Associate Professor Aaron Schindeler

Head, Bioengineering &
Molecular Medicine (BAMM) Laboratory, The Children's Hospital at Westmead
Associate Professor, School of Chemical and Biomolecular Engineering
Conjoint Associate Professor, The Children&rsquo
s Hospital at Westmead Clinical School

Telephone 02 98451451
Fax 02 98453078

Website Honours in Medical Sciences at Westmead

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Biographical details

A/Prof Schindeler heads the Bioengineering & Molecular Medicine laboratory at The Children’s Hospital at Westmead and holds academic positions in the faculties of Medicine & Health and Engineering & IT at the University of Sydney. He leads a multidisciplinary team of scientists, engineers, and medical and allied health professionals that tackle major clinical issues affecting children’s bone health. He has a strong research track record with 100+ peer-review publications and seven NHMRC project grants. He is a passionate mentor of junior researchers, with former students and postdoctoral researcher achieving leading roles in national and international research institutes.

A/Prof Schindeler has been working at The Children’s Hospital at Westmead since 2003, after completing his PhD at the Victor Chang Cardiac Research Institute.

Research interests

A/Prof Schindeler has a diverse range of research interests across the fields of medicine, health, and engineering. Key focus areas include the development of novel tools for functional genomics and gene therapy for bone fragility disorders; pharmaceutical modulation of bone healing; bone tissue engineering using novel biomaterials and 3D printing; and treating the musculoskeletal complications associated with Neurofibromatosis type 1.

“My research aims to target major problems affecting children’s health. To accomplish this, I am working to create new tools for understanding the mechanisms of disease and subsequent disease treatment. In some cases we are repurposing old drugs, in other cases we are designing new drugs as well as new gene editing strategies using technologies such as CRISPR.

“One example of the timeline of such research can be seen in the treatment of the genetic disease neurofibromatosis type I or NF1. Children with this condition have a broad range of complications, but my work has focused on those affecting muscle and bone. Together with my colleagues we found that other drugs used for treatment of non-unions combined with adult osteoporosis drugs could reduce the number of amputations seen in children with crippling bone non-unions. More recently, we found that specific over-the-counter dietary supplements were able to effectively treat muscle weakness in a preclinical model, and this work has now moved into clinical trials.

“Another exciting advance is how we are using CRISPR gene editing to develop functional genomics methods to identify causes of bone disease in hospital patients. However the real challenge will be to then find ways to repair these mutations. Recently we had a major advance, developing an adeno-associated viral vector system that specifically targets the bone and that can affect gene editing throughout the skeleton with a single injection. While there is a lot of work to be done before we can cure genetic bone diseases, this is a critical first step.”

Current research students

Project title Research student
Treating muscle weakness in Neurofibromatosis type 1 Emily VASILJEVSKI

Themes

Materials and structures; Reproductive, Maternal and Child Health

Keywords

Musculoskeletal diseases; Orthopaedics

Clinical Specialty

Paediatrics

Selected grants

2018

  • Optimising bone regeneration using advanced design and fabrication technologies; Zreiqat H, Little D, Li Q, Roohaniesfahani S, Schindeler A, Woodruff M; National Health and Medical Research Council (NHMRC)/Project Grants.

2016

  • Prevention and treatment of bone infection with CSA-90; Little D, Schindeler A, Isaacs D, Tagil M; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Pre-clinical validation of a novel implant for bone tissue engineering; Little D, Cooper-White J, Ruys A, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • The role of muscle and the application of muscle-cell therapies in bone repair; Little D, Schindeler A, Hamrick M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1); Little D, Alexander I, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT); Little D, Baldock P, Schindeler A, Alexander I; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • The role of muscle cells in bone repair; Little D, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Arab, M., Bahramian, B., Schindeler, A., Fathi, A., Valtchev, P., McConchie, R., Dehghani, F. (2019). A benign process for the recovery of solanesol from tomato leaf waste. Heliyon, 5, 1-17. [More Information]
  • Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), e1801307. [More Information]
  • Daly, S., Fathi, A., Bahramian, B., Manavi Tehrani, I., McClure, D., Valtchev, P., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). A green process for the purification of biodegradable poly(B-hydroxybutyrate). The Journal of Supercritical Fluids, 135, 84-90. [More Information]
  • Torabian, G., Bahramian, B., Zambon, A., Spilimbergo, S., Adil, Q., Schindeler, A., Valtchev, P., Dehghani, F. (2018). A hybrid process for increasing the shelf life of elderberry juice. The Journal of Supercritical Fluids, 140, 406-414. [More Information]
  • Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
  • Summers, M., Vasiljevski, E., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse. Molecular Genetics and Metabolism, 123(4), 518-525. [More Information]
  • Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [More Information]
  • Summers, M., Rupasinghe, T., Vasiljevski, E., Evesson, F., Mikulec, K., Peacock, L., Quinlan (nee Edwards), K., Cooper, S., Roessner, U., Stevenson, D., Little, D., Schindeler, A. (2018). Dietary intervention rescues myopathy associated with neurofibromatosis type 1. Human Molecular Genetics, 27(4), 577-588. [More Information]
  • Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
  • McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
  • Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(3), 930-936. [More Information]
  • Deo, N., El-Hoss, J., Kolind, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). JNK inhibitor CC-930 reduces fibrosis in a murine model of Nf1-deficient fracture repair. Journal of Applied Biomedicine, 16(4), 350-357. [More Information]
  • Vasiljevski, E., Summers, M., Little, D., Schindeler, A. (2018). Lipid storage myopathies: Current treatments and future directions. Progress In Lipid Research, 72, 1-17. [More Information]
  • Tarento, T., McClure, D., Vasiljevski, E., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). Microalgae as a source of vitamin K1. Algal Research, 36, 77-87. [More Information]
  • Schindeler, A., Mills, R., Bobyn, J., Little, D. (2018). Preclinical Models for Orthopedic Research and Bone Tissue Engineering. Journal of Orthopaedic Research, 36(3), 832-840. [More Information]
  • Naficy, S., Oveissi, F., Patrick, B., Schindeler, A., Dehghani, F. (2018). Printed, Flexible pH Sensor Hydrogels for Wet Environments. Advanced Materials Technologies, 3(11), 1-10. [More Information]
  • Morse, A., Schindeler, A., McDonald, M., Kneissel, M., Kramer, I., Little, D. (2018). Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of Bone and Mineral Research, 33(3), 486-498. [More Information]
  • McDonald, M., Morse, A., Birke, O., Yu, N., Mikulec, K., Peacock, L., Schindeler, A., Liu, M., Ke, H., Little, D. (2018). Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(4), 1106-1113. [More Information]
  • Manavi Tehrani, I., Fathi, A., Schindeler, A., Dehghani, F. (2018). Sustained Protein Release from a Core-Shell Drug Carrier System Comprised of Mesoporous Nanoparticles and an Injectable Hydrogel. Macromolecular Bioscience, 18(12), 1-9. [More Information]
  • Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
  • Yang, I., Gottliebsen, M., Martinkevich, P., Schindeler, A., Little, D. (2017). Guided Growth: Current Perspectives and Future Challenges. JBJS Reviews, 5(11), 1-12. [More Information]
  • Summers, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2017). Limitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscle. International Journal of Developmental Biology, 61(8-Sep), 531-536. [More Information]
  • Yu, N., Fathi, A., Murphy, C., Mikulec, K., Peacock, L., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2017). Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105B (1), 136-144. [More Information]
  • Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]
  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Murphy, C., Duffy, G., Schindeler, A., O'Brien, F. (2016). Effect of Collagen-Glycosaminoglycan Scaffold Pore Size on Matrix Mineralisation and Cellular Behaviour in Different Cell Types. Journal of Biomedical Materials Research A, 104(1), 291-304. [More Information]
  • Casanova, M., Herelle, J., Thomas, M., Softley, R., Schindeler, A., Little, D., Schneider, P., Muller, R. (2016). Effect of combined treatment with zoledronic acid and parathyroid hormone on mouse bone callus structure and composition. Bone, 92, 70-78. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]
  • Bobyn, J., Little, D., Gray, R., Schindeler, A. (2015). Animal Models of Scoliosis. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 33(4), 458-467. [More Information]
  • Ravarian, R., Murphy, C., Schindeler, A., Rawal, A., Hook, J., Dehghani, F. (2015). Bioactive poly(methyl methacrylate) for bone fixation. RSC Advances, 5(75), 60681-60690. [More Information]
  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Seime, T., Kolind, M., Mikulec, K., Summers, M., Cantrill, L., Little, D., Schindeler, A. (2015). Inducible cell labeling and lineage tracking during fracture repair. Development, Growth and Differentiation, 57(1), 10-23. [More Information]
  • Kolind, M., Bobyn, J., Matthews, B., Mikulec, K., Aiken, A., Little, D., Kalajzici, I., Schindeler, A. (2015). Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation. Bone, 81, 53-59. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
  • Murphy, C., Schindeler, A., Cantrill, L., Mikulec, K., Peacock, L., Little, D. (2015). PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats. Journal of Bone and Mineral Research, 30(6), 1022-1029. [More Information]
  • Summers, M., Quinlan (nee Edwards), K., Payne, J., Little, D., North, K., Schindeler, A. (2015). Skeletal muscle and motor deficits in Neurofibromatosis Type 1. Journal of Musculoskeletal and Neuronal Interactions, 15(2), 161-170.
  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • El-Hoss, J., Cheng, T., Carpenter, E., Sullivan, K., Deo, N., Mikulec, K., Little, D., Schindeler, A. (2014). A combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosis. Journal of Bone and Joint Surgery: American Volume, 96(14), 1-11. [More Information]
  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
  • Bobyn, J., Rasch, A., Kathy, M., Little, D., Schindeler, A. (2014). Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice. Journal of Orthopaedic Research, 32(8), 1090-1094. [More Information]
  • Morse, A., McDonald, M., Kelly, N., Melville, K., Schindeler, A., Kramer, I., Kneissel, M., Van Der Meulen, M., Little, D. (2014). Mechanical Load Increases in Bone Formation Via a Sclerostin-Independent Pathway. Journal of Bone and Mineral Research, 29(11), 2456-2467. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Casanova, M., Schindeler, A., Little, D., Muller, R., Schneider, P. (2014). Quantitative phenotyping of bone fracture repair: a review. BoneKEy Reports, 3, 1-8. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111. [More Information]
  • Plotkin, S., Albers, A., Babovic-Vuksanovic, D., Blakeley, J., Breakefield, X., Dunn, C., Evans, D., Fisher, M., Friedman, J., Giovannini, M., Schindeler, A., et al (2014). Update from the 2013 International Neurofibromatosis Conference. American Journal of Medical Genetics, Part A, 164A (12), 2969-2978. [More Information]
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience, 4E(7), 2647-2653. [More Information]
  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18. [More Information]
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics, Part A, 149(10), 2327-2338. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]
  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87B(2), 482-491. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]
  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]
  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

Conferences

  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.

2019

  • Arab, M., Bahramian, B., Schindeler, A., Fathi, A., Valtchev, P., McConchie, R., Dehghani, F. (2019). A benign process for the recovery of solanesol from tomato leaf waste. Heliyon, 5, 1-17. [More Information]
  • Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), e1801307. [More Information]

2018

  • Daly, S., Fathi, A., Bahramian, B., Manavi Tehrani, I., McClure, D., Valtchev, P., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). A green process for the purification of biodegradable poly(B-hydroxybutyrate). The Journal of Supercritical Fluids, 135, 84-90. [More Information]
  • Torabian, G., Bahramian, B., Zambon, A., Spilimbergo, S., Adil, Q., Schindeler, A., Valtchev, P., Dehghani, F. (2018). A hybrid process for increasing the shelf life of elderberry juice. The Journal of Supercritical Fluids, 140, 406-414. [More Information]
  • Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
  • Summers, M., Vasiljevski, E., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse. Molecular Genetics and Metabolism, 123(4), 518-525. [More Information]
  • Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [More Information]
  • Summers, M., Rupasinghe, T., Vasiljevski, E., Evesson, F., Mikulec, K., Peacock, L., Quinlan (nee Edwards), K., Cooper, S., Roessner, U., Stevenson, D., Little, D., Schindeler, A. (2018). Dietary intervention rescues myopathy associated with neurofibromatosis type 1. Human Molecular Genetics, 27(4), 577-588. [More Information]
  • Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
  • McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
  • Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(3), 930-936. [More Information]
  • Deo, N., El-Hoss, J., Kolind, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). JNK inhibitor CC-930 reduces fibrosis in a murine model of Nf1-deficient fracture repair. Journal of Applied Biomedicine, 16(4), 350-357. [More Information]
  • Vasiljevski, E., Summers, M., Little, D., Schindeler, A. (2018). Lipid storage myopathies: Current treatments and future directions. Progress In Lipid Research, 72, 1-17. [More Information]
  • Tarento, T., McClure, D., Vasiljevski, E., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). Microalgae as a source of vitamin K1. Algal Research, 36, 77-87. [More Information]
  • Schindeler, A., Mills, R., Bobyn, J., Little, D. (2018). Preclinical Models for Orthopedic Research and Bone Tissue Engineering. Journal of Orthopaedic Research, 36(3), 832-840. [More Information]
  • Naficy, S., Oveissi, F., Patrick, B., Schindeler, A., Dehghani, F. (2018). Printed, Flexible pH Sensor Hydrogels for Wet Environments. Advanced Materials Technologies, 3(11), 1-10. [More Information]
  • Morse, A., Schindeler, A., McDonald, M., Kneissel, M., Kramer, I., Little, D. (2018). Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of Bone and Mineral Research, 33(3), 486-498. [More Information]
  • McDonald, M., Morse, A., Birke, O., Yu, N., Mikulec, K., Peacock, L., Schindeler, A., Liu, M., Ke, H., Little, D. (2018). Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(4), 1106-1113. [More Information]
  • Manavi Tehrani, I., Fathi, A., Schindeler, A., Dehghani, F. (2018). Sustained Protein Release from a Core-Shell Drug Carrier System Comprised of Mesoporous Nanoparticles and an Injectable Hydrogel. Macromolecular Bioscience, 18(12), 1-9. [More Information]

2017

  • Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
  • Yang, I., Gottliebsen, M., Martinkevich, P., Schindeler, A., Little, D. (2017). Guided Growth: Current Perspectives and Future Challenges. JBJS Reviews, 5(11), 1-12. [More Information]
  • Summers, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2017). Limitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscle. International Journal of Developmental Biology, 61(8-Sep), 531-536. [More Information]
  • Yu, N., Fathi, A., Murphy, C., Mikulec, K., Peacock, L., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2017). Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105B (1), 136-144. [More Information]
  • Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]

2016

  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Murphy, C., Duffy, G., Schindeler, A., O'Brien, F. (2016). Effect of Collagen-Glycosaminoglycan Scaffold Pore Size on Matrix Mineralisation and Cellular Behaviour in Different Cell Types. Journal of Biomedical Materials Research A, 104(1), 291-304. [More Information]
  • Casanova, M., Herelle, J., Thomas, M., Softley, R., Schindeler, A., Little, D., Schneider, P., Muller, R. (2016). Effect of combined treatment with zoledronic acid and parathyroid hormone on mouse bone callus structure and composition. Bone, 92, 70-78. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]

2015

  • Bobyn, J., Little, D., Gray, R., Schindeler, A. (2015). Animal Models of Scoliosis. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 33(4), 458-467. [More Information]
  • Ravarian, R., Murphy, C., Schindeler, A., Rawal, A., Hook, J., Dehghani, F. (2015). Bioactive poly(methyl methacrylate) for bone fixation. RSC Advances, 5(75), 60681-60690. [More Information]
  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Seime, T., Kolind, M., Mikulec, K., Summers, M., Cantrill, L., Little, D., Schindeler, A. (2015). Inducible cell labeling and lineage tracking during fracture repair. Development, Growth and Differentiation, 57(1), 10-23. [More Information]
  • Kolind, M., Bobyn, J., Matthews, B., Mikulec, K., Aiken, A., Little, D., Kalajzici, I., Schindeler, A. (2015). Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation. Bone, 81, 53-59. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
  • Murphy, C., Schindeler, A., Cantrill, L., Mikulec, K., Peacock, L., Little, D. (2015). PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats. Journal of Bone and Mineral Research, 30(6), 1022-1029. [More Information]
  • Summers, M., Quinlan (nee Edwards), K., Payne, J., Little, D., North, K., Schindeler, A. (2015). Skeletal muscle and motor deficits in Neurofibromatosis Type 1. Journal of Musculoskeletal and Neuronal Interactions, 15(2), 161-170.

2014

  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • El-Hoss, J., Cheng, T., Carpenter, E., Sullivan, K., Deo, N., Mikulec, K., Little, D., Schindeler, A. (2014). A combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosis. Journal of Bone and Joint Surgery: American Volume, 96(14), 1-11. [More Information]
  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
  • Bobyn, J., Rasch, A., Kathy, M., Little, D., Schindeler, A. (2014). Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice. Journal of Orthopaedic Research, 32(8), 1090-1094. [More Information]
  • Morse, A., McDonald, M., Kelly, N., Melville, K., Schindeler, A., Kramer, I., Kneissel, M., Van Der Meulen, M., Little, D. (2014). Mechanical Load Increases in Bone Formation Via a Sclerostin-Independent Pathway. Journal of Bone and Mineral Research, 29(11), 2456-2467. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Casanova, M., Schindeler, A., Little, D., Muller, R., Schneider, P. (2014). Quantitative phenotyping of bone fracture repair: a review. BoneKEy Reports, 3, 1-8. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111. [More Information]
  • Plotkin, S., Albers, A., Babovic-Vuksanovic, D., Blakeley, J., Breakefield, X., Dunn, C., Evans, D., Fisher, M., Friedman, J., Giovannini, M., Schindeler, A., et al (2014). Update from the 2013 International Neurofibromatosis Conference. American Journal of Medical Genetics, Part A, 164A (12), 2969-2978. [More Information]

2013

  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]

2012

  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience, 4E(7), 2647-2653. [More Information]

2011

  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18. [More Information]
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]

2010

  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]

2009

  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics, Part A, 149(10), 2327-2338. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

2008

  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87B(2), 482-491. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]

2007

  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]

2006

  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]

2005

  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

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