Dr Aaron Schindeler

Senior Lecturer
Paediatrics & Child Health, Children's Hospital, Westmead

Telephone 02 98451451
Fax 02 98453078

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Selected grants

2012

  • Pre-clinical validation of a novel implant for bone tissue engineering; Little D, Cooper-White J, Ruys A, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1); Little D, Alexander I, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of muscle and the application of muscle-cell therapies in bone repair; Little D, Schindeler A, Hamrick M; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT); Little D, Baldock P, Schindeler A, Alexander I; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • The role of muscle cells in bone repair; Little D, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111.
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PLoS One, 7(7), 1-17. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience (Elite Edition), 4E(7), 2647-2653. [More Information]
  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18.
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics. Part A, 149(10), 2327-2338. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]
  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B(2), 482-491. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]
  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]
  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

Conferences

  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.

2014

  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111.

2013

  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]

2012

  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PLoS One, 7(7), 1-17. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience (Elite Edition), 4E(7), 2647-2653. [More Information]

2011

  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18.
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]

2010

  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]

2009

  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics. Part A, 149(10), 2327-2338. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

2008

  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B(2), 482-491. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]

2007

  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]

2006

  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]

2005

  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

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