Dr Aisling McMahon

Senior Research Fellow
Medicine, Concord Clinical School

Telephone 02 97679160
Fax 02 97679101

Map

Selected grants

2014

  • EVOS® FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.

2011

  • MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA; Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • ICD100 Intensified MyoCam CCD Video Camera + Controller IMGACQ IonOptix Digital Image acquisition software FCS2 Micro-Perfusion Pump+ Micro-Perfusion pump Rod Mounting Clamp; North K, Gunning P, Winlaw D, McMahon A, Thomas S, Butler T; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Book Chapters

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care?, (pp. 39-64). India: Transworld Research Network.
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.

Journals

  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Benson, V., McMahon, A., Khachigian, L., Lowe, H. (2013). Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction. International Journal of Cardiology, 168(2), 1679-1680. [More Information]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
  • Groebler, L., Wang, X., Kim, H., Shanu, A., Hossain, F., McMahon, A., Witting, P. (2012). Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free Radical Biology and Medicine, 52(9), 1918-1928. [More Information]
  • Bhindi, R., Fahmy, R., McMahon, A., Khachigian, L., Lowe, H. (2012). Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. Journal of Pathology, 227(3), 157-164. [More Information]
  • Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
  • Kim, H., Shanu, A., Wood, S., Parry, S., McGee-Collett, M., McMahon, A., Witting, P. (2011). Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radical Research, 45(9), 1000-1012. [More Information]
  • Hing, A., Watson, A., Hicks, M., Gao, L., Faddy, S., McMahon, A., Kesteven, S., Wilson, M., Jansz, P., Feneley, M., et al (2009). Combining cariporide with glyceryl trinitrate optimizes cardiac preservation during porcine heart transplantation. American Journal Of Transplantation, 9(9), 2048-9056. [More Information]
  • Egan, J., Butler, T., Graf, F., Au, C., McMahon, A., North, K., Winlaw, D. (2009). Dysfunction induced by ischemia versus edema: does edema matter? The Journal of Thoracic and Cardiovascular Surgery, 138(1), 141-147. [More Information]
  • Walters, K., McTavish, K., Seneviratne, M., Jimenez, M., McMahon, A., Allan, C., Salamonsen, L., Handelsman, D. (2009). Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function. Endocrinology, 150(7), 3274-3282. [More Information]
  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]
  • Benson, V., McMahon, A., Lowe, H. (2007). ICAM-1 in acute myocardial infarction: a potential therapeutic target. Current Molecular Medicine, 7(2), 219-227. [More Information]
  • Benson, V., McMahon, A., Lowe, H. (2007). sICAM-1 measurements are independent of processing method and sampling site in patients with coronary artery disease. Journal of Thrombosis and Thrombolysis, 24(3), 307-8. [More Information]
  • McMahon, A., Naqvi, R., Hurst, M., Raine, A., Macleod, K. (2006). Diastolic dysfunction and abnormality of the Na+/Ca2+ exchanger in single uremic cardiac myocytes. Kidney International, 69(5), 846-851. [More Information]
  • Akbar, A., Bhindi, R., McMahon, A., Brieger, D., Kritharides, L., Lowe, H. (2006). Distal protection in cardiovascular medicine: Current status. American Heart Journal, 152(2), 207-216. [More Information]
  • McMahon, A., Hong Duong, T., Brieger, D., Witting, P. (2006). Is there potential for antioxidants to enhance thrombolysis therapy in patients with ischemic stroke? Future Cardiology, 2, 659-665.
  • Bhindi, R., Witting, P., McMahon, A., Khachigian, L., Lowe, H. (2006). Rat models of myocardial infarction. Pathogenetic insights and clinical relevance. Thrombosis and Haemostasis, 96(5), 602-610. [More Information]
  • McMahon, A., Kritharides, L., Lowe, H. (2005). Animal models of atherosclerosis progression: current concepts. Cardiovascular and Haematological Disorders, 5(6), 433-40. [More Information]
  • Nikolova, V., Leimena, C., McMahon, A., Tan, J., Chandar, S., Jogia, D., Kesteven, S., Michalicek, J., Otway, R., Verheyen, F., Feneley, M., et al (2004). Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice. Journal of Clinical Investigation, 113(3), 357-369.

2014

  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]

2013

  • Benson, V., McMahon, A., Khachigian, L., Lowe, H. (2013). Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction. International Journal of Cardiology, 168(2), 1679-1680. [More Information]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]

2012

  • Groebler, L., Wang, X., Kim, H., Shanu, A., Hossain, F., McMahon, A., Witting, P. (2012). Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free Radical Biology and Medicine, 52(9), 1918-1928. [More Information]
  • Bhindi, R., Fahmy, R., McMahon, A., Khachigian, L., Lowe, H. (2012). Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. Journal of Pathology, 227(3), 157-164. [More Information]
  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.

2011

  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care?, (pp. 39-64). India: Transworld Research Network.
  • Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
  • Kim, H., Shanu, A., Wood, S., Parry, S., McGee-Collett, M., McMahon, A., Witting, P. (2011). Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radical Research, 45(9), 1000-1012. [More Information]

2010

  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.

2009

  • Hing, A., Watson, A., Hicks, M., Gao, L., Faddy, S., McMahon, A., Kesteven, S., Wilson, M., Jansz, P., Feneley, M., et al (2009). Combining cariporide with glyceryl trinitrate optimizes cardiac preservation during porcine heart transplantation. American Journal Of Transplantation, 9(9), 2048-9056. [More Information]
  • Egan, J., Butler, T., Graf, F., Au, C., McMahon, A., North, K., Winlaw, D. (2009). Dysfunction induced by ischemia versus edema: does edema matter? The Journal of Thoracic and Cardiovascular Surgery, 138(1), 141-147. [More Information]
  • Walters, K., McTavish, K., Seneviratne, M., Jimenez, M., McMahon, A., Allan, C., Salamonsen, L., Handelsman, D. (2009). Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function. Endocrinology, 150(7), 3274-3282. [More Information]

2008

  • McMahon, A., Zreiqat, H., Lowe, H. (2008). Carotid artery stenting in the Zucker rat: a novel, potentially 'diabetes-specific' model of in-stent restenosis. Diabetes and Vascular Disease Research, 5(2), 145-146. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]

2007

  • Benson, V., McMahon, A., Lowe, H. (2007). ICAM-1 in acute myocardial infarction: a potential therapeutic target. Current Molecular Medicine, 7(2), 219-227. [More Information]
  • Benson, V., McMahon, A., Lowe, H. (2007). sICAM-1 measurements are independent of processing method and sampling site in patients with coronary artery disease. Journal of Thrombosis and Thrombolysis, 24(3), 307-8. [More Information]

2006

  • McMahon, A., Naqvi, R., Hurst, M., Raine, A., Macleod, K. (2006). Diastolic dysfunction and abnormality of the Na+/Ca2+ exchanger in single uremic cardiac myocytes. Kidney International, 69(5), 846-851. [More Information]
  • Akbar, A., Bhindi, R., McMahon, A., Brieger, D., Kritharides, L., Lowe, H. (2006). Distal protection in cardiovascular medicine: Current status. American Heart Journal, 152(2), 207-216. [More Information]
  • McMahon, A., Hong Duong, T., Brieger, D., Witting, P. (2006). Is there potential for antioxidants to enhance thrombolysis therapy in patients with ischemic stroke? Future Cardiology, 2, 659-665.
  • Bhindi, R., Witting, P., McMahon, A., Khachigian, L., Lowe, H. (2006). Rat models of myocardial infarction. Pathogenetic insights and clinical relevance. Thrombosis and Haemostasis, 96(5), 602-610. [More Information]

2005

  • McMahon, A., Kritharides, L., Lowe, H. (2005). Animal models of atherosclerosis progression: current concepts. Cardiovascular and Haematological Disorders, 5(6), 433-40. [More Information]

2004

  • Nikolova, V., Leimena, C., McMahon, A., Tan, J., Chandar, S., Jogia, D., Kesteven, S., Michalicek, J., Otway, R., Verheyen, F., Feneley, M., et al (2004). Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice. Journal of Clinical Investigation, 113(3), 357-369.

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