%0 Journal Article
%~ PubMed
%A Ng, Ethan
%A Lu, Yaxin
%A Hambly, Brett
%A Jelinek, Herbert F
%A Yu, Bing
%A Matthews, Slade
%A McLachlan, Craig S
%T Angiotensin-converting enzyme gene DD genotype is associated with increased systolic blood pressure in an Australian Rural Type 2 Diabetic Cohort.
%B Hypertension Research
%D 2013
%C United Kingdom
%I Nature Publishing Group
%V 36
%N 4
%P 381-382
%@ 1348-4214
%X 
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A Kane, Alice
%A Mitchell, Sarah J
%A Carroll, Peter R
%A Matthews, Slade
%A Hilmer, Sarah N
%T Characteristics of older and younger patients with suspected paracetamol toxicity.
%B Australasian Journal on Ageing
%D 2012
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 31
%N 3
%P 190-193
%@ 1741-6612
%X Aim:??? The aim of this study was to compare the characteristics of older and younger patients with suspected paracetamol toxicity. Methods:??? A retrospective audit of the medical records of older (???65 years, n= 25) and younger (20-30 years, n= 50) patients with a detectable paracetamol level at a Sydney hospital. Results:??? Older patients showed a different clinical pattern of suspected paracetamol toxicity and were more likely than younger patients to have multifactorial elevation of liver function tests. Additionally, older age was more likely to be associated with chronic therapeutic paracetamol dosing (71% older, 6% younger, P < 0.001), or with accidental toxic exposure (90% older, 29% younger, P < 0.001), while younger patients were more likely to have a deliberate high-dose exposure (10% older, 71% younger, P < 0.001). Conclusions:??? The age-related differences in paracetamol exposure, paracetamol levels and liver function tests described in this population should be considered when ordering and interpreting paracetamol levels.
%Z FOR Codes: 111502


%0 Journal Article
%~ PubMed
%A Kemp, Andrew H
%A Quintana, Daniel S
%A Felmingham, Kim L
%A Matthews, Slade
%A Jelinek, Herbert F
%T Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk.
%B PloS One
%D 2012
%C United States
%I Public Library of Science
%V 7
%N 2
%P e30777
%@ 1932-6203
%X There is evidence that heart rate variability (HRV) is reduced in major depressive disorder (MDD), although there is debate about whether this effect is caused by medication or the disorder per se. MDD is associated with a two to fourfold increase in the risk of cardiac mortality, and HRV is a robust predictor of cardiac mortality; determining a direct link between HRV and not only MDD, but common comorbid anxiety disorders, will point to psychiatric indicators for cardiovascular risk reduction.
%Z FOR Codes: 110201 111502


%0 Journal Article
%~ PubMed
%A Matthews, Slade
%A Succar, Petter
%A Jelinek, Herbert
%A McParland, Brent
%A Buckland, Michael
%A McLachlan, Craig S
%T Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century.
%B Asia-Pacific Journal of Clinical Oncology
%D 2012
%C United Kingdom
%I Wiley-Blackwell Publishing Ltd.
%V 8
%N 3
%P 213-216
%@ 1743-7563
%X Advances in molecular genetics are currently challenging the traditional morphological categorization of gliomas. Recurrent molecular and cytogenetic aberrations add prognostic and predictive information over and above that provided by standard histomorphological techniques and may influence decisions to re-operate or observe, to deliver radiation or not, or to administer chemotherapy to glioma patients. The importance of routine hematoxylin and eosin (H-E pathological stains cannot be underestimated, especially in resource-poor areas and developing countries where there is likely to be a significant economic opportunity cost for molecular diagnosis services. New research tools for image analyses of histological H-E slides, such as the precise measures of cell area, curvature and nuclear roundness, may provide an increased ability to provide an accurate classification for an inherently subjective process of histological assessment. We discuss the current trends, limitations and impact of molecular classification in this mini review.
%Z FOR Codes: 10401 111202


%0 Conference Proceedings
%A Jelinek, Herbert F
%A Ahammer, Helmut
%A Matthews, Slade
%A Succar, Peter
%A McLachlan, Craig S
%A Buckland, Michael
%T Establishing a Reference Range for Oligondendroglioma Classification using Higuchi Dimension Analysis
%B Ninth IASTED International Conference on Biomedical Engineering
%D 2012
%C Innsbruck, Austria Feb 15-17
%I ACTA Press
%V 
%N 
%P 
%@ 9780889869097
%E Hamza, MH
%E Simsik, D
%X 
%Z FOR Codes: 90302


%0 Journal Article
%~ PubMed
%A Matthews, S
%A Jelinek, H
%A Vafaeiafraz, S
%A McLachlan, C S
%T Heart rate stability and decreased parasympathetic heart rate variability in healthy young adults during perceived stress.
%B International Journal of Cardiology
%D 2012
%C Ireland
%I Elsevier Ireland Ltd
%V 156
%N 3
%P 337-338
%@ 0167-5273
%X 
%Z FOR Codes: 110201 10401


%0 Conference Proceedings
%A Matthews, Slade
%A Spence, Ian
%A Jelinek, Herbert F
%A McLachlan, Craig S
%T Neuron cell classification using machine learning algorithms: methodological considerations
%B International Conference: Biomedical Engineering
%D 2012
%C Innsbruck, Austria Feb 15-17
%I ACTA Press
%V 
%N 
%P 
%@ 
%E Hamza, MH
%E Simsik, D
%X 
%Z FOR Codes: 90303


%0 Conference Proceedings
%A Ng, Ethan
%A Hambly, Brett
%A Matthews, Slade
%A McLachlan, Craig S
%A Jelinek, Herbert F
%T WEKA machine learning classification in identifying autonomic dysfunction parameters associated with ACE insertion/deletion genotypes
%B International Conference: Biomedical Engineering
%D 2012
%C Innsbruck, Austria Feb 15-17
%I ACTA Press
%V 
%N 
%P 
%@ 
%E Simsik, D
%E Hamza, MH
%X 
%Z FOR Codes: 90302


%0 Journal Article
%A Johnston, CF
%A Carroll, Peter
%A Matthews, Slade
%A Mitchell, Sarah
%A Hilmer, Sarah
%T 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital
%B Journal of Pharmacy Practice and Research
%D 2011
%C Australia
%I Society of Hospital Pharmacists of Australia
%V 41
%N 4
%P 275-277
%@ 1445-937X
%X 
%Z FOR Codes: 111502


%0 Journal Article
%~ PubMed
%A Hilmer, Sarah N
%A Tran, Kim
%A Rubie, Patrick
%A Wright, Jason
%A Gnjidic, Danijela
%A Mitchell, Sarah J
%A Matthews, Slade
%A Carroll, Peter R
%T Gentamicin pharmacokinetics in old age and frailty.
%B British Journal of Clinical Pharmacology
%D 2011
%C United Kingdom
%I Wiley-Blackwell Publishing Ltd.
%V 71
%N 2
%P 224-231
%@ 1365-2125
%X WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT ??Gentamicin pharmacokinetics show wide inter-individual variability across all age groups and impaired gentamicin clearance is associated with impaired creatinine clearance in older people. ??Changes in body composition and renal function with old age and frailty are likely to affect the pharmacokinetics of gentamicin. ??There is current debate on whether the Modification of Diet in Renal Disease (MDRD) equation estimate of glomerular filtration rate (GFR) should replace the Cockcroft Gault equation estimate of creatinine clearance for calculation of doses of renally excreted drugs. WHAT THIS STUDY ADDS ??The volume of distribution of gentamicin is not significantly lower in frail than in non frail older people. ??The correlation between volume of distribution of gentamicin and actual bodyweight is poor in frail and moderate in non frail older people. ??Gentamicin clearance is significantly lower in frail than in non frail older people. ??The Cockcroft Gault calculation of creatinine clearance, calculated using ideal bodyweight, gave the best estimate of gentamicin clearance in this population of frail and non frail older people. ??The MDRD estimate of GFR and Cockcroft Gault estimate of creatinine clearance, calculated using actual bodyweight, overestimate gentamicin clearance in frail and non frail older people. AIMS Frailty, a syndrome of decreased physiological reserve that is prevalent in old age, impacts on clinical pharmacology. The aims of the study were to (1) determine whether frailty affects the pharmacokinetics of gentamicin and (2) assess the accuracy of different estimates of body size and renal clearance as estimates of gentamicin pharmacokinetics in older inpatients. METHODS This was an observational study of gentamicin pharmacokinetics in a cohort of Australian hospital inpatients aged ?65 years, who were administered prophylactic intravenous gentamicin. RESULTS Of the 31 participants, 14 were frail and 17 non frail on the Reported Edmonton Frail Scale. The mean volume of distribution of gentamicin was 14.8 ± 1.4?l in frail participants and 15.3 ± 2.2?l in non frail (NS). Volume of distribution correlated best with lean bodyweight. Gentamicin clearance was significantly lower in frail participants (46.6 ± 10.7?ml?min(-1) ) than in non frail (58.2 ± 12.4?ml?min(-1) , P= 0.01). The Cockcroft Gault estimate of creatinine clearance calculated using ideal bodyweight gave the best estimate of gentamicin clearance (mean error - 0.15?ml?min(-1) , 95% CI -2.67, 2.39). The Cockcroft Gault creatinine clearance calculated using actual bodyweight and the estimated glomerular filtration rate from the modified diet in renal disease equation overestimated gentamicin clearance, with mean errors of -10.15?ml?min(-1) (95%CI -13.60, -6.71) and -18.86?ml?min(-1) (95% CI -22.45, -15.27), respectively. The Cockcroft Gault creatinine clearance calculated using lean bodyweight underestimated gentamicin clearance (mean error 6.54?ml?min(-1) , 95% CI 4.18, 8.90). CONCLUSIONS Frail older people have significantly lower gentamicin clearance than non frail. The best estimate of gentamicin clearance is obtained from the Cockcroft Gault creatinine clearance calculated using ideal bodyweight.
%Z FOR Codes: 111502


%0 Journal Article
%~ PubMed
%A McMahon, Vanessa A
%A Matthews, Slade
%A Capper, Hugh
%A Chudleigh, Jessica B
%A McLachlan, Craig S
%T Understanding decision and enabling factors influencing clinical trial participation in australia: a view point.
%B Asian Pacific Journal of Cancer Prevention
%D 2011
%C Thailand
%I Asian Pacific Organization for Cancer Prevention
%V 12
%N 11
%P 3153-3156
%@ 1513-7368
%X Understanding patient decision making with respect to clinical trial participation has the potential to improve both the efficiency of recruitment for clinical trials and their management. In this mini-review we consider 3 key factors influencing clinical trial recruitment outcomes that include; 1) patient personal characteristics, 2) enabling factors that involve patient centered attitudes or circumstances, and 3) aversion. These factors are explored across both Australian rural and urban settings and contrasted to reported outcomes from research across other countries. Australia has the lowest number of publications on rural clinical trial participation when compared to rural research in America and Canada. Across Australian urban areas where all 3 factors have been studied, trends are similar to those reported in other developed countries. In conclusion we suggest that trial participation could be improved if participants are better informed about a trial as this is a valuable factor to enable recruitment.
%Z FOR Codes: 111599


%0 Journal Article
%~ PubMed
%A Wang, Chun-Ming
%A Almsherqi, Zakaria A
%A McLachlan, Craig S
%A Matthews, Slade
%A Ramachandran, Malarmathy
%A Tay, Stacey Kh
%A Deng, Yuru
%T Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function.
%B Stress (Amsterdam, Netherlands)
%D 2010
%C United Kingdom, Fran
%I Informa Healthcare
%V 14
%N 
%P 66-72
%@ 1607-8888
%X Associations between uncoupling protein (UCP) expression and functional changes in myocardial mitochondrial bio-energetics have not been well studied during periods of starvation stress. Our aim was to study the effects of acute starvation, for 24 or 48 h, on combined cardiac mitochondrial function and UCP expression in mice. Isolated heart mitochondria from female mice starved for 48 h compared to that from mice fed revealed a significantly (p < 0.05) decreased adenosine diphosphate-to-oxygen ratio, a significantly increased proton leak and an increased GTP inhibition on palmitic acid-induced state 4 oxygen consumption (p < 0.05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression. In conclusion, our findings suggest that increased UCP2 and UCP3 levels may contribute to decreased myocardial mitochondrial bio-energetic function due to starvation.
%Z FOR Codes: 60101


%0 Journal Article
%A Mitchell, Sarah J
%A Hilmer, Sarah
%A Murnion, Bridin Patricia
%A Matthews, Slade
%T Hepatotoxicity of therapeutic short-course paracetamol in
hospital inpatients: impact of ageing and frailty
%B Journal of Clinical Pharmacy and Therapeutics
%D 2010
%C United Kingdom
%I Wiley-Blackwell Publishing Ltd.
%V 0
%N 
%P doi:10.1111/j.1365-2710.2010.01193
%@ 0269-4727
%X 
%Z FOR Codes: 111503


%0 Journal Article
%~ PubMed
%A McLachlan, Craig S
%A Ocsan, Ryan
%A Spence, Ian
%A Hambly, Brett
%A Matthews, Slade
%A Wang, Lexin
%A Jelinek, Herbert F
%T Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia.
%B Baylor University Medical Center Proceedings
%D 2010
%C United States
%I Baylor University Medical Center
%V 23
%N 4
%P 368-370
%@ 0899-8280
%X Sinus bradycardia can be defined as a sinus rhythm with a resting heart rate of 60 beats per minute or less. While it is assumed that increased autonomic parasympathetic activity is associated with sinus bradycardia, such an association has yet to be proven. The aims of this study were to compute a number of heart rate variability (HRV) parameters in healthy individuals with sinus bradycardia and determine whether there was a significant vagal component to sinus bradycardia. Forty-three healthy adults with normal sinus rhythm and 25 healthy adults with sinus bradycardia had an electrocardiogram recorded for 20 minutes, from which HRV indices were calculated. Results showed significant increases in SDNN (standard deviation of NN intervals) (P < 0.05), RMSDD (square root of the mean squared differences of successive NN intervals) (P < 0.05), and DFA32 (detrended fluctuation analysis) (P < 0.05) in bradycardic subjects compared with subjects with normal sinus rhythm. There were no significant differences in sympathetic frequency domain indices between the two groups. In conclusion, there were significant increases in total heart variability and increased parasympathetic drive in subjects with bradycardia. Clinically, bradycardia is likely to be cardioprotective in aging populations based upon these HRV findings.
%Z FOR Codes: 110201


%0 Journal Article
%~ PubMed
%A McLachan, C S
%A Taylor, C B
%A Li, Y
%A Willenberg, L
%A Matthews, S
%A Glass, P
%A Myburgh, J
%T Severe falciparum malaria patients transferred "late" to a high level ICU in India represents a difficult research capture point to comment on predictors of mortality and related organ dysfunction.
%B Singapore Medical Journal
%D 2010
%C Singapore
%I Singapore Medical Association
%V 51
%N 9
%P 752-753
%@ 0037-5675
%X 
%Z FOR Codes: 110310


%0 Journal Article
%A Slack, K
%A Billing, Robyn
%A Matthews, Slade
%A Allbutt, Haydn
%A Einstein, Rosemarie
%A Henderson, Jasmine
%T Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat
%B Parkinson''s Disease
%D 2010
%C United States
%I Sage - Hindawi Access to Research
%V 2010
%N 
%P 427810
%@ 2042-0080
%X 
%Z FOR Codes: 110201


%0 Journal Article
%A Mitchell, Sarah J
%A Murnion, Bridin Patricia
%A Matthews, Slade
%A Hilmer, Sarah
%T Compliance with Paracetamol Prescribing Policies at a Sydney Hospital
%B Journal of Pharmacy Practice and Research
%D 2009
%C Australia
%I Society of Hospital Pharmacists of Australia
%V 39
%N 2
%P 122-127
%@ 1445-937X
%X 
%Z FOR Codes: 111503


%0 Journal Article
%~ PubMed
%A Hilmer, Sarah N
%A Perera, Vidya
%A Mitchell, Sarah
%A Murnion, Bridin P
%A Dent, Jonathan
%A Bajorek, Beata
%A Matthews, Slade
%A Rolfson, Darryl B
%T The assessment of frailty in older people in acute care.
%B Australasian Journal on Ageing
%D 2009
%C Australia
%I Wiley-Blackwell Publishing Asia
%V 28
%N 4
%P 182-188
%@ 1741-6612
%X Aim: Develop a measure of frailty for older acute inpatients to be performed by non-geriatricians. Method: The Reported Edmonton Frail Scale (REFS) was adapted from the Edmonton Frail Scale for use with Australian acute inpatients. With acute patients aged over 70 years admitted to an Australian teaching hospital, we validated REFS against the Geriatrician''s Clinical Impression of Frailty (GCIF), measures of cognition, comorbidity and function, and assessed inter-rater reliability. Results: REFS was moderately correlated with GCIF (n = 105, R = 0.61, P < 0.01), Mini-Mental State Examination impairment (n = 61, R = 0.49, P < 0.001), Charlson Comorbidity Index (n = 59, R = 0.51, P < 0.001) and Katz Daily Living Scale (n = 59, R = 0.51, P < 0.001). Inter-rater reliability of REFS administered by two researchers without medical training was excellent (kappa = 0.84, n = 31). Conclusion: In this cohort of older acute inpatients, REFS is a valid, reliable test of frailty, and may be a valuable research tool to assess the impact of frailty on prognosis and response to therapy.
%Z FOR Codes: 110308


%0 Journal Article
%~ PubMed
%A Perera, Vidya
%A Bajorek, Beata V
%A Matthews, Slade
%A Hilmer, Sarah N
%T The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation.
%B Age and ageing
%D 2009
%C United Kingdom
%I Oxford University Press
%V 38
%N 2
%P 156-62
%@ 0002-0729
%X to investigate the impact of frailty on the utilisation of antithrombotics and on clinical outcomes in older people with atrial fibrillation (AF).
%Z FOR Codes: 110308


%0 Journal Article
%~ PubMed
%A Brancatisano, Anthony
%A Wahlroos, Sara
%A Matthews, Slade
%A Brancatisano, Roy
%T Gastric banding for the treatment of type 2 diabetes mellitus in morbidly obese.
%B Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
%D 2008
%C United States
%I Elsevier Inc.
%V 4
%N 3
%P 423-9
%@ 1550-7289
%X To assess the efficacy of the Swedish adjustable gastric band in the treatment of type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), and the metabolic syndrome (MS) in the morbidly obese.
%Z FOR Codes: 110323


%0 Journal Article
%~ PubMed
%A McLachlan, Craig S
%A Almsherqi, Zakaria
%A Deng, Yuru
%A Matthews, Slade
%A Mossop, Peter
%T Vitamin C and mitochondrial uncoupling protein in enhanced dobutamine myocardial contractility.
%B American Heart Journal
%D 2008
%C United States
%I Mosby
%V 155
%N 4
%P e29
%@ 0002-8703
%X 
%Z FOR Codes: 110302