery
%V 12
%N 5
%P 863-5
%@ 1569-9285
%X This report describes the clinical course and management of a patient with Loeys-Dietz syndrome (LDS) type 2. In 2003, a 31-year-old male was diagnosed with acute aortic dissection type B; in the following six years he underwent multiple surgical and endovascular aortic procedures at different thoracic and abdominal levels secondary to progressive enlargement of both the non-dissected thoracic aorta and the false lumen distal to the left subclavian artery. LDS is characterized by arterial tortuosity and aneurysms as a result of heterozygous mutations in genes encoding transforming growth factor-?? receptor 1 and 2. Further studies are required to establish the proper surgical management.
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Cao, Christopher Q
%A Boyer, Michael
%A Tin, Mo Mo
%A Kennedy, Catherine
%A McLean, Jocelyn
%A Bannon, Paul G
%A McCaughan, Brian C
%T Improving survival results after surgical management of malignant pleural mesothelioma: an Australian institution experience.
%B Annals of Thoracic and Cardiovascular Surgery
%D 2011
%C Japan
%I Medikaru Toribyun
%V 17
%N 3
%P 243-249
%@ 1341-1098
%X Background: There has been an evolving role of surgery for malignant pleural mesothelioma (MPM) over the past 25 years. The objective of this study was to investigate whether the survival results for MPM patients after surgery have improved within this time period by an analysis of a prospective cohort of 540 patients. Methods: Five hundred and forty consecutive patients with MPM were treated by a thoracic surgical team. These patients were categorized into two groups: Group I (before September 1999, n = 270) and Group II (after September 1999, n = 270). The two groups were compared for clinicopathologic data and survival results. The statistical analyses of all prognostic parameters used overall survival as the endpoint. Results: Group II had higher proportions of epithelial tumors and patients who had preoperative PET scan, extrapleural pneumonectomy (EPP), postoperative radiotherapy and pemetrexed chemotherapy. The overall survival results were significantly better in Group II compared with Group I (p = 0.004). Four factors were found to be independently associated with an improved survival in multivariate analysis: epithelial subtype (p <0.001); surgeon''s experience with >100 cases (p = 0.006), patients who underwent EPP (p = 0.001) and those who received pemetrexed chemotherapy (p = 0.016). The median survival for patients selected for EPP was 20 months, as compared to 9 months for pleurodesis/decortication and pleurodesis. Conclusions: Significant improvement of overall survival results has been achieved in the more recent 270 MPM patients through accumulated experience in a specialist treatment center.
%Z FOR Codes: 111209 110323


%0 Journal Article
%~ PubMed
%A Forrest, P
%A Cheong, J Y
%A Vallely, M P
%A Torzillo, P J
%A Hendel, P N
%A Wilson, M K
%A Bannontt, P G
%A Bayfield, M S
%A Herkes, R
%A Walker, S W
%T International retrieval of adults on extracorporeal membrane oxygenation support.
%B Anaesthesia and Intensive Care
%D 2011
%C Australia, New Zealand
%I Australian Society of Anaesthetists Ltd.
%V 39
%N 6
%P 1082-1085
%@ 0310-057X
%X A retrieval service was established in New South Wales to provide mobile extracorporeal membrane oxygenation support to patients with severe, acute cardiac or respiratory failure. This service has also retrieved four adult patients from Noum??a, New Caledonia to Sydney on extracorporeal membrane oxygenation support, which are the first international retrievals of this type from Australia. We discuss our experience with these patients, three of whom survived to hospital discharge. However, one patient referred from New Caledonia died before extracorporeal membrane oxygenation could be established.
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Cooper, Edward A
%A Edelman, J James B
%A Wilson, Michael K
%A Bannon, Paul G
%A Vallely, Michael P
%T Off-pump Coronary Artery Bypass Grafting in Elderly and High-risk Patients - A Review.
%B Heart, lung & circulation
%D 2011
%C Australia
%I Elsevier Australia
%V 20
%N 11
%P 694-703
%@ 1443-9506
%X Elderly and high-risk patients are increasingly being considered for myocardial revascularisation. Most trials comparing the various options for revascularisation exclude elderly and ''high-risk'' patients. We have reviewed the options for myocardial revascularisation for elderly patients, and for patients with a number of common ''high-risk'' co-morbidities--diabetes mellitus, renal insufficiency, poor left ventricular ejection fraction, peripheral vascular disease, left main coronary artery disease and chronic obstructive pulmonary disease--with a focus on coronary artery bypass grafting without the use of cardiopulmonary bypass and aortic manipulation.
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Rahnavardi, Mohammad
%A Yan, Tristan D
%A Cao, Christopher
%A Vallely, Michael P
%A Bannon, Paul G
%A Wilson, Michael K
%T Pulmonary Thromboendarterectomy for Chronic Thromboembolic Pulmonary Hypertension : A Systematic Review.
%B Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
%D 2011
%C Japan
%I Medikaru Toribyun
%V 17
%N 5
%P 435-45
%@ 1341-1098
%X Pulmonary thromboendarterectomy (PTE) is a treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). The present systematic review was performed to assess the safety and efficacy of PTE for CTEPH.
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Poh, C L
%A Yan, T D
%A Vallely, M P
%A Bannon, P G
%A McCaughan, B C
%T Pulmonary parenchymal endometriosis presenting as bilateral pneumothoraces.
%B Journal of Obstetrics and Gynaecology
%D 2011
%C United Kingdom
%I Informa Healthcare
%V 31
%N 5
%P 452-453
%@ 1364-6893
%X 
%Z FOR Codes: 1103


%0 Journal Article
%~ PubMed
%A Edelman, J James B
%A Yan, Tristan D
%A Vallely, Michael P
%A Bannon, Paul G
%T Reply to the editor.
%B The Journal of thoracic and cardiovascular surgery
%D 2011
%C United States
%I Mosby, Inc.
%V 142
%N 1
%P 242-243
%@ 1097-685X
%X 
%Z FOR Codes: 110201 10402


%0 Journal Article
%~ PubMed
%A Cao, Christopher
%A Andvik, Sarah Karen Krog
%A Yan, Tristan D
%A Kennedy, Catherine
%A Bannon, Paul G
%A McCaughan, Brian C
%T Staging of patients after extrapleural pneumonectomy for malignant pleural mesothelioma - institutional review and current update.
%B Interactive cardiovascular and thoracic surgery
%D 2011
%C Switzerland
%I European Association for Cardio-Thoracic Surgery
%V 12
%N 5
%P 754-7
%@ 1569-9285
%X Extrapleural pneumonectomy (EPP) has been established as a viable surgical option in the treatment of malignant pleural mesothelioma (MPM) for selected patients. A number of pathological staging systems have been developed to prognosticate survival outcomes. We assessed 91 patients with MPM who underwent EPP in our institution and evaluated the applicability of the most updated staging systems in the current literature. After a mean follow-up of 20 months, the median overall survival was 27.6 months. Postoperative pathological staging according to the International Mesothelioma Interest Group criteria (P = 0.026) and the Brigham and Women''s Hospital criteria (P = 0.039) were both found to be significant prognostic factors. Adjuvant chemotherapy (P = 0.022) and radiotherapy (P = 0.008) were associated with improved survival outcomes. These findings are consistent with previous reports that demonstrated the usefulness of pathological staging systems as a prognostic tool in patients with MPM after undergoing EPP. However, preoperative clinical staging systems need to be developed to facilitate the patient selection process prior to surgery.
%Z FOR Codes: 111204


%0 Journal Article
%~ PubMed
%A Cao, Christopher
%A Yan, Tristan D
%A Bannon, Paul G
%A McCaughan, Brian C
%T Summary of Prognostic Factors and Patient Selection for Extrapleural Pneumonectomy in the Treatment of Malignant Pleural Mesothelioma.
%B Annals of surgical oncology
%D 2011
%C United States
%I Springer New York LLC
%V 18
%N 10
%P 2973-9
%@ 1068-9265
%X Extrapleural pneumonectomy (EPP) has been shown to improve long-term survival outcomes in selected patients with malignant pleural mesothelioma (MPM). The present study aimed to evaluate potential prognostic factors on overall survival for patients who underwent EPP for MPM and to examine the patient selection process in major referral centers that perform EPP.
%Z FOR Codes: 111204


%0 Journal Article
%~ PubMed
%A Cao, Christopher Q
%A Bannon, Paul G
%A Shee, Rachel
%A Yan, Tristan D
%T Thoracic Endovascular Aortic Repair-indications and Evidence.
%B Annals of Thoracic and Cardiovascular Surgery
%D 2011
%C Japan
%I Medikaru Toribyun
%V 17
%N 1
%P 1-6
%@ 1341-1098
%X Purpose: Since its introduction more than a decade ago, thoracic endovascular aortic repair (TEVAR) has shown promising results for patients with various thoracic aortic diseases. The aim of the current review is to assess the current literature to evaluate the safety and efficacy of TEVAR. Methods: A thorough search of the existing literature on TEVAR was conducted on electronic databases, including Medline, Pubmed, EMBASE and Database of Abstracts of Review of Effectiveness. The most recent results were categorized according to the indications of performing TEVAR. Results: A number of case-series studies and reviews have shown reduced early morbidity and mortality rates in a range of thoracic aortic diseases for TEVAR in comparison to open surgical repair. However, there is a lack of robust clinical data to suggest any improvement in long-term overall survival. Conclusion: Despite numerous encouraging results from a large number of publications in recent years, there remains a lack of level 1 evidence to support an improvement of long-term overall survival for patients who underwent TEVAR when compared with traditional treatment modalities. There appears to be an urgent need to conduct well-designed randomized-controlled trials in this rapidly expanding intervention.
%Z FOR Codes: 110299


%0 Journal Article
%~ PubMed
%A Ramponi, Fabio
%A Vallely, Michael P
%A Stephen, Michael S
%A Bannon, Paul G
%A Bayfield, Matthew S
%A White, Geoffrey H
%T Transapical wire-assisted endovascular repair of thoracic aortic dissection.
%B Journal of Endovascular Therapy
%D 2011
%C United States
%I Allen Press Inc.
%V 18
%N 3
%P 350-354
%@ 1545-1550
%X Abstract Purpose: To describe a technique for transapical wire-assisted endograft deployment under rapid ventricular pacing for a type B dissection involving the proximal left subclavian artery and extending to the aortic bifurcation. Case Report: A 58-year-old man presented with a symptomatic thoracic aneurysm as a complication of a chronic type B dissection, with a short proximal neck in zone 1. After arch vessel debranching, the patient underwent endoluminal repair with deployment of a closed web, tapered Valiant thoracic endograft over a through-and-through wire from the left groin to the apex of the left ventricle, using rapid ventricular pacing to reduce cardiac output. The remaining dissected aorta was covered with a second Valiant endograft down to the distal third of the descending thoracic aorta and bare Z stents down to the aortic bifurcation to re-expand the true lumen. A freeflow Valiant endograft was deployed as a proximal extension to treat a proximal type I endoleak. The recovery was complicated by retrograde type A aortic dissection, considered secondary to the bare stent. The complication was repaired surgically; postoperative computed tomography after recovery was unremarkable. Conclusion: Transapical wire-assisted deployment with rapid ventricular pacing is feasible and may provide improved stability for stenting within the aortic arch. The use of a stent-graft with a proximal bare stent is associated with a higher risk of retrograde extension of the dissection and warrants lifelong imaging follow-up.
%Z FOR Codes: 1102 1103


%0 Journal Article
%~ PubMed
%A Cao, Christopher Q
%A Yan, Tristan D
%A Bannon, Paul G
%A McCaughan, Brian C
%T A Systematic Review of Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma.
%B Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
%D 2010
%C United States
%I Lippincott Williams & Wilkins
%V 5
%N 10
%P 1692-703
%@ 1556-1380
%X The primary objective of the present systematic review was to evaluate the safety and efficacy of extrapleural pneumonectomy (EPP) for patients with malignant pleural mesothelioma.
%Z FOR Codes: 104


%0 Journal Article
%~ PubMed
%A Byrom, Michael J
%A Bannon, Paul G
%A White, Geoffrey H
%A Ng, Martin K C
%T Animal models for the assessment of novel vascular conduits.
%B Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter
%D 2010
%C United States
%I Mosby, Inc.
%V 52
%N 1
%P 176-95
%@ 1097-6809
%X The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article examines the rationale behind animal models used in the assessment of small-diameter vascular conduits encompassing the commonly used species: baboons, sheep, pigs, dogs, rabbits, and rodents. Studies on the comparative hematology for these species relative to humans are summarized, and the hydrodynamic values for common implant locations are also compared. The large- and small-animal models are then explored, highlighting the characteristics of each that determine their relative utility in the assessment of vascular conduits. Where possible, the performance of expanded polytetrafluoroethylene is given in each animal and in each location to allow direct comparisons between species. New challenges in animal modeling are outlined for the assessment of tissue-engineered graft designs. Finally, recommendations are given for the selection of animal models for the assessment of future vascular conduits.
%Z FOR Codes: 601 903


%0 Journal Article
%~ PubMed
%A Vallely, Michael P
%A Bannon, Paul G
%A Bayfield, Matthew S
%A Hughes, Clifford F
%A Kritharides, Len
%T Endothelial Activation After Coronary Artery Bypass Surgery: Comparison Between On-Pump and Off-Pump Techniques.
%B Heart, lung & circulation
%D 2010
%C Australia, United St
%I Wiley-Blackwell Publishing Asia
%V 19
%N 8
%P 445-52
%@ 1444-2892
%X The effects of off-pump coronary artery bypass (OPCAB) surgery on endothelial cell activation are poorly understood. Endothelial cell adhesion molecules (CAMs) are expressed and released when the endothelium is activated. We compared plasma CAMs (E-selectin, ICAM-1 and VCAM-1) and HUVEC expression of the same CAMs when exposed to plasma taken before, during and after OPCAB or on-pump coronary surgery (CABG).
%Z FOR Codes: 110201 110323


%0 Journal Article
%~ PubMed
%A Edelman, J James
%A Yan, Tristan D
%A Padang, Ratnasari
%A Bannon, Paul G
%A Vallely, Michael P
%T Off-Pump Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention: A Meta-Analysis of Randomized and Nonrandomized Studies.
%B The Annals of Thoracic Surgery
%D 2010
%C United States
%I Elsevier Inc.
%V 90
%N 4
%P 1384-1390
%@ 0003-4975
%X We performed a meta-analysis of all studies comparing off-pump coronary artery bypass graft surgery (OPCABG) and percutaneous coronary intervention (PCI) for patients with coronary artery disease. Ten studies were included in the meta-analysis and 4,821 patients were compared, of whom 3,450 patients underwent PCI and 1,371 patients underwent OPCABG. The rates of stroke, myocardial infarction, cardiac mortality, and all-cause mortality were similar. The 12-month rate of major adverse cardiac or cerebrovascular events and need for repeat revascularization was significantly lower in the OPCABG group when compared with the PCI group.
%Z FOR Codes: 1102


%0 Journal Article
%~ PubMed
%A Chow, Vincent
%A Ranasinghe, Isuru
%A Lau, Jerrett
%A Stowe, Hughina
%A Bannon, Paul
%A Hendel, Nick
%A Kritharides, Leonard
%T Peri-procedural Anticoagulation and the Incidence of Haematoma Formation after Permanent Pacemaker Implantation in the Elderly.
%B Heart, lung & circulation
%D 2010
%C United States
%I Elsevier Inc.
%V 19
%N 12
%P 706-12
%@ 1443-9506
%X Haematoma formation is a recognised complication after permanent pacemaker (PPM) implantation. The contribution of peri-procedural anticoagulation to the risk of haematoma formation is unclear.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Cao, Christopher
%A Martens-Nielsen, Julie
%A Padang, Ratnasari
%A Ng, Martin
%A Vallely, Michael P
%A Bannon, Paul G
%T Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic review.
%B The Journal of thoracic and cardiovascular surgery
%D 2010
%C United States
%I Mosby, Inc.
%V 139
%N 6
%P 1519-28
%@ 1097-685X
%X The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Boyer, Michael
%A Tin, Mo Mo
%A Wong, Daniel
%A Kennedy, Catherine
%A McLean, Jocelyn
%A Bannon, Paul G
%A McCaughan, Brian C
%T Extrapleural pneumonectomy for malignant pleural mesothelioma: outcomes of treatment and prognostic factors.
%B The Journal of Thoracic and Cardiovascular Surgery
%D 2009
%C United States
%I Mosby, Inc.
%V 138
%N 3
%P 619-624
%@ 1097-685X
%X OBJECTIVE: This study aimed to evaluate the perioperative and long-term outcomes associated with extrapleural pneumonectomy for patients with malignant pleural mesothelioma. METHODS: From October 1994 to April 2008, 70 patients were selected for extrapleural pneumonectomy. Univariate analysis was performed using the Kaplan-Meier method and compared using the log-rank test. Multivariate analysis with entering and removing limits of P less than .10 and P greater than .05, respectively, was used. The prognostic factors included age, gender, side of disease, asbestos exposure, histology, positron emission tomography, date of surgery, neoadjuvant chemotherapy, completeness of cytoreduction, lymph node involvement, perioperative morbidity, adjuvant radiotherapy, and pemetrexed-based chemotherapy. RESULTS: The mean age of patients was 55 years (standard deviation = 10). Fifty-eight patients had epithelial tumors. Six patients received neoadjuvant chemotherapy, 28 patients received adjuvant radiotherapy, and 16 patients received postoperative pemetrexed-based chemotherapy. Forty-four patients had no lymph node involvement. The perioperative morbidity and mortality were 37% and 5.7%, respectively. Complications included hemothorax (n = 7), atrial fibrillation (n = 6), empyema (n = 4), bronchopulmonary fistula (n = 3), right-sided heart failure (n = 2), pneumonia (n = 1), constrictive pericarditis (n = 1), acute pulmonary edema (n = 1), small bowel herniation (n = 1), and disseminated intravascular coagulopathy (n = 1). The median survival was 20 months, with a 3-year survival of 30%. Asbestos exposure, negative lymph node involvement, and receipt of adjuvant radiation or postoperative pemetrexed-based chemotherapy were associated with improved survival on both univariate and multivariate analyses. CONCLUSION: The present study supports the use of extrapleural pneumonectomy-based multimodal therapy in carefully selected patients with malignant pleural mesothelioma.
%Z FOR Codes: 1107


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Boyer, Michael
%A Tin, Mo Mo
%A Sim, Junyang
%A Kennedy, Catherine
%A McLean, Jocelyn
%A Bannon, Paul G
%A McCaughan, Brian C
%T Prognostic features of long-term survivors after surgical management of malignant pleural mesothelioma.
%B The Annals of Thoracic Surgery
%D 2009
%C United States
%I Elsevier
%V 87
%N 5
%P 1552-1556
%@ 0003-4975
%X BACKGROUND: The primary aim of this study was to evaluate prognostic features of long-term survivors with pleural mesothelioma. METHODS: Overall survival outcome was analyzed in 456 patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (EPP), pleurectomy/decortications, or pleurodesis/biopsy with at least 18 months of follow-up. Prospectively collected clinicopathologic and treatment data were assessed for their correlations with actual 18-month survivors in both univariate and multivariate analyses. RESULTS: The actual 18-month survival was 28%. Epithelial subtype was present in 185 patients (41%) and nonepithelial subtype in 183 (40%). Procedures were EPP in 59 patients (13%), pleurectomy/decortication in 250 (55%), and pleurodesis/biopsy in 147 (32%). Forty-two patients (9%) underwent positron emission tomography (PET) scanning. Forty patients (9%) received adjuvant radiotherapy and 45 (10%) received postoperative pemetrexed combination chemotherapy. In univariate analysis, age 65 years or younger (p < 0.001), malignant pleural effusion (p = 0.041), epithelial subtype (p < 0.001), EPP (p < 0.001), PET scan (p = 0.012), adjuvant radiotherapy (p = 0.042), and postoperative pemetrexed combination chemotherapy (p = 0.035) were strongly associated with 18-month survivors. In multivariate analysis, epithelial histopathologic subtype (p < 0.001) and EPP (p < 0.001) were independently associated with 18-month survivors. CONCLUSIONS: The actual 18-month survival was 28% in 456 pleural mesothelioma patients who underwent operation. Epithelial histologic subtype and EPP were identified as independent predictors for 18-month survivors.
%Z FOR Codes: 104


%0 Journal Article
%~ PubMed
%A Vallely, Michael P
%A Bannon, Paul G
%A Bayfield, Matthew S
%A Hughes, Clifford F
%A Kritharides, Len
%T Quantitative and Temporal Differences in Coagulation, Fibrinolysis and Platelet Activation after On-Pump and Off-Pump Coronary Artery Bypass Surgery.
%B Heart, lung & circulation
%D 2009
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 18
%N 2
%P 123-30
%@ 1444-2892
%X With the increasing use of OPCAB, potentially devastating thromboembolic events, including graft thrombosis may become increasingly evident. We present a study of the quantitative and temporal differences of the coagulation system, fibrinolysis and platelet activation after coronary artery surgery with or without cardiopulmonary bypass.
%Z FOR Codes: 1102


%0 Journal Article
%~ PubMed
%A Sy, Raymond W
%A Bannon, Paul G
%A Bayfield, Matthew S
%A Brown, Chris
%A Kritharides, Leonard
%T Survivor treatment selection bias and outcomes research: a case study of surgery in infective endocarditis.
%B Circulation. Cardiovascular Quality and Outcomes
%D 2009
%C United States
%I Lippincott Williams & Wilkins
%V 2
%N 5
%P 469-474
%@ 1941-7705
%X BACKGROUND: Recent studies in infective endocarditis have suggested an association between surgery and reduced mortality. However, these studies did not account for survivor treatment selection bias, which is an underrecognized source of error in observational studies. Therefore, we sought to evaluate the effects of survivor bias on surgical outcomes in infective endocarditis. METHODS AND RESULTS: We studied 223 patients admitted with left-sided infective endocarditis between 1996 and 2006 and compared all-cause mortality between surgically treated and medically treated patients using Cox regression analysis. Propensity scores were used to account for selection bias, and time-dependent analyses were performed to account for survivor bias. Compared with medical patients (n=161), surgical patients (n=62) had lower mortality during a median follow-up of 5.2 years (32% versus 51%; P=0.02) with an unadjusted hazard ratio of 0.54 (95% CI, 0.33 to 0.88, P=0.01). After adjustment for baseline differences in propensity for surgery and risk of mortality, there remained a significant benefit for surgery (hazard ratio, 0.50; 95% CI, 0.28 to 0.88; P=0.02). However, this was diminished after time-dependent analysis (hazard ratio, 0.77; 95% CI, 0.42 to 1.40; P=0.39). Conditional Kaplan-Meier analyses confirmed the effect of survivor bias because the apparent benefit of surgery was primarily attributable to excess mortality in the medical group during early hospitalization when surgery was not frequently performed. CONCLUSIONS: Survivor bias significantly affects the evaluation of surgical outcomes in infective endocarditis, and it should be considered in other areas of outcomes research where randomized controlled trials are not feasible. Survivor bias is not corrected by propensity analysis alone but may be reduced by time-dependent survival analysis.
%Z FOR Codes: 605 104 1108


%0 Journal Article
%~ PubMed
%A Yan, Tristan D
%A Black, Deborah
%A Bannon, Paul G
%A McCaughan, Brian C
%T Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer.
%B Journal of Clinical Oncology
%D 2009
%C United States
%I American Society of Clinical Oncology
%V 27
%N 15
%P 2553-2562
%@ 1527-7755
%X PURPOSE: The current randomized trials comparing video-assisted thoracic surgery (VATS) lobectomy with open lobectomy for patients with early-stage non-small-cell lung cancer (NSCLC) have been of small size. We performed the present meta-analysis of the randomized and nonrandomized comparative studies in an attempt to assess the safety and efficacy of VATS lobectomy. METHODS: Electronic searches identified 21 eligible comparative studies (two randomized and 19 nonrandomized) for inclusion. Two reviewers independently appraised each study. Meta-analysis was performed by combining the results of reported incidence of morbidity and mortality, recurrence, and 5-year mortality rates. The relative risk (RR) was used as a summary statistic. RESULTS: There were no significant statistical differences between VATS and open lobectomy in terms of postoperative prolonged air leak (P = .71), arrhythmia (P = .86), pneumonia (P = .09), and mortality (P = .49). VATS did not demonstrate any significant difference in locoregional recurrence (P = .24), as compared with the open lobectomy arm, but the data suggested a reduced systemic recurrence rate (P = .03) and an improved 5-year mortality rate of VATS (P = .04). There was no evidence to suggest heterogeneity of trial results. Fourteen studies reported VATS to open lobectomy conversion rate ranging from 0% to 15.7% (median = 8.1%). CONCLUSION: Both randomized and nonrandomized trials suggest that VATS lobectomy is an appropriate procedure for selected patients with early-stage NSCLC when compared with open surgery.
%Z FOR Codes: 1112 1103


%0 Journal Article
%A Yan, Tristan
%A Tin, MoMo
%A Boyer, Michael
%A McLean, Jocelyn
%A Bannon, Paul
%A McCaughan, Brian
%T Treatment Failure after Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
%B Journal of Thoracic Disease,
%D 2009
%C China
%I Pioneer Bioscience Publishing Co., Ltd
%V 1
%N 1
%P 23-28
%@ 2077-6624
%X 
%Z FOR Codes: 111204


%0 Journal Article
%~ PubMed
%A Stadler, Nadina
%A Stanley, Naomi
%A Heeneman, Sylvia
%A Vacata, Vladimir
%A Daemen, Mat J A P
%A Bannon, Paul G
%A Waltenberger, Johannes
%A Davies, Michael J
%T Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation.
%B Arteriosclerosis, Thrombosis, and Vascular Biology
%D 2008
%C United States
%I Lippincott Williams & Wilkins
%V 28
%N 5
%P 1024-1030
%@ 1079-5642
%X OBJECTIVE: Oxidized lipids and proteins, as well as decreased antioxidant levels, have been detected in human atherosclerotic lesions, with oxidation catalyzed by iron and copper postulated to contribute to lesion development. Zinc has been postulated to displace iron from critical sites and thereby protect against damage. In this study, metal ion and protein oxidation levels were quantified in human carotid and abdominal artery specimens containing early-to-advanced lesions, to determine whether zinc concentrations correlate inversely with iron levels and protein oxidation. METHODS AND RESULTS: Metal ions were quantified by EPR and inductively coupled plasma mass spectroscopy. Native and oxidized protein side-chains were quantified by high-performance liquid chromatography. Elevated levels of zinc ( approximately 6-fold) were detected in advanced lesions compared to healthy tissue or early lesions. Zinc did not correlate negatively with iron or copper levels suggesting that zinc does not displace these metal ions. Highly significant positive correlations (P<0.005) were detected between zinc and calcium levels. CONCLUSIONS: Zinc did not correlate with low iron levels and reduced protein oxidation. These data indicate that zinc does not prevent protein oxidation in advanced lesions. The reported protective effect of zinc accumulation is proposed to be associated with lesion calcification.
%Z FOR Codes: 110101


%0 Journal Article
%~ PubMed
%A Vallely, Michael P
%A Semsarian, Christopher
%A Bannon, Paul G
%T Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease.
%B Heart, lung & circulation
%D 2008
%C Australia
%I Wiley-Blackwell
%V 17
%N 5
%P 357-63
%@ 1444-2892
%X Bicuspid aortic valve (BAV) disease is the most common form of congenital heart disease, affecting 1-2% of the population. Only 20% of patients will maintain normal valve function throughout their life and more than 30% of patients will develop serious morbidity. It is a highly heritable condition, with transmission likely to be autosomal dominant. Patients with BAV have a 10-fold risk of aortic dissection when compared to the normal population. Management of BAV associated aortopathy represents a significant clinical challenge.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Orr, Y
%A Taylor, J M
%A Cartland, S
%A Bannon, P G
%A Geczy, C
%A Kritharides, L
%T Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils.
%B Journal of leukocyte biology
%D 2007
%C United States
%I Federation of American Societies for Experimental
%V 82
%N 0
%P 1115-25
%@ 0741-5400
%X Membrane-activated complex 1 (Mac-1; CD11b/CD18) is a beta(2) integrin implicated in the pathophysiology of neutrophil-mediated tissue injury whose functional capacity is determined by stimulus-induced conformational activation rather than up-regulation. Mac-1 up-regulation and conformational activation, together with shedding of L-selectin, are reported after in vitro neutrophil activation. However, their regulation on circulating human neutrophils during acute inflammation is unclear. Using flow cytometry, we investigated neutrophil expression of Mac-1, its activation-reporter neo-epitope CBRM1/5, and L-selectin during the inflammatory stimulus of cardiac surgery. A subpopulation of circulating neutrophils expressed CBRM1/5 (CBRM1/5+) under basal conditions (6.28+/-2.59%) and was persistently expanded (9.95+/-4.0%-15.2+/-4.2%; P<0.0001) peri-operatively, whereas total CD11b expression increased only transiently, intra-operatively. L-selectin expression was unchanged on CBRM1/5+ neutrophils, and soluble L-selectin levels decreased intra-operatively (P<0.01), indicating that L-selectin was not shed. Increased CBRM1/5 expression without L-selectin loss or CD11b up-regulation was replicated in vitro by neutrophil stimulation with IL-8, C3a, and platelet-activating factor. Heparin, a known CD11b ligand, which is administered during cardiac surgery, markedly reduced neutrophil expression of conformationally active CD11b in vivo and in vitro, identifying a potential mechanism for its anti-inflammatory properties. We conclude that conformational activation of CD11b occurs on circulating neutrophils in vivo and can occur in the absence of CD11b up-regulation and L-selectin shedding.
%Z FOR Codes: 111201