Associate Professor Alexandra Sharland

Associate Professor
Surgery, Central Clinical School

Telephone +61 2 9351 2897 or +61 2 9515 5416
Fax +61 2 9036 7083

Map

Research interests

Basic and translational research in transplantation

Selected grants

2014

  • Gene therapy for transplantation tolerance - exploratory studies; Sharland A; DVC Research/Bridging Support Grant.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Liver-directed MHC gene transfer for the induction of transplantation tolerance; from proof of principle to a robust and clinically-applicable strategy.; Sharland A, Bowen D, Bishop A; RPA Transplant Institute/Research Support.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Gene therapy approaches to minimising ischaemia-reperfusion injury and transplantation rejection; Sharland A, Bishop A; Perpetual Trustees Charitable Trusts/Research Support.
  • Strategies to achieve kidney transplant tolerance in a clinically-relevant model; Sharland A, Chadban S, Bishop A, Wu H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • no title on file; Sharland A, Habib M.
  • MICROSEARCH FOUNDATION OF AUSTRALIA; Bishop A, Sharland A; Perpetual Trustees Charitable Trusts/Research Support.
  • Breaking down the barriers to transplantation tolerance; Sharland A, Chadban S, Bishop A, Wu H; Heart Foundation of Australia/Grants-in-Aid.
  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Breaking down the barriers to Transplantation Tolerance; Sharland A; DVC Research/Thompson Fellowships.

2009

  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Kidney transplantation: Improving outcomes.; Alexander S, Bishop A, Sharland A; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop A, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho J, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role of tryptophan metabolism in liver transplant tolerance and rejection; Bishop A, Hall B, McCaughan G, Sharland A, Alexander I, Earl J, Hall B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Liquid and chemical handling equipment; Bishop A, Chadban S, Sharland A, Allen R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.

2006

  • Interplay between innate and adaptive immunity in kidney allograft rejection; Chadban S, Wu H, Sharland A; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Collaborative facility for gene measurement and expression; Bishop A, Sharland A, Chadban S, Allen R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Cooled gradient palm cycler and rotor-shake genie; Bishop A, Sharland A, Allen R, Gorrell M, Chadban S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D; Sharland A; Roche Organ Transplant Research Foundation (ROTRF)/Research Grant.
  • High Speed Centrifuge For Dna Preparation; Sharland A; Clive & Vera Ramaciotti Foundation/General Grants.

2004

  • An integrated approach to application of novel developments in basic transplantation research to cli; Chadban S, Hennessy A, Allen R, McCaughan G, Bishop A, Sharland A, Eris J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Basic mechanism of spontaneous tolerance of liver allografts in a rat model; Wang C, Bishop A, McCaughan G, Rasko J, Sharland A; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Strategies to overcome human anti-pig NK cell-mediated cytoxity; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Sharland, A. (2012). Pancreatic beta-cell failure in the pathogenesis of type 1 diabetes. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 70-86). Sydney, Australia: Sydney University Press.

Journals

  • Wang, Z., Wang, C., Cunningham, E., Allen, R., Sharland, A., Bishop, A. (2014). Optimized method for ureteric reconstruction in a mouse kidney transplant model. ANZ Journal of Surgery, 84(6), 481-485. [More Information]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Cunningham, E., Sharland, A., Bishop, A. (2013). Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect? Clinical & Developmental Immunology, 2013, 1-9. [More Information]
  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Ganbold, A., Andersen, S., Tay, S., Cunningham, E., Ilie, V., Krishnan, S., Wang, C., McCaughan, G., Sharland, A., Bishop, A. (2012). Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model. Transplant Immunology, 27(2-3), 89-94. [More Information]
  • Cubitt, J., Pennington, T., Wang, C., Allen, R., Bishop, A., Sharland, A. (2012). Reliable and reproducible murine models for commonly used abdominal plastic surgical flaps. Journal of Reconstructive Microsurgery, 28(3), 161-166. [More Information]
  • Bishop, A., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011). Approaching the promise of operational tolerance in clinical transplantation. Transplantation, 91(10), 1065-1074. [More Information]
  • Bishop, A., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011). Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation, 92(8), e39-e39. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Chen, G., Wu, H., Ma, J., Chadban, S., Sharland, A. (2011). Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 26(12), 3873-3881. [More Information]
  • Wang, C., Tay, S., Tran, G., Hodgkinson, S., Allen, R., Hall, B., McCaughan, G., Sharland, A., Bishop, A. (2010). Donor IL-4 treatment induces alternatively activated liver macrophages and IDO-Expressing NK cells and promotes rat liver allograft acceptance. Transplant Immunology, 22(3-4), 172-178. [More Information]
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010). Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery? Discovery Medicine, 9(49), 519-527. [More Information]
  • Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology (Baltimore Md.), 50(6), 2037-40. [More Information]
  • Laurence, J., McCaughan, G., Logan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Gene therapy in transplantation. Transplantation Reviews, 23(3), 159-170. [More Information]
  • Obeidy, P., Sharland, A. (2009). Molecules in Focus: NKG2D and its ligands. The International Journal of Biochemistry and Cell Biology, 41(12), 2364-2367. [More Information]
  • Laurence, J., Wang, C., Zheng, M., Cunningham, S., Earl, J., Tay, S., Allen, R., McCaughan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation, 15(2), 233-241. [More Information]
  • Laurence, J., Wang, C., Park, E., Buchanan, A., Clouston, A., Allen, R., McCaughan, G., Bishop, A., Sharland, A. (2008). Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation, 85(9), 1357-1361. [More Information]
  • Lam, V., Taylor, C., Laurence, J., Wang, C., Sharland, A., McCaughan, G., Hodgkinson, S., Allen, R., Hall, B., Bishop, A. (2008). Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: Effect on foxp3 and cytokine expression and graft infiltration. Transplant Immunology, 19(1), 20-24. [More Information]
  • Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
  • Sharland, A. (2008). The inhaled route to improved liver function. Hepatology (Baltimore Md.), 47(2), 755-756. [More Information]
  • Tovey, E., Kemp, A., Almqvist, C., Sharland, A., Marks, G. (2007). Do immune responses to inhaled skin flakes modulate the expression of allergic disease? Clinical and Experimental Allergy, 37(8), 1199-1203. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • Sadeghi, A., Xiao, C., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2006). Cytokine common gamma chain expression and its relation to liver transplant tolerance and rejection in a rat model. Immunology and Cell Biology, 84(1), A30-A30.
  • Cordoba, S., Wang, C., Williams, R., Li, J., Smit, L., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2006). Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction. Liver Transplantation, 12(4), 636-643. [More Information]
  • Lam, V., Laurence, J., Sharland, A., McCaughan, G., Hodgkinson, S., Hall, B., Allen, R., Bishop, A. (2006). Induction of long-term cardiac allograft survival using anti-lymphocyte antibodies in the rat model. Immunology and Cell Biology, 84(1), A27-A27.
  • Benseler, V., Cordoba, S., Wang, C., Zvolynska, A., Sharland, A., Shlitt, H., McCaughan, G., Allen, R., Bishop, A. (2006). Microarray analysis of spontaneously tolerant compared to rejecting rat liver allografts. Immunology and Cell Biology, 84(1), A31-A32.
  • Laurence, J., Wang, C., Park, T., Vis, A., Allen, R., Bishop, A., Sharland, A. (2006). Role of indoleamine dioxygenase (IDO) in rat models of transplantation rejection and tolerance. Immunology and Cell Biology, 84(1), A30-A30.
  • Cordoba, S., Wang, C., Sharland, A., McCaughan, G., Allen, R., Bishop, A. (2006). Transcriptomics of tolerant and rejecting renal allografts. Immunology and Cell Biology, 84(1), A2-A2.
  • Cordoba, S., Wang, C., Williams, R., Sharland, A., McCaughan, G., Bishop, A. (2005). Meta-analysis of transcriptional profiles in three models of transplant tolerance identifies the STAT-1/IRF-1 pathway. Immunology and Cell Biology, 83(4), A31-A31.
  • Cordoba, S., Wang, C., Williams, R., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2005). The STAT-1/IRF-1 signalling pathway and complement cascade are increased in rat liver transplant tolerance identified by meta-analysis of high-throughput screening techniques. Hepatology, 42(4 S1), 314A-314A.
  • Yan, Y., Putten, K., Bowen, D., Painter, D., Kohar, J., Sharland, A., McCaughan, G., Bishop, A. (2002). Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with TH2 cytokine expression in long-term accepted grafts. Transplantation, 73(7), 1123-1130.
  • Bishop, A., Wang, C., Sharland, A., McCaughan, G. (2002). Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunology and Cell Biology, 80(1), 93-100.
  • Yan, Y., Shastry, S., Richards, C., Wang, C., Bowen, D., Sharland, A., Painter, D., McCaughan, G., Bishop, A. (2001). Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology, 166, 5258-5264.
  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

Conferences

  • Tran, P., Hing, A., Hicks, M., Gao, L., Faddy, S., Kesteven, S., Stewart, G., Macdonald, P., Sharland, A. (2006). Expression of NKG2D ligands following brain-death. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Hing, A., Hicks, M., Gao, L., Faddy, S., Tran, P., Kwan, J., Kesteven, S., Sharland, A., Stewart, G., MacDonald, P. (2006). Hormone resuscitation of the brain dead donor and its effects on transplantable organs: Early results. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Tran, P., Christiansen, D., Sandrin, M., Sharland, A. (2005). Identification and characterisation of porcine ligands for the human NK cell activating receptor NKG2D. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2014

  • Wang, Z., Wang, C., Cunningham, E., Allen, R., Sharland, A., Bishop, A. (2014). Optimized method for ureteric reconstruction in a mouse kidney transplant model. ANZ Journal of Surgery, 84(6), 481-485. [More Information]

2013

  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Cunningham, E., Sharland, A., Bishop, A. (2013). Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect? Clinical & Developmental Immunology, 2013, 1-9. [More Information]

2012

  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Ganbold, A., Andersen, S., Tay, S., Cunningham, E., Ilie, V., Krishnan, S., Wang, C., McCaughan, G., Sharland, A., Bishop, A. (2012). Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model. Transplant Immunology, 27(2-3), 89-94. [More Information]
  • Sharland, A. (2012). Pancreatic beta-cell failure in the pathogenesis of type 1 diabetes. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 70-86). Sydney, Australia: Sydney University Press.
  • Cubitt, J., Pennington, T., Wang, C., Allen, R., Bishop, A., Sharland, A. (2012). Reliable and reproducible murine models for commonly used abdominal plastic surgical flaps. Journal of Reconstructive Microsurgery, 28(3), 161-166. [More Information]

2011

  • Bishop, A., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011). Approaching the promise of operational tolerance in clinical transplantation. Transplantation, 91(10), 1065-1074. [More Information]
  • Bishop, A., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011). Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation, 92(8), e39-e39. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Chen, G., Wu, H., Ma, J., Chadban, S., Sharland, A. (2011). Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 26(12), 3873-3881. [More Information]

2010

  • Wang, C., Tay, S., Tran, G., Hodgkinson, S., Allen, R., Hall, B., McCaughan, G., Sharland, A., Bishop, A. (2010). Donor IL-4 treatment induces alternatively activated liver macrophages and IDO-Expressing NK cells and promotes rat liver allograft acceptance. Transplant Immunology, 22(3-4), 172-178. [More Information]
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010). Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery? Discovery Medicine, 9(49), 519-527. [More Information]

2009

  • Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology (Baltimore Md.), 50(6), 2037-40. [More Information]
  • Laurence, J., McCaughan, G., Logan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Gene therapy in transplantation. Transplantation Reviews, 23(3), 159-170. [More Information]
  • Obeidy, P., Sharland, A. (2009). Molecules in Focus: NKG2D and its ligands. The International Journal of Biochemistry and Cell Biology, 41(12), 2364-2367. [More Information]
  • Laurence, J., Wang, C., Zheng, M., Cunningham, S., Earl, J., Tay, S., Allen, R., McCaughan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation, 15(2), 233-241. [More Information]

2008

  • Laurence, J., Wang, C., Park, E., Buchanan, A., Clouston, A., Allen, R., McCaughan, G., Bishop, A., Sharland, A. (2008). Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation, 85(9), 1357-1361. [More Information]
  • Lam, V., Taylor, C., Laurence, J., Wang, C., Sharland, A., McCaughan, G., Hodgkinson, S., Allen, R., Hall, B., Bishop, A. (2008). Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: Effect on foxp3 and cytokine expression and graft infiltration. Transplant Immunology, 19(1), 20-24. [More Information]
  • Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
  • Sharland, A. (2008). The inhaled route to improved liver function. Hepatology (Baltimore Md.), 47(2), 755-756. [More Information]

2007

  • Tovey, E., Kemp, A., Almqvist, C., Sharland, A., Marks, G. (2007). Do immune responses to inhaled skin flakes modulate the expression of allergic disease? Clinical and Experimental Allergy, 37(8), 1199-1203. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]

2006

  • Sadeghi, A., Xiao, C., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2006). Cytokine common gamma chain expression and its relation to liver transplant tolerance and rejection in a rat model. Immunology and Cell Biology, 84(1), A30-A30.
  • Tran, P., Hing, A., Hicks, M., Gao, L., Faddy, S., Kesteven, S., Stewart, G., Macdonald, P., Sharland, A. (2006). Expression of NKG2D ligands following brain-death. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Cordoba, S., Wang, C., Williams, R., Li, J., Smit, L., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2006). Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction. Liver Transplantation, 12(4), 636-643. [More Information]
  • Hing, A., Hicks, M., Gao, L., Faddy, S., Tran, P., Kwan, J., Kesteven, S., Sharland, A., Stewart, G., MacDonald, P. (2006). Hormone resuscitation of the brain dead donor and its effects on transplantable organs: Early results. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Lam, V., Laurence, J., Sharland, A., McCaughan, G., Hodgkinson, S., Hall, B., Allen, R., Bishop, A. (2006). Induction of long-term cardiac allograft survival using anti-lymphocyte antibodies in the rat model. Immunology and Cell Biology, 84(1), A27-A27.
  • Benseler, V., Cordoba, S., Wang, C., Zvolynska, A., Sharland, A., Shlitt, H., McCaughan, G., Allen, R., Bishop, A. (2006). Microarray analysis of spontaneously tolerant compared to rejecting rat liver allografts. Immunology and Cell Biology, 84(1), A31-A32.
  • Laurence, J., Wang, C., Park, T., Vis, A., Allen, R., Bishop, A., Sharland, A. (2006). Role of indoleamine dioxygenase (IDO) in rat models of transplantation rejection and tolerance. Immunology and Cell Biology, 84(1), A30-A30.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Cordoba, S., Wang, C., Sharland, A., McCaughan, G., Allen, R., Bishop, A. (2006). Transcriptomics of tolerant and rejecting renal allografts. Immunology and Cell Biology, 84(1), A2-A2.

2005

  • Tran, P., Christiansen, D., Sandrin, M., Sharland, A. (2005). Identification and characterisation of porcine ligands for the human NK cell activating receptor NKG2D. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Cordoba, S., Wang, C., Williams, R., Sharland, A., McCaughan, G., Bishop, A. (2005). Meta-analysis of transcriptional profiles in three models of transplant tolerance identifies the STAT-1/IRF-1 pathway. Immunology and Cell Biology, 83(4), A31-A31.
  • Cordoba, S., Wang, C., Williams, R., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2005). The STAT-1/IRF-1 signalling pathway and complement cascade are increased in rat liver transplant tolerance identified by meta-analysis of high-throughput screening techniques. Hepatology, 42(4 S1), 314A-314A.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2002

  • Yan, Y., Putten, K., Bowen, D., Painter, D., Kohar, J., Sharland, A., McCaughan, G., Bishop, A. (2002). Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with TH2 cytokine expression in long-term accepted grafts. Transplantation, 73(7), 1123-1130.
  • Bishop, A., Wang, C., Sharland, A., McCaughan, G. (2002). Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunology and Cell Biology, 80(1), 93-100.

2001

  • Yan, Y., Shastry, S., Richards, C., Wang, C., Bowen, D., Sharland, A., Painter, D., McCaughan, G., Bishop, A. (2001). Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology, 166, 5258-5264.

2000

  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

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