Dr Alessandra Warren

Research Fellow
Medicine, Concord Clinical School

Telephone +61 2 9767 5953

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Selected publications

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Book Chapters

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.

Journals

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PloS One, 7(9), 1-9. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
  • Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]
  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]
  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.

2014

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]

2013

  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]

2012

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PloS One, 7(9), 1-9. [More Information]

2011

  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]

2010

  • Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]
  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.

2008

  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]

2007

  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]

2006

  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]

2005

  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.

2004

  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.

2003

  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]

2002

  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.

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